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Protein

Tax1-binding protein 3

Gene

TAX1BP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.3 Publications

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

BioCyciZFISH:G66-33830-MONOMER.
BRENDAi3.5.1.2. 2681.
ReactomeiR-HSA-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 3
Alternative name(s):
Glutaminase-interacting protein 3
Tax interaction protein 1
Short name:
TIP-1
Tax-interacting protein 1
Gene namesi
Name:TAX1BP3Imported
Synonyms:TIP1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30684. TAX1BP3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi20K → A: Abolishes interaction with KCNJ4. 1 Publication1
Mutagenesisi90H → A: Abolishes interaction with KCNJ4. 1 Publication1

Organism-specific databases

DisGeNETi30851.
OpenTargetsiENSG00000213977.
PharmGKBiPA134950693.

Polymorphism and mutation databases

BioMutaiTAX1BP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002339432 – 124Tax1-binding protein 3Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei61PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14907.
MaxQBiO14907.
PaxDbiO14907.
PeptideAtlasiO14907.
PRIDEiO14907.
TopDownProteomicsiO14907.

2D gel databases

UCD-2DPAGEO14907.

PTM databases

iPTMnetiO14907.
PhosphoSitePlusiO14907.

Expressioni

Tissue specificityi

Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes.3 Publications

Gene expression databases

BgeeiENSG00000213977.
CleanExiHS_TAX1BP3.
ExpressionAtlasiO14907. baseline and differential.
GenevisibleiO14907. HS.

Organism-specific databases

HPAiHPA046410.
HPA063078.

Interactioni

Subunit structurei

Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1. Interacts with HTLV-1 TAX protein. Interacts (via PDZ domain) with ARHGEF16. Interacts (via PDZ domain) with KCNJ4 (via C-terminus). Competes with LIN7A for KCNJ4 binding. Interacts with ADGRB2 (PubMed:21787750).9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
E6P031262EBI-723259,EBI-1177242From a different organism.
RNF183Q96D593EBI-723259,EBI-743938

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119061. 17 interactors.
IntActiO14907. 16 interactors.
MINTiMINT-142501.
STRINGi9606.ENSP00000225525.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 11Combined sources3
Beta strandi12 – 19Combined sources8
Beta strandi21 – 23Combined sources3
Beta strandi26 – 28Combined sources3
Beta strandi30 – 35Combined sources6
Beta strandi37 – 39Combined sources3
Helixi41 – 43Combined sources3
Turni45 – 47Combined sources3
Beta strandi48 – 50Combined sources3
Beta strandi54 – 60Combined sources7
Beta strandi62 – 64Combined sources3
Helixi65 – 69Combined sources5
Beta strandi76 – 80Combined sources5
Beta strandi83 – 85Combined sources3
Helixi90 – 97Combined sources8
Beta strandi98 – 101Combined sources4
Beta strandi103 – 111Combined sources9
Beta strandi115 – 118Combined sources4
Turni121 – 123Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KG2NMR-A2-124[»]
2L4SNMR-A1-124[»]
2L4TNMR-A1-124[»]
2VZ5X-ray1.74A13-113[»]
3GJ9X-ray2.80A/B1-124[»]
3SFJX-ray1.24A/C10-112[»]
4E3BX-ray1.50A/B11-112[»]
4NNLX-ray1.50A/B10-112[»]
4NNMX-ray1.60A/B10-120[»]
ProteinModelPortaliO14907.
SMRiO14907.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14907.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 112PDZPROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3553. Eukaryota.
ENOG4111IK0. LUCA.
GeneTreeiENSGT00390000002877.
HOGENOMiHOG000015753.
HOVERGENiHBG052814.
InParanoidiO14907.
OMAiDPTQNPF.
OrthoDBiEOG091G0UZR.
PhylomeDBiO14907.
TreeFamiTF318964.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017268. Tax1-binding_p3.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PIRSFiPIRSF037712. Tax1-binding_p3. 1 hit.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK
60 70 80 90 100
TDKGIYVTRV SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR
110 120
SEEVVRLLVT RQSLQKAVQQ SMLS
Length:124
Mass (Da):13,735
Last modified:March 1, 2001 - v2
Checksum:iFF0BCDF475F682CD
GO

