Krueppel-like factor 11 - Homo sapiens (Human)

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O14901 (KLF11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 115. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Krueppel-like factor 11

Alternative name(s):
Transforming growth factor-beta-inducible early growth response protein 2
Short name=TGFB-inducible early growth response protein 2
Short name=TIEG-2

Gene names

Name:	KLF11
Synonyms:	FKLF, TIEG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Ref.2
Subcellular location	Nucleus.
Tissue specificity	Ubiquitous. Higher expression in erythroid cells. Ref.2
Induction	By TGFB1.
Involvement in disease	Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Ref.5
Sequence similarities	Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.
Caution	Ref.3 sequence was originally thought to originate from mouse.

Ontologies

Keywords
Biological process	Apoptosis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Disease	Diabetes mellitus Disease mutation
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell proliferation Inferred from direct assay. Source: BHF-UCL negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: BHF-UCL positive regulation of apoptotic process Inferred from direct assay. Source: BHF-UCL regulation of transcription involved in S phase of mitotic cell cycle Inferred from direct assay. Source: BHF-UCL
Cellular component	nucleus Traceable author statement. Source: ProtInc
Molecular function	sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from direct assay. Source: BHF-UCL transcription regulatory region DNA binding Inferred from direct assay. Source: BHF-UCL zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 512

512

Krueppel-like factor 11

PRO_0000047180

Regions

Zinc finger

394 – 418

C2H2-type 1

Zinc finger

424 – 448

C2H2-type 2

Zinc finger

454 – 476

C2H2-type 3

Natural variations

Natural variant

Q → R High frequency in individuals with diabetes mellitus type 2; increased repression activity; increased binding to mSin3A; impairs activation of insulin promoter. Ref.5
Corresponds to variant rs35927125 [ dbSNP | Ensembl ].

VAR_031522

Natural variant

220

T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to mSin3A. Ref.5
Corresponds to variant rs34336420 [ dbSNP | Ensembl ].

VAR_031523

Natural variant

347

A → S in MODY7; increased repression activity; no alteration in binding affinity to mSin3A. Ref.5

VAR_031524

Natural variant

378

S → F.
Corresponds to variant rs35476458 [ dbSNP | Ensembl ].

VAR_052717

Experimental info

Sequence conflict

125

P → S Ref.3

Sequence conflict

144 – 150

VVARALS → QWPDSD Ref.3

Sequence conflict

371

P → L Ref.3

Sequence conflict

415

L → V Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

O14901 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: A69863B5467FB068
Show »

FASTA

512

55,139

        10         20         30         40         50         60 
MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA LVCMSSWGQR 

        70         80         90        100        110        120 
SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS LSTLCITPPQ SPDLVEPSTR 

       130        140        150        160        170        180 
TPVSPQVTDS KACTATDVLQ SSAVVARALS GGAERGLLGL EPVPSSPCRA KGTSVIRHTG 

       190        200        210        220        230        240 
ESPAACFPTI QTPDCRLSDS REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG 

       250        260        270        280        290        300 
LLLTDKGQQA GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP 

       310        320        330        340        350        360 
AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP PAPCAANVMA 

       370        380        390        400        410        420 
AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG CRKTYFKSSH LKAHLRTHTG 

       430        440        450        460        470        480 
EKPFNCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD RRFMRSDHLT KHARRHMTTK 

       490        500        510 
KIPGWQAEVG KLNRIASAES PGSPLVSMPA SA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth." Cook T., Gebelein B., Mesa K., Mladek A., Urrutia R. J. Biol. Chem. 273:25929-25936(1998) [PubMed: 9748269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Pancreas.
[2]	"FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes." Asano H., Li X.S., Stamatoyannopoulos G. Mol. Cell. Biol. 19:3571-3579(1999) [PubMed: 10207080] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Erythroid cell.
[3]	"Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family." Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P.-L., Van Vooren P., Riviere M., Szpirer J., Szpirer C. Genomics 70:93-101(2000) [PubMed: 11087666] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hepatoma.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function." Neve B., Fernandez-Zapico M.E., Ashkenazi-Katalan V., Dina C., Hamid Y.H., Joly E., Vaillant E., Benmezroua Y., Durand E., Bakaher N., Delannoy V., Vaxillaire M., Cook T., Dallinga-Thie G.M., Jansen H., Charles M.-A., Clement K., Galan P. Froguel P. Proc. Natl. Acad. Sci. U.S.A. 102:4807-4812(2005) [PubMed: 15774581] [Abstract] Cited for: VARIANTS MODY7 MET-220 AND SER-347, VARIANT ARG-62, CHARACTERIZATION OF VARIANTS MODY7 MET-220 AND SER-347, CHARACTERIZATION OF VARIANT ARG-62.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF028008 mRNA. Translation: AAC61880.1.
AF272830 mRNA. Translation: AAF75793.1.
BC063286 mRNA. Translation: AAH63286.1.
BC069383 mRNA. Translation: AAH69383.1.
BC074922 mRNA. Translation: AAH74922.1.

IPI

IPI00024692.

RefSeq

NP_001171187.1. NM_001177716.1.
NP_001171189.1. NM_001177718.1.
NP_003588.1. NM_003597.4.

UniGene

Hs.12229.
Hs.694968.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PO4	model	-	A	40-52	[»]

ProteinModelPortal

O14901.

SMR

O14901. Positions 368-480.

ModBase

Search...

Protein-protein interaction databases

IntAct

O14901. 6 interactions.

MINT

MINT-2795353.

STRING

O14901.

PTM databases

PhosphoSite

O14901.

Proteomic databases

PRIDE

O14901.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000305883; ENSP00000307023; ENSG00000172059.

GeneID

8462.

KEGG

hsa:8462.

UCSC

uc002raf.1. human.

Organism-specific databases

CTD

8462.

GeneCards

GC02P010100.

H-InvDB

HIX0200263.

HGNC

HGNC:11811. KLF11.

MIM

603301. gene.
606391. phenotype.
610508. phenotype.

neXtProt

NX_O14901.

Orphanet

552. MODY syndrome.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG12506.

HOGENOM

HBG713719.

HOVERGEN

HBG052264.

InParanoid

O14901.

OMA

CSPKNYE.

PhylomeDB

O14901.

Gene expression databases

ArrayExpress

O14901.

Bgee

O14901.

CleanEx

HS_KLF11.

Genevestigator

O14901.

GermOnline

ENSG00000172059. Homo sapiens.

Family and domain databases

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Gene3D

G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.

K09209.

Pfam

PF00096. zf-C2H2. 3 hits.
[Graphical view]

SMART

SM00355. ZnF_C2H2. 3 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

31670.

SOURCE

Search...

Entry information

Entry name

KLF11_HUMAN

Accession

Primary (citable) accession number: O14901
Secondary accession number(s): Q9EPF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1998
Last modified:	December 14, 2011
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents