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O14908

- GIPC1_HUMAN

UniProt

O14908 - GIPC1_HUMAN

Protein

PDZ domain-containing protein GIPC1

Gene

GIPC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (01 Aug 1999)
      Previous versions | rss
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    Functioni

    May be involved in G protein-linked signaling.

    GO - Molecular functioni

    1. actin binding Source: BHF-UCL
    2. myosin binding Source: BHF-UCL
    3. protein binding Source: UniProtKB
    4. protein homodimerization activity Source: BHF-UCL
    5. receptor binding Source: UniProtKB

    GO - Biological processi

    1. endothelial cell migration Source: BHF-UCL
    2. glutamate secretion Source: BHF-UCL
    3. G-protein coupled receptor signaling pathway Source: UniProtKB
    4. negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
    5. positive regulation of cytokinesis Source: UniProt
    6. positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
    7. protein targeting Source: BHF-UCL
    8. regulation of protein stability Source: BHF-UCL
    9. regulation of synaptic plasticity Source: BHF-UCL
    10. synaptic transmission Source: BHF-UCL

    Enzyme and pathway databases

    SignaLinkiO14908.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PDZ domain-containing protein GIPC1
    Alternative name(s):
    GAIP C-terminus-interacting protein
    RGS-GAIP-interacting protein
    RGS19-interacting protein 1
    Synectin
    Tax interaction protein 2
    Short name:
    TIP-2
    Gene namesi
    Name:GIPC1
    Synonyms:C19orf3, GIPC, RGS19IP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1226. GIPC1.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border Source: Ensembl
    2. cell cortex Source: UniProtKB
    3. cytoplasm Source: BHF-UCL
    4. cytoplasmic membrane-bounded vesicle Source: UniProtKB
    5. cytosol Source: UniProtKB
    6. dendritic shaft Source: BHF-UCL
    7. dendritic spine Source: BHF-UCL
    8. endocytic vesicle Source: Ensembl
    9. extracellular vesicular exosome Source: UniProt
    10. membrane Source: UniProtKB
    11. synaptic vesicle Source: BHF-UCL
    12. vesicle membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34371.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333PDZ domain-containing protein GIPC1PRO_0000087492Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei225 – 2251Phosphoserine1 Publication
    Modified residuei232 – 2321Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO14908.
    PaxDbiO14908.
    PeptideAtlasiO14908.
    PRIDEiO14908.

    PTM databases

    PhosphoSiteiO14908.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiO14908.
    BgeeiO14908.
    CleanExiHS_GIPC1.
    GenevestigatoriO14908.

    Organism-specific databases

    HPAiHPA043958.

    Interactioni

    Subunit structurei

    Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C By similarity. Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TGFBR3Q031673EBI-373132,EBI-2852679
    TYRP1P176433EBI-373132,EBI-7900408

    Protein-protein interaction databases

    BioGridi115978. 33 interactions.
    IntActiO14908. 10 interactions.
    MINTiMINT-5003771.
    STRINGi9606.ENSP00000340698.

    Structurei

    3D structure databases

    ProteinModelPortaliO14908.
    SMRiO14908. Positions 127-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 21381PDZPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi36 – 427Poly-Gly
    Compositional biasi48 – 525Poly-Pro

    Sequence similaritiesi

    Belongs to the GIPC family.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG313930.
    HOGENOMiHOG000293347.
    HOVERGENiHBG000898.
    InParanoidiO14908.
    OMAiTHKVDME.
    OrthoDBiEOG793B86.
    PhylomeDBiO14908.
    TreeFamiTF313878.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR017379. UCP038083_PDZ.
    [Graphical view]
    PfamiPF00595. PDZ. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038083. UCP038083_GIPC. 1 hit.
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14908-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP    50
    PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC 100
    TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN 150
    GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE 200
    LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP 250
    ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL 300
    AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY 333
    Length:333
    Mass (Da):36,049
    Last modified:August 1, 1999 - v2
    Checksum:iAA980A4B907E3FD9
    GO
    Isoform 2 (identifier: O14908-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-97: Missing.

    Show »
    Length:236
    Mass (Da):26,072
    Checksum:iD1DEC176B95C53B1
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9797Missing in isoform 2. 1 PublicationVSP_044296Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089816 mRNA. Translation: AAC67548.1.
    AK290948 mRNA. Translation: BAF83637.1.
    AC008569 Genomic DNA. No translation available.
    AC012318 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84423.1.
    CH471106 Genomic DNA. Translation: EAW84425.1.
    BC000410 mRNA. Translation: AAH00410.1.
    BC004226 mRNA. Translation: AAH04226.2.
    BC012810 mRNA. Translation: AAH12810.1.
    BC016169 mRNA. Translation: AAH16169.1.
    AF028824 mRNA. Translation: AAB84249.1.
    CCDSiCCDS12310.1. [O14908-1]
    CCDS12311.1. [O14908-2]
    RefSeqiNP_005707.1. NM_005716.3. [O14908-1]
    NP_974197.1. NM_202468.2. [O14908-1]
    NP_974198.1. NM_202469.2. [O14908-2]
    NP_974199.1. NM_202470.2. [O14908-1]
    NP_974223.1. NM_202494.2. [O14908-2]
    UniGeneiHs.655012.
    Hs.741240.

