O14908 (GIPC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PDZ domain-containing protein GIPC1

Alternative name(s):
GAIP C-terminus-interacting protein
RGS-GAIP-interacting protein
RGS19-interacting protein 1
Tax interaction protein 2
Short name=TIP-2

Gene names

Name:	GIPC1
Synonyms:	C19orf3, GIPC, RGS19IP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in G protein-linked signaling.
Subunit structure	Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C By similarity. Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain. Ref.1 Ref.6
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the GIPC family. Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Non-traceable author statement Ref.1. Source: UniProtKB endothelial cell migration Inferred from sequence or structural similarity. Source: BHF-UCL glutamate secretion Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of proteasomal ubiquitin-dependent protein catabolic process Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL protein targeting Inferred from sequence or structural similarity. Source: BHF-UCL regulation of protein stability Inferred from sequence or structural similarity. Source: BHF-UCL regulation of synaptic plasticity Inferred from sequence or structural similarity. Source: BHF-UCL synaptic transmission Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	brush border Inferred from electronic annotation. Source: Compara cell cortex Inferred from direct assay PubMed 12857860. Source: UniProtKB cytosol Inferred from sequence or structural similarity. Source: UniProtKB cytosolic part Inferred from electronic annotation. Source: Compara dendritic shaft Inferred from sequence or structural similarity. Source: BHF-UCL dendritic spine Inferred from sequence or structural similarity. Source: BHF-UCL endocytic vesicle Inferred from electronic annotation. Source: Compara synaptic vesicle Inferred from sequence or structural similarity. Source: BHF-UCL vesicle membrane Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	actin binding Inferred from sequence or structural similarity. Source: BHF-UCL myosin binding Inferred from sequence or structural similarity. Source: BHF-UCL protein homodimerization activity Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14908-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14908-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	PDZ domain-containing protein GIPC1		PRO_0000087492
Regions
	Domain	133 – 213	81	PDZ
	Compositional bias	36 – 42	7	Poly-Gly
	Compositional bias	48 – 52	5	Poly-Pro
Amino acid modifications
	Modified residue	225	1	Phosphoserine Ref.8
	Modified residue	232	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 97	97	Missing in isoform 2.		VSP_044296

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1999. Version 2. Checksum: AA980A4B907E3FD9	FASTA	333	36,049
	10 20 30 40 50 60 MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP PPALRPRLVF 70 80 90 100 110 120 HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC TLNTHKVDMD KLLGGQIGLE 130 140 150 160 170 180 DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIH LISVGDMIEA 190 200 210 220 230 240 INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR 250 260 270 280 290 300 GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL 310 320 330 AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
	Isoform 2 [UniParc]. Checksum: D1DEC176B95C53B1	FASTA	236	26,072
	10 20 30 40 50 60 MFCTLNTHKV DMDKLLGGQI GLEDFIFAHV KGQRKEVEVF KSEDALGLTI TDNGAGYAFI 70 80 90 100 110 120 KRIKEGSVID HIHLISVGDM IEAINGQSLL GCRHYEVARL LKELPRGRTF TLKLTEPRKA 130 140 150 160 170 180 FDMISQRSAG GRPGSGPQLG TGRGTLRLRS RGPATVEDLP SAFEEKAIEK VDDLLESYMG 190 200 210 220 230 IRDTELAATM VELGKDKRNP DELAEALDER LGDFAFPDEF VFDVWGAIGD AKVGRY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GIPC, a PDZ domain containing protein, interacts specifically with the C-terminus of RGS-GAIP." De Vries L., Lou X., Zhao G., Zheng B., Farquhar M.G. Proc. Natl. Acad. Sci. U.S.A. 95:12340-12345(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RGS19. Tissue: Pituitary.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung and Muscle.
[6]	"The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins." Rousset R., Fabre S., Desbois C., Bantignies F., Jalinot P. Oncogene 16:643-654(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 78-333 (ISOFORM 1/2), INTERACTION WITH HTLV-I TAX.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225 AND SER-232, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF089816 mRNA. Translation: AAC67548.1. AK290948 mRNA. Translation: BAF83637.1. AC008569 Genomic DNA. No translation available. AC012318 Genomic DNA. No translation available. CH471106 Genomic DNA. Translation: EAW84423.1. CH471106 Genomic DNA. Translation: EAW84425.1. BC000410 mRNA. Translation: AAH00410.1. BC004226 mRNA. Translation: AAH04226.2. BC012810 mRNA. Translation: AAH12810.1. BC016169 mRNA. Translation: AAH16169.1. AF028824 mRNA. Translation: AAB84249.1.
IPI	IPI00024705.
RefSeq	NP_005707.1. NM_005716.3. NP_974197.1. NM_202468.2. NP_974198.1. NM_202469.2. NP_974199.1. NM_202470.2. NP_974223.1. NM_202494.2.
UniGene	Hs.655012. Hs.741240.
3D structure databases
ProteinModelPortal	O14908.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14908. 6 interactions.
MINT	MINT-5003771.
STRING	9606.ENSP00000340698.
PTM databases
PhosphoSite	O14908.
Proteomic databases
PaxDb	O14908.
PeptideAtlas	O14908.
PRIDE	O14908.
Protocols and materials databases
DNASU	10755.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000345425; ENSP00000340698; ENSG00000123159. ENST00000351277; ENSP00000341425; ENSG00000123159. ENST00000393028; ENSP00000376748; ENSG00000123159. ENST00000393029; ENSP00000376749; ENSG00000123159. ENST00000393033; ENSP00000376753; ENSG00000123159. ENST00000586027; ENSP00000466747; ENSG00000123159. ENST00000591349; ENSP00000467077; ENSG00000123159.
GeneID	10755.
KEGG	hsa:10755.
UCSC	uc002myt.3. human.
Organism-specific databases
CTD	10755.
GeneCards	GC19M014593.
HGNC	HGNC:1226. GIPC1.
HPA	HPA043958.
MIM	605072. gene.
neXtProt	NX_O14908.
PharmGKB	PA34371.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG313930.
HOGENOM	HOG000293347.
HOVERGEN	HBG000898.
InParanoid	O14908.
OMA	IELWGAI.
OrthoDB	EOG498V1F.
PhylomeDB	O14908.
Enzyme and pathway databases
Pathway_Interaction_DB	trkrpathway. Neurotrophic factor-mediated Trk receptor signaling. syndecan_4_pathway. Syndecan-4-mediated signaling events.
Gene expression databases
ArrayExpress	O14908.
Bgee	O14908.
CleanEx	HS_GIPC1.
Genevestigator	O14908.
GermOnline	ENSG00000123159. Homo sapiens.
Family and domain databases
InterPro	IPR001478. PDZ. IPR017379. UCP038083_PDZ. [Graphical view]
Pfam	PF00595. PDZ. 1 hit. [Graphical view]
PIRSF	PIRSF038083. UCP038083_GIPC. 1 hit.
SMART	SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS50106. PDZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GIPC1. human.
GenomeRNAi	10755.
NextBio	40843.
SOURCE	Search...

Entry information

Entry name

GIPC1_HUMAN

Accession

Primary (citable) accession number: O14908
Secondary accession number(s): A8K4I3, A8MZG3, Q9BTC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	August 1, 1999
Last modified:	May 1, 2013
This is version 116 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.