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Protein

Transmembrane 4 L6 family member 5

Gene

TM4SF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 5
Alternative name(s):
Tetraspan transmembrane protein L6H
Gene namesi
Name:TM4SF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000142484.6.
HGNCiHGNC:11857. TM4SF5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 46ExtracellularSequence analysisAdd BLAST16
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 90CytoplasmicSequence analysisAdd BLAST23
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 157ExtracellularSequence analysisAdd BLAST46
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 197CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9032.
OpenTargetsiENSG00000142484.
PharmGKBiPA36558.

Polymorphism and mutation databases

BioMutaiTM4SF5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193031 – 197Transmembrane 4 L6 family member 5Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO14894.
PeptideAtlasiO14894.
PRIDEiO14894.

Expressioni

Tissue specificityi

Intestine. Overexpressed in pancreatic cancers.

Gene expression databases

BgeeiENSG00000142484.
CleanExiHS_TM4SF5.
GenevisibleiO14894. HS.

Organism-specific databases

HPAiHPA055674.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000270560.

Structurei

3D structure databases

ProteinModelPortaliO14894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXVM. Eukaryota.
ENOG4111JUZ. LUCA.
GeneTreeiENSGT00390000010992.
HOGENOMiHOG000030899.
HOVERGENiHBG000076.
InParanoidiO14894.
OMAiNRCRMLR.
OrthoDBiEOG091G0QEF.
PhylomeDBiO14894.
TreeFamiTF331371.

Family and domain databases

InterProiView protein in InterPro
IPR008661. L6_membrane.
PANTHERiPTHR14198. PTHR14198. 1 hit.
PfamiView protein in Pfam
PF05805. L6_membrane. 1 hit.

Sequencei

Sequence statusi: Complete.

O14894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTGKCARCV GLSLITLCLV CIVANALLLV PNGETSWTNT NHLSLQVWLM
60 70 80 90 100
GGFIGGGLMV LCPGIAAVRA GGKGCCGAGC CGNRCRMLRS VFSSAFGVLG
110 120 130 140 150
AIYCLSVSGA GLRNGPRCLM NGEWGYHFED TAGAYLLNRT LWDRCEAPPR
160 170 180 190
VVPWNVTLFS LLVAASCLEI VLCGIQLVNA TIGVFCGDCR KKQDTPH
Length:197
Mass (Da):20,823
Last modified:June 21, 2005 - v2
Checksum:i051AEB5ECCE1075C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19L → F in AAB82947 (PubMed:9479038).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027204 mRNA. Translation: AAB82947.1.
CR456925 mRNA. Translation: CAG33206.1.
BC069519 mRNA. Translation: AAH69519.1.
BC093688 mRNA. Translation: AAH93688.1.
BC117163 mRNA. Translation: AAI17164.1.
CCDSiCCDS11054.1.
PIRiJC6544.
RefSeqiNP_003954.2. NM_003963.2.
UniGeneiHs.184194.

Genome annotation databases

EnsembliENST00000270560; ENSP00000270560; ENSG00000142484.
GeneIDi9032.
KEGGihsa:9032.
UCSCiuc002fyw.1. human.

Similar proteinsi

Entry informationi

Entry nameiT4S5_HUMAN
AccessioniPrimary (citable) accession number: O14894
Secondary accession number(s): Q17RW9, Q6IB79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 21, 2005
Last modified: November 22, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families