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Protein

Protein Wnt-9a

Gene

WNT9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  1. frizzled binding Source: GO_Central

GO - Biological processi

  1. canonical Wnt signaling pathway Source: Ensembl
  2. cell-cell signaling Source: UniProtKB
  3. cell fate commitment Source: GO_Central
  4. cellular response to retinoic acid Source: UniProtKB
  5. cornea development in camera-type eye Source: BHF-UCL
  6. embryonic forelimb morphogenesis Source: Ensembl
  7. embryonic skeletal joint development Source: BHF-UCL
  8. embryonic skeletal system morphogenesis Source: Ensembl
  9. iris morphogenesis Source: BHF-UCL
  10. mitotic cell cycle checkpoint Source: BHF-UCL
  11. multicellular organismal development Source: UniProtKB
  12. negative regulation of canonical Wnt signaling pathway Source: Reactome
  13. negative regulation of cell proliferation Source: BHF-UCL
  14. negative regulation of chondrocyte differentiation Source: BHF-UCL
  15. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  16. neuron differentiation Source: UniProtKB
  17. positive regulation of cell differentiation Source: Ensembl
  18. positive regulation of smoothened signaling pathway Source: Ensembl
  19. Wnt signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9a
Alternative name(s):
Protein Wnt-14
Gene namesi
Name:WNT9A
Synonyms:WNT14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:12778. WNT9A.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: GO_Central
  3. extracellular vesicular exosome Source: UniProtKB
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37379.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 365336Protein Wnt-9aPRO_0000041455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi93 ↔ 104By similarity
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi141 ↔ 149By similarity
Disulfide bondi151 ↔ 168By similarity
Disulfide bondi215 ↔ 229By similarity
Disulfide bondi217 ↔ 224By similarity
Lipidationi221 – 2211O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi313 ↔ 324By similarity
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoylation at Ser-221 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO14904.
PRIDEiO14904.

Expressioni

Gene expression databases

BgeeiO14904.
CleanExiHS_WNT9A.
ExpressionAtlasiO14904. baseline and differential.
GenevestigatoriO14904.

Organism-specific databases

HPAiHPA011223.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000272164.

Structurei

3D structure databases

ProteinModelPortaliO14904.
SMRiO14904. Positions 92-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG291879.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO14904.
KOiK01064.
OMAiVECKQCT.
OrthoDBiEOG7G7KP9.
PhylomeDBiO14904.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013303. Wnt9a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01894. WNT14PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDGSPLARW LAAAFGLTLL LAALRPSAAY FGLTGSEPLT ILPLTLEPEA
60 70 80 90 100
AAQAHYKACD RLKLERKQRR MCRRDPGVAE TLVEAVSMSA LECQFQFRFE
110 120 130 140 150
RWNCTLEGRY RASLLKRGFK ETAFLYAISS AGLTHALAKA CSAGRMERCT
160 170 180 190 200
CDEAPDLENR EAWQWGGCGD NLKYSSKFVK EFLGRRSSKD LRARVDFHNN
210 220 230 240 250
LVGVKVIKAG VETTCKCHGV SGSCTVRTCW RQLAPFHEVG KHLKHKYETA
260 270 280 290 300
LKVGSTTNEA AGEAGAISPP RGRASGAGGS DPLPRTPELV HLDDSPSFCL
310 320 330 340 350
AGRFSPGTAG RRCHREKNCE SICCGRGHNT QSRVVTRPCQ CQVRWCCYVE
360
CRQCTQREEV YTCKG
Length:365
Mass (Da):40,320
Last modified:May 10, 2002 - v2
Checksum:i1E1284D744C6A9B2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti260 – 2601A → T.
Corresponds to variant rs8192633 [ dbSNP | Ensembl ].
VAR_052956

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060283 mRNA. Translation: BAB61051.1.
AL360269 Genomic DNA. Translation: CAH71122.1.
CH471098 Genomic DNA. Translation: EAW69821.1.
BC111960 mRNA. Translation: AAI11961.1.
BC113431 mRNA. Translation: AAI13432.1.
AF028702 Genomic DNA. Translation: AAC39550.1.
CCDSiCCDS31045.1.
RefSeqiNP_003386.1. NM_003395.2.
UniGeneiHs.149504.

Genome annotation databases

EnsembliENST00000272164; ENSP00000272164; ENSG00000143816.
GeneIDi7483.
KEGGihsa:7483.
UCSCiuc001hri.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060283 mRNA. Translation: BAB61051.1.
AL360269 Genomic DNA. Translation: CAH71122.1.
CH471098 Genomic DNA. Translation: EAW69821.1.
BC111960 mRNA. Translation: AAI11961.1.
BC113431 mRNA. Translation: AAI13432.1.
AF028702 Genomic DNA. Translation: AAC39550.1.
CCDSiCCDS31045.1.
RefSeqiNP_003386.1. NM_003395.2.
UniGeneiHs.149504.

3D structure databases

ProteinModelPortaliO14904.
SMRiO14904. Positions 92-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000272164.

Proteomic databases

PaxDbiO14904.
PRIDEiO14904.

Protocols and materials databases

DNASUi7483.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272164; ENSP00000272164; ENSG00000143816.
GeneIDi7483.
KEGGihsa:7483.
UCSCiuc001hri.2. human.

Organism-specific databases

CTDi7483.
GeneCardsiGC01M228106.
HGNCiHGNC:12778. WNT9A.
HPAiHPA011223.
MIMi602863. gene.
neXtProtiNX_O14904.
PharmGKBiPA37379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG291879.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO14904.
KOiK01064.
OMAiVECKQCT.
OrthoDBiEOG7G7KP9.
PhylomeDBiO14904.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.

Miscellaneous databases

ChiTaRSiWNT9A. human.
GeneWikiiWNT9A.
GenomeRNAii7483.
NextBioi29314.
PROiO14904.
SOURCEiSearch...

Gene expression databases

BgeeiO14904.
CleanExiHS_WNT9A.
ExpressionAtlasiO14904. baseline and differential.
GenevestigatoriO14904.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013303. Wnt9a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01894. WNT14PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region."
    Saitoh T., Hirai M., Katoh M.
    Biochem. Biophys. Res. Commun. 284:1168-1175(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
    Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
    Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 221-343.

Entry informationi

Entry nameiWNT9A_HUMAN
AccessioniPrimary (citable) accession number: O14904
Secondary accession number(s): A6NLW2
, Q2M2J3, Q5VWU0, Q96S50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2002
Last modified: March 4, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.