O14879 (IFIT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon-induced protein with tetratricopeptide repeats 3
Short name=IFIT-3

Alternative name(s):
CIG49
ISG-60
Interferon-induced 60 kDa protein
Short name=IFI-60K
Interferon-induced protein with tetratricopeptide repeats 4
Short name=IFIT-4
Retinoic acid-induced gene G protein
Short name=RIG-G

Gene names

Name:	IFIT3
Synonyms:	IFI60, IFIT4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the IFIT family. Contains 8 TPR repeats.

Ontologies

Keywords
Domain	Repeat TPR repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular response to interferon-alpha Inferred from electronic annotation. Source: InterPro type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular component	cytosol Traceable author statement. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC37	Q16543	4	EBI-745127,EBI-295634
IFIT1	P09914	5	EBI-745127,EBI-745117
IFIT2	P09913	4	EBI-745127,EBI-3507167

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Interferon-induced protein with tetratricopeptide repeats 3		PRO_0000106349
Regions
	Repeat	51 – 84	34	TPR 1
	Repeat	94 – 127	34	TPR 2
	Repeat	136 – 169	34	TPR 3
	Repeat	172 – 206	35	TPR 4
	Repeat	207 – 240	34	TPR 5
	Repeat	241 – 274	34	TPR 6
	Repeat	415 – 448	34	TPR 7
	Repeat	450 – 481	32	TPR 8
Amino acid modifications
	Modified residue	203	1	Phosphoserine Ref.6 Ref.7 Ref.8
	Modified residue	237	1	Phosphoserine Ref.7
Experimental info
	Sequence conflict	44	1	F → S in AAH04977. Ref.5
	Sequence conflict	359	1	Q → QQ in AAB40606. Ref.2
	Sequence conflict	435	1	Missing in AAB40606. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O14879 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: B9F042D4DF7151D2	FASTA	490	55,985
	10 20 30 40 50 60 MSEVTKNSLE KILPQLKCHF TWNLFKEDSV SRDLEDRVCN QIEFLNTEFK ATMYNLLAYI 70 80 90 100 110 120 KHLDGNNEAA LECLRQAEEL IQQEHADQAE IRSLVTWGNY AWVYYHLGRL SDAQIYVDKV 130 140 150 160 170 180 KQTCKKFSNP YSIEYSELDC EEGWTQLKCG RNERAKVCFE KALEEKPNNP EFSSGLAIAM 190 200 210 220 230 240 YHLDNHPEKQ FSTDVLKQAI ELSPDNQYVK VLLGLKLQKM NKEAEGEQFV EEALEKSPCQ 250 260 270 280 290 300 TDVLRSAAKF YRRKGDLDKA IELFQRVLES TPNNGYLYHQ IGCCYKAKVR QMQNTGESEA 310 320 330 340 350 360 SGNKEMIEAL KQYAMDYSNK ALEKGLNPLN AYSDLAEFLE TECYQTPFNK EVPDAEKQQS 370 380 390 400 410 420 HQRYCNLQKY NGKSEDTAVQ HGLEGLSISK KSTDKEEIKD QPQNVSENLL PQNAPNYWYL 430 440 450 460 470 480 QGLIHKQNGD LLQAAKCYEK ELGRLLRDAP SGIGSIFLSA SELEDGSEEM GQGAVSSSPR 490 ELLSNSEQLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs." Zhu H., Cong J.-P., Shenk T. Proc. Natl. Acad. Sci. U.S.A. 94:13985-13990(1997) [PubMed: 9391139] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Foreskin.
[2]	"IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes." de Veer M.J., Sim H., Whisstock J.C., Devenish R.J., Ralph S.J. Genomics 54:267-277(1998) [PubMed: 9828129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"RIG-G, a novel gene induced by ATRA in acute promyelocytic leukemia cells, is a new member of the ISG family." Yu M., Tong J., Mao M., Chen S., Chen Z. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[6]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND SER-237, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF026939 mRNA. Translation: AAB95160.1. AF083470 mRNA. Translation: AAC63524.1. U52513 mRNA. Translation: AAB40606.1. BT007284 mRNA. Translation: AAP35948.1. BC001383 mRNA. Translation: AAH01383.1. BC004977 mRNA. Translation: AAH04977.1.
IPI	IPI00024254.
RefSeq	NP_001026853.1. NM_001031683.2. NP_001540.2. NM_001549.4.
UniGene	Hs.47338.
3D structure databases
ProteinModelPortal	O14879.
SMR	O14879. Positions 52-328.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14879. 51 interactions.
MINT	MINT-1448195.
STRING	O14879.
PTM databases
PhosphoSite	O14879.
Proteomic databases
PeptideAtlas	O14879.
PRIDE	O14879.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371811; ENSP00000360876; ENSG00000119917. ENST00000371818; ENSP00000360883; ENSG00000119917.
GeneID	3437.
KEGG	hsa:3437.
UCSC	uc001kgf.1. human.
Organism-specific databases
CTD	3437.
GeneCards	GC10P091077.
H-InvDB	HIX0009021.
HGNC	HGNC:5411. IFIT3.
MIM	604650. gene.
neXtProt	NX_O14879.
PharmGKB	PA29651.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04733.
HOGENOM	HBG447196.
HOVERGEN	HBG066330.
InParanoid	O14879.
OMA	IAMYHLD.
OrthoDB	EOG4NVZK4.
PhylomeDB	O14879.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	O14879.
Bgee	O14879.
CleanEx	HS_IFIT3.
Genevestigator	O14879.
GermOnline	ENSG00000119917. Homo sapiens.
Family and domain databases
InterPro	IPR024122. Interferon-induced_IFIT3. IPR013026. TPR-contain. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 2 hits.
PANTHER	PTHR10271:SF3. PTHR10271:SF3. 1 hit.
SMART	SM00028. TPR. 4 hits. [Graphical view]
PROSITE	PS50005. TPR. 5 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13544.
SOURCE	Search...

Entry information

Entry name

IFIT3_HUMAN

Accession

Primary (citable) accession number: O14879
Secondary accession number(s): Q99634, Q9BSK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.