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O14905

- WNT9B_HUMAN

UniProt

O14905 - WNT9B_HUMAN

Protein

Protein Wnt-9b

Gene

WNT9B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome

    GO - Biological processi

    1. branching involved in ureteric bud morphogenesis Source: Ensembl
    2. cell-cell signaling Source: UniProtKB
    3. cell fate commitment Source: RefGenome
    4. cellular response to retinoic acid Source: UniProtKB
    5. collecting duct development Source: Ensembl
    6. cornea development in camera-type eye Source: BHF-UCL
    7. embryonic cranial skeleton morphogenesis Source: Ensembl
    8. establishment of planar polarity involved in nephron morphogenesis Source: Ensembl
    9. in utero embryonic development Source: Ensembl
    10. kidney rudiment formation Source: Ensembl
    11. male genitalia development Source: Ensembl
    12. mesonephric duct formation Source: Ensembl
    13. metanephric tubule development Source: Ensembl
    14. multicellular organismal development Source: UniProtKB
    15. neuron differentiation Source: UniProtKB
    16. palate development Source: Ensembl
    17. positive regulation of catalytic activity Source: Ensembl
    18. regulation of asymmetric cell division Source: Ensembl
    19. regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
    20. regulation of protein phosphorylation Source: Ensembl
    21. regulation of tube size Source: Ensembl
    22. response to retinoic acid Source: BHF-UCL
    23. uterus morphogenesis Source: Ensembl
    24. Wnt signaling pathway Source: RefGenome
    25. Wnt signaling pathway, planar cell polarity pathway Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-9b
    Alternative name(s):
    Protein Wnt-14b
    Protein Wnt-15
    Gene namesi
    Name:WNT9B
    Synonyms:WNT14B, WNT15
    ORF Names:UNQ6973/PRO21956
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:12779. WNT9B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: RefGenome
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 357335Protein Wnt-9bPRO_0000041458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi89 ↔ 100By similarity
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi135 ↔ 143By similarity
    Disulfide bondi145 ↔ 162By similarity
    Disulfide bondi210 ↔ 224By similarity
    Disulfide bondi212 ↔ 219By similarity
    Lipidationi216 – 2161O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi305 ↔ 316By similarity
    Disulfide bondi331 ↔ 346By similarity
    Disulfide bondi333 ↔ 343By similarity
    Disulfide bondi338 ↔ 339By similarity

    Post-translational modificationi

    Palmitoylation at Ser-216 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiO14905.
    PRIDEiO14905.

    PTM databases

    PhosphoSiteiO14905.

    Expressioni

    Tissue specificityi

    Moderately expressed in fetal kidney and adult kidney. Also found in brain.

    Gene expression databases

    ArrayExpressiO14905.
    BgeeiO14905.
    CleanExiHS_WNT9B.
    GenevestigatoriO14905.

    Organism-specific databases

    HPAiHPA058361.
    HPA059572.

    Interactioni

    Subunit structurei

    Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.1 Publication

    Protein-protein interaction databases

    BioGridi113321. 1 interaction.
    STRINGi9606.ENSP00000290015.

    Structurei

    3D structure databases

    ProteinModelPortaliO14905.
    SMRiO14905. Positions 85-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG291879.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiO14905.
    KOiK01064.
    OMAiEEEVYTC.
    PhylomeDBiO14905.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026535. WNT9B.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF84. PTHR12027:SF84. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14905-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPPPALALA GLCLLALPAA AASYFGLTGR EVLTPFPGLG TAAAPAQGGA    50
    HLKQCDLLKL SRRQKQLCRR EPGLAETLRD AAHLGLLECQ FQFRHERWNC 100
    SLEGRMGLLK RGFKETAFLY AVSSAALTHT LARACSAGRM ERCTCDDSPG 150
    LESRQAWQWG VCGDNLKYST KFLSNFLGSK RGNKDLRARA DAHNTHVGIK 200
    AVKSGLRTTC KCHGVSGSCA VRTCWKQLSP FRETGQVLKL RYDSAVKVSS 250
    ATNEALGRLE LWAPARQGSL TKGLAPRSGD LVYMEDSPSF CRPSKYSPGT 300
    AGRVCSREAS CSSLCCGRGY DTQSRLVAFS CHCQVQWCCY VECQQCVQEE 350
    LVYTCKH 357
    Length:357
    Mass (Da):39,001
    Last modified:November 30, 2010 - v3
    Checksum:iCC22162F9D294CB8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061M → T.1 Publication
    Corresponds to variant rs4968281 [ dbSNP | Ensembl ].
    VAR_030839

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063483 mRNA. Translation: BAB70499.1.
    AY358217 mRNA. Translation: AAQ88584.1.
    AC015855 Genomic DNA. No translation available.
    AF028703 Genomic DNA. Translation: AAC39551.1.
    CCDSiCCDS11506.1.
    RefSeqiNP_003387.1. NM_003396.1.
    UniGeneiHs.326420.

    Genome annotation databases

    EnsembliENST00000290015; ENSP00000290015; ENSG00000158955.
    GeneIDi7484.
    KEGGihsa:7484.
    UCSCiuc002ikw.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063483 mRNA. Translation: BAB70499.1 .
    AY358217 mRNA. Translation: AAQ88584.1 .
    AC015855 Genomic DNA. No translation available.
    AF028703 Genomic DNA. Translation: AAC39551.1 .
    CCDSi CCDS11506.1.
    RefSeqi NP_003387.1. NM_003396.1.
    UniGenei Hs.326420.

    3D structure databases

    ProteinModelPortali O14905.
    SMRi O14905. Positions 85-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113321. 1 interaction.
    STRINGi 9606.ENSP00000290015.

    PTM databases

    PhosphoSitei O14905.

    Proteomic databases

    PaxDbi O14905.
    PRIDEi O14905.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000290015 ; ENSP00000290015 ; ENSG00000158955 .
    GeneIDi 7484.
    KEGGi hsa:7484.
    UCSCi uc002ikw.1. human.

    Organism-specific databases

    CTDi 7484.
    GeneCardsi GC17P044910.
    H-InvDB HIX0027116.
    HGNCi HGNC:12779. WNT9B.
    HPAi HPA058361.
    HPA059572.
    MIMi 602864. gene.
    neXtProti NX_O14905.
    PharmGKBi PA37380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291879.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi O14905.
    KOi K01064.
    OMAi EEEVYTC.
    PhylomeDBi O14905.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Miscellaneous databases

    GenomeRNAii 7484.
    NextBioi 29318.
    PROi O14905.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14905.
    Bgeei O14905.
    CleanExi HS_WNT9B.
    Genevestigatori O14905.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026535. WNT9B.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF84. PTHR12027:SF84. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family."
      Kirikoshi H., Sekihara H., Katoh M.
      Int. J. Oncol. 19:947-952(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-106.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
      Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
      Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-335.
    5. "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
      Bourhis E., Tam C., Franke Y., Bazan J.F., Ernst J., Hwang J., Costa M., Cochran A.G., Hannoush R.N.
      J. Biol. Chem. 285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LRP6 IN THE WNT/FZD/LRP6 COMPLEX.

    Entry informationi

    Entry nameiWNT9B_HUMAN
    AccessioniPrimary (citable) accession number: O14905
    Secondary accession number(s): Q6UXT4, Q96Q09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3