Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O14910

- LIN7A_HUMAN

UniProt

O14910 - LIN7A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein lin-7 homolog A

Gene

LIN7A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.1 Publication

GO - Molecular functioni

  1. L27 domain binding Source: BHF-UCL

GO - Biological processi

  1. exocytosis Source: ProtInc
  2. inner ear development Source: Ensembl
  3. neurotransmitter secretion Source: Ensembl
  4. protein complex assembly Source: ProtInc
  5. protein transport Source: UniProtKB-KW
  6. synaptic vesicle transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-7 homolog A
Short name:
Lin-7A
Short name:
hLin-7
Alternative name(s):
Mammalian lin-seven protein 1
Short name:
MALS-1
Tax interaction protein 33
Short name:
TIP-33
Vertebrate lin-7 homolog 1
Short name:
Veli-1
Gene namesi
Name:LIN7A
Synonyms:MALS1, VELI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17787. LIN7A.

Subcellular locationi

Cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Basolateral cell membrane 1 Publication; Peripheral membrane protein 1 Publication. Cell junction By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity; Peripheral membrane protein By similarity. Cell junctiontight junction By similarity. Cell junctionsynapsesynaptosome By similarity
Note: Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells.By similarity

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. neuron projection Source: UniProtKB-KW
  4. postsynaptic membrane Source: UniProtKB-KW
  5. tight junction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134881936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Protein lin-7 homolog APRO_0000189623Add
BLAST

Proteomic databases

MaxQBiO14910.
PaxDbiO14910.
PRIDEiO14910.

PTM databases

PhosphoSiteiO14910.

Expressioni

Tissue specificityi

Expressed in brain, testis, kidney, placenta and liver.1 Publication

Gene expression databases

BgeeiO14910.
CleanExiHS_LIN7A.
ExpressionAtlasiO14910. baseline and differential.
GenevestigatoriO14910.

Interactioni

Subunit structurei

Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4, GRIN2B and MARCH11 as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CASKO149363EBI-2513988,EBI-1215506

Protein-protein interaction databases

BioGridi114352. 14 interactions.
IntActiO14910. 18 interactions.
MINTiMINT-1539466.
STRINGi9606.ENSP00000261203.

Structurei

3D structure databases

ProteinModelPortaliO14910.
SMRiO14910. Positions 21-79, 108-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 8056L27PROSITE-ProRule annotationAdd
BLAST
Domaini108 – 19083PDZPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi14 – 2815Kinase interacting siteAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi210 – 2134Poly-Gln
Compositional biasi217 – 22913Poly-GlnAdd
BLAST

Domaini

The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.1 Publication
The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.1 Publication
The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.By similarity

Sequence similaritiesi

Belongs to the lin-7 family.Curated
Contains 1 L27 domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG320117.
GeneTreeiENSGT00550000074582.
HOGENOMiHOG000285929.
HOVERGENiHBG052329.
InParanoidiO14910.
OMAiPGHKLQS.
OrthoDBiEOG75MVXG.
PhylomeDBiO14910.
TreeFamiTF316850.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR004172. L27.
IPR014775. L27_C.
IPR017365. Lin-7_homologue.
IPR001478. PDZ.
[Graphical view]
PfamiPF02828. L27. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038039. Lin-7_homologue. 1 hit.
SMARTiSM00569. L27. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51022. L27. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14910-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKPSVTSAP TADMATLTVV QPLTLDRDVA RAIELLEKLQ ESGEVPVHKL
60 70 80 90 100
QSLKKVLQSE FCTAIREVYQ YMHETITVNG CPEFRARATA KATVAAFAAS
110 120 130 140 150
EGHSHPRVVE LPKTDEGLGF NVMGGKEQNS PIYISRIIPG GVAERHGGLK
160 170 180 190 200
RGDQLLSVNG VSVEGEHHEK AVELLKAAKD SVKLVVRYTP KVLEEMEARF
210 220 230
EKLRTARRRQ QQQLLIQQQQ QQQQQQTQQN HMS
Length:233
Mass (Da):25,997
Last modified:May 1, 1999 - v2
Checksum:iD8D05EF16A93BE7B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571S → P in CAG28608. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087693 mRNA. Translation: AAC78481.1.
AF173081 mRNA. Translation: AAD48500.1.
CR407680 mRNA. Translation: CAG28608.1.
AK315321 mRNA. Translation: BAG37724.1.
BC099921 mRNA. Translation: AAH99921.1.
BC118609 mRNA. Translation: AAI18610.1.
BC122561 mRNA. Translation: AAI22562.1.
AF028826 mRNA. Translation: AAB84251.1.
CCDSiCCDS9021.1.
RefSeqiNP_004655.1. NM_004664.2.
UniGeneiHs.144333.