Sequence cautioni

The sequence AAF43104 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07396633I → T Found in a patient with dilated cardiomyopathy and septo-optic dysplasia; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028823 mRNA. Translation: AAB84248.2.
AF168787 Genomic DNA. Translation: AAF43104.1. Different initiation.
AF234997 mRNA. Translation: AAG44368.1.
AF277318 mRNA. Translation: AAK69111.1.
AK315408 mRNA. Translation: BAG37800.1.
CH471108 Genomic DNA. Translation: EAW90491.1.
CH471108 Genomic DNA. Translation: EAW90492.1.
BC023980 mRNA. Translation: AAH23980.1.
CCDSiCCDS11032.1.
RefSeqiNP_001191627.1. NM_001204698.1.
NP_055419.1. NM_014604.3.
UniGeneiHs.12956.
Hs.731607.

Genome annotation databases

EnsembliENST00000225525; ENSP00000225525; ENSG00000213977.
GeneIDi30851.
KEGGihsa:30851.
UCSCiuc002fwc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028823 mRNA. Translation: AAB84248.2.
AF168787 Genomic DNA. Translation: AAF43104.1. Different initiation.
AF234997 mRNA. Translation: AAG44368.1.
AF277318 mRNA. Translation: AAK69111.1.
AK315408 mRNA. Translation: BAG37800.1.
CH471108 Genomic DNA. Translation: EAW90491.1.
CH471108 Genomic DNA. Translation: EAW90492.1.
BC023980 mRNA. Translation: AAH23980.1.
CCDSiCCDS11032.1.
RefSeqiNP_001191627.1. NM_001204698.1.
NP_055419.1. NM_014604.3.
UniGeneiHs.12956.
Hs.731607.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KG2NMR-A2-124[»]
2L4SNMR-A1-124[»]
2L4TNMR-A1-124[»]
2VZ5X-ray1.74A13-113[»]
3GJ9X-ray2.80A/B1-124[»]
3SFJX-ray1.24A/C10-112[»]
4E3BX-ray1.50A/B11-112[»]
4NNLX-ray1.50A/B10-112[»]
4NNMX-ray1.60A/B10-120[»]
ProteinModelPortaliO14907.
SMRiO14907.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119061. 17 interactors.
IntActiO14907. 16 interactors.
MINTiMINT-142501.
STRINGi9606.ENSP00000225525.

PTM databases

iPTMnetiO14907.
PhosphoSitePlusiO14907.

Polymorphism and mutation databases

BioMutaiTAX1BP3.

2D gel databases

UCD-2DPAGEO14907.

Proteomic databases

EPDiO14907.
MaxQBiO14907.
PaxDbiO14907.
PeptideAtlasiO14907.
PRIDEiO14907.
TopDownProteomicsiO14907.

Protocols and materials databases

DNASUi30851.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225525; ENSP00000225525; ENSG00000213977.
GeneIDi30851.
KEGGihsa:30851.
UCSCiuc002fwc.4. human.

Organism-specific databases

CTDi30851.
DisGeNETi30851.
GeneCardsiTAX1BP3.
HGNCiHGNC:30684. TAX1BP3.
HPAiHPA046410.
HPA063078.
MIMi616476. gene.
neXtProtiNX_O14907.
OpenTargetsiENSG00000213977.
PharmGKBiPA134950693.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3553. Eukaryota.
ENOG4111IK0. LUCA.
GeneTreeiENSGT00390000002877.
HOGENOMiHOG000015753.
HOVERGENiHBG052814.
InParanoidiO14907.
OMAiDPTQNPF.
OrthoDBiEOG091G0UZR.
PhylomeDBiO14907.
TreeFamiTF318964.

Enzyme and pathway databases

BioCyciZFISH:G66-33830-MONOMER.
BRENDAi3.5.1.2. 2681.
ReactomeiR-HSA-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Miscellaneous databases

ChiTaRSiTAX1BP3. human.
EvolutionaryTraceiO14907.
GeneWikiiTAX1BP3.
GenomeRNAii30851.
PROiO14907.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213977.
CleanExiHS_TAX1BP3.
ExpressionAtlasiO14907. baseline and differential.
GenevisibleiO14907. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017268. Tax1-binding_p3.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
PIRSFiPIRSF037712. Tax1-binding_p3. 1 hit.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTX1B3_HUMAN
AccessioniPrimary (citable) accession number: O14907
Secondary accession number(s): B2RD53, D3DTJ6, Q7LCQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.