O14905 (WNT9B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-9b

Alternative name(s):
Protein Wnt-14b
Protein Wnt-15

Gene names

Name:	WNT9B
Synonyms:	WNT14B, WNT15
ORF Names:	UNQ6973/PRO21956

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.
Subunit structure	Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6. Ref.5
Subcellular location	Secreted › extracellular space › extracellular matrix.
Tissue specificity	Moderately expressed in fetal kidney and adult kidney. Also found in brain.
Post-translational modification	Palmitoylation at Ser-216 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-89. Palmitoylation is necessary for proper trafficking to cell surface By similarity.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway, planar cell polarity pathway Inferred from Biological aspect of Ancestor. Source: RefGenome anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome branching involved in ureteric bud morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cell-cell signaling Non-traceable author statement Ref.4. Source: UniProtKB cellular response to retinoic acid Inferred from sequence or structural similarity. Source: UniProtKB collecting duct development Inferred from Biological aspect of Ancestor. Source: RefGenome cornea development in camera-type eye Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL embryonic cranial skeleton morphogenesis Inferred from electronic annotation. Source: Compara embryonic skeletal system morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome endoderm development Inferred from Biological aspect of Ancestor. Source: RefGenome establishment of planar polarity involved in nephron morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome in utero embryonic development Inferred from electronic annotation. Source: Compara kidney rudiment formation Inferred from Biological aspect of Ancestor. Source: RefGenome male genitalia development Inferred from Biological aspect of Ancestor. Source: RefGenome mesonephric duct formation Inferred from Biological aspect of Ancestor. Source: RefGenome metanephric tubule development Inferred from Biological aspect of Ancestor. Source: RefGenome neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB palate development Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of catalytic activity Inferred from electronic annotation. Source: Compara regulation of asymmetric cell division Inferred from electronic annotation. Source: Compara regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara regulation of tube size Inferred from electronic annotation. Source: Compara uterus morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 357	335	Protein Wnt-9b		PRO_0000041458
Amino acid modifications
	Lipidation	89	1	S-palmitoyl cysteine By similarity
	Lipidation	216	1	O-palmitoyl serine; by PORCN By similarity
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	106	1	M → T. Ref.1 Corresponds to variant rs4968281 [ dbSNP | Ensembl ].		VAR_030839

Sequences

	Sequence		Length	Mass (Da)
	O14905 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: CC22162F9D294CB8	FASTA	357	39,001
	10 20 30 40 50 60 MRPPPALALA GLCLLALPAA AASYFGLTGR EVLTPFPGLG TAAAPAQGGA HLKQCDLLKL 70 80 90 100 110 120 SRRQKQLCRR EPGLAETLRD AAHLGLLECQ FQFRHERWNC SLEGRMGLLK RGFKETAFLY 130 140 150 160 170 180 AVSSAALTHT LARACSAGRM ERCTCDDSPG LESRQAWQWG VCGDNLKYST KFLSNFLGSK 190 200 210 220 230 240 RGNKDLRARA DAHNTHVGIK AVKSGLRTTC KCHGVSGSCA VRTCWKQLSP FRETGQVLKL 250 260 270 280 290 300 RYDSAVKVSS ATNEALGRLE LWAPARQGSL TKGLAPRSGD LVYMEDSPSF CRPSKYSPGT 310 320 330 340 350 AGRVCSREAS CSSLCCGRGY DTQSRLVAFS CHCQVQWCCY VECQQCVQEE LVYTCKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family." Kirikoshi H., Sekihara H., Katoh M. Int. J. Oncol. 19:947-952(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-106.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21." Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C. Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-335.
[5]	"Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6." Bourhis E., Tam C., Franke Y., Bazan J.F., Ernst J., Hwang J., Costa M., Cochran A.G., Hannoush R.N. J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH LRP6 IN THE WNT/FZD/LRP6 COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB063483 mRNA. Translation: BAB70499.1. AY358217 mRNA. Translation: AAQ88584.1. AC015855 Genomic DNA. No translation available. AF028703 Genomic DNA. Translation: AAC39551.1.
IPI	IPI00298876.
RefSeq	NP_003387.1. NM_003396.1.
UniGene	Hs.326420.
3D structure databases
ProteinModelPortal	O14905.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000290015.
PTM databases
PhosphoSite	O14905.
Proteomic databases
PaxDb	O14905.
PRIDE	O14905.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000290015; ENSP00000290015; ENSG00000158955.
GeneID	7484.
KEGG	hsa:7484.
UCSC	uc002ikw.1. human.
Organism-specific databases
CTD	7484.
GeneCards	GC17P044910.
H-InvDB	HIX0027116.
HGNC	HGNC:12779. WNT9B.
MIM	602864. gene.
neXtProt	NX_O14905.
PharmGKB	PA37380.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG291879.
HOGENOM	HOG000039529.
HOVERGEN	HBG001595.
InParanoid	O14905.
KO	K01064.
OMA	GLLECQF.
PhylomeDB	O14905.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O14905.
Bgee	O14905.
CleanEx	HS_WNT9B.
Genevestigator	O14905.
GermOnline	ENSG00000158955. Homo sapiens.
Family and domain databases
InterPro	IPR005817. Wnt. IPR026535. Wnt9. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF4. PTHR12027:SF4. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7484.
NextBio	29318.
SOURCE	Search...

Entry information

Entry name

WNT9B_HUMAN

Accession

Primary (citable) accession number: O14905
Secondary accession number(s): Q6UXT4, Q96Q09

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 30, 2010
Last modified:	April 3, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.