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O14879 (IFIT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon-induced protein with tetratricopeptide repeats 3

Short name=IFIT-3
Alternative name(s):
CIG49
ISG-60
Interferon-induced 60 kDa protein
Short name=IFI-60K
Interferon-induced protein with tetratricopeptide repeats 4
Short name=IFIT-4
Retinoic acid-induced gene G protein
Short name=RIG-G
Gene names
Name:IFIT3
Synonyms:IFI60, IFIT4
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the IFIT family.

Contains 8 TPR repeats.

Ontologies

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Interferon-induced protein with tetratricopeptide repeats 3
PRO_0000106349

Regions

Repeat51 – 8434TPR 1
Repeat94 – 12734TPR 2
Repeat136 – 16934TPR 3
Repeat172 – 20635TPR 4
Repeat207 – 24034TPR 5
Repeat241 – 27434TPR 6
Repeat415 – 44834TPR 7
Repeat450 – 48132TPR 8

Amino acid modifications

Modified residue2031Phosphoserine Ref.6 Ref.7 Ref.8
Modified residue2371Phosphoserine Ref.7

Experimental info

Sequence conflict441F → S in AAH04977. Ref.5
Sequence conflict3591Q → QQ in AAB40606. Ref.2
Sequence conflict4351Missing in AAB40606. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O14879 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: B9F042D4DF7151D2

FASTA49055,985
        10         20         30         40         50         60 
MSEVTKNSLE KILPQLKCHF TWNLFKEDSV SRDLEDRVCN QIEFLNTEFK ATMYNLLAYI 

        70         80         90        100        110        120 
KHLDGNNEAA LECLRQAEEL IQQEHADQAE IRSLVTWGNY AWVYYHLGRL SDAQIYVDKV 

       130        140        150        160        170        180 
KQTCKKFSNP YSIEYSELDC EEGWTQLKCG RNERAKVCFE KALEEKPNNP EFSSGLAIAM 

       190        200        210        220        230        240 
YHLDNHPEKQ FSTDVLKQAI ELSPDNQYVK VLLGLKLQKM NKEAEGEQFV EEALEKSPCQ 

       250        260        270        280        290        300 
TDVLRSAAKF YRRKGDLDKA IELFQRVLES TPNNGYLYHQ IGCCYKAKVR QMQNTGESEA 

       310        320        330        340        350        360 
SGNKEMIEAL KQYAMDYSNK ALEKGLNPLN AYSDLAEFLE TECYQTPFNK EVPDAEKQQS 

       370        380        390        400        410        420 
HQRYCNLQKY NGKSEDTAVQ HGLEGLSISK KSTDKEEIKD QPQNVSENLL PQNAPNYWYL 

       430        440        450        460        470        480 
QGLIHKQNGD LLQAAKCYEK ELGRLLRDAP SGIGSIFLSA SELEDGSEEM GQGAVSSSPR 

       490 
ELLSNSEQLN 

« Hide

References

« Hide 'large scale' references
[1]"Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs."
Zhu H., Cong J.-P., Shenk T.
Proc. Natl. Acad. Sci. U.S.A. 94:13985-13990(1997) [PubMed: 9391139] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Foreskin.
[2]"IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes."
de Veer M.J., Sim H., Whisstock J.C., Devenish R.J., Ralph S.J.
Genomics 54:267-277(1998) [PubMed: 9828129] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"RIG-G, a novel gene induced by ATRA in acute promyelocytic leukemia cells, is a new member of the ISG family."
Yu M., Tong J., Mao M., Chen S., Chen Z.
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[6]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND SER-237, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF026939 mRNA. Translation: AAB95160.1.
AF083470 mRNA. Translation: AAC63524.1.
U52513 mRNA. Translation: AAB40606.1.
BT007284 mRNA. Translation: AAP35948.1.
BC001383 mRNA. Translation: AAH01383.1.
BC004977 mRNA. Translation: AAH04977.1.
IPIIPI00024254.
RefSeqNP_001026853.1. NM_001031683.2.
NP_001540.2. NM_001549.4.
UniGeneHs.47338.

3D structure databases

ProteinModelPortalO14879.
SMRO14879. Positions 52-328.
ModBaseSearch...

Protein-protein interaction databases

IntActO14879. 51 interactions.
MINTMINT-1448195.
STRINGO14879.

PTM databases

PhosphoSiteO14879.

Proteomic databases

PeptideAtlasO14879.
PRIDEO14879.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371811; ENSP00000360876; ENSG00000119917.
ENST00000371818; ENSP00000360883; ENSG00000119917.
GeneID3437.
KEGGhsa:3437.
UCSCuc001kgf.1. human.

Organism-specific databases

CTD3437.
GeneCardsGC10P091077.
H-InvDBHIX0009021.
HGNCHGNC:5411. IFIT3.
MIM604650. gene.
neXtProtNX_O14879.
PharmGKBPA29651.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG04733.
HOGENOMHBG447196.
HOVERGENHBG066330.
InParanoidO14879.
OMAIAMYHLD.
OrthoDBEOG4NVZK4.
PhylomeDBO14879.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressO14879.
BgeeO14879.
CleanExHS_IFIT3.
GenevestigatorO14879.
GermOnlineENSG00000119917. Homo sapiens.

Family and domain databases

InterProIPR024122. Interferon-induced_IFIT3.
IPR013026. TPR-contain.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
Gene3DG3DSA:1.25.40.10. TPR-like_helical. 2 hits.
PANTHERPTHR10271:SF3. PTHR10271:SF3. 1 hit.
SMARTSM00028. TPR. 4 hits.
[Graphical view]
PROSITEPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13544.
SOURCESearch...

Entry information

Entry nameIFIT3_HUMAN
AccessionPrimary (citable) accession number: O14879
Secondary accession number(s): Q99634, Q9BSK7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families