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O14908

- GIPC1_HUMAN

UniProt

O14908 - GIPC1_HUMAN

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Protein

PDZ domain-containing protein GIPC1

Gene

GIPC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in G protein-linked signaling.

GO - Molecular functioni

  1. actin binding Source: BHF-UCL
  2. myosin binding Source: BHF-UCL
  3. protein homodimerization activity Source: BHF-UCL
  4. receptor binding Source: UniProtKB

GO - Biological processi

  1. endothelial cell migration Source: BHF-UCL
  2. glutamate secretion Source: BHF-UCL
  3. G-protein coupled receptor signaling pathway Source: UniProtKB
  4. negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  5. positive regulation of cytokinesis Source: UniProt
  6. positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  7. protein targeting Source: BHF-UCL
  8. regulation of protein stability Source: BHF-UCL
  9. regulation of synaptic plasticity Source: BHF-UCL
  10. synaptic transmission Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiO14908.

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC1
Alternative name(s):
GAIP C-terminus-interacting protein
RGS-GAIP-interacting protein
RGS19-interacting protein 1
Synectin
Tax interaction protein 2
Short name:
TIP-2
Gene namesi
Name:GIPC1
Synonyms:C19orf3, GIPC, RGS19IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1226. GIPC1.

Subcellular locationi

GO - Cellular componenti

  1. brush border Source: Ensembl
  2. cell cortex Source: UniProtKB
  3. cytoplasm Source: BHF-UCL
  4. cytoplasmic membrane-bounded vesicle Source: UniProtKB
  5. cytosol Source: UniProtKB
  6. dendritic shaft Source: BHF-UCL
  7. dendritic spine Source: BHF-UCL
  8. endocytic vesicle Source: Ensembl
  9. extracellular vesicular exosome Source: UniProt
  10. membrane Source: UniProtKB
  11. synaptic vesicle Source: BHF-UCL
  12. vesicle membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333PDZ domain-containing protein GIPC1PRO_0000087492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei225 – 2251Phosphoserine1 Publication
Modified residuei232 – 2321Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14908.
PaxDbiO14908.
PeptideAtlasiO14908.
PRIDEiO14908.

PTM databases

PhosphoSiteiO14908.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiO14908.
CleanExiHS_GIPC1.
ExpressionAtlasiO14908. baseline.
GenevestigatoriO14908.

Organism-specific databases

HPAiHPA043958.

Interactioni

Subunit structurei

Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TGFBR3Q031673EBI-373132,EBI-2852679
TYRP1P176433EBI-373132,EBI-7900408

Protein-protein interaction databases

BioGridi115978. 33 interactions.
IntActiO14908. 10 interactions.
MINTiMINT-5003771.
STRINGi9606.ENSP00000340698.

Structurei

3D structure databases

ProteinModelPortaliO14908.
SMRiO14908. Positions 127-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 21381PDZPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 427Poly-Gly
Compositional biasi48 – 525Poly-Pro

Sequence similaritiesi

Belongs to the GIPC family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG313930.
GeneTreeiENSGT00390000003420.
HOGENOMiHOG000293347.
HOVERGENiHBG000898.
InParanoidiO14908.
OMAiTHKVDME.
OrthoDBiEOG793B86.
PhylomeDBiO14908.
TreeFamiTF313878.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017379. UCP038083_PDZ.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038083. UCP038083_GIPC. 1 hit.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14908-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP
60 70 80 90 100
PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC
110 120 130 140 150
TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN
160 170 180 190 200
GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE
210 220 230 240 250
LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP
260 270 280 290 300
ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL
310 320 330
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
Length:333
Mass (Da):36,049
Last modified:August 1, 1999 - v2
Checksum:iAA980A4B907E3FD9
GO
Isoform 2 (identifier: O14908-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:236
Mass (Da):26,072
Checksum:iD1DEC176B95C53B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797Missing in isoform 2. 1 PublicationVSP_044296Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089816 mRNA. Translation: AAC67548.1.
AK290948 mRNA. Translation: BAF83637.1.
AC008569 Genomic DNA. No translation available.
AC012318 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84423.1.
CH471106 Genomic DNA. Translation: EAW84425.1.
BC000410 mRNA. Translation: AAH00410.1.
BC004226 mRNA. Translation: AAH04226.2.
BC012810 mRNA. Translation: AAH12810.1.
BC016169 mRNA. Translation: AAH16169.1.
AF028824 mRNA. Translation: AAB84249.1.
CCDSiCCDS12310.1. [O14908-1]
CCDS12311.1. [O14908-2]
RefSeqiNP_005707.1. NM_005716.3. [O14908-1]
NP_974197.1. NM_202468.2. [O14908-1]
NP_974198.1. NM_202469.2. [O14908-2]
NP_974199.1. NM_202470.2. [O14908-1]
NP_974223.1. NM_202494.2. [O14908-2]
UniGeneiHs.655012.
Hs.741240.

