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O14880

- MGST3_HUMAN

UniProt

O14880 - MGST3_HUMAN

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Protein
Microsomal glutathione S-transferase 3
Gene
MGST3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Also functions as a glutathione peroxidase.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione peroxidase activity Source: RefGenome
  2. glutathione transferase activity Source: RefGenome
  3. peroxidase activity Source: ProtInc

GO - Biological processi

  1. glutathione derivative biosynthetic process Source: Reactome
  2. lipid metabolic process Source: ProtInc
  3. oxidation-reduction process Source: GOC
  4. signal transduction Source: ProtInc
  5. small molecule metabolic process Source: Reactome
  6. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_6926. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
Short name:
Microsomal GST-3
Alternative name(s):
Microsomal GST-III
Gene namesi
Name:MGST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7064. MGST3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Reviewed prediction
Add
BLAST
Transmembranei71 – 9121Helical; Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. intracellular membrane-bounded organelle Source: ProtInc
  5. membrane Source: ProtInc
  6. nuclear envelope Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi150 – 1501C → S: Abolishes S-acylation; when associated with S-151. 1 Publication
Mutagenesisi151 – 1511C → S: Abolishes S-acylation; when associated with S-150. 1 Publication

Organism-specific databases

PharmGKBiPA30793.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Microsomal glutathione S-transferase 3
PRO_0000217741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi150 – 1501S-palmitoyl cysteine1 Publication
Lipidationi151 – 1511S-palmitoyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiO14880.
PaxDbiO14880.
PRIDEiO14880.

PTM databases

PhosphoSiteiO14880.

Expressioni

Tissue specificityi

Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.

Gene expression databases

ArrayExpressiO14880.
BgeeiO14880.
CleanExiHS_MGST3.
GenevestigatoriO14880.

Interactioni

Protein-protein interaction databases

BioGridi110415. 11 interactions.
IntActiO14880. 2 interactions.
MINTiMINT-4990775.
STRINGi9606.ENSP00000356859.

Structurei

3D structure databases

ProteinModelPortaliO14880.
SMRiO14880. Positions 9-133.

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84007.
HOGENOMiHOG000116372.
HOVERGENiHBG052472.
InParanoidiO14880.
KOiK00799.
OrthoDBiEOG7PCJKH.
PhylomeDBiO14880.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14880-1 [UniParc]FASTAAdd to Basket

« Hide

MAVLSKEYGF VLLTGAASFI MVAHLAINVS KARKKYKVEY PIMYSTDPEN    50
GHIFNCIQRA HQNTLEVYPP FLFFLAVGGV YHPRIASGLG LAWIVGRVLY 100
AYGYYTGEPS KRSRGALGSI ALLGLVGTTV CSAFQHLGWV KSGLGSGPKC 150
CH 152
Length:152
Mass (Da):16,516
Last modified:January 1, 1998 - v1
Checksum:iB721527247415E78
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151G → C.
Corresponds to variant rs1802087 [ dbSNP | Ensembl ].
VAR_012061
Natural varianti48 – 481P → S.
Corresponds to variant rs1802088 [ dbSNP | Ensembl ].
VAR_012062

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF026977 mRNA. Translation: AAB82609.1.
CR450359 mRNA. Translation: CAG29355.1.
AY388493 Genomic DNA. Translation: AAQ81301.1.
AK312103 mRNA. Translation: BAG35039.1.
AL451074 Genomic DNA. Translation: CAH74057.1.
CH471067 Genomic DNA. Translation: EAW90752.1.
BC000505 mRNA. Translation: AAH00505.1.
BC003034 mRNA. Translation: AAH03034.1.
BC005964 mRNA. Translation: AAH05964.1.
CCDSiCCDS1249.1.
RefSeqiNP_004519.1. NM_004528.3.
UniGeneiHs.191734.
Hs.732686.

Genome annotation databases

EnsembliENST00000367884; ENSP00000356859; ENSG00000143198.
ENST00000367889; ENSP00000356864; ENSG00000143198.
GeneIDi4259.
KEGGihsa:4259.
UCSCiuc001gdf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF026977 mRNA. Translation: AAB82609.1 .
CR450359 mRNA. Translation: CAG29355.1 .
AY388493 Genomic DNA. Translation: AAQ81301.1 .
AK312103 mRNA. Translation: BAG35039.1 .
AL451074 Genomic DNA. Translation: CAH74057.1 .
CH471067 Genomic DNA. Translation: EAW90752.1 .
BC000505 mRNA. Translation: AAH00505.1 .
BC003034 mRNA. Translation: AAH03034.1 .
BC005964 mRNA. Translation: AAH05964.1 .
CCDSi CCDS1249.1.
RefSeqi NP_004519.1. NM_004528.3.
UniGenei Hs.191734.
Hs.732686.

3D structure databases

ProteinModelPortali O14880.
SMRi O14880. Positions 9-133.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110415. 11 interactions.
IntActi O14880. 2 interactions.
MINTi MINT-4990775.
STRINGi 9606.ENSP00000356859.

Chemistry

ChEMBLi CHEMBL1743186.
DrugBanki DB00143. Glutathione.

PTM databases

PhosphoSitei O14880.

Proteomic databases

MaxQBi O14880.
PaxDbi O14880.
PRIDEi O14880.

Protocols and materials databases

DNASUi 4259.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367884 ; ENSP00000356859 ; ENSG00000143198 .
ENST00000367889 ; ENSP00000356864 ; ENSG00000143198 .
GeneIDi 4259.
KEGGi hsa:4259.
UCSCi uc001gdf.3. human.

Organism-specific databases

CTDi 4259.
GeneCardsi GC01P165600.
HGNCi HGNC:7064. MGST3.
MIMi 604564. gene.
neXtProti NX_O14880.
PharmGKBi PA30793.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84007.
HOGENOMi HOG000116372.
HOVERGENi HBG052472.
InParanoidi O14880.
KOi K00799.
OrthoDBi EOG7PCJKH.
PhylomeDBi O14880.
TreeFami TF105328.

Enzyme and pathway databases

Reactomei REACT_6926. Glutathione conjugation.

Miscellaneous databases

ChiTaRSi MGST3. human.
GeneWikii MGST3.
GenomeRNAii 4259.
NextBioi 16801.
PROi O14880.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14880.
Bgeei O14880.
CleanExi HS_MGST3.
Genevestigatori O14880.

Family and domain databases

Gene3Di 1.20.120.550. 1 hit.
InterProi IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view ]
Pfami PF01124. MAPEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities."
    Jakobsson P.-J., Mancini J.A., Riendeau D., Ford-Hutchinson A.W.
    J. Biol. Chem. 272:22934-22939(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIEHS SNPs program
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Lung.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Site-specific analysis of protein S-acylation by resin-assisted capture."
    Forrester M.T., Hess D.T., Thompson J.W., Hultman R., Moseley M.A., Stamler J.S., Casey P.J.
    J. Lipid Res. 52:393-398(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-150 AND CYS-151, PALMITOYLATION AT CYS-150 AND CYS-151.

Entry informationi

Entry nameiMGST3_HUMAN
AccessioniPrimary (citable) accession number: O14880
Secondary accession number(s): B2R592, Q6ICN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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