O14901 (KLF11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Krueppel-like factor 11

Alternative name(s):
Transforming growth factor-beta-inducible early growth response protein 2
Short name=TGFB-inducible early growth response protein 2
Short name=TIEG-2

Gene names

Name:	KLF11
Synonyms:	FKLF, TIEG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Ref.2
Subcellular location	Nucleus.
Tissue specificity	Ubiquitous. Higher expression in erythroid cells. Ref.2
Induction	By TGFB1.
Involvement in disease	Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8
Sequence similarities	Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.
Caution	Ref.3 sequence was originally thought to originate from mouse.

Ontologies

Keywords
Biological process	Apoptosis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Diabetes mellitus Disease mutation
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell proliferation Inferred from direct assay PubMed 21171965. Source: BHF-UCL negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 21171965. Source: BHF-UCL positive regulation of apoptotic process Inferred from direct assay PubMed 21171965. Source: BHF-UCL regulation of transcription involved in S phase of mitotic cell cycle Inferred from direct assay PubMed 21171965. Source: BHF-UCL
Cellular_component	nucleus Traceable author statement Ref.1. Source: ProtInc
Molecular_function	sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from direct assay PubMed 21171965. Source: BHF-UCL transcription regulatory region DNA binding Inferred from direct assay PubMed 21171965. Source: BHF-UCL zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14901-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14901-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Krueppel-like factor 11		PRO_0000047180
Regions
	Zinc finger	394 – 418	25	C2H2-type 1
	Zinc finger	424 – 448	25	C2H2-type 2
	Zinc finger	454 – 476	23	C2H2-type 3
Natural variations
	Alternative sequence	1 – 17	17	Missing in isoform 2.		VSP_042695
	Natural variant	62	1	Q → R High frequency in individuals with diabetes mellitus type 2; increased repression activity; increased binding to mSin3A; impairs activation of insulin promoter. Ref.8 Corresponds to variant rs35927125 [ dbSNP | Ensembl ].		VAR_031522
	Natural variant	220	1	T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to mSin3A. Ref.8 Corresponds to variant rs34336420 [ dbSNP | Ensembl ].		VAR_031523
	Natural variant	347	1	A → S in MODY7; increased repression activity; no alteration in binding affinity to mSin3A. Ref.8		VAR_031524
	Natural variant	378	1	S → F. Corresponds to variant rs35476458 [ dbSNP | Ensembl ].		VAR_052717
Experimental info
	Sequence conflict	125	1	P → S Ref.3
	Sequence conflict	144 – 150	7	VVARALS → QWPDSD Ref.3
	Sequence conflict	371	1	P → L Ref.3
	Sequence conflict	415	1	L → V Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 2. Checksum: A69863B5467FB068	FASTA	512	55,139
	10 20 30 40 50 60 MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA LVCMSSWGQR 70 80 90 100 110 120 SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS LSTLCITPPQ SPDLVEPSTR 130 140 150 160 170 180 TPVSPQVTDS KACTATDVLQ SSAVVARALS GGAERGLLGL EPVPSSPCRA KGTSVIRHTG 190 200 210 220 230 240 ESPAACFPTI QTPDCRLSDS REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG 250 260 270 280 290 300 LLLTDKGQQA GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP 310 320 330 340 350 360 AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP PAPCAANVMA 370 380 390 400 410 420 AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG CRKTYFKSSH LKAHLRTHTG 430 440 450 460 470 480 EKPFNCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD RRFMRSDHLT KHARRHMTTK 490 500 510 KIPGWQAEVG KLNRIASAES PGSPLVSMPA SA
	Isoform 2 [UniParc]. Checksum: 08456765041CB571	FASTA	495	53,329
	10 20 30 40 50 60 MDICESILER KRHDSERSTC SILEQTDMEA VEALVCMSSW GQRSQKGDLL RIRPLTPVSD 70 80 90 100 110 120 SGDVTTTVHM DAATPELPKD FHSLSTLCIT PPQSPDLVEP STRTPVSPQV TDSKACTATD 130 140 150 160 170 180 VLQSSAVVAR ALSGGAERGL LGLEPVPSSP CRAKGTSVIR HTGESPAACF PTIQTPDCRL 190 200 210 220 230 240 SDSREGEEQL LGHFETLQDT HLTDSLLSTN LVSCQPCLHK SGGLLLTDKG QQAGWPGAVQ 250 260 270 280 290 300 TCSPKNYEND LPRKTTPLIS VSVPAPPVLC QMIPVTGQSS MLPAFLKPPP QLSVGTVRPI 310 320 330 340 350 360 LAQAAPAPQP VFVGPAVPQG AVMLVLPQGA LPPPAPCAAN VMAAGNTKLL PLAPAPVFIT 370 380 390 400 410 420 SSQNCVPQVD FSRRRNYVCS FPGCRKTYFK SSHLKAHLRT HTGEKPFNCS WDGCDKKFAR 430 440 450 460 470 480 SDELSRHRRT HTGEKKFVCP VCDRRFMRSD HLTKHARRHM TTKKIPGWQA EVGKLNRIAS 490 AESPGSPLVS MPASA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth." Cook T., Gebelein B., Mesa K., Mladek A., Urrutia R. J. Biol. Chem. 273:25929-25936(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION. Tissue: Pancreas.
[2]	"FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes." Asano H., Li X.S., Stamatoyannopoulos G. Mol. Cell. Biol. 19:3571-3579(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Erythroid cell.
[3]	"Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family." Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P.-L., Van Vooren P., Riviere M., Szpirer J., Szpirer C. Genomics 70:93-101(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Hepatoma.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[8]	"Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function." Neve B., Fernandez-Zapico M.E., Ashkenazi-Katalan V., Dina C., Hamid Y.H., Joly E., Vaillant E., Benmezroua Y., Durand E., Bakaher N., Delannoy V., Vaxillaire M., Cook T., Dallinga-Thie G.M., Jansen H., Charles M.-A., Clement K., Galan P. , Hercberg S., Helbecque N., Charpentier G., Prentki M., Hansen T., Pedersen O., Urrutia R., Melloul D., Froguel P. Proc. Natl. Acad. Sci. U.S.A. 102:4807-4812(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MODY7 MET-220 AND SER-347, VARIANT ARG-62, CHARACTERIZATION OF VARIANTS MODY7 MET-220 AND SER-347, CHARACTERIZATION OF VARIANT ARG-62.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF028008 mRNA. Translation: AAC61880.1.
AF272830 mRNA. Translation: AAF75793.1.
AK302880 mRNA. Translation: BAG64059.1.
AC104794 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00972.1.
BC063286 mRNA. Translation: AAH63286.1.
BC069383 mRNA. Translation: AAH69383.1.
BC074922 mRNA. Translation: AAH74922.1.

