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Protein

Protein Wnt-9b

Gene

WNT9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158955-MONOMER.
ReactomeiR-HSA-3238698. WNT ligand biogenesis and trafficking.
R-HSA-373080. Class B/2 (Secretin family receptors).
SIGNORiO14905.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9b
Alternative name(s):
Protein Wnt-14b
Protein Wnt-15
Gene namesi
Name:WNT9B
Synonyms:WNT14B, WNT15
ORF Names:UNQ6973/PRO21956
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:12779. WNT9B.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7484.
OpenTargetsiENSG00000158955.
ENSG00000276799.
PharmGKBiPA37380.

Polymorphism and mutation databases

BioMutaiWNT9B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004145823 – 357Protein Wnt-9bAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 100By similarity
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi135 ↔ 143By similarity
Disulfide bondi145 ↔ 162By similarity
Disulfide bondi210 ↔ 224By similarity
Disulfide bondi212 ↔ 219By similarity
Lipidationi216O-palmitoleyl serine; by PORCNBy similarity1
Disulfide bondi305 ↔ 316By similarity
Disulfide bondi331 ↔ 346By similarity
Disulfide bondi333 ↔ 343By similarity
Disulfide bondi338 ↔ 339By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiO14905.
PRIDEiO14905.

PTM databases

iPTMnetiO14905.
PhosphoSitePlusiO14905.

Expressioni

Tissue specificityi

Moderately expressed in fetal kidney and adult kidney. Also found in brain.

Gene expression databases

BgeeiENSG00000158955.
CleanExiHS_WNT9B.
ExpressionAtlasiO14905. baseline and differential.
GenevisibleiO14905. HS.

Organism-specific databases

HPAiHPA058361.
HPA059572.

Interactioni

Subunit structurei

Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113321. 5 interactors.
STRINGi9606.ENSP00000290015.

Structurei

3D structure databases

ProteinModelPortaliO14905.
SMRiO14905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO14905.
KOiK01064.
OMAiCAKDTSC.
OrthoDBiEOG091G0OFF.
PhylomeDBiO14905.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026535. WNT9B.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF84. PTHR12027:SF84. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPPALALA GLCLLALPAA AASYFGLTGR EVLTPFPGLG TAAAPAQGGA
60 70 80 90 100
HLKQCDLLKL SRRQKQLCRR EPGLAETLRD AAHLGLLECQ FQFRHERWNC
110 120 130 140 150
SLEGRMGLLK RGFKETAFLY AVSSAALTHT LARACSAGRM ERCTCDDSPG
160 170 180 190 200
LESRQAWQWG VCGDNLKYST KFLSNFLGSK RGNKDLRARA DAHNTHVGIK
210 220 230 240 250
AVKSGLRTTC KCHGVSGSCA VRTCWKQLSP FRETGQVLKL RYDSAVKVSS
260 270 280 290 300
ATNEALGRLE LWAPARQGSL TKGLAPRSGD LVYMEDSPSF CRPSKYSPGT
310 320 330 340 350
AGRVCSREAS CSSLCCGRGY DTQSRLVAFS CHCQVQWCCY VECQQCVQEE

LVYTCKH
Length:357
Mass (Da):39,001
Last modified:November 30, 2010 - v3
Checksum:iCC22162F9D294CB8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030839106M → T.1 PublicationCorresponds to variant rs4968281dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063483 mRNA. Translation: BAB70499.1.
AY358217 mRNA. Translation: AAQ88584.1.
AC015855 Genomic DNA. No translation available.
AF028703 Genomic DNA. Translation: AAC39551.1.
CCDSiCCDS11506.1.
RefSeqiNP_003387.1. NM_003396.2.
UniGeneiHs.326420.

Genome annotation databases

EnsembliENST00000290015; ENSP00000290015; ENSG00000158955.
ENST00000613753; ENSP00000482127; ENSG00000276799.
GeneIDi7484.
KEGGihsa:7484.
UCSCiuc002ikw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063483 mRNA. Translation: BAB70499.1.
AY358217 mRNA. Translation: AAQ88584.1.
AC015855 Genomic DNA. No translation available.
AF028703 Genomic DNA. Translation: AAC39551.1.
CCDSiCCDS11506.1.
RefSeqiNP_003387.1. NM_003396.2.
UniGeneiHs.326420.

3D structure databases

ProteinModelPortaliO14905.
SMRiO14905.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113321. 5 interactors.
STRINGi9606.ENSP00000290015.

PTM databases

iPTMnetiO14905.
PhosphoSitePlusiO14905.

Polymorphism and mutation databases

BioMutaiWNT9B.

Proteomic databases

PaxDbiO14905.
PRIDEiO14905.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290015; ENSP00000290015; ENSG00000158955.
ENST00000613753; ENSP00000482127; ENSG00000276799.
GeneIDi7484.
KEGGihsa:7484.
UCSCiuc002ikw.2. human.

Organism-specific databases

CTDi7484.
DisGeNETi7484.
GeneCardsiWNT9B.
H-InvDBHIX0027116.
HGNCiHGNC:12779. WNT9B.
HPAiHPA058361.
HPA059572.
MIMi602864. gene.
neXtProtiNX_O14905.
OpenTargetsiENSG00000158955.
ENSG00000276799.
PharmGKBiPA37380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO14905.
KOiK01064.
OMAiCAKDTSC.
OrthoDBiEOG091G0OFF.
PhylomeDBiO14905.
TreeFamiTF105310.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158955-MONOMER.
ReactomeiR-HSA-3238698. WNT ligand biogenesis and trafficking.
R-HSA-373080. Class B/2 (Secretin family receptors).
SIGNORiO14905.

Miscellaneous databases

ChiTaRSiWNT9B. human.
GenomeRNAii7484.
PROiO14905.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158955.
CleanExiHS_WNT9B.
ExpressionAtlasiO14905. baseline and differential.
GenevisibleiO14905. HS.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026535. WNT9B.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF84. PTHR12027:SF84. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWNT9B_HUMAN
AccessioniPrimary (citable) accession number: O14905
Secondary accession number(s): Q6UXT4, Q96Q09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.