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Protein

Protein lin-7 homolog A

Gene

LIN7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.1 Publication

GO - Molecular functioni

  • L27 domain binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111052-MONOMER.
ReactomeiR-HSA-212676. Dopamine Neurotransmitter Release Cycle.
R-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-7 homolog A
Short name:
Lin-7A
Short name:
hLin-7
Alternative name(s):
Mammalian lin-seven protein 1
Short name:
MALS-1
Tax interaction protein 33
Short name:
TIP-33
Vertebrate lin-7 homolog 1
Short name:
Veli-1
Gene namesi
Name:LIN7A
Synonyms:MALS1, VELI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17787. LIN7A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi8825.
OpenTargetsiENSG00000111052.
PharmGKBiPA134881936.

Polymorphism and mutation databases

BioMutaiLIN7A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896231 – 233Protein lin-7 homolog AAdd BLAST233

Proteomic databases

EPDiO14910.
MaxQBiO14910.
PaxDbiO14910.
PeptideAtlasiO14910.
PRIDEiO14910.

PTM databases

iPTMnetiO14910.
PhosphoSitePlusiO14910.

Expressioni

Tissue specificityi

Expressed in brain, testis, kidney, placenta and liver.1 Publication

Gene expression databases

BgeeiENSG00000111052.
CleanExiHS_LIN7A.
ExpressionAtlasiO14910. baseline and differential.
GenevisibleiO14910. HS.

Organism-specific databases

HPAiCAB034258.

Interactioni

Subunit structurei

Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4, GRIN2B and MARCH11 as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CASKO149366EBI-2513988,EBI-1215506
FAM9BQ8IZU03EBI-2513988,EBI-10175124
GOLGA2Q083793EBI-2513988,EBI-618309
MPP2Q14168-23EBI-2513988,EBI-10181752
MPP3Q133684EBI-2513988,EBI-716157
MPP5Q8N3R97EBI-2513988,EBI-2513978
MPP6Q9NZW53EBI-2513988,EBI-2683764
MPP7Q5T2T15EBI-2513988,EBI-2514004
NOTCH2NLQ7Z3S93EBI-2513988,EBI-945833
ZYXQ159423EBI-2513988,EBI-444225

GO - Molecular functioni

  • L27 domain binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114352. 31 interactors.
IntActiO14910. 25 interactors.
MINTiMINT-1539466.
STRINGi9606.ENSP00000447488.

Structurei

3D structure databases

ProteinModelPortaliO14910.
SMRiO14910.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 80L27PROSITE-ProRule annotationAdd BLAST56
Domaini108 – 190PDZPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 28Kinase interacting siteAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi210 – 213Poly-Gln4
Compositional biasi217 – 229Poly-GlnAdd BLAST13

Domaini

The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.1 Publication
The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.1 Publication
The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.By similarity

Sequence similaritiesi

Belongs to the lin-7 family.Curated
Contains 1 L27 domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3550. Eukaryota.
ENOG410XP5T. LUCA.
GeneTreeiENSGT00550000074582.
HOGENOMiHOG000285929.
HOVERGENiHBG052329.
InParanoidiO14910.
KOiK19931.
OMAiVPGHKLQ.
OrthoDBiEOG091G0PR4.
PhylomeDBiO14910.
TreeFamiTF316850.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR014775. L27_C.
IPR004172. L27_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF02828. L27. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00569. L27. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKPSVTSAP TADMATLTVV QPLTLDRDVA RAIELLEKLQ ESGEVPVHKL
60 70 80 90 100
QSLKKVLQSE FCTAIREVYQ YMHETITVNG CPEFRARATA KATVAAFAAS
110 120 130 140 150
EGHSHPRVVE LPKTDEGLGF NVMGGKEQNS PIYISRIIPG GVAERHGGLK
160 170 180 190 200
RGDQLLSVNG VSVEGEHHEK AVELLKAAKD SVKLVVRYTP KVLEEMEARF
210 220 230
EKLRTARRRQ QQQLLIQQQQ QQQQQQTQQN HMS
Length:233
Mass (Da):25,997
Last modified:May 1, 1999 - v2
Checksum:iD8D05EF16A93BE7B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157S → P in CAG28608 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087693 mRNA. Translation: AAC78481.1.
AF173081 mRNA. Translation: AAD48500.1.
CR407680 mRNA. Translation: CAG28608.1.
AK315321 mRNA. Translation: BAG37724.1.
BC099921 mRNA. Translation: AAH99921.1.
BC118609 mRNA. Translation: AAI18610.1.
BC122561 mRNA. Translation: AAI22562.1.
AF028826 mRNA. Translation: AAB84251.1.
CCDSiCCDS9021.1.
RefSeqiNP_004655.1. NM_004664.3.
UniGeneiHs.144333.
Hs.586760.

Genome annotation databases

EnsembliENST00000552864; ENSP00000447488; ENSG00000111052.
GeneIDi8825.
KEGGihsa:8825.
UCSCiuc001szi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087693 mRNA. Translation: AAC78481.1.
AF173081 mRNA. Translation: AAD48500.1.
CR407680 mRNA. Translation: CAG28608.1.
AK315321 mRNA. Translation: BAG37724.1.
BC099921 mRNA. Translation: AAH99921.1.
BC118609 mRNA. Translation: AAI18610.1.
BC122561 mRNA. Translation: AAI22562.1.
AF028826 mRNA. Translation: AAB84251.1.
CCDSiCCDS9021.1.
RefSeqiNP_004655.1. NM_004664.3.
UniGeneiHs.144333.
Hs.586760.

3D structure databases

ProteinModelPortaliO14910.
SMRiO14910.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114352. 31 interactors.
IntActiO14910. 25 interactors.
MINTiMINT-1539466.
STRINGi9606.ENSP00000447488.

PTM databases

iPTMnetiO14910.
PhosphoSitePlusiO14910.

Polymorphism and mutation databases

BioMutaiLIN7A.

Proteomic databases

EPDiO14910.
MaxQBiO14910.
PaxDbiO14910.
PeptideAtlasiO14910.
PRIDEiO14910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000552864; ENSP00000447488; ENSG00000111052.
GeneIDi8825.
KEGGihsa:8825.
UCSCiuc001szi.4. human.

Organism-specific databases

CTDi8825.
DisGeNETi8825.
GeneCardsiLIN7A.
HGNCiHGNC:17787. LIN7A.
HPAiCAB034258.
MIMi603380. gene.
neXtProtiNX_O14910.
OpenTargetsiENSG00000111052.
PharmGKBiPA134881936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3550. Eukaryota.
ENOG410XP5T. LUCA.
GeneTreeiENSGT00550000074582.
HOGENOMiHOG000285929.
HOVERGENiHBG052329.
InParanoidiO14910.
KOiK19931.
OMAiVPGHKLQ.
OrthoDBiEOG091G0PR4.
PhylomeDBiO14910.
TreeFamiTF316850.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111052-MONOMER.
ReactomeiR-HSA-212676. Dopamine Neurotransmitter Release Cycle.
R-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

GeneWikiiLIN7A.
GenomeRNAii8825.
PROiO14910.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111052.
CleanExiHS_LIN7A.
ExpressionAtlasiO14910. baseline and differential.
GenevisibleiO14910. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR014775. L27_C.
IPR004172. L27_dom.
IPR001478. PDZ.
[Graphical view]
PfamiPF02828. L27. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00569. L27. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIN7A_HUMAN
AccessioniPrimary (citable) accession number: O14910
Secondary accession number(s): A4FTY3
, Q147W1, Q6LES3, Q7LDS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.