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Protein

Microsomal glutathione S-transferase 3

Gene

MGST3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Also functions as a glutathione peroxidase.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  • glutathione peroxidase activity Source: GO_Central
  • glutathione transferase activity Source: GO_Central
  • peroxidase activity Source: ProtInc

GO - Biological processi

  • glutathione derivative biosynthetic process Source: Reactome
  • lipid metabolic process Source: ProtInc
  • response to organonitrogen compound Source: Ensembl
  • signal transduction Source: ProtInc
  • xenobiotic metabolic process Source: Reactome

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-HSA-156590. Glutathione conjugation.
R-HSA-5423646. Aflatoxin activation and detoxification.

Chemistry databases

SwissLipidsiSLP:000001463.

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
Short name:
Microsomal GST-3
Alternative name(s):
Microsomal GST-III
Gene namesi
Name:MGST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7064. MGST3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: GO_Central
  • endoplasmic reticulum membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: ProtInc
  • membrane Source: UniProtKB
  • nuclear envelope Source: GO_Central
  • organelle membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi150C → S: Abolishes S-acylation; when associated with S-151. 1 Publication1
Mutagenesisi151C → S: Abolishes S-acylation; when associated with S-150. 1 Publication1

Organism-specific databases

DisGeNETi4259.
OpenTargetsiENSG00000143198.
PharmGKBiPA30793.

Chemistry databases

ChEMBLiCHEMBL1743186.
DrugBankiDB00143. Glutathione.

Polymorphism and mutation databases

BioMutaiMGST3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177411 – 152Microsomal glutathione S-transferase 3Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi150S-palmitoyl cysteine1 Publication1
Lipidationi151S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiO14880.
MaxQBiO14880.
PaxDbiO14880.
PeptideAtlasiO14880.
PRIDEiO14880.
TopDownProteomicsiO14880.

PTM databases

iPTMnetiO14880.
PhosphoSitePlusiO14880.
SwissPalmiO14880.

Expressioni

Tissue specificityi

Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000143198.
CleanExiHS_MGST3.
ExpressionAtlasiO14880. baseline and differential.
GenevisibleiO14880. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNCP248633EBI-724754,EBI-395261

Protein-protein interaction databases

BioGridi110415. 30 interactors.
IntActiO14880. 10 interactors.
MINTiMINT-4990775.
STRINGi9606.ENSP00000356859.

Structurei

3D structure databases

ProteinModelPortaliO14880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J29S. Eukaryota.
ENOG4111URX. LUCA.
GeneTreeiENSGT00390000008608.
HOGENOMiHOG000116372.
HOVERGENiHBG052472.
InParanoidiO14880.
KOiK00799.
PhylomeDBiO14880.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiView protein in InterPro
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
PfamiView protein in Pfam
PF01124. MAPEG. 1 hit.

Sequencei

Sequence statusi: Complete.

O14880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLSKEYGF VLLTGAASFI MVAHLAINVS KARKKYKVEY PIMYSTDPEN
60 70 80 90 100
GHIFNCIQRA HQNTLEVYPP FLFFLAVGGV YHPRIASGLG LAWIVGRVLY
110 120 130 140 150
AYGYYTGEPS KRSRGALGSI ALLGLVGTTV CSAFQHLGWV KSGLGSGPKC

CH
Length:152
Mass (Da):16,516
Last modified:January 1, 1998 - v1
Checksum:iB721527247415E78
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01206115G → C. Corresponds to variant dbSNP:rs1802087Ensembl.1
Natural variantiVAR_01206248P → S. Corresponds to variant dbSNP:rs1802088Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026977 mRNA. Translation: AAB82609.1.
CR450359 mRNA. Translation: CAG29355.1.
AY388493 Genomic DNA. Translation: AAQ81301.1.
AK312103 mRNA. Translation: BAG35039.1.
AL451074 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW90752.1.
BC000505 mRNA. Translation: AAH00505.1.
BC003034 mRNA. Translation: AAH03034.1.
BC005964 mRNA. Translation: AAH05964.1.
CCDSiCCDS1249.1.
RefSeqiNP_004519.1. NM_004528.3.
XP_005245231.2. XM_005245174.3.
UniGeneiHs.191734.
Hs.732686.

Genome annotation databases

EnsembliENST00000367884; ENSP00000356859; ENSG00000143198.
ENST00000367889; ENSP00000356864; ENSG00000143198.
GeneIDi4259.
KEGGihsa:4259.
UCSCiuc001gdf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMGST3_HUMAN
AccessioniPrimary (citable) accession number: O14880
Secondary accession number(s): B2R592, Q6ICN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families