Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O14880

- MGST3_HUMAN

UniProt

O14880 - MGST3_HUMAN

Protein

Microsomal glutathione S-transferase 3

Gene

MGST3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Also functions as a glutathione peroxidase.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: RefGenome
    2. glutathione transferase activity Source: RefGenome
    3. peroxidase activity Source: ProtInc

    GO - Biological processi

    1. glutathione derivative biosynthetic process Source: Reactome
    2. lipid metabolic process Source: ProtInc
    3. oxidation-reduction process Source: GOC
    4. signal transduction Source: ProtInc
    5. small molecule metabolic process Source: Reactome
    6. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_6926. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
    Short name:
    Microsomal GST-3
    Alternative name(s):
    Microsomal GST-III
    Gene namesi
    Name:MGST3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:7064. MGST3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular membrane-bounded organelle Source: ProtInc
    5. membrane Source: UniProtKB
    6. nuclear envelope Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi150 – 1501C → S: Abolishes S-acylation; when associated with S-151. 1 Publication
    Mutagenesisi151 – 1511C → S: Abolishes S-acylation; when associated with S-150. 1 Publication

    Organism-specific databases

    PharmGKBiPA30793.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 152152Microsomal glutathione S-transferase 3PRO_0000217741Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi150 – 1501S-palmitoyl cysteine1 Publication
    Lipidationi151 – 1511S-palmitoyl cysteine1 Publication

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiO14880.
    PaxDbiO14880.
    PRIDEiO14880.

    PTM databases

    PhosphoSiteiO14880.

    Expressioni

    Tissue specificityi

    Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.

    Gene expression databases

    ArrayExpressiO14880.
    BgeeiO14880.
    CleanExiHS_MGST3.
    GenevestigatoriO14880.

    Interactioni

    Protein-protein interaction databases

    BioGridi110415. 11 interactions.
    IntActiO14880. 2 interactions.
    MINTiMINT-4990775.
    STRINGi9606.ENSP00000356859.

    Structurei

    3D structure databases

    ProteinModelPortaliO14880.
    SMRiO14880. Positions 9-133.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MAPEG family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84007.
    HOGENOMiHOG000116372.
    HOVERGENiHBG052472.
    InParanoidiO14880.
    KOiK00799.
    OrthoDBiEOG7PCJKH.
    PhylomeDBiO14880.
    TreeFamiTF105328.

    Family and domain databases

    Gene3Di1.20.120.550. 1 hit.
    InterProiIPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view]
    PfamiPF01124. MAPEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14880-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLSKEYGF VLLTGAASFI MVAHLAINVS KARKKYKVEY PIMYSTDPEN    50
    GHIFNCIQRA HQNTLEVYPP FLFFLAVGGV YHPRIASGLG LAWIVGRVLY 100
    AYGYYTGEPS KRSRGALGSI ALLGLVGTTV CSAFQHLGWV KSGLGSGPKC 150
    CH 152
    Length:152
    Mass (Da):16,516
    Last modified:January 1, 1998 - v1
    Checksum:iB721527247415E78
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151G → C.
    Corresponds to variant rs1802087 [ dbSNP | Ensembl ].
    VAR_012061
    Natural varianti48 – 481P → S.
    Corresponds to variant rs1802088 [ dbSNP | Ensembl ].
    VAR_012062

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026977 mRNA. Translation: AAB82609.1.
    CR450359 mRNA. Translation: CAG29355.1.
    AY388493 Genomic DNA. Translation: AAQ81301.1.
    AK312103 mRNA. Translation: BAG35039.1.
    AL451074 Genomic DNA. Translation: CAH74057.1.
    CH471067 Genomic DNA. Translation: EAW90752.1.
    BC000505 mRNA. Translation: AAH00505.1.
    BC003034 mRNA. Translation: AAH03034.1.
    BC005964 mRNA. Translation: AAH05964.1.
    CCDSiCCDS1249.1.
    RefSeqiNP_004519.1. NM_004528.3.
    UniGeneiHs.191734.
    Hs.732686.

    Genome annotation databases

    EnsembliENST00000367884; ENSP00000356859; ENSG00000143198.
    ENST00000367889; ENSP00000356864; ENSG00000143198.
    GeneIDi4259.
    KEGGihsa:4259.
    UCSCiuc001gdf.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026977 mRNA. Translation: AAB82609.1 .
    CR450359 mRNA. Translation: CAG29355.1 .
    AY388493 Genomic DNA. Translation: AAQ81301.1 .
    AK312103 mRNA. Translation: BAG35039.1 .
    AL451074 Genomic DNA. Translation: CAH74057.1 .
    CH471067 Genomic DNA. Translation: EAW90752.1 .
    BC000505 mRNA. Translation: AAH00505.1 .
    BC003034 mRNA. Translation: AAH03034.1 .
    BC005964 mRNA. Translation: AAH05964.1 .
    CCDSi CCDS1249.1.
    RefSeqi NP_004519.1. NM_004528.3.
    UniGenei Hs.191734.
    Hs.732686.

    3D structure databases

    ProteinModelPortali O14880.
    SMRi O14880. Positions 9-133.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110415. 11 interactions.
    IntActi O14880. 2 interactions.
    MINTi MINT-4990775.
    STRINGi 9606.ENSP00000356859.

    Chemistry

    ChEMBLi CHEMBL1743186.
    DrugBanki DB00143. Glutathione.

    PTM databases

    PhosphoSitei O14880.

    Proteomic databases

    MaxQBi O14880.
    PaxDbi O14880.
    PRIDEi O14880.

    Protocols and materials databases

    DNASUi 4259.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367884 ; ENSP00000356859 ; ENSG00000143198 .
    ENST00000367889 ; ENSP00000356864 ; ENSG00000143198 .
    GeneIDi 4259.
    KEGGi hsa:4259.
    UCSCi uc001gdf.3. human.

    Organism-specific databases

    CTDi 4259.
    GeneCardsi GC01P165600.
    HGNCi HGNC:7064. MGST3.
    MIMi 604564. gene.
    neXtProti NX_O14880.
    PharmGKBi PA30793.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84007.
    HOGENOMi HOG000116372.
    HOVERGENi HBG052472.
    InParanoidi O14880.
    KOi K00799.
    OrthoDBi EOG7PCJKH.
    PhylomeDBi O14880.
    TreeFami TF105328.

    Enzyme and pathway databases

    Reactomei REACT_6926. Glutathione conjugation.

    Miscellaneous databases

    ChiTaRSi MGST3. human.
    GeneWikii MGST3.
    GenomeRNAii 4259.
    NextBioi 16801.
    PROi O14880.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14880.
    Bgeei O14880.
    CleanExi HS_MGST3.
    Genevestigatori O14880.

    Family and domain databases

    Gene3Di 1.20.120.550. 1 hit.
    InterProi IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view ]
    Pfami PF01124. MAPEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities."
      Jakobsson P.-J., Mancini J.A., Riendeau D., Ford-Hutchinson A.W.
      J. Biol. Chem. 272:22934-22939(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. NIEHS SNPs program
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Lung.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Site-specific analysis of protein S-acylation by resin-assisted capture."
      Forrester M.T., Hess D.T., Thompson J.W., Hultman R., Moseley M.A., Stamler J.S., Casey P.J.
      J. Lipid Res. 52:393-398(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF CYS-150 AND CYS-151, PALMITOYLATION AT CYS-150 AND CYS-151.

    Entry informationi

    Entry nameiMGST3_HUMAN
    AccessioniPrimary (citable) accession number: O14880
    Secondary accession number(s): B2R592, Q6ICN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3