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O14901

- KLF11_HUMAN

UniProt

O14901 - KLF11_HUMAN

Protein

Krueppel-like factor 11

Gene

KLF11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri394 – 41825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: BHF-UCL
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc
    4. transcription regulatory region DNA binding Source: BHF-UCL

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cellular response to peptide Source: Ensembl
    3. negative regulation of cell proliferation Source: BHF-UCL
    4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    5. positive regulation of apoptotic process Source: BHF-UCL
    6. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: BHF-UCL
    7. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    SignaLinkiO14901.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 11
    Alternative name(s):
    Transforming growth factor-beta-inducible early growth response protein 2
    Short name:
    TGFB-inducible early growth response protein 2
    Short name:
    TIEG-2
    Gene namesi
    Name:KLF11
    Synonyms:FKLF, TIEG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:11811. KLF11.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti220 – 2201T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 Publication
    Corresponds to variant rs34336420 [ dbSNP | Ensembl ].
    VAR_031523
    Natural varianti347 – 3471A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 Publication
    VAR_031524

    Keywords - Diseasei

    Diabetes mellitus, Disease mutation

    Organism-specific databases

    MIMi606391. phenotype.
    610508. phenotype.
    Orphaneti552. MODY syndrome.
    PharmGKBiPA36518.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Krueppel-like factor 11PRO_0000047180Add
    BLAST

    Proteomic databases

    PaxDbiO14901.
    PRIDEiO14901.

    PTM databases

    PhosphoSiteiO14901.

    Expressioni

    Tissue specificityi

    Ubiquitous. Higher expression in erythroid cells.1 Publication

    Inductioni

    By TGFB1.

    Gene expression databases

    ArrayExpressiO14901.
    BgeeiO14901.
    CleanExiHS_KLF11.
    GenevestigatoriO14901.

    Interactioni

    Subunit structurei

    May interact with SIN3A.

    Protein-protein interaction databases

    BioGridi114040. 15 interactions.
    IntActiO14901. 7 interactions.
    MINTiMINT-2795353.
    STRINGi9606.ENSP00000307023.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PO4model-A40-52[»]
    ProteinModelPortaliO14901.
    SMRiO14901. Positions 378-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri394 – 41825C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri424 – 44825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri454 – 47623C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000059558.
    HOVERGENiHBG052264.
    InParanoidiO14901.
    KOiK09209.
    OMAiQNCAPQV.
    PhylomeDBiO14901.
    TreeFamiTF315506.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14901-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA    50
    LVCMSSWGQR SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS 100
    LSTLCITPPQ SPDLVEPSTR TPVSPQVTDS KACTATDVLQ SSAVVARALS 150
    GGAERGLLGL EPVPSSPCRA KGTSVIRHTG ESPAACFPTI QTPDCRLSDS 200
    REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG LLLTDKGQQA 250
    GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP 300
    AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP 350
    PAPCAANVMA AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG 400
    CRKTYFKSSH LKAHLRTHTG EKPFNCSWDG CDKKFARSDE LSRHRRTHTG 450
    EKKFVCPVCD RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRIASAES 500
    PGSPLVSMPA SA 512
    Length:512
    Mass (Da):55,139
    Last modified:November 1, 1998 - v2
    Checksum:iA69863B5467FB068
    GO
    Isoform 2 (identifier: O14901-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-17: Missing.

    Show »
    Length:495
    Mass (Da):53,329
    Checksum:i08456765041CB571
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti125 – 1251P → S(PubMed:11087666)Curated
    Sequence conflicti144 – 1507VVARALS → QWPDSD(PubMed:11087666)Curated
    Sequence conflicti371 – 3711P → L(PubMed:11087666)Curated
    Sequence conflicti415 – 4151L → V(PubMed:11087666)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti62 – 621Q → R High frequency in individuals with diabetes mellitus type 2; increased repression activity; increased binding to SIN3A; impairs activation of insulin promoter. 1 Publication
    Corresponds to variant rs35927125 [ dbSNP | Ensembl ].
    VAR_031522
    Natural varianti220 – 2201T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 Publication
    Corresponds to variant rs34336420 [ dbSNP | Ensembl ].
    VAR_031523
    Natural varianti347 – 3471A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 Publication
    VAR_031524
    Natural varianti378 – 3781S → F.
    Corresponds to variant rs35476458 [ dbSNP | Ensembl ].
    VAR_052717

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1717Missing in isoform 2. 1 PublicationVSP_042695Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF028008 mRNA. Translation: AAC61880.1.
    AF272830 mRNA. Translation: AAF75793.1.
    AK302880 mRNA. Translation: BAG64059.1.
    AC104794 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00972.1.
    BC063286 mRNA. Translation: AAH63286.1.
    BC069383 mRNA. Translation: AAH69383.1.
    BC074922 mRNA. Translation: AAH74922.1.
    CCDSiCCDS1668.1. [O14901-1]
    CCDS54333.1. [O14901-2]
    RefSeqiNP_001171187.1. NM_001177716.1. [O14901-2]
    NP_001171189.1. NM_001177718.1. [O14901-2]
    NP_003588.1. NM_003597.4. [O14901-1]
    XP_005246236.1. XM_005246179.2. [O14901-2]
    UniGeneiHs.12229.