Genome annotation databases

EnsembliENST00000345425; ENSP00000340698; ENSG00000123159. [O14908-1]
ENST00000393028; ENSP00000376748; ENSG00000123159. [O14908-2]
ENST00000393033; ENSP00000376753; ENSG00000123159. [O14908-1]
ENST00000586027; ENSP00000466747; ENSG00000123159. [O14908-1]
ENST00000591349; ENSP00000467077; ENSG00000123159. [O14908-2]
GeneIDi10755.
KEGGihsa:10755.
UCSCiuc002myt.4. human. [O14908-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF089816 mRNA. Translation: AAC67548.1 .
AK290948 mRNA. Translation: BAF83637.1 .
AC008569 Genomic DNA. No translation available.
AC012318 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84423.1 .
CH471106 Genomic DNA. Translation: EAW84425.1 .
BC000410 mRNA. Translation: AAH00410.1 .
BC004226 mRNA. Translation: AAH04226.2 .
BC012810 mRNA. Translation: AAH12810.1 .
BC016169 mRNA. Translation: AAH16169.1 .
AF028824 mRNA. Translation: AAB84249.1 .
CCDSi CCDS12310.1. [O14908-1 ]
CCDS12311.1. [O14908-2 ]
RefSeqi NP_005707.1. NM_005716.3. [O14908-1 ]
NP_974197.1. NM_202468.2. [O14908-1 ]
NP_974198.1. NM_202469.2. [O14908-2 ]
NP_974199.1. NM_202470.2. [O14908-1 ]
NP_974223.1. NM_202494.2. [O14908-2 ]
UniGenei Hs.655012.
Hs.741240.

3D structure databases

ProteinModelPortali O14908.
SMRi O14908. Positions 127-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115978. 33 interactions.
IntActi O14908. 10 interactions.
MINTi MINT-5003771.
STRINGi 9606.ENSP00000340698.

PTM databases

PhosphoSitei O14908.

Proteomic databases

MaxQBi O14908.
PaxDbi O14908.
PeptideAtlasi O14908.
PRIDEi O14908.

Protocols and materials databases

DNASUi 10755.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345425 ; ENSP00000340698 ; ENSG00000123159 . [O14908-1 ]
ENST00000393028 ; ENSP00000376748 ; ENSG00000123159 . [O14908-2 ]
ENST00000393033 ; ENSP00000376753 ; ENSG00000123159 . [O14908-1 ]
ENST00000586027 ; ENSP00000466747 ; ENSG00000123159 . [O14908-1 ]
ENST00000591349 ; ENSP00000467077 ; ENSG00000123159 . [O14908-2 ]
GeneIDi 10755.
KEGGi hsa:10755.
UCSCi uc002myt.4. human. [O14908-1 ]

Organism-specific databases

CTDi 10755.
GeneCardsi GC19M014600.
HGNCi HGNC:1226. GIPC1.
HPAi HPA043958.
MIMi 605072. gene.
neXtProti NX_O14908.
PharmGKBi PA34371.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313930.
GeneTreei ENSGT00390000003420.
HOGENOMi HOG000293347.
HOVERGENi HBG000898.
InParanoidi O14908.
OMAi THKVDME.
OrthoDBi EOG793B86.
PhylomeDBi O14908.
TreeFami TF313878.

Enzyme and pathway databases

SignaLinki O14908.

Miscellaneous databases

ChiTaRSi GIPC1. human.
GeneWikii GIPC1.
GenomeRNAii 10755.
NextBioi 40843.
PROi O14908.
SOURCEi Search...

Gene expression databases

Bgeei O14908.
CleanExi HS_GIPC1.
ExpressionAtlasi O14908. baseline.
Genevestigatori O14908.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
IPR017379. UCP038083_PDZ.
[Graphical view ]
Pfami PF00595. PDZ. 1 hit.
[Graphical view ]
PIRSFi PIRSF038083. UCP038083_GIPC. 1 hit.
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP."
    De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G.
    Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RGS19.
    Tissue: Pituitary.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Muscle.
  6. "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins."
    Rousset R., Fabre S., Desbois C., Bantignies F., Jalinot P.
    Oncogene 16:643-654(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 78-333 (ISOFORM 1/2), INTERACTION WITH HTLV-I TAX.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225 AND SER-232, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGIPC1_HUMAN
AccessioniPrimary (citable) accession number: O14908
Secondary accession number(s): A8K4I3, A8MZG3, Q9BTC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 1, 1999
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3