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O14874

- BCKD_HUMAN

UniProt

O14874 - BCKD_HUMAN

Protein

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Gene

BCKDK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex By similarity.By similarity

    Catalytic activityi

    ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate.

    GO - Molecular functioni

    1. [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity Source: UniProtKB-EC
    2. ATP binding Source: HGNC
    3. kinase activity Source: HGNC
    4. protein binding Source: IntAct
    5. protein serine/threonine kinase activity Source: HGNC

    GO - Biological processi

    1. branched-chain amino acid catabolic process Source: HGNC
    2. cellular amino acid catabolic process Source: UniProtKB
    3. phosphorylation Source: HGNC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (EC:2.7.11.4)
    Alternative name(s):
    Branched-chain alpha-ketoacid dehydrogenase kinase
    Short name:
    BCKD-kinase
    Short name:
    BCKDHKIN
    Gene namesi
    Name:BCKDK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:16902. BCKDK.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial alpha-ketoglutarate dehydrogenase complex Source: HGNC
    2. mitochondrion Source: UniProt

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Branched-chain ketoacid dehydrogenase kinase deficiency (BCKDKD) [MIM:614923]: A metabolic disorder characterized by autism, epilepsy, intellectual disability, and reduced branched-chain amino acids.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry. A diet enriched in branched amino acids (BCAAs) allows to normalize plasma BCAA levels. This suggests that it may be possible to treat patients with mutations in BCKDK with BCAA supplementation.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti224 – 2241R → P in BCKDKD. 1 Publication
    VAR_069037

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi614923. phenotype.
    Orphaneti308410. Autism-epilepsy syndrome due to branched chain ketoacid dehydrogenase kinase deficiency.
    PharmGKBiPA134899581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030MitochondrionBy similarityAdd
    BLAST
    Chaini31 – 412382[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrialPRO_0000023452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 521Phosphoserine; by autocatalysisBy similarity
    Modified residuei192 – 1921N6-acetyllysine1 Publication
    Modified residuei233 – 2331N6-acetyllysine1 Publication

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO14874.
    PaxDbiO14874.
    PRIDEiO14874.

    PTM databases

    PhosphoSiteiO14874.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiO14874.
    BgeeiO14874.
    CleanExiHS_BCKDK.
    GenevestigatoriO14874.

    Organism-specific databases

    HPAiHPA017995.
    HPA056067.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q9WMX22EBI-1046765,EBI-6863741From a different organism.
    STAT3P407632EBI-1046765,EBI-518675

    Protein-protein interaction databases

    BioGridi115583. 15 interactions.
    IntActiO14874. 5 interactions.
    MINTiMINT-2998419.
    STRINGi9606.ENSP00000219794.

    Structurei

    3D structure databases

    ProteinModelPortaliO14874.
    SMRiO14874. Positions 68-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini159 – 404246Histidine kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PDK/BCKDK protein kinase family.Curated
    Contains 1 histidine kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0642.
    HOGENOMiHOG000164315.
    HOVERGENiHBG004829.
    InParanoidiO14874.
    KOiK00905.
    OMAiTIANNDV.
    OrthoDBiEOG7TQV0S.
    PhylomeDBiO14874.
    TreeFamiTF331303.

    Family and domain databases

    Gene3Di1.20.140.20. 1 hit.
    3.30.565.10. 1 hit.
    InterProiIPR018955. BCDHK/PDK_N.
    IPR003594. HATPase_ATP-bd.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    [Graphical view]
    PfamiPF10436. BCDHK_Adom3. 1 hit.
    PF02518. HATPase_c. 1 hit.
    [Graphical view]
    PRINTSiPR00344. BCTRLSENSOR.
    SMARTiSM00387. HATPase_c. 1 hit.
    [Graphical view]
    SUPFAMiSSF55874. SSF55874. 1 hit.
    SSF69012. SSF69012. 1 hit.
    PROSITEiPS50109. HIS_KIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14874-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MILASVLRSG PGGGLPLRPL LGPALALRAR STSATDTHHV EMARERSKTV    50
    TSFYNQSAID AAAEKPSVRL TPTMMLYAGR SQDGSHLLKS ARYLQQELPV 100
    RIAHRIKGFR CLPFIIGCNP TILHVHELYI RAFQKLTDFP PIKDQADEAQ 150
    YCQLVRQLLD DHKDVVTLLA EGLRESRKHI EDEKLVRYFL DKTLTSRLGI 200
    RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR LCEHKYGNAP 250
    RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI 300
    TIANNDVDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRISPLFG 350
    HLDMHSGAQS GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL 400
    RHIDGREESF RI 412
    Length:412
    Mass (Da):46,360
    Last modified:June 6, 2002 - v2
    Checksum:iAC97CF5D151FEFB4
    GO
    Isoform 2 (identifier: O14874-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         282-311: Missing.
         366-412: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:335
    Mass (Da):37,768
    Checksum:iB66E1F96C0718C57
    GO
    Isoform 3 (identifier: O14874-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         366-412: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:365
    Mass (Da):41,090
    Checksum:i8702A3E7E94341DC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31L → P in AK130145. (PubMed:14702039)Curated
    Sequence conflicti114 – 1141F → S in AK130145. (PubMed:14702039)Curated
    Sequence conflicti218 – 2181V → F in AAB82714. 1 PublicationCurated
    Sequence conflicti227 – 2271P → S in AK130145. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti224 – 2241R → P in BCKDKD. 1 Publication
    VAR_069037

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei282 – 31130Missing in isoform 2. 1 PublicationVSP_054604Add
    BLAST
    Alternative sequencei366 – 41247Missing in isoform 2 and isoform 3. 2 PublicationsVSP_054605Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026548 mRNA. Translation: AAB82714.1.
    AK130145 mRNA. No translation available.
    CR542093 mRNA. Translation: CAG46890.1.
    AC135050 Genomic DNA. No translation available.
    CH471192 Genomic DNA. Translation: EAW52160.1.
    CH471192 Genomic DNA. Translation: EAW52161.1.
    CH471192 Genomic DNA. Translation: EAW52163.1.
    BC007363 mRNA. Translation: AAH07363.1.
    BC009872 mRNA. Translation: AAH09872.1.
    CCDSiCCDS10705.1. [O14874-1]
    CCDS45467.1. [O14874-3]
    CCDS61917.1. [O14874-2]
    RefSeqiNP_001116429.1. NM_001122957.2. [O14874-3]
    NP_001258855.1. NM_001271926.1. [O14874-2]
    NP_005872.2. NM_005881.3. [O14874-1]
    UniGeneiHs.513520.

    Genome annotation databases

    EnsembliENST00000219794; ENSP00000219794; ENSG00000103507. [O14874-1]
    ENST00000287507; ENSP00000287507; ENSG00000103507. [O14874-2]
    ENST00000394950; ENSP00000378404; ENSG00000103507. [O14874-3]
    ENST00000394951; ENSP00000378405; ENSG00000103507. [O14874-1]
    GeneIDi10295.
    KEGGihsa:10295.
    UCSCiuc002eav.5. human. [O14874-1]
    uc010cai.4. human.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The silence within - Issue 147 of March 2013

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026548 mRNA. Translation: AAB82714.1 .
    AK130145 mRNA. No translation available.
    CR542093 mRNA. Translation: CAG46890.1 .
    AC135050 Genomic DNA. No translation available.
    CH471192 Genomic DNA. Translation: EAW52160.1 .
    CH471192 Genomic DNA. Translation: EAW52161.1 .
    CH471192 Genomic DNA. Translation: EAW52163.1 .
    BC007363 mRNA. Translation: AAH07363.1 .
    BC009872 mRNA. Translation: AAH09872.1 .
    CCDSi CCDS10705.1. [O14874-1 ]
    CCDS45467.1. [O14874-3 ]
    CCDS61917.1. [O14874-2 ]
    RefSeqi NP_001116429.1. NM_001122957.2. [O14874-3 ]
    NP_001258855.1. NM_001271926.1. [O14874-2 ]
    NP_005872.2. NM_005881.3. [O14874-1 ]
    UniGenei Hs.513520.

    3D structure databases

    ProteinModelPortali O14874.
    SMRi O14874. Positions 68-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115583. 15 interactions.
    IntActi O14874. 5 interactions.
    MINTi MINT-2998419.
    STRINGi 9606.ENSP00000219794.

    PTM databases

    PhosphoSitei O14874.

    Proteomic databases

    MaxQBi O14874.
    PaxDbi O14874.
    PRIDEi O14874.

    Protocols and materials databases

    DNASUi 10295.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219794 ; ENSP00000219794 ; ENSG00000103507 . [O14874-1 ]
    ENST00000287507 ; ENSP00000287507 ; ENSG00000103507 . [O14874-2 ]
    ENST00000394950 ; ENSP00000378404 ; ENSG00000103507 . [O14874-3 ]
    ENST00000394951 ; ENSP00000378405 ; ENSG00000103507 . [O14874-1 ]
    GeneIDi 10295.
    KEGGi hsa:10295.
    UCSCi uc002eav.5. human. [O14874-1 ]
    uc010cai.4. human.

    Organism-specific databases

    CTDi 10295.
    GeneCardsi GC16P031117.
    HGNCi HGNC:16902. BCKDK.
    HPAi HPA017995.
    HPA056067.
    MIMi 614901. gene.
    614923. phenotype.
    neXtProti NX_O14874.
    Orphaneti 308410. Autism-epilepsy syndrome due to branched chain ketoacid dehydrogenase kinase deficiency.
    PharmGKBi PA134899581.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0642.
    HOGENOMi HOG000164315.
    HOVERGENi HBG004829.
    InParanoidi O14874.
    KOi K00905.
    OMAi TIANNDV.
    OrthoDBi EOG7TQV0S.
    PhylomeDBi O14874.
    TreeFami TF331303.

    Miscellaneous databases

    GeneWikii BCKDK.
    GenomeRNAii 10295.
    NextBioi 39014.
    PROi O14874.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14874.
    Bgeei O14874.
    CleanExi HS_BCKDK.
    Genevestigatori O14874.

    Family and domain databases

    Gene3Di 1.20.140.20. 1 hit.
    3.30.565.10. 1 hit.
    InterProi IPR018955. BCDHK/PDK_N.
    IPR003594. HATPase_ATP-bd.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    [Graphical view ]
    Pfami PF10436. BCDHK_Adom3. 1 hit.
    PF02518. HATPase_c. 1 hit.
    [Graphical view ]
    PRINTSi PR00344. BCTRLSENSOR.
    SMARTi SM00387. HATPase_c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55874. SSF55874. 1 hit.
    SSF69012. SSF69012. 1 hit.
    PROSITEi PS50109. HIS_KIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Chuang J.C., Cox R.P., Chuang D.T.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung and Placenta.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-192 AND LYS-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANT BCKDKD PRO-224.

    Entry informationi

    Entry nameiBCKD_HUMAN
    AccessioniPrimary (citable) accession number: O14874
    Secondary accession number(s): A8MY43
    , Q6FGL4, Q96G95, Q96IN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

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