Krueppel-like factor 11 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot O14901 (KLF11_HUMAN)

Last modified November 3, 2009. Version 96. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Krueppel-like factor 11
Alternative name(s):
    Transforming growth factor-beta-inducible early growth response protein 2
      Short name=TGFB-inducible early growth response protein 2
      Short name=TIEG-2

Gene names

Name:	KLF11
Synonyms:	FKLF, TIEG2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Ref.2
Subcellular location	Nucleus.
Tissue specificity	Ubiquitous. Higher expression in erythroid cells. Ref.2
Induction	By TGF-beta.
Involvement in disease	Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY [MIM:606391] has an autosomal dominant inheritance, onset at age less than 25 years and a primary defect in insulin secretion. MODY pedigrees are usually multigenerational families with penetrance of 80 to 95%. Patients have a nonobese body habitus and the so-called metabolic syndrome characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent. Ref.5
Sequence similarities	Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.
Caution	Ref.3 sequence was originally thought to originate from mouse.

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Ontologies

Keywords
Biological process	Apoptosis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Disease	Diabetes mellitus Disease mutation
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell proliferation Ref.1 Traceable author statement. Source: ProtInc negative regulation of transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Ref.1 Traceable author statement. Source: ProtInc
Molecular function	transcription factor activity Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 512

512

Krueppel-like factor 11

PRO_0000047180

Regions

Zinc finger

394 – 418

C2H2-type 1

Zinc finger

424 – 448

C2H2-type 2

Zinc finger

454 – 476

C2H2-type 3

Natural variations

Natural variant

Q → R High frequency in individuals with diabetes mellitus type 2; increased repression activity; increased binding to mSin3A; impairs activation of insulin promoter. dbSNP rs35927125. Ref.5

VAR_031522

Natural variant

220

T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to mSin3A. dbSNP rs34336420. Ref.5

VAR_031523

Natural variant

347

A → S in MODY7; increased repression activity; no alteration in binding affinity to mSin3A. Ref.5

VAR_031524

Natural variant

378

S → F: dbSNP rs35476458.

VAR_052717

Experimental info

Sequence conflict

125

P → S Ref.3

Sequence conflict

144 – 150

VVARALS → QWPDSD Ref.3

Sequence conflict

371

P → L Ref.3

Sequence conflict

415

L → V Ref.3

Secondary structure

512

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

O14901-1 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: A69863B5467FB068
Show »

FASTA

512

55,139

        10         20         30         40         50         60 
MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA LVCMSSWGQR 

        70         80         90        100        110        120 
SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS LSTLCITPPQ SPDLVEPSTR 

       130        140        150        160        170        180 
TPVSPQVTDS KACTATDVLQ SSAVVARALS GGAERGLLGL EPVPSSPCRA KGTSVIRHTG 

       190        200        210        220        230        240 
ESPAACFPTI QTPDCRLSDS REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG 

       250        260        270        280        290        300 
LLLTDKGQQA GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP 

       310        320        330        340        350        360 
AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP PAPCAANVMA 

       370        380        390        400        410        420 
AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG CRKTYFKSSH LKAHLRTHTG 

       430        440        450        460        470        480 
EKPFNCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD RRFMRSDHLT KHARRHMTTK 

       490        500        510 
KIPGWQAEVG KLNRIASAES PGSPLVSMPA SA

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth." Cook T., Gebelein B., Mesa K., Mladek A., Urrutia R. J. Biol. Chem. 273:25929-25936(1998) [PubMed: 9748269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Pancreas.
[2]	"FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes." Asano H., Li X.S., Stamatoyannopoulos G. Mol. Cell. Biol. 19:3571-3579(1999) [PubMed: 10207080] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Erythroid cell.
[3]	"Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family." Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P.-L., Van Vooren P., Riviere M., Szpirer J., Szpirer C. Genomics 70:93-101(2000) [PubMed: 11087666] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hepatoma.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function." Neve B., Fernandez-Zapico M.E., Ashkenazi-Katalan V., Dina C., Hamid Y.H., Joly E., Vaillant E., Benmezroua Y., Durand E., Bakaher N., Delannoy V., Vaxillaire M., Cook T., Dallinga-Thie G.M., Jansen H., Charles M.-A., Clement K., Galan P. Froguel P. Proc. Natl. Acad. Sci. U.S.A. 102:4807-4812(2005) [PubMed: 15774581] [Abstract] Cited for: VARIANTS MODY7 MET-220 AND SER-347, VARIANT ARG-62, CHARACTERIZATION OF VARIANTS MODY7 MET-220 AND SER-347, CHARACTERIZATION OF VARIANT ARG-62.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

AF028008 mRNA. Translation: AAC61880.1.
AF272830 mRNA. Translation: AAF75793.1.
BC063286 mRNA. Translation: AAH63286.1.
BC069383 mRNA. Translation: AAH69383.1.
BC074922 mRNA. Translation: AAH74922.1.

IPI

IPI00024692.

RefSeq

NP_003588.1.

UniGene

Hs.12229
Hs.694968

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PO4	model	-	A	40-52	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

O14901. 1 interaction.

STRING

O14901.

PTM databases

PhosphoSite

O14901.

Proteomic databases

PRIDE

O14901.

Genome annotation databases

Ensembl

ENST00000305883; ENSP00000307023; ENSG00000172059; Homo sapiens. [Genome view]
ENST00000401510; ENSP00000386058; ENSG00000172059; Homo sapiens. [Genome view]
ENST00000440320; ENSP00000388263; ENSG00000172059; Homo sapiens. [Genome view]
ENST00000448523; ENSP00000387866; ENSG00000172059; Homo sapiens. [Genome view]

GeneID

8462.

KEGG

hsa:8462.

UCSC

uc002raf.1. human.

Organism-specific databases

CTD

8462.

GeneCards

GC02P010100.

H-InvDB

HIX0001814.

HGNC

HGNC:11811. KLF11.

MIM

603301. gene.
606391. phenotype.
610508. phenotype.

Orphanet

552. MODY syndrome.

PharmGKB

PA36518.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

O14901.

HOVERGEN

O14901.

OMA

CSPKNYE.

Gene expression databases

ArrayExpress

O14901.

Bgee

O14901.

CleanEx

HS_KLF11.

Genevestigator

O14901.

GermOnline

ENSG00000172059. Homo sapiens.

Family and domain databases

InterPro

IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Gene3D

G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.

Pfam

PF00096. zf-C2H2. 3 hits.
[Graphical view]

ProDom

PD000003. Znf_C2H2. 2 hits.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00355. ZnF_C2H2. 3 hits.
[Graphical view]

PROSITE

PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

31670.

SOURCE

Search...

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Entry information

Entry name

KLF11_HUMAN

Accession

Primary (citable) accession number: O14901
Secondary accession number(s): Q9EPF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1998
Last modified:	November 3, 2009
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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