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Protein

Interferon-induced protein with tetratricopeptide repeats 3

Gene

IFIT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.5 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • cellular response to interferon-alpha Source: InterPro
  • defense response to virus Source: GO_Central
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • response to virus Source: UniProtKB
  • type I interferon signaling pathway Source: Reactome

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein with tetratricopeptide repeats 3
Short name:
IFIT-3
Alternative name(s):
CIG49
ISG-60
Interferon-induced 60 kDa protein
Short name:
IFI-60K
Interferon-induced protein with tetratricopeptide repeats 4
Short name:
IFIT-4
Retinoic acid-induced gene G protein
Short name:
P60
Short name:
RIG-G
Gene namesi
Name:IFIT3
Synonyms:CIG-49, IFI60, IFIT4, ISG60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000119917.13
HGNCiHGNC:5411 IFIT3
MIMi604650 gene
neXtProtiNX_O14879

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi3437
OpenTargetsiENSG00000119917
PharmGKBiPA29651

Polymorphism and mutation databases

BioMutaiIFIT3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063491 – 490Interferon-induced protein with tetratricopeptide repeats 3Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14879
PaxDbiO14879
PeptideAtlasiO14879
PRIDEiO14879

PTM databases

iPTMnetiO14879
PhosphoSitePlusiO14879

Expressioni

Tissue specificityi

Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver.1 Publication

Inductioni

By type I interferons, dsRNAs and viruses.1 Publication

Gene expression databases

BgeeiENSG00000119917
CleanExiHS_IFIT3
ExpressionAtlasiO14879 baseline and differential
GenevisibleiO14879 HS

Organism-specific databases

HPAiHPA059914

Interactioni

Subunit structurei

Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT2. Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58. Interacts with COPS5.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi109660, 70 interactors
DIPiDIP-37890N
IntActiO14879, 56 interactors
MINTiO14879
STRINGi9606.ENSP00000360876

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6C6KX-ray2.54C/D416-459[»]
ProteinModelPortaliO14879
SMRiO14879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 84TPR 1Add BLAST34
Repeati94 – 127TPR 2Add BLAST34
Repeati136 – 169TPR 3Add BLAST34
Repeati172 – 206TPR 4Add BLAST35
Repeati207 – 240TPR 5Add BLAST34
Repeati241 – 274TPR 6Add BLAST34
Repeati415 – 448TPR 7Add BLAST34
Repeati450 – 481TPR 8Add BLAST32

Sequence similaritiesi

Belongs to the IFIT family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000013876
HOGENOMiHOG000001558
HOVERGENiHBG066330
InParanoidiO14879
OMAiNGYLYHQ
OrthoDBiEOG091G06GX
PhylomeDBiO14879
TreeFamiTF342671

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR024122 Interferon-induced_IFIT3
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR10271:SF3 PTHR10271:SF3, 1 hit
PfamiView protein in Pfam
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O14879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVTKNSLE KILPQLKCHF TWNLFKEDSV SRDLEDRVCN QIEFLNTEFK
60 70 80 90 100
ATMYNLLAYI KHLDGNNEAA LECLRQAEEL IQQEHADQAE IRSLVTWGNY
110 120 130 140 150
AWVYYHLGRL SDAQIYVDKV KQTCKKFSNP YSIEYSELDC EEGWTQLKCG
160 170 180 190 200
RNERAKVCFE KALEEKPNNP EFSSGLAIAM YHLDNHPEKQ FSTDVLKQAI
210 220 230 240 250
ELSPDNQYVK VLLGLKLQKM NKEAEGEQFV EEALEKSPCQ TDVLRSAAKF
260 270 280 290 300
YRRKGDLDKA IELFQRVLES TPNNGYLYHQ IGCCYKAKVR QMQNTGESEA
310 320 330 340 350
SGNKEMIEAL KQYAMDYSNK ALEKGLNPLN AYSDLAEFLE TECYQTPFNK
360 370 380 390 400
EVPDAEKQQS HQRYCNLQKY NGKSEDTAVQ HGLEGLSISK KSTDKEEIKD
410 420 430 440 450
QPQNVSENLL PQNAPNYWYL QGLIHKQNGD LLQAAKCYEK ELGRLLRDAP
460 470 480 490
SGIGSIFLSA SELEDGSEEM GQGAVSSSPR ELLSNSEQLN
Length:490
Mass (Da):55,985
Last modified:January 1, 1998 - v1
Checksum:iB9F042D4DF7151D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44F → S in AAH04977 (PubMed:15489334).Curated1
Sequence conflicti359Q → QQ in AAB40606 (PubMed:9828129).Curated1
Sequence conflicti435Missing in AAB40606 (PubMed:9828129).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026939 mRNA Translation: AAB95160.1
AF083470 mRNA Translation: AAC63524.1
U52513 mRNA Translation: AAB40606.1
BT007284 mRNA Translation: AAP35948.1
BC001383 mRNA Translation: AAH01383.1
BC004977 mRNA Translation: AAH04977.1
CCDSiCCDS31241.1
CCDS7402.1
RefSeqiNP_001026853.1, NM_001031683.3
NP_001540.2, NM_001549.5
UniGeneiHs.47338
Hs.744072

Genome annotation databases

EnsembliENST00000371811; ENSP00000360876; ENSG00000119917
ENST00000371818; ENSP00000360883; ENSG00000119917
GeneIDi3437
KEGGihsa:3437

Similar proteinsi

Entry informationi

Entry nameiIFIT3_HUMAN
AccessioniPrimary (citable) accession number: O14879
Secondary accession number(s): Q99634, Q9BSK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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