    Genome annotation databases

    EnsembliENST00000345425; ENSP00000340698; ENSG00000123159. [O14908-1]
    ENST00000393028; ENSP00000376748; ENSG00000123159. [O14908-2]
    ENST00000393033; ENSP00000376753; ENSG00000123159. [O14908-1]
    ENST00000586027; ENSP00000466747; ENSG00000123159. [O14908-1]
    ENST00000591349; ENSP00000467077; ENSG00000123159. [O14908-2]
    GeneIDi10755.
    KEGGihsa:10755.
    UCSCiuc002myt.4. human. [O14908-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089816 mRNA. Translation: AAC67548.1 .
    AK290948 mRNA. Translation: BAF83637.1 .
    AC008569 Genomic DNA. No translation available.
    AC012318 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84423.1 .
    CH471106 Genomic DNA. Translation: EAW84425.1 .
    BC000410 mRNA. Translation: AAH00410.1 .
    BC004226 mRNA. Translation: AAH04226.2 .
    BC012810 mRNA. Translation: AAH12810.1 .
    BC016169 mRNA. Translation: AAH16169.1 .
    AF028824 mRNA. Translation: AAB84249.1 .
    CCDSi CCDS12310.1. [O14908-1 ]
    CCDS12311.1. [O14908-2 ]
    RefSeqi NP_005707.1. NM_005716.3. [O14908-1 ]
    NP_974197.1. NM_202468.2. [O14908-1 ]
    NP_974198.1. NM_202469.2. [O14908-2 ]
    NP_974199.1. NM_202470.2. [O14908-1 ]
    NP_974223.1. NM_202494.2. [O14908-2 ]
    UniGenei Hs.655012.
    Hs.741240.

    3D structure databases

    ProteinModelPortali O14908.
    SMRi O14908. Positions 127-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115978. 33 interactions.
    IntActi O14908. 10 interactions.
    MINTi MINT-5003771.
    STRINGi 9606.ENSP00000340698.

    PTM databases

    PhosphoSitei O14908.

    Proteomic databases

    MaxQBi O14908.
    PaxDbi O14908.
    PeptideAtlasi O14908.
    PRIDEi O14908.

    Protocols and materials databases

    DNASUi 10755.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345425 ; ENSP00000340698 ; ENSG00000123159 . [O14908-1 ]
    ENST00000393028 ; ENSP00000376748 ; ENSG00000123159 . [O14908-2 ]
    ENST00000393033 ; ENSP00000376753 ; ENSG00000123159 . [O14908-1 ]
    ENST00000586027 ; ENSP00000466747 ; ENSG00000123159 . [O14908-1 ]
    ENST00000591349 ; ENSP00000467077 ; ENSG00000123159 . [O14908-2 ]
    GeneIDi 10755.
    KEGGi hsa:10755.
    UCSCi uc002myt.4. human. [O14908-1 ]

    Organism-specific databases

    CTDi 10755.
    GeneCardsi GC19M014600.
    HGNCi HGNC:1226. GIPC1.
    HPAi HPA043958.
    MIMi 605072. gene.
    neXtProti NX_O14908.
    PharmGKBi PA34371.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313930.
    HOGENOMi HOG000293347.
    HOVERGENi HBG000898.
    InParanoidi O14908.
    OMAi THKVDME.
    OrthoDBi EOG793B86.
    PhylomeDBi O14908.
    TreeFami TF313878.

    Enzyme and pathway databases

    SignaLinki O14908.

    Miscellaneous databases

    ChiTaRSi GIPC1. human.
    GeneWikii GIPC1.
    GenomeRNAii 10755.
    NextBioi 40843.
    PROi O14908.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14908.
    Bgeei O14908.
    CleanExi HS_GIPC1.
    Genevestigatori O14908.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR017379. UCP038083_PDZ.
    [Graphical view ]
    Pfami PF00595. PDZ. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038083. UCP038083_GIPC. 1 hit.
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP."
      De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G.
      Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RGS19.
      Tissue: Pituitary.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Muscle.
    6. "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins."
      Rousset R., Fabre S., Desbois C., Bantignies F., Jalinot P.
      Oncogene 16:643-654(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 78-333 (ISOFORM 1/2), INTERACTION WITH HTLV-I TAX.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225 AND SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGIPC1_HUMAN
    AccessioniPrimary (citable) accession number: O14908
    Secondary accession number(s): A8K4I3, A8MZG3, Q9BTC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: August 1, 1999
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3