Reviewed, UniProtKB/Swiss-Prot O14907 (TX1B3_HUMAN)

Names and origin

Protein names

Recommended name:
    Tax1-binding protein 3
Alternative name(s):
    Tax interaction protein 1
      Short name=TIP-1
    Glutaminase-interacting protein 3

Gene names

Name:	TAX1BP3
Synonyms:	TIP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the Rho signaling pathway. May act as an inhibitor of the Wnt signaling pathway. Ref.6 UniProtKB Q9DBG9
Subunit structure	Interacts via its PDZ domain with GLS2. Interacts via its PDZ domain with the C-terminal region of RTKN. This interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts via its PDZ domain with CTNNB1. This interaction inhibits the transcriptional activity of CTNNB1. Interacts with HTLV-1 TAX protein. Ref.6 Ref.1 Ref.3
Subcellular location	Cytoplasm. Nucleus. Ref.6
Tissue specificity	Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes. Ref.6
Sequence similarities	Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	Rho protein signal transduction Ref.6 Inferred from direct assay. Source: UniProtKB Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Ref.6 Non-traceable author statement. Source: UniProtKB nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 124	124	Tax1-binding protein 3		PRO_0000233943
Regions
	Domain	15 – 112	98	PDZ
Amino acid modifications
	Modified residue	61	1	Phosphoserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	O14907-1 [UniParc]. Last modified March 1, 2001. Version 2. Checksum: FF0BCDF475F682CD	FASTA	124	13,735
	10 20 30 40 50 60 MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV 70 80 90 100 110 120 SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ SMLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins." Rousset R., Fabre S., Desbois C., Bantignies F., Jalinot P. Oncogene 16:643-654(1998) [PubMed: 9482110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HTLV-1 TAX. Tissue: Peripheral blood lymphocyte.
[2]	"The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion." Touchman J.W., Anikster Y., Dietrich N.L., Maduro V.V.B., McDowell G., Shotelersuk V., Bouffard G.G., Beckstrom-Sternberg S.M., Gahl W.A., Green E.D. Genome Res. 10:165-173(2000) [PubMed: 10673275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins." Olalla L., Aledo J.C., Bannenberg G., Marquez J. FEBS Lett. 488:116-122(2001) [PubMed: 11163757] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH GLS2. Tissue: Brain.
[4]	"hPWP1-interacting proteins 2 and 11 (Tax-interacting protein 1)." Honore B. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[6]	"The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element." Reynaud C., Fabre S., Jalinot P. J. Biol. Chem. 275:33962-33968(2000) [PubMed: 10940294] [Abstract] Cited for: FUNCTION, INTERACTION WITH RTKN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF028823 mRNA. Translation: AAB84248.2.
AF168787 Genomic DNA. Translation: AAF43104.1. Different initiation.
AF234997 mRNA. Translation: AAG44368.1.
AF277318 mRNA. Translation: AAK69111.1.
BC023980 mRNA. Translation: AAH23980.1.

IPI

IPI00005585.

RefSeq

NP_055419.1.

UniGene

Hs.12956

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2VZ5	X-ray	1.74	A	13-124	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

O14907. 1 interaction.

PTM databases

PhosphoSite

O14907.

Proteomic databases

PRIDE

O14907.

Genome annotation databases

Ensembl

ENSG00000213977. Homo sapiens. [Contig view]

GeneID

30851.

KEGG

hsa:30851.

Organism-specific databases

GeneCards

GC17M003512.

H-InvDB

HIX0013429.

HGNC

HGNC:30684. TAX1BP3.

PharmGKB

PA134950693.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

O14907.

OMA

O14907. DNLILGF.

Enzyme and pathway databases

BRENDA

3.5.1.2. 247.

Gene expression databases

Bgee

O14907.

CleanEx

HS_TAX1BP3.

GermOnline

ENSG00000083454. Homo sapiens.

Family and domain databases

InterPro

IPR001478. PDZ/DHR/GLGF.
IPR017268. Tax1-binding_p3.
[Graphical view]

Pfam

PF00595. PDZ. 1 hit.
[Graphical view]

PIRSF

PIRSF037712. Tax1-binding_p3. 1 hit.

SMART

SM00228. PDZ. 1 hit.
[Graphical view]

PROSITE

PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

52992.

Entry information

Entry name

TX1B3_HUMAN

Accession

Primary (citable) accession number: O14907
Secondary accession number(s): Q7LCQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)