Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O14904

- WNT9A_HUMAN

UniProt

O14904 - WNT9A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein Wnt-9a

Gene

WNT9A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  1. frizzled binding Source: RefGenome

GO - Biological processi

  1. canonical Wnt signaling pathway Source: Ensembl
  2. cell-cell signaling Source: UniProtKB
  3. cell fate commitment Source: RefGenome
  4. cellular response to retinoic acid Source: UniProtKB
  5. cornea development in camera-type eye Source: BHF-UCL
  6. embryonic forelimb morphogenesis Source: Ensembl
  7. embryonic skeletal joint development Source: BHF-UCL
  8. embryonic skeletal system morphogenesis Source: Ensembl
  9. iris morphogenesis Source: BHF-UCL
  10. mitotic cell cycle checkpoint Source: BHF-UCL
  11. multicellular organismal development Source: UniProtKB
  12. negative regulation of cartilage development Source: Ensembl
  13. negative regulation of cell death Source: Ensembl
  14. negative regulation of cell proliferation Source: BHF-UCL
  15. negative regulation of chondrocyte differentiation Source: BHF-UCL
  16. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  17. neuron differentiation Source: UniProtKB
  18. positive regulation of cell differentiation Source: Ensembl
  19. positive regulation of smoothened signaling pathway Source: Ensembl
  20. Wnt signaling pathway Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9a
Alternative name(s):
Protein Wnt-14
Gene namesi
Name:WNT9A
Synonyms:WNT14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:12778. WNT9A.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: RefGenome
  3. extracellular vesicular exosome Source: UniProt
  4. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 365336Protein Wnt-9aPRO_0000041455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi93 ↔ 104By similarity
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi141 ↔ 149By similarity
Disulfide bondi151 ↔ 168By similarity
Disulfide bondi215 ↔ 229By similarity
Disulfide bondi217 ↔ 224By similarity
Lipidationi221 – 2211O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi313 ↔ 324By similarity
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoylation at Ser-221 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO14904.
PRIDEiO14904.

Expressioni

Gene expression databases

BgeeiO14904.
CleanExiHS_WNT9A.
ExpressionAtlasiO14904. baseline and differential.
GenevestigatoriO14904.

Organism-specific databases

HPAiHPA011223.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000272164.

Structurei

3D structure databases

ProteinModelPortaliO14904.
SMRiO14904. Positions 92-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG291879.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO14904.
KOiK01064.
OMAiVECKQCT.
OrthoDBiEOG7G7KP9.
PhylomeDBiO14904.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013303. Wnt9a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01894. WNT14PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14904-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDGSPLARW LAAAFGLTLL LAALRPSAAY FGLTGSEPLT ILPLTLEPEA
60 70 80 90 100
AAQAHYKACD RLKLERKQRR MCRRDPGVAE TLVEAVSMSA LECQFQFRFE
110 120 130 140 150
RWNCTLEGRY RASLLKRGFK ETAFLYAISS AGLTHALAKA CSAGRMERCT
160 170 180 190 200
CDEAPDLENR EAWQWGGCGD NLKYSSKFVK EFLGRRSSKD LRARVDFHNN
210 220 230 240 250
LVGVKVIKAG VETTCKCHGV SGSCTVRTCW RQLAPFHEVG KHLKHKYETA
260 270 280 290 300
LKVGSTTNEA AGEAGAISPP RGRASGAGGS DPLPRTPELV HLDDSPSFCL
310 320 330 340 350
AGRFSPGTAG RRCHREKNCE SICCGRGHNT QSRVVTRPCQ CQVRWCCYVE
360
CRQCTQREEV YTCKG
Length:365
Mass (Da):40,320
Last modified:May 10, 2002 - v2
Checksum:i1E1284D744C6A9B2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti260 – 2601A → T.
Corresponds to variant rs8192633 [ dbSNP | Ensembl ].
VAR_052956

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060283 mRNA. Translation: BAB61051.1.
AL360269 Genomic DNA. Translation: CAH71122.1.
CH471098 Genomic DNA. Translation: EAW69821.1.
BC111960 mRNA. Translation: AAI11961.1.
BC113431 mRNA. Translation: AAI13432.1.
AF028702 Genomic DNA. Translation: AAC39550.1.
CCDSiCCDS31045.1.
RefSeqiNP_003386.1. NM_003395.2.
UniGeneiHs.149504.

Genome annotation databases

EnsembliENST00000272164; ENSP00000272164; ENSG00000143816.
GeneIDi7483.
KEGGihsa:7483.
UCSCiuc001hri.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB060283 mRNA. Translation: BAB61051.1 .
AL360269 Genomic DNA. Translation: CAH71122.1 .
CH471098 Genomic DNA. Translation: EAW69821.1 .
BC111960 mRNA. Translation: AAI11961.1 .
BC113431 mRNA. Translation: AAI13432.1 .
AF028702 Genomic DNA. Translation: AAC39550.1 .
CCDSi CCDS31045.1.
RefSeqi NP_003386.1. NM_003395.2.
UniGenei Hs.149504.

3D structure databases

ProteinModelPortali O14904.
SMRi O14904. Positions 92-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000272164.

Proteomic databases

PaxDbi O14904.
PRIDEi O14904.

Protocols and materials databases

DNASUi 7483.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272164 ; ENSP00000272164 ; ENSG00000143816 .
GeneIDi 7483.
KEGGi hsa:7483.
UCSCi uc001hri.2. human.

Organism-specific databases

CTDi 7483.
GeneCardsi GC01M228106.
HGNCi HGNC:12778. WNT9A.
HPAi HPA011223.
MIMi 602863. gene.
neXtProti NX_O14904.
PharmGKBi PA37379.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291879.
GeneTreei ENSGT00690000101857.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi O14904.
KOi K01064.
OMAi VECKQCT.
OrthoDBi EOG7G7KP9.
PhylomeDBi O14904.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Miscellaneous databases

ChiTaRSi WNT9A. human.
GeneWikii WNT9A.
GenomeRNAii 7483.
NextBioi 29314.
PROi O14904.
SOURCEi Search...

Gene expression databases

Bgeei O14904.
CleanExi HS_WNT9A.
ExpressionAtlasi O14904. baseline and differential.
Genevestigatori O14904.

Family and domain databases

InterProi IPR005817. Wnt.
IPR013303. Wnt9a.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01894. WNT14PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region."
    Saitoh T., Hirai M., Katoh M.
    Biochem. Biophys. Res. Commun. 284:1168-1175(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
    Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
    Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 221-343.

Entry informationi

Entry nameiWNT9A_HUMAN
AccessioniPrimary (citable) accession number: O14904
Secondary accession number(s): A6NLW2
, Q2M2J3, Q5VWU0, Q96S50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2002
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3