Genome annotation databases

EnsembliENST00000552864; ENSP00000447488; ENSG00000111052.
GeneIDi8825.
KEGGihsa:8825.
UCSCiuc001szj.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087693 mRNA. Translation: AAC78481.1 .
AF173081 mRNA. Translation: AAD48500.1 .
CR407680 mRNA. Translation: CAG28608.1 .
AK315321 mRNA. Translation: BAG37724.1 .
BC099921 mRNA. Translation: AAH99921.1 .
BC118609 mRNA. Translation: AAI18610.1 .
BC122561 mRNA. Translation: AAI22562.1 .
AF028826 mRNA. Translation: AAB84251.1 .
CCDSi CCDS9021.1.
RefSeqi NP_004655.1. NM_004664.2.
UniGenei Hs.144333.

3D structure databases

ProteinModelPortali O14910.
SMRi O14910. Positions 21-79, 108-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114352. 14 interactions.
IntActi O14910. 18 interactions.
MINTi MINT-1539466.
STRINGi 9606.ENSP00000261203.

PTM databases

PhosphoSitei O14910.

Proteomic databases

MaxQBi O14910.
PaxDbi O14910.
PRIDEi O14910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000552864 ; ENSP00000447488 ; ENSG00000111052 .
GeneIDi 8825.
KEGGi hsa:8825.
UCSCi uc001szj.1. human.

Organism-specific databases

CTDi 8825.
GeneCardsi GC12M081166.
HGNCi HGNC:17787. LIN7A.
MIMi 603380. gene.
neXtProti NX_O14910.
PharmGKBi PA134881936.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320117.
GeneTreei ENSGT00550000074582.
HOGENOMi HOG000285929.
HOVERGENi HBG052329.
InParanoidi O14910.
OMAi PGHKLQS.
OrthoDBi EOG75MVXG.
PhylomeDBi O14910.
TreeFami TF316850.

Miscellaneous databases

GeneWikii LIN7A.
GenomeRNAii 8825.
NextBioi 33110.
PROi O14910.
SOURCEi Search...

Gene expression databases

Bgeei O14910.
CleanExi HS_LIN7A.
ExpressionAtlasi O14910. baseline and differential.
Genevestigatori O14910.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR004172. L27.
IPR014775. L27_C.
IPR017365. Lin-7_homologue.
IPR001478. PDZ.
[Graphical view ]
Pfami PF02828. L27. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PIRSFi PIRSF038039. Lin-7_homologue. 1 hit.
SMARTi SM00569. L27. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS51022. L27. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain."
    Butz S., Okamoto M., Suedhof T.C.
    Cell 94:773-782(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH APBA1; CASK; DLG2 AND DLG3.
    Tissue: Testis.
  2. "Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex."
    Jo K., Derin R., Li M., Bredt D.S.
    J. Neurosci. 19:4189-4199(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Corpus callosum.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  6. "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins."
    Rousset R., Fabre S., Desbois C., Bantignies F., Jalinot P.
    Oncogene 16:643-654(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-233, INTERACTION WITH VIRAL ONCOPROTEIN TAX.
  7. "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain."
    Tseng T.-C., Marfatia S.M., Bryant P.J., Pack S., Zhuang Z., O'Brien J.E., Lin L., Hanada T., Chishti A.H.
    Biochim. Biophys. Acta 1518:249-259(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MPP6, TISSUE SPECIFICITY.
  8. "Polar expression of ErbB-2/HER2 in epithelia. Bimodal regulation by Lin-7."
    Shelly M., Mosesson Y., Citri A., Lavi S., Zwang Y., Melamed-Book N., Aroeti B., Yarden Y.
    Dev. Cell 5:475-486(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH EGFR; ERBB2; ERBB3 AND ERBB4, FUNCTION, DOMAIN.
  9. "The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions."
    Bohl J., Brimer N., Lyons C., Vande Pol S.B.
    J. Biol. Chem. 282:9392-9400(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DLG1 AND MPP7.

Entry informationi

Entry nameiLIN7A_HUMAN
AccessioniPrimary (citable) accession number: O14910
Secondary accession number(s): A4FTY3
, Q147W1, Q6LES3, Q7LDS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3