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O14867

- BACH1_HUMAN

UniProt

O14867 - BACH1_HUMAN

Protein

Transcription regulator protein BACH1

Gene

BACH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

    GO - Molecular functioni

    1. heme binding Source: UniProtKB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB
    3. regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
    4. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
    5. regulation of transcription involved in G2/M transition of mitotic cell cycle Source: UniProtKB

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription regulator protein BACH1
    Alternative name(s):
    BTB and CNC homolog 1
    HA2303
    Gene namesi
    Name:BACH1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:935. BACH1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25234.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 736736Transcription regulator protein BACH1PRO_0000076454Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei445 – 4451Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO14867.
    PaxDbiO14867.
    PRIDEiO14867.

    PTM databases

    PhosphoSiteiO14867.

    Expressioni

    Gene expression databases

    ArrayExpressiO14867.
    BgeeiO14867.
    CleanExiHS_BACH1.
    GenevestigatoriO14867.

    Organism-specific databases

    HPAiHPA003175.
    HPA034949.

    Interactioni

    Protein-protein interaction databases

    BioGridi107047. 31 interactions.
    DIPiDIP-24223N.
    IntActiO14867. 5 interactions.
    MINTiMINT-196655.
    STRINGi9606.ENSP00000286800.

    Structurei

    Secondary structure

    1
    736
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 125
    Helixi16 – 3015
    Beta strandi36 – 405
    Beta strandi43 – 475
    Helixi49 – 557
    Helixi57 – 637
    Beta strandi71 – 744
    Helixi81 – 9313
    Beta strandi94 – 996
    Turni100 – 1023
    Helixi103 – 11311
    Beta strandi115 – 1173
    Helixi120 – 1245

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IHCX-ray2.44A/B/C/D7-128[»]
    ProteinModelPortaliO14867.
    SMRiO14867. Positions 7-126, 524-617.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14867.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 10067BTBPROSITE-ProRule annotationAdd
    BLAST
    Domaini557 – 62064bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni562 – 57817Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni582 – 5898Leucine-zipperPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the bZIP family. CNC subfamily.Curated
    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG308993.
    HOGENOMiHOG000231712.
    HOVERGENiHBG099852.
    InParanoidiO14867.
    KOiK09042.
    OMAiENKNVQT.
    OrthoDBiEOG73V6JP.
    PhylomeDBiO14867.
    TreeFamiTF326681.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF03131. bZIP_Maf. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    SM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14867-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS    50
    VLAACSSYFH SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK 100
    ENVDEVCKCV EFLSVHNIEE SCFQFLKFKF LDSTADQQEC PRKKCFSSHC 150
    QKTDLKLSLL DQRDLETDEV EEFLENKNVQ TPQCKLRRYQ GNAKASPPLQ 200
    DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR TGESSVKDIH 250
    ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP 300
    TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP 350
    LSGTDVQEKT FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG 400
    FWSDICSTDT PCQMQLSPAV AKDGSEQISQ KRSECPWLGI RISESPEPGQ 450
    RTFTTLSSVN CPFISTLSTE GCSSNLEIGN DDYVSEPQQE PCPYACVISL 500
    GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND FQSLLKMHKL 550
    TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL 600
    KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF 650
    LISEKDKSTP DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ 700
    MSTATSEQAG PAEQCRQSGG ISDFCQQMTD KCTTDE 736
    Length:736
    Mass (Da):81,958
    Last modified:May 30, 2000 - v2
    Checksum:iCAAEECC63D46571B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti158 – 1581S → T in AAB84100. (PubMed:9544839)Curated
    Sequence conflicti171 – 1711E → G in AAB84100. (PubMed:9544839)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti314 – 3141S → P.
    Corresponds to variant rs35474725 [ dbSNP | Ensembl ].
    VAR_048441

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026199 mRNA. Translation: AAB84100.1.
    AF026200 mRNA. Translation: AAB84101.1.
    AB002803 mRNA. Translation: BAA24932.1.
    AF124731 Genomic DNA. Translation: AAD14689.1.
    AL163249 Genomic DNA. Translation: CAB90435.1.
    AP001705 Genomic DNA. Translation: BAA95505.1.
    BC063307 mRNA. Translation: AAH63307.1.
    CCDSiCCDS13585.1.
    PIRiT00023.
    RefSeqiNP_001177.1. NM_001186.2.
    NP_996749.1. NM_206866.1.
    XP_005261069.1. XM_005261012.1.
    XP_005261070.1. XM_005261013.2.
    XP_005261071.1. XM_005261014.1.
    UniGeneiHs.154276.

    Genome annotation databases

    EnsembliENST00000286800; ENSP00000286800; ENSG00000156273.
    ENST00000399921; ENSP00000382805; ENSG00000156273.
    GeneIDi571.
    KEGGihsa:571.
    UCSCiuc002ynj.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026199 mRNA. Translation: AAB84100.1 .
    AF026200 mRNA. Translation: AAB84101.1 .
    AB002803 mRNA. Translation: BAA24932.1 .
    AF124731 Genomic DNA. Translation: AAD14689.1 .
    AL163249 Genomic DNA. Translation: CAB90435.1 .
    AP001705 Genomic DNA. Translation: BAA95505.1 .
    BC063307 mRNA. Translation: AAH63307.1 .
    CCDSi CCDS13585.1.
    PIRi T00023.
    RefSeqi NP_001177.1. NM_001186.2.
    NP_996749.1. NM_206866.1.
    XP_005261069.1. XM_005261012.1.
    XP_005261070.1. XM_005261013.2.
    XP_005261071.1. XM_005261014.1.
    UniGenei Hs.154276.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IHC X-ray 2.44 A/B/C/D 7-128 [» ]
    ProteinModelPortali O14867.
    SMRi O14867. Positions 7-126, 524-617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107047. 31 interactions.
    DIPi DIP-24223N.
    IntActi O14867. 5 interactions.
    MINTi MINT-196655.
    STRINGi 9606.ENSP00000286800.

    PTM databases

    PhosphoSitei O14867.

    Proteomic databases

    MaxQBi O14867.
    PaxDbi O14867.
    PRIDEi O14867.

    Protocols and materials databases

    DNASUi 571.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000286800 ; ENSP00000286800 ; ENSG00000156273 .
    ENST00000399921 ; ENSP00000382805 ; ENSG00000156273 .
    GeneIDi 571.
    KEGGi hsa:571.
    UCSCi uc002ynj.3. human.

    Organism-specific databases

    CTDi 571.
    GeneCardsi GC21P030570.
    HGNCi HGNC:935. BACH1.
    HPAi HPA003175.
    HPA034949.
    MIMi 602751. gene.
    neXtProti NX_O14867.
    PharmGKBi PA25234.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308993.
    HOGENOMi HOG000231712.
    HOVERGENi HBG099852.
    InParanoidi O14867.
    KOi K09042.
    OMAi ENKNVQT.
    OrthoDBi EOG73V6JP.
    PhylomeDBi O14867.
    TreeFami TF326681.

    Miscellaneous databases

    ChiTaRSi BACH1. human.
    EvolutionaryTracei O14867.
    GeneWikii BACH1.
    GenomeRNAii 571.
    NextBioi 2323.
    PROi O14867.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14867.
    Bgeei O14867.
    CleanExi HS_BACH1.
    Genevestigatori O14867.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR008917. TF_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF03131. bZIP_Maf. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1."
      Blouin J.-L., Duriaux Sail G., Guipponi M., Rossier C., Pappasavas M.-P., Antonarakis S.E.
      Hum. Genet. 102:282-288(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1."
      Ohira M., Seki N., Nagase T., Ishikawa K., Nomura N., Ohara O.
      Genomics 47:300-306(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Taudien S., Dagand E., Delabar J., Nordsiek G., Drescher B., Weber J., Schattevoy R., Yaspo M.-L., Rosenthal A.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Crystal structure of the bric-a-brac (BTB) domain of human BACH1."
      Structural genomics consortium (SGC)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 7-128.

    Entry informationi

    Entry nameiBACH1_HUMAN
    AccessioniPrimary (citable) accession number: O14867
    Secondary accession number(s): O43285
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3