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Protein

Transcription regulator protein BACH1

Gene

BACH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

GO - Molecular functioni

GO - Biological processi

  • DNA recombination Source: InterPro
  • DNA repair Source: CACAO
  • double-strand break repair Source: InterPro
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • protein ubiquitination Source: GOC
  • regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
  • regulation of transcription involved in G2/M transition of mitotic cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156273-MONOMER.
BRENDAi3.6.4.12. 2681.
SIGNORiO14867.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH1
Alternative name(s):
BTB and CNC homolog 1
HA2303
Gene namesi
Name:BACH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:935. BACH1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: GO_Central
  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi571.
MalaCardsiBACH1.
OpenTargetsiENSG00000156273.
PharmGKBiPA25234.

Polymorphism and mutation databases

BioMutaiBACH1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764541 – 736Transcription regulator protein BACH1Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14867.
PaxDbiO14867.
PeptideAtlasiO14867.
PRIDEiO14867.

PTM databases

iPTMnetiO14867.
PhosphoSitePlusiO14867.

Expressioni

Gene expression databases

BgeeiENSG00000156273.
CleanExiHS_BACH1.
ExpressionAtlasiO14867. baseline and differential.
GenevisibleiO14867. HS.

Organism-specific databases

HPAiHPA003175.
HPA034949.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAFO754442EBI-1263541,EBI-2805091
MAFBQ9Y5Q32EBI-1263541,EBI-3649340
MAFGO155253EBI-1263541,EBI-713514
MDV005Q9DGW52EBI-1263541,EBI-10889526From a different organism.

Protein-protein interaction databases

BioGridi107047. 58 interactors.
DIPiDIP-24223N.
IntActiO14867. 30 interactors.
MINTiMINT-196655.
STRINGi9606.ENSP00000286800.

Structurei

Secondary structure

1736
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi16 – 30Combined sources15
Beta strandi36 – 40Combined sources5
Beta strandi43 – 47Combined sources5
Helixi49 – 55Combined sources7
Helixi57 – 63Combined sources7
Beta strandi71 – 74Combined sources4
Helixi81 – 93Combined sources13
Beta strandi94 – 99Combined sources6
Turni100 – 102Combined sources3
Helixi103 – 113Combined sources11
Beta strandi115 – 117Combined sources3
Helixi120 – 124Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IHCX-ray2.44A/B/C/D7-128[»]
ProteinModelPortaliO14867.
SMRiO14867.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14867.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100BTBPROSITE-ProRule annotationAdd BLAST67
Domaini557 – 620bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni562 – 578Basic motifPROSITE-ProRule annotationAdd BLAST17
Regioni582 – 589Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISV2. Eukaryota.
ENOG410Z743. LUCA.
GeneTreeiENSGT00830000128250.
HOGENOMiHOG000231712.
HOVERGENiHBG099852.
InParanoidiO14867.
KOiK09042.
OMAiENKNVQT.
OrthoDBiEOG091G02EB.
PhylomeDBiO14867.
TreeFamiTF326681.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
1.20.5.370. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR011333. SKP1/BTB/POZ.
IPR008917. TF_DNA-bd.
IPR014751. XRCC4_C.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS
60 70 80 90 100
VLAACSSYFH SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK