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Protein

Transcription regulator protein BACH1

Gene

BACH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

GO - Molecular functioni

  1. heme binding Source: UniProtKB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  3. RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  6. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB
  3. regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
  4. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
  5. regulation of transcription involved in G2/M transition of mitotic cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH1
Alternative name(s):
BTB and CNC homolog 1
HA2303
Gene namesi
Name:BACH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:935. BACH1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleoplasm Source: HPA
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Transcription regulator protein BACH1PRO_0000076454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei445 – 4451Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14867.
PaxDbiO14867.
PRIDEiO14867.

PTM databases

PhosphoSiteiO14867.

Expressioni

Gene expression databases

BgeeiO14867.
CleanExiHS_BACH1.
ExpressionAtlasiO14867. baseline and differential.
GenevestigatoriO14867.

Organism-specific databases

HPAiHPA003175.
HPA034949.

Interactioni

Protein-protein interaction databases

BioGridi107047. 37 interactions.
DIPiDIP-24223N.
IntActiO14867. 5 interactions.
MINTiMINT-196655.
STRINGi9606.ENSP00000286800.

Structurei

Secondary structure

1
736
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 125Combined sources
Helixi16 – 3015Combined sources
Beta strandi36 – 405Combined sources
Beta strandi43 – 475Combined sources
Helixi49 – 557Combined sources
Helixi57 – 637Combined sources
Beta strandi71 – 744Combined sources
Helixi81 – 9313Combined sources
Beta strandi94 – 996Combined sources
Turni100 – 1023Combined sources
Helixi103 – 11311Combined sources
Beta strandi115 – 1173Combined sources
Helixi120 – 1245Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IHCX-ray2.44A/B/C/D7-128[»]
ProteinModelPortaliO14867.
SMRiO14867. Positions 7-126, 524-617.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14867.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10067BTBPROSITE-ProRule annotationAdd
BLAST
Domaini557 – 62064bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni562 – 57817Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni582 – 5898Leucine-zipperPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG308993.
GeneTreeiENSGT00550000074399.
HOGENOMiHOG000231712.
HOVERGENiHBG099852.
InParanoidiO14867.
KOiK09042.
OMAiENKNVQT.
OrthoDBiEOG73V6JP.
PhylomeDBiO14867.
TreeFamiTF326681.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS
60 70 80 90 100
VLAACSSYFH SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK
110 120 130 140 150
ENVDEVCKCV EFLSVHNIEE SCFQFLKFKF LDSTADQQEC PRKKCFSSHC
160 170 180 190 200
QKTDLKLSLL DQRDLETDEV EEFLENKNVQ TPQCKLRRYQ GNAKASPPLQ
210 220 230 240 250
DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR TGESSVKDIH
260 270 280 290 300
ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP
310 320 330 340 350
TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP
360 370 380 390 400
LSGTDVQEKT FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG
410 420 430 440 450
FWSDICSTDT PCQMQLSPAV AKDGSEQISQ KRSECPWLGI RISESPEPGQ
460 470 480 490 500
RTFTTLSSVN CPFISTLSTE GCSSNLEIGN DDYVSEPQQE PCPYACVISL
510 520 530 540 550
GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND FQSLLKMHKL
560 570 580 590 600
TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL
610 620 630 640 650
KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF
660 670 680 690 700
LISEKDKSTP DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ
710 720 730
MSTATSEQAG PAEQCRQSGG ISDFCQQMTD KCTTDE
Length:736
Mass (Da):81,958
Last modified:May 30, 2000 - v2
Checksum:iCAAEECC63D46571B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581S → T in AAB84100 (PubMed:9544839).Curated
Sequence conflicti171 – 1711E → G in AAB84100 (PubMed:9544839).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti314 – 3141S → P.
Corresponds to variant rs35474725 [ dbSNP | Ensembl ].
VAR_048441

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026199 mRNA. Translation: AAB84100.1.
AF026200 mRNA. Translation: AAB84101.1.
AB002803 mRNA. Translation: BAA24932.1.
AF124731 Genomic DNA. Translation: AAD14689.1.
AK313791 mRNA. Translation: BAG36528.1.
CR450303 mRNA. Translation: CAG29299.1.
AL163249 Genomic DNA. Translation: CAB90435.1.
AP001705 Genomic DNA. Translation: BAA95505.1.
CH471079 Genomic DNA. Translation: EAX09913.1.
BC063307 mRNA. Translation: AAH63307.1.
CCDSiCCDS13585.1.
PIRiT00023.
RefSeqiNP_001177.1. NM_001186.3.
NP_996749.1. NM_206866.2.
XP_005261069.1. XM_005261012.1.
XP_005261070.1. XM_005261013.2.
XP_005261071.1. XM_005261014.1.
UniGeneiHs.154276.

