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O14901

- KLF11_HUMAN

UniProt

O14901 - KLF11_HUMAN

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Protein

Krueppel-like factor 11

Gene

KLF11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri394 – 41825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: BHF-UCL
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc
  4. transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cellular response to peptide Source: Ensembl
  3. negative regulation of cell proliferation Source: BHF-UCL
  4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  5. positive regulation of apoptotic process Source: BHF-UCL
  6. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: BHF-UCL
  7. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiO14901.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 11
Alternative name(s):
Transforming growth factor-beta-inducible early growth response protein 2
Short name:
TGFB-inducible early growth response protein 2
Short name:
TIEG-2
Gene namesi
Name:KLF11
Synonyms:FKLF, TIEG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:11811. KLF11.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti220 – 2201T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 Publication
Corresponds to variant rs34336420 [ dbSNP | Ensembl ].
VAR_031523
Natural varianti347 – 3471A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 Publication
VAR_031524

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

MIMi606391. phenotype.
610508. phenotype.
Orphaneti552. MODY syndrome.
PharmGKBiPA36518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Krueppel-like factor 11PRO_0000047180Add
BLAST

Proteomic databases

MaxQBiO14901.
PaxDbiO14901.
PRIDEiO14901.

PTM databases

PhosphoSiteiO14901.

Expressioni

Tissue specificityi

Ubiquitous. Higher expression in erythroid cells.1 Publication

Inductioni

By TGFB1.

Gene expression databases

BgeeiO14901.
CleanExiHS_KLF11.
ExpressionAtlasiO14901. baseline and differential.
GenevestigatoriO14901.

Interactioni

Subunit structurei

Interacts with SIN3A.1 Publication

Protein-protein interaction databases

BioGridi114040. 15 interactions.
IntActiO14901. 7 interactions.
MINTiMINT-2795353.
STRINGi9606.ENSP00000307023.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PO4model-A40-52[»]
ProteinModelPortaliO14901.
SMRiO14901. Positions 378-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri394 – 41825C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000059558.
HOVERGENiHBG052264.
InParanoidiO14901.
KOiK09209.
OMAiQNCAPQV.
PhylomeDBiO14901.
TreeFamiTF315506.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14901-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA
60 70 80 90 100
LVCMSSWGQR SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS
110 120 130 140 150
LSTLCITPPQ SPDLVEPSTR TPVSPQVTDS KACTATDVLQ SSAVVARALS
160 170 180 190 200
GGAERGLLGL EPVPSSPCRA KGTSVIRHTG ESPAACFPTI QTPDCRLSDS
210 220 230 240 250
REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG LLLTDKGQQA
260 270 280 290 300
GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP
310 320 330 340 350
AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP
360 370 380 390 400
PAPCAANVMA AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG
410 420 430 440 450
CRKTYFKSSH LKAHLRTHTG EKPFNCSWDG CDKKFARSDE LSRHRRTHTG
460 470 480 490 500
EKKFVCPVCD RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRIASAES
510
PGSPLVSMPA SA
Length:512
Mass (Da):55,139
Last modified:November 1, 1998 - v2
Checksum:iA69863B5467FB068
GO
Isoform 2 (identifier: O14901-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Show »
Length:495
Mass (Da):53,329
Checksum:i08456765041CB571
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251P → S(PubMed:11087666)Curated
Sequence conflicti144 – 1507VVARALS → QWPDSD(PubMed:11087666)Curated
Sequence conflicti371 – 3711P → L(PubMed:11087666)Curated
Sequence conflicti415 – 4151L → V(PubMed:11087666)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621Q → R High frequency in individuals with diabetes mellitus type 2; increased repression activity; increased binding to SIN3A; impairs activation of insulin promoter. 1 Publication
Corresponds to variant rs35927125 [ dbSNP | Ensembl ].
VAR_031522
Natural varianti220 – 2201T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 Publication
Corresponds to variant rs34336420 [ dbSNP | Ensembl ].
VAR_031523
Natural varianti347 – 3471A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 Publication
VAR_031524
Natural varianti378 – 3781S → F.
Corresponds to variant rs35476458 [ dbSNP | Ensembl ].
VAR_052717

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717Missing in isoform 2. 1 PublicationVSP_042695Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF028008 mRNA. Translation: AAC61880.1.
AF272830 mRNA. Translation: AAF75793.1.
AK302880 mRNA. Translation: BAG64059.1.
AC104794 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00972.1.
BC063286 mRNA. Translation: AAH63286.1.
BC069383 mRNA. Translation: AAH69383.1.
BC074922 mRNA. Translation: AAH74922.1.
CCDSiCCDS1668.1. [O14901-1]
CCDS54333.1. [O14901-2]
RefSeqiNP_001171187.1. NM_001177716.1. [O14901-2]
NP_001171189.1. NM_001177718.1. [O14901-2]
NP_003588.1. NM_003597.4. [O14901-1]
XP_005246236.1. XM_005246179.2. [O14901-2]
UniGeneiHs.12229.

Genome annotation databases

EnsembliENST00000305883; ENSP00000307023; ENSG00000172059. [O14901-1]
ENST00000535335; ENSP00000442722; ENSG00000172059. [O14901-2]
ENST00000540845; ENSP00000444690; ENSG00000172059. [O14901-2]
GeneIDi8462.
KEGGihsa:8462.
UCSCiuc002raf.1. human. [O14901-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF028008 mRNA. Translation: AAC61880.1 .
AF272830 mRNA. Translation: AAF75793.1 .
AK302880 mRNA. Translation: BAG64059.1 .
AC104794 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00972.1 .
BC063286 mRNA. Translation: AAH63286.1 .
BC069383 mRNA. Translation: AAH69383.1 .
BC074922 mRNA. Translation: AAH74922.1 .
CCDSi CCDS1668.1. [O14901-1 ]
CCDS54333.1. [O14901-2 ]
RefSeqi NP_001171187.1. NM_001177716.1. [O14901-2 ]
NP_001171189.1. NM_001177718.1. [O14901-2 ]
NP_003588.1. NM_003597.4. [O14901-1 ]
XP_005246236.1. XM_005246179.2. [O14901-2 ]
UniGenei Hs.12229.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PO4 model - A 40-52 [» ]
ProteinModelPortali O14901.
SMRi O14901. Positions 378-476.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114040. 15 interactions.
IntActi O14901. 7 interactions.
MINTi MINT-2795353.
STRINGi 9606.ENSP00000307023.

PTM databases

PhosphoSitei O14901.

Proteomic databases

MaxQBi O14901.
PaxDbi O14901.
PRIDEi O14901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305883 ; ENSP00000307023 ; ENSG00000172059 . [O14901-1 ]
ENST00000535335 ; ENSP00000442722 ; ENSG00000172059 . [O14901-2 ]
ENST00000540845 ; ENSP00000444690 ; ENSG00000172059 . [O14901-2 ]
GeneIDi 8462.
KEGGi hsa:8462.
UCSCi uc002raf.1. human. [O14901-1 ]

Organism-specific databases

CTDi 8462.
GeneCardsi GC02P010182.
HGNCi HGNC:11811. KLF11.
MIMi 603301. gene.
606391. phenotype.
610508. phenotype.
neXtProti NX_O14901.
Orphaneti 552. MODY syndrome.
PharmGKBi PA36518.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118984.
HOGENOMi HOG000059558.
HOVERGENi HBG052264.
InParanoidi O14901.
KOi K09209.
OMAi QNCAPQV.
PhylomeDBi O14901.
TreeFami TF315506.

Enzyme and pathway databases

SignaLinki O14901.

Miscellaneous databases

ChiTaRSi KLF11. human.
GeneWikii KLF11.
GenomeRNAii 8462.
NextBioi 31670.
PROi O14901.
SOURCEi Search...

Gene expression databases

Bgeei O14901.
CleanExi HS_KLF11.
ExpressionAtlasi O14901. baseline and differential.
Genevestigatori O14901.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth."
    Cook T., Gebelein B., Mesa K., Mladek A., Urrutia R.
    J. Biol. Chem. 273:25929-25936(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
    Tissue: Pancreas.
  2. "FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes."
    Asano H., Li X.S., Stamatoyannopoulos G.
    Mol. Cell. Biol. 19:3571-3579(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Erythroid cell.
  3. "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family."
    Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P.-L., Van Vooren P., Riviere M., Szpirer J., Szpirer C.
    Genomics 70:93-101(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hepatoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  8. Cited for: VARIANTS MODY7 MET-220 AND SER-347, VARIANT ARG-62, CHARACTERIZATION OF VARIANTS MODY7 MET-220 AND SER-347, CHARACTERIZATION OF VARIANT ARG-62, INTERACTION WITH SIN3A.

Entry informationi

Entry nameiKLF11_HUMAN
AccessioniPrimary (citable) accession number: O14901
Secondary accession number(s): B4DZE7, Q9EPF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:11087666 sequence was originally thought to originate from mouse.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3