    Genome annotation databases

    EnsembliENST00000305883; ENSP00000307023; ENSG00000172059. [O14901-1]
    ENST00000535335; ENSP00000442722; ENSG00000172059. [O14901-2]
    ENST00000540845; ENSP00000444690; ENSG00000172059. [O14901-2]
    GeneIDi8462.
    KEGGihsa:8462.
    UCSCiuc002raf.1. human. [O14901-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF028008 mRNA. Translation: AAC61880.1 .
    AF272830 mRNA. Translation: AAF75793.1 .
    AK302880 mRNA. Translation: BAG64059.1 .
    AC104794 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00972.1 .
    BC063286 mRNA. Translation: AAH63286.1 .
    BC069383 mRNA. Translation: AAH69383.1 .
    BC074922 mRNA. Translation: AAH74922.1 .
    CCDSi CCDS1668.1. [O14901-1 ]
    CCDS54333.1. [O14901-2 ]
    RefSeqi NP_001171187.1. NM_001177716.1. [O14901-2 ]
    NP_001171189.1. NM_001177718.1. [O14901-2 ]
    NP_003588.1. NM_003597.4. [O14901-1 ]
    XP_005246236.1. XM_005246179.2. [O14901-2 ]
    UniGenei Hs.12229.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PO4 model - A 40-52 [» ]
    ProteinModelPortali O14901.
    SMRi O14901. Positions 378-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114040. 15 interactions.
    IntActi O14901. 7 interactions.
    MINTi MINT-2795353.
    STRINGi 9606.ENSP00000307023.

    PTM databases

    PhosphoSitei O14901.

    Proteomic databases

    PaxDbi O14901.
    PRIDEi O14901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305883 ; ENSP00000307023 ; ENSG00000172059 . [O14901-1 ]
    ENST00000535335 ; ENSP00000442722 ; ENSG00000172059 . [O14901-2 ]
    ENST00000540845 ; ENSP00000444690 ; ENSG00000172059 . [O14901-2 ]
    GeneIDi 8462.
    KEGGi hsa:8462.
    UCSCi uc002raf.1. human. [O14901-1 ]

    Organism-specific databases

    CTDi 8462.
    GeneCardsi GC02P010182.
    HGNCi HGNC:11811. KLF11.
    MIMi 603301. gene.
    606391. phenotype.
    610508. phenotype.
    neXtProti NX_O14901.
    Orphaneti 552. MODY syndrome.
    PharmGKBi PA36518.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000059558.
    HOVERGENi HBG052264.
    InParanoidi O14901.
    KOi K09209.
    OMAi QNCAPQV.
    PhylomeDBi O14901.
    TreeFami TF315506.

    Enzyme and pathway databases

    SignaLinki O14901.

    Miscellaneous databases

    ChiTaRSi KLF11. human.
    GeneWikii KLF11.
    GenomeRNAii 8462.
    NextBioi 31670.
    PROi O14901.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14901.
    Bgeei O14901.
    CleanExi HS_KLF11.
    Genevestigatori O14901.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth."
      Cook T., Gebelein B., Mesa K., Mladek A., Urrutia R.
      J. Biol. Chem. 273:25929-25936(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
      Tissue: Pancreas.
    2. "FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes."
      Asano H., Li X.S., Stamatoyannopoulos G.
      Mol. Cell. Biol. 19:3571-3579(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Tissue: Erythroid cell.
    3. "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family."
      Scohy S., Gabant P., Van Reeth T., Hertveldt V., Dreze P.-L., Van Vooren P., Riviere M., Szpirer J., Szpirer C.
      Genomics 70:93-101(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hepatoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    8. Cited for: VARIANTS MODY7 MET-220 AND SER-347, VARIANT ARG-62, CHARACTERIZATION OF VARIANTS MODY7 MET-220 AND SER-347, CHARACTERIZATION OF VARIANT ARG-62, INTERACTION WITH SIN3A.

    Entry informationi

    Entry nameiKLF11_HUMAN
    AccessioniPrimary (citable) accession number: O14901
    Secondary accession number(s): B4DZE7, Q9EPF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    PubMed:11087666 sequence was originally thought to originate from mouse.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3