IPI

IPI00024692.

RefSeq

NP_001171187.1. NM_001177716.1.
NP_001171189.1. NM_001177718.1.
NP_003588.1. NM_003597.4.

UniGene

Hs.12229.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PO4	model	-	A	40-52	[»]

ProteinModelPortal

O14901.

ModBase

Search...

Protein-protein interaction databases

IntAct

O14901. 6 interactions.

MINT

MINT-2795353.

STRING

9606.ENSP00000307023.

PTM databases

PhosphoSite

O14901.

Proteomic databases

PaxDb

O14901.

PRIDE

O14901.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000305883; ENSP00000307023; ENSG00000172059.
ENST00000535335; ENSP00000442722; ENSG00000172059.
ENST00000540845; ENSP00000444690; ENSG00000172059.

GeneID

8462.

KEGG

hsa:8462.

UCSC

uc002raf.1. human.

Organism-specific databases

CTD

8462.

GeneCards

GC02P010182.

HGNC

HGNC:11811. KLF11.

MIM

603301. gene.
606391. phenotype.
610508. phenotype.

neXtProt

NX_O14901.

Orphanet

552. MODY syndrome.

PharmGKB

PA36518.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5048.

HOGENOM

HOG000059558.

HOVERGEN

HBG052264.

InParanoid

O14901.

KO

K09209.

OMA

PQVDFSR.

PhylomeDB

O14901.

Gene expression databases

ArrayExpress

O14901.

Bgee

O14901.

CleanEx

HS_KLF11.

Genevestigator

O14901.

GermOnline

ENSG00000172059. Homo sapiens.

Family and domain databases

Gene3D

3.30.160.60. 3 hits.

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 3 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

KLF11. human.

GenomeRNAi

8462.

NextBio

31670.

SOURCE

Search...

Entry information

Entry name

KLF11_HUMAN

Accession

Primary (citable) accession number: O14901
Secondary accession number(s): B4DZE7, Q9EPF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 129 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.