Reviewed, UniProtKB/Swiss-Prot O14894 (T4S5_HUMAN)

Names and origin

Protein names

Recommended name:
    Transmembrane 4 L6 family member 5
Alternative name(s):
    Tetraspan transmembrane protein L6H

Gene names

Name:

TM4SF5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Intestine. Overexpressed in pancreatic cancers.
Sequence similarities	Belongs to the L6 tetraspanin family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid N-linked glycosylation Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Transmembrane 4 L6 family member 5		PRO_0000219303
Regions
	Topological domain	1 – 9	9	Cytoplasmic Potential
	Transmembrane	10 – 30	21	Potential
	Topological domain	31 – 46	16	Extracellular Potential
	Transmembrane	47 – 67	21	Potential
	Topological domain	68 – 90	23	Cytoplasmic Potential
	Transmembrane	91 – 111	21	Potential
	Topological domain	112 – 157	46	Extracellular Potential
	Transmembrane	158 – 178	21	Potential
	Topological domain	179 – 197	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
	Glycosylation	155	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	19	1	L → F in AAB82947. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O14894-1 [UniParc]. Last modified June 21, 2005. Version 2. Checksum: 051AEB5ECCE1075C	FASTA	197	20,823
	10 20 30 40 50 60 MCTGKCARCV GLSLITLCLV CIVANALLLV PNGETSWTNT NHLSLQVWLM GGFIGGGLMV 70 80 90 100 110 120 LCPGIAAVRA GGKGCCGAGC CGNRCRMLRS VFSSAFGVLG AIYCLSVSGA GLRNGPRCLM 130 140 150 160 170 180 NGEWGYHFED TAGAYLLNRT LWDRCEAPPR VVPWNVTLFS LLVAASCLEI VLCGIQLVNA 190 TIGVFCGDCR KKQDTPH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer." Mueller-Pillasch F., Wallrapp C., Lacher U., Friess H., Buchler M., Adler G., Gress T.M. Gene 208:25-30(1998) [PubMed: 9479038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF027204 mRNA. Translation: AAB82947.1. CR456925 mRNA. Translation: CAG33206.1. BC069519 mRNA. Translation: AAH69519.1. BC093688 mRNA. Translation: AAH93688.1. BC117163 mRNA. Translation: AAI17164.1.
IPI	IPI00024287.
PIR	JC6544.
RefSeq	NP_003954.2.
UniGene	Hs.184194
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O14894.
Genome annotation databases
Ensembl	ENSG00000142484. Homo sapiens. [Contig view]
GeneID	9032.
KEGG	hsa:9032.
Organism-specific databases
GeneCards	GC17P004621.
HGNC	HGNC:11857. TM4SF5.
MIM	604657. gene.
PharmGKB	PA36558.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O14894.
HOVERGEN	O14894.
OMA	O14894. LQVWLMG.
Gene expression databases
ArrayExpress	O14894.
Bgee	O14894.
CleanEx	HS_TM4SF5.
GermOnline	ENSG00000142484. Homo sapiens.
Family and domain databases
InterPro	IPR008661. L6_membrane. [Graphical view]
Pfam	PF05805. L6_membrane. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33839.
SOURCE	Search...

Entry information

Entry name

T4S5_HUMAN

Accession

Primary (citable) accession number: O14894
Secondary accession number(s): Q17RW9, Q6IB79

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 21, 2005
Last modified:	May 5, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)