Reviewed, UniProtKB/Swiss-Prot O14908 (GIPC1_HUMAN)

Names and origin

Protein names

Recommended name:
    PDZ domain-containing protein GIPC1
Alternative name(s):
    RGS19-interacting protein 1
    GAIP C-terminus-interacting protein
    RGS-GAIP-interacting protein
    Tax interaction protein 2
      Short name=TIP-2

Gene names

Name:	GIPC1
Synonyms:	C19orf3, GIPC, RGS19IP1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in G protein-linked signaling.
Subunit structure	Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C By similarity. Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain.
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the GIPC family. Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Ref.1 Non-traceable author statement. Source: UniProtKB endothelial cell migration Inferred from sequence or structural similarity. Source: UniProtKB glutamate secretion Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB protein targeting Inferred from sequence or structural similarity. Source: UniProtKB regulation of protein stability Inferred from sequence or structural similarity. Source: UniProtKB regulation of synaptic plasticity Inferred from sequence or structural similarity. Source: UniProtKB synaptic transmission Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cell cortex Inferred from direct assay. Source: UniProtKB cytosol Inferred from sequence or structural similarity. Source: UniProtKB dendritic shaft Inferred from sequence or structural similarity. Source: UniProtKB dendritic spine Inferred from sequence or structural similarity. Source: UniProtKB membrane fraction Ref.1 Inferred from direct assay. Source: UniProtKB soluble fraction Ref.1 Inferred from direct assay. Source: UniProtKB synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB vesicle membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	actin binding Inferred from sequence or structural similarity. Source: UniProtKB myosin binding Inferred from sequence or structural similarity. Source: UniProtKB protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB receptor binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GEMIN4	P57678	1	EBI-373132,EBI-356700
MARS	P56192	1	EBI-373132,EBI-355848
MCM7	P33993	1	EBI-373132,EBI-355924
MMS19	Q96T76	1	EBI-373132,EBI-1044169
MYO1C	O00159	1	EBI-373132,EBI-350423
MYO6	Q9UM54	1	EBI-373132,EBI-350606
NUP93	Q8N1F7	1	EBI-373132,EBI-1042703
PDXDC1	Q6P996	1	EBI-373132,EBI-1049813
SH3BP4	Q9P0V3	1	EBI-373132,EBI-1049513
TAGLN	Q01995	1	EBI-373132,EBI-1054248
ZNF408	Q9H9D4	1	EBI-373132,EBI-347633

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	PDZ domain-containing protein GIPC1		PRO_0000087492
Regions
	Domain	133 – 213	81	PDZ
	Compositional bias	36 – 42	7	Poly-Gly
	Compositional bias	48 – 52	5	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	O14908-1 [UniParc]. Last modified August 1, 1999. Version 2. Checksum: AA980A4B907E3FD9	FASTA	333	36,049
	10 20 30 40 50 60 MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP PPALRPRLVF 70 80 90 100 110 120 HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC TLNTHKVDMD KLLGGQIGLE 130 140 150 160 170 180 DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIH LISVGDMIEA 190 200 210 220 230 240 INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR 250 260 270 280 290 300 GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL 310 320 330 AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP." De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G. Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998) [PubMed: 9770488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RGS19. Tissue: Pituitary.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Muscle.
[3]	"The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins." Rousset R., Fabre S., Desbois C., Bantignies F., Jalinot P. Oncogene 16:643-654(1998) [PubMed: 9482110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 78-333, INTERACTION WITH HTLV-I TAX.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF089816 mRNA. Translation: AAC67548.1. BC000410 mRNA. Translation: AAH00410.1. BC004226 mRNA. Translation: AAH04226.2. BC012810 mRNA. Translation: AAH12810.1. BC016169 mRNA. Translation: AAH16169.1. AF028824 mRNA. Translation: AAB84249.1.
IPI	IPI00024705.
RefSeq	NP_005707.1. NP_974196.1. NP_974197.1. NP_974198.1. NP_974199.1. NP_974223.1.
UniGene	Hs.655012
3D structure databases
HSSP	HSSP built from PDB template 1QAV based on UniProtKB P29476.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14908. 15 interactions.
PTM databases
PhosphoSite	O14908.
Proteomic databases
PeptideAtlas	O14908.
PRIDE	O14908.
Genome annotation databases
Ensembl	ENSG00000123159. Homo sapiens. [Contig view]
GeneID	10755.
KEGG	hsa:10755.
UCSC	uc002myt.1. human.
Organism-specific databases
GeneCards	GC19M014450.
H-InvDB	HIX0021049.
HGNC	HGNC:1226. GIPC1.
MIM	605072. gene.
PharmGKB	PA34371.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O14908.
HOVERGEN	O14908.
OMA	O14908. DHIQLIS.
Enzyme and pathway databases
Pathway_Interaction_DB	trkrpathway. Neurotrophic factor-mediated Trk receptor signaling. syndecan_4_pathway. Syndecan-4-mediated signaling events.
Gene expression databases
ArrayExpress	O14908.
Bgee	O14908.
CleanEx	HS_GIPC1.
GermOnline	ENSG00000123159. Homo sapiens.
Family and domain databases
InterPro	IPR001478. PDZ/DHR/GLGF. IPR017379. UCP038083_PDZ. [Graphical view]
Pfam	PF00595. PDZ. 1 hit. [Graphical view]
PIRSF	PIRSF038083. UCP038083_GIPC. 1 hit.
SMART	SM00228. PDZ. 1 hit. [Graphical view]
PROSITE	PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40843.
SOURCE	Search...

Entry information

Entry name

GIPC1_HUMAN

Accession

Primary (citable) accession number: O14908
Secondary accession number(s): Q9BTC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	August 1, 1999
Last modified:	July 7, 2009
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)