O14904 (WNT9A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-9a

Alternative name(s):
Protein Wnt-14

Gene names

Name:	WNT9A
Synonyms:	WNT14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Post-translational modification	Palmitoylation at Ser-221 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-93. Palmitoylation is necessary for proper trafficking to cell surface By similarity.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cell-cell signaling Non-traceable author statement Ref.5. Source: UniProtKB cellular response to retinoic acid Inferred from sequence or structural similarity. Source: UniProtKB cornea development in camera-type eye Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL embryonic forelimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic skeletal joint development Inferred from sequence or structural similarity. Source: BHF-UCL embryonic skeletal system morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome endoderm development Inferred from Biological aspect of Ancestor. Source: RefGenome iris morphogenesis Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL mitotic cell cycle checkpoint Inferred from mutant phenotype PubMed 17351820. Source: BHF-UCL negative regulation of cartilage development Inferred from electronic annotation. Source: Compara negative regulation of cell death Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from mutant phenotype PubMed 17351820. Source: BHF-UCL negative regulation of chondrocyte differentiation Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of smoothened signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular matrix structural constituent Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 365	336	Protein Wnt-9a		PRO_0000041455
Amino acid modifications
	Lipidation	93	1	S-palmitoyl cysteine By similarity
	Lipidation	221	1	O-palmitoyl serine; by PORCN By similarity
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	260	1	A → T. Corresponds to variant rs8192633 [ dbSNP | Ensembl ].		VAR_052956

Sequences

	Sequence		Length	Mass (Da)
	O14904 [UniParc]. Last modified May 10, 2002. Version 2. Checksum: 1E1284D744C6A9B2	FASTA	365	40,320
	10 20 30 40 50 60 MLDGSPLARW LAAAFGLTLL LAALRPSAAY FGLTGSEPLT ILPLTLEPEA AAQAHYKACD 70 80 90 100 110 120 RLKLERKQRR MCRRDPGVAE TLVEAVSMSA LECQFQFRFE RWNCTLEGRY RASLLKRGFK 130 140 150 160 170 180 ETAFLYAISS AGLTHALAKA CSAGRMERCT CDEAPDLENR EAWQWGGCGD NLKYSSKFVK 190 200 210 220 230 240 EFLGRRSSKD LRARVDFHNN LVGVKVIKAG VETTCKCHGV SGSCTVRTCW RQLAPFHEVG 250 260 270 280 290 300 KHLKHKYETA LKVGSTTNEA AGEAGAISPP RGRASGAGGS DPLPRTPELV HLDDSPSFCL 310 320 330 340 350 360 AGRFSPGTAG RRCHREKNCE SICCGRGHNT QSRVVTRPCQ CQVRWCCYVE CRQCTQREEV YTCKG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region." Saitoh T., Hirai M., Katoh M. Biochem. Biophys. Res. Commun. 284:1168-1175(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21." Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C. Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 221-343.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB060283 mRNA. Translation: BAB61051.1. AL360269 Genomic DNA. Translation: CAH71122.1. CH471098 Genomic DNA. Translation: EAW69821.1. BC111960 mRNA. Translation: AAI11961.1. BC113431 mRNA. Translation: AAI13432.1. AF028702 Genomic DNA. Translation: AAC39550.1.
IPI	IPI00220170.
RefSeq	NP_003386.1. NM_003395.2.
UniGene	Hs.149504.
3D structure databases
ProteinModelPortal	O14904.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000272164.
Proteomic databases
PaxDb	O14904.
PRIDE	O14904.
Protocols and materials databases
DNASU	7483.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272164; ENSP00000272164; ENSG00000143816.
GeneID	7483.
KEGG	hsa:7483.
UCSC	uc001hri.2. human.
Organism-specific databases
CTD	7483.
GeneCards	GC01M228106.
HGNC	HGNC:12778. WNT9A.
HPA	HPA011223.
MIM	602863. gene.
neXtProt	NX_O14904.
PharmGKB	PA37379.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG291879.
HOGENOM	HOG000039529.
HOVERGEN	HBG001595.
InParanoid	O14904.
KO	K01064.
OMA	VECKQCT.
OrthoDB	EOG45QHDJ.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O14904.
Bgee	O14904.
CleanEx	HS_WNT9A.
Genevestigator	O14904.
GermOnline	ENSG00000143816. Homo sapiens.
Family and domain databases
InterPro	IPR005817. Wnt. IPR026535. Wnt9. IPR013303. Wnt9a. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF4. PTHR12027:SF4. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01894. WNT14PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WNT9A. human.
GenomeRNAi	7483.
NextBio	29314.
SOURCE	Search...

Entry information

Entry name

WNT9A_HUMAN

Accession

Primary (citable) accession number: O14904
Secondary accession number(s): A6NLW2 , Q2M2J3, Q5VWU0, Q96S50

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 10, 2002
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.