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Protein

PDZ domain-containing protein GIPC1

Gene

GIPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in G protein-linked signaling.

GO - Molecular functioni

  • actin binding Source: BHF-UCL
  • cadherin binding Source: BHF-UCL
  • myosin binding Source: BHF-UCL
  • PDZ domain binding Source: Ensembl
  • protein homodimerization activity Source: BHF-UCL
  • receptor binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

SignaLinkiO14908.

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC1
Alternative name(s):
GAIP C-terminus-interacting protein
RGS-GAIP-interacting protein
RGS19-interacting protein 1
Synectin
Tax interaction protein 2
Short name:
TIP-2
Gene namesi
Name:GIPC1
Synonyms:C19orf3, GIPC, RGS19IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000123159.15.
HGNCiHGNC:1226. GIPC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10755.
OpenTargetsiENSG00000123159.
PharmGKBiPA34371.

Polymorphism and mutation databases

BioMutaiGIPC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874921 – 333PDZ domain-containing protein GIPC1Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei242PhosphothreonineCombined sources1
Modified residuei247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14908.
MaxQBiO14908.
PaxDbiO14908.
PeptideAtlasiO14908.
PRIDEiO14908.

PTM databases

iPTMnetiO14908.
PhosphoSitePlusiO14908.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000123159.
CleanExiHS_GIPC1.
ExpressionAtlasiO14908. baseline and differential.
GenevisibleiO14908. HS.

Organism-specific databases

HPAiHPA043958.
HPA061786.

Interactioni

Subunit structurei

Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: BHF-UCL
  • cadherin binding Source: BHF-UCL
  • myosin binding Source: BHF-UCL
  • PDZ domain binding Source: Ensembl
  • protein homodimerization activity Source: BHF-UCL
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115978. 39 interactors.
CORUMiO14908.
DIPiDIP-31142N.
IntActiO14908. 18 interactors.
MINTiMINT-5003771.
STRINGi9606.ENSP00000340698.

Structurei

3D structure databases

ProteinModelPortaliO14908.
SMRiO14908.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 213PDZPROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 42Poly-Gly7
Compositional biasi48 – 52Poly-Pro5

Sequence similaritiesi

Belongs to the GIPC family.Curated

Phylogenomic databases

eggNOGiKOG3938. Eukaryota.
ENOG410XQ87. LUCA.
GeneTreeiENSGT00390000003420.
HOGENOMiHOG000293347.
HOVERGENiHBG000898.
InParanoidiO14908.
KOiK20056.
OMAiMIESING.
OrthoDBiEOG091G0D3X.
PhylomeDBiO14908.
TreeFamiTF313878.

Family and domain databases

InterProiView protein in InterPro
IPR017379. GIPC1/2/3.
IPR001478. PDZ.
IPR036034. PDZ_sf.
PANTHERiPTHR12259. PTHR12259. 1 hit.
PfamiView protein in Pfam
PF00595. PDZ. 1 hit.
PIRSFiPIRSF038083. UCP038083_GIPC. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiView protein in PROSITE
PS50106. PDZ. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14908-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP
60 70 80 90 100
PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC
110 120 130 140 150
TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN
160 170 180 190 200
GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE
210 220 230 240 250
LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP
260 270 280 290 300
ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL
310 320 330
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
Length:333
Mass (Da):36,049
Last modified:August 1, 1999 - v2
Checksum:iAA980A4B907E3FD9
GO
Isoform 2 (identifier: O14908-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:236
Mass (Da):26,072
Checksum:iD1DEC176B95C53B1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442961 – 97Missing in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089816 mRNA. Translation: AAC67548.1.
AK290948 mRNA. Translation: BAF83637.1.
AC008569 Genomic DNA. No translation available.
AC012318 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84423.1.
CH471106 Genomic DNA. Translation: EAW84425.1.
BC000410 mRNA. Translation: AAH00410.1.
BC004226 mRNA. Translation: AAH04226.2.
BC012810 mRNA. Translation: AAH12810.1.
BC016169 mRNA. Translation: AAH16169.1.
AF028824 mRNA. Translation: AAB84249.1.
CCDSiCCDS12310.1. [O14908-1]
CCDS12311.1. [O14908-2]
RefSeqiNP_005707.1. NM_005716.3. [O14908-1]
NP_974197.1. NM_202468.2. [O14908-1]
NP_974198.1. NM_202469.2. [O14908-2]
NP_974199.1. NM_202470.2. [O14908-1]
NP_974223.1. NM_202494.2. [O14908-2]
XP_016881636.1. XM_017026147.1. [O14908-1]
XP_016881637.1. XM_017026148.1. [O14908-2]
UniGeneiHs.655012.
Hs.741240.

Genome annotation databases

EnsembliENST00000345425; ENSP00000340698; ENSG00000123159. [O14908-1]
ENST00000393028; ENSP00000376748; ENSG00000123159. [O14908-2]
ENST00000393033; ENSP00000376753; ENSG00000123159. [O14908-1]
ENST00000586027; ENSP00000466747; ENSG00000123159. [O14908-1]
ENST00000591349; ENSP00000467077; ENSG00000123159. [O14908-2]
GeneIDi10755.
KEGGihsa:10755.
UCSCiuc002myt.5. human. [O14908-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGIPC1_HUMAN
AccessioniPrimary (citable) accession number: O14908
Secondary accession number(s): A8K4I3, A8MZG3, Q9BTC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 1, 1999
Last modified: October 25, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families