Genome annotation databases

EnsembliENST00000286800; ENSP00000286800; ENSG00000156273.
ENST00000399921; ENSP00000382805; ENSG00000156273.
GeneIDi571.
KEGGihsa:571.
UCSCiuc002ynj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026199 mRNA. Translation: AAB84100.1.
AF026200 mRNA. Translation: AAB84101.1.
AB002803 mRNA. Translation: BAA24932.1.
AF124731 Genomic DNA. Translation: AAD14689.1.
AK313791 mRNA. Translation: BAG36528.1.
CR450303 mRNA. Translation: CAG29299.1.
AL163249 Genomic DNA. Translation: CAB90435.1.
AP001705 Genomic DNA. Translation: BAA95505.1.
CH471079 Genomic DNA. Translation: EAX09913.1.
BC063307 mRNA. Translation: AAH63307.1.
CCDSiCCDS13585.1.
PIRiT00023.
RefSeqiNP_001177.1. NM_001186.3.
NP_996749.1. NM_206866.2.
XP_005261069.1. XM_005261012.1.
XP_005261070.1. XM_005261013.2.
XP_005261071.1. XM_005261014.1.
UniGeneiHs.154276.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IHCX-ray2.44A/B/C/D7-128[»]
ProteinModelPortaliO14867.
SMRiO14867. Positions 7-126, 524-617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107047. 37 interactions.
DIPiDIP-24223N.
IntActiO14867. 5 interactions.
MINTiMINT-196655.
STRINGi9606.ENSP00000286800.

PTM databases

PhosphoSiteiO14867.

Proteomic databases

MaxQBiO14867.
PaxDbiO14867.
PRIDEiO14867.

Protocols and materials databases

DNASUi571.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286800; ENSP00000286800; ENSG00000156273.
ENST00000399921; ENSP00000382805; ENSG00000156273.
GeneIDi571.
KEGGihsa:571.
UCSCiuc002ynj.3. human.

Organism-specific databases

CTDi571.
GeneCardsiGC21P030570.
HGNCiHGNC:935. BACH1.
HPAiHPA003175.
HPA034949.
MIMi602751. gene.
neXtProtiNX_O14867.
PharmGKBiPA25234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG308993.
GeneTreeiENSGT00550000074399.
HOGENOMiHOG000231712.
HOVERGENiHBG099852.
InParanoidiO14867.
KOiK09042.
OMAiENKNVQT.
OrthoDBiEOG73V6JP.
PhylomeDBiO14867.
TreeFamiTF326681.

Miscellaneous databases

ChiTaRSiBACH1. human.
EvolutionaryTraceiO14867.
GeneWikiiBACH1.
GenomeRNAii571.
NextBioi2323.
PROiO14867.
SOURCEiSearch...

Gene expression databases

BgeeiO14867.
CleanExiHS_BACH1.
ExpressionAtlasiO14867. baseline and differential.
GenevestigatoriO14867.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1."
    Blouin J.-L., Duriaux Sail G., Guipponi M., Rossier C., Pappasavas M.-P., Antonarakis S.E.
    Hum. Genet. 102:282-288(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1."
    Ohira M., Seki N., Nagase T., Ishikawa K., Nomura N., Ohara O.
    Genomics 47:300-306(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Taudien S., Dagand E., Delabar J., Nordsiek G., Drescher B., Weber J., Schattevoy R., Yaspo M.-L., Rosenthal A.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TracheaImported.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Crystal structure of the bric-a-brac (BTB) domain of human BACH1."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 7-128.

Entry informationi

Entry nameiBACH1_HUMAN
AccessioniPrimary (citable) accession number: O14867
Secondary accession number(s): O43285, Q6ICU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: March 4, 2015
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.