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O14905 (WNT9B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-9b
Alternative name(s):
Protein Wnt-14b
Protein Wnt-15
Gene names
Name:WNT9B
Synonyms:WNT14B, WNT15
ORF Names:UNQ6973/PRO21956
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subunit structure

Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6. Ref.5

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Moderately expressed in fetal kidney and adult kidney. Also found in brain.

Post-translational modification

Palmitoylation at Ser-216 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-89. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

Wnt signaling pathway, planar cell polarity pathway

Inferred from electronic annotation. Source: Ensembl

branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell-cell signaling

Non-traceable author statement Ref.4. Source: UniProtKB

cellular response to retinoic acid

Inferred from sequence or structural similarity. Source: UniProtKB

collecting duct development

Inferred from electronic annotation. Source: Ensembl

cornea development in camera-type eye

Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL

embryonic cranial skeleton morphogenesis

Inferred from electronic annotation. Source: Ensembl

establishment of planar polarity involved in nephron morphogenesis

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

kidney rudiment formation

Inferred from electronic annotation. Source: Ensembl

male genitalia development

Inferred from electronic annotation. Source: Ensembl

mesonephric duct formation

Inferred from electronic annotation. Source: Ensembl

metanephric tubule development

Inferred from electronic annotation. Source: Ensembl

multicellular organismal development

Non-traceable author statement Ref.4. Source: UniProtKB

neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

palate development

Inferred from electronic annotation. Source: Ensembl

positive regulation of catalytic activity

Inferred from electronic annotation. Source: Ensembl

regulation of asymmetric cell division

Inferred from electronic annotation. Source: Ensembl

regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

regulation of tube size

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Non-traceable author statement Ref.1. Source: BHF-UCL

uterus morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Non-traceable author statement Ref.4. Source: UniProtKB

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 357335Protein Wnt-9b
PRO_0000041458

Amino acid modifications

Lipidation891S-palmitoyl cysteine By similarity
Lipidation2161O-palmitoyl serine; by PORCN By similarity
Glycosylation991N-linked (GlcNAc...) Potential

Natural variations

Natural variant1061M → T. Ref.1
Corresponds to variant rs4968281 [ dbSNP | Ensembl ].
VAR_030839

Sequences

Sequence LengthMass (Da)Tools
O14905 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: CC22162F9D294CB8

FASTA35739,001
        10         20         30         40         50         60 
MRPPPALALA GLCLLALPAA AASYFGLTGR EVLTPFPGLG TAAAPAQGGA HLKQCDLLKL 

        70         80         90        100        110        120 
SRRQKQLCRR EPGLAETLRD AAHLGLLECQ FQFRHERWNC SLEGRMGLLK RGFKETAFLY 

       130        140        150        160        170        180 
AVSSAALTHT LARACSAGRM ERCTCDDSPG LESRQAWQWG VCGDNLKYST KFLSNFLGSK 

       190        200        210        220        230        240 
RGNKDLRARA DAHNTHVGIK AVKSGLRTTC KCHGVSGSCA VRTCWKQLSP FRETGQVLKL 

       250        260        270        280        290        300 
RYDSAVKVSS ATNEALGRLE LWAPARQGSL TKGLAPRSGD LVYMEDSPSF CRPSKYSPGT 

       310        320        330        340        350 
AGRVCSREAS CSSLCCGRGY DTQSRLVAFS CHCQVQWCCY VECQQCVQEE LVYTCKH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family."
Kirikoshi H., Sekihara H., Katoh M.
Int. J. Oncol. 19:947-952(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-106.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-335.
[5]"Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
Bourhis E., Tam C., Franke Y., Bazan J.F., Ernst J., Hwang J., Costa M., Cochran A.G., Hannoush R.N.
J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LRP6 IN THE WNT/FZD/LRP6 COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB063483 mRNA. Translation: BAB70499.1.
AY358217 mRNA. Translation: AAQ88584.1.
AC015855 Genomic DNA. No translation available.
AF028703 Genomic DNA. Translation: AAC39551.1.
RefSeqNP_003387.1. NM_003396.1.
UniGeneHs.326420.

3D structure databases

ProteinModelPortalO14905.
SMRO14905. Positions 69-355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113321. 1 interaction.
STRING9606.ENSP00000290015.

PTM databases

PhosphoSiteO14905.

Proteomic databases

PaxDbO14905.
PRIDEO14905.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000290015; ENSP00000290015; ENSG00000158955.
GeneID7484.
KEGGhsa:7484.
UCSCuc002ikw.1. human.

Organism-specific databases

CTD7484.
GeneCardsGC17P044910.
H-InvDBHIX0027116.
HGNCHGNC:12779. WNT9B.
HPAHPA058361.
HPA059572.
MIM602864. gene.
neXtProtNX_O14905.
PharmGKBPA37380.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG291879.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidO14905.
KOK01064.
OMAEEEVYTC.
PhylomeDBO14905.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO14905.
BgeeO14905.
CleanExHS_WNT9B.
GenevestigatorO14905.

Family and domain databases

InterProIPR005817. Wnt.
IPR026535. Wnt9.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF4. PTHR12027:SF4. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7484.
NextBio29318.
PROO14905.
SOURCESearch...

Entry information

Entry nameWNT9B_HUMAN
AccessionPrimary (citable) accession number: O14905
Secondary accession number(s): Q6UXT4, Q96Q09
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM