Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O14905

- WNT9B_HUMAN

UniProt

O14905 - WNT9B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein Wnt-9b

Gene

WNT9B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  1. frizzled binding Source: RefGenome

GO - Biological processi

  1. branching involved in ureteric bud morphogenesis Source: Ensembl
  2. canonical Wnt signaling pathway Source: Ensembl
  3. cell-cell signaling Source: UniProtKB
  4. cell fate commitment Source: RefGenome
  5. cellular response to retinoic acid Source: UniProtKB
  6. cellular response to starvation Source: Ensembl
  7. collecting duct development Source: Ensembl
  8. cornea development in camera-type eye Source: BHF-UCL
  9. embryonic cranial skeleton morphogenesis Source: Ensembl
  10. establishment of planar polarity involved in nephron morphogenesis Source: Ensembl
  11. in utero embryonic development Source: Ensembl
  12. kidney rudiment formation Source: Ensembl
  13. male genitalia development Source: Ensembl
  14. mesenchymal stem cell maintenance involved in nephron morphogenesis Source: Ensembl
  15. mesonephric duct formation Source: Ensembl
  16. metanephric tubule formation Source: Ensembl
  17. multicellular organismal development Source: UniProtKB
  18. neuron differentiation Source: UniProtKB
  19. palate development Source: Ensembl
  20. positive regulation of catalytic activity Source: Ensembl
  21. regulation of asymmetric cell division Source: Ensembl
  22. regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  23. regulation of protein phosphorylation Source: Ensembl
  24. regulation of tube size Source: Ensembl
  25. response to retinoic acid Source: BHF-UCL
  26. uterus morphogenesis Source: Ensembl
  27. Wnt signaling pathway Source: RefGenome
  28. Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9b
Alternative name(s):
Protein Wnt-14b
Protein Wnt-15
Gene namesi
Name:WNT9B
Synonyms:WNT14B, WNT15
ORF Names:UNQ6973/PRO21956
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:12779. WNT9B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: RefGenome
  3. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 357335Protein Wnt-9bPRO_0000041458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi89 ↔ 100By similarity
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi135 ↔ 143By similarity
Disulfide bondi145 ↔ 162By similarity
Disulfide bondi210 ↔ 224By similarity
Disulfide bondi212 ↔ 219By similarity
Lipidationi216 – 2161O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi305 ↔ 316By similarity
Disulfide bondi331 ↔ 346By similarity
Disulfide bondi333 ↔ 343By similarity
Disulfide bondi338 ↔ 339By similarity

Post-translational modificationi

Palmitoylation at Ser-216 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO14905.
PRIDEiO14905.

PTM databases

PhosphoSiteiO14905.

Expressioni

Tissue specificityi

Moderately expressed in fetal kidney and adult kidney. Also found in brain.

Gene expression databases

BgeeiO14905.
CleanExiHS_WNT9B.
ExpressionAtlasiO14905. baseline.
GenevestigatoriO14905.

Organism-specific databases

HPAiHPA058361.
HPA059572.

Interactioni

Subunit structurei

Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.1 Publication

Protein-protein interaction databases

BioGridi113321. 5 interactions.
STRINGi9606.ENSP00000290015.

Structurei

3D structure databases

ProteinModelPortaliO14905.
SMRiO14905. Positions 85-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG291879.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO14905.
KOiK01064.
OMAiEEEVYTC.
PhylomeDBiO14905.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026535. WNT9B.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF84. PTHR12027:SF84. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14905-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPPPALALA GLCLLALPAA AASYFGLTGR EVLTPFPGLG TAAAPAQGGA
60 70 80 90 100
HLKQCDLLKL SRRQKQLCRR EPGLAETLRD AAHLGLLECQ FQFRHERWNC
110 120 130 140 150
SLEGRMGLLK RGFKETAFLY AVSSAALTHT LARACSAGRM ERCTCDDSPG
160 170 180 190 200
LESRQAWQWG VCGDNLKYST KFLSNFLGSK RGNKDLRARA DAHNTHVGIK
210 220 230 240 250
AVKSGLRTTC KCHGVSGSCA VRTCWKQLSP FRETGQVLKL RYDSAVKVSS
260 270 280 290 300
ATNEALGRLE LWAPARQGSL TKGLAPRSGD LVYMEDSPSF CRPSKYSPGT
310 320 330 340 350
AGRVCSREAS CSSLCCGRGY DTQSRLVAFS CHCQVQWCCY VECQQCVQEE

LVYTCKH
Length:357
Mass (Da):39,001
Last modified:November 30, 2010 - v3
Checksum:iCC22162F9D294CB8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061M → T.1 Publication
Corresponds to variant rs4968281 [ dbSNP | Ensembl ].
VAR_030839

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB063483 mRNA. Translation: BAB70499.1.
AY358217 mRNA. Translation: AAQ88584.1.
AC015855 Genomic DNA. No translation available.
AF028703 Genomic DNA. Translation: AAC39551.1.
CCDSiCCDS11506.1.
RefSeqiNP_003387.1. NM_003396.1.
UniGeneiHs.326420.

Genome annotation databases

EnsembliENST00000290015; ENSP00000290015; ENSG00000158955.
GeneIDi7484.
KEGGihsa:7484.
UCSCiuc002ikw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB063483 mRNA. Translation: BAB70499.1 .
AY358217 mRNA. Translation: AAQ88584.1 .
AC015855 Genomic DNA. No translation available.
AF028703 Genomic DNA. Translation: AAC39551.1 .
CCDSi CCDS11506.1.
RefSeqi NP_003387.1. NM_003396.1.
UniGenei Hs.326420.

3D structure databases

ProteinModelPortali O14905.
SMRi O14905. Positions 85-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113321. 5 interactions.
STRINGi 9606.ENSP00000290015.

PTM databases

PhosphoSitei O14905.

Proteomic databases

PaxDbi O14905.
PRIDEi O14905.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000290015 ; ENSP00000290015 ; ENSG00000158955 .
GeneIDi 7484.
KEGGi hsa:7484.
UCSCi uc002ikw.1. human.

Organism-specific databases

CTDi 7484.
GeneCardsi GC17P044910.
H-InvDB HIX0027116.
HGNCi HGNC:12779. WNT9B.
HPAi HPA058361.
HPA059572.
MIMi 602864. gene.
neXtProti NX_O14905.
PharmGKBi PA37380.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291879.
GeneTreei ENSGT00690000101857.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi O14905.
KOi K01064.
OMAi EEEVYTC.
PhylomeDBi O14905.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).

Miscellaneous databases

GenomeRNAii 7484.
NextBioi 29318.
PROi O14905.
SOURCEi Search...

Gene expression databases

Bgeei O14905.
CleanExi HS_WNT9B.
ExpressionAtlasi O14905. baseline.
Genevestigatori O14905.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026535. WNT9B.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF84. PTHR12027:SF84. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family."
    Kirikoshi H., Sekihara H., Katoh M.
    Int. J. Oncol. 19:947-952(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-106.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
    Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
    Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-335.
  5. "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
    Bourhis E., Tam C., Franke Y., Bazan J.F., Ernst J., Hwang J., Costa M., Cochran A.G., Hannoush R.N.
    J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LRP6 IN THE WNT/FZD/LRP6 COMPLEX.

Entry informationi

Entry nameiWNT9B_HUMAN
AccessioniPrimary (citable) accession number: O14905
Secondary accession number(s): Q6UXT4, Q96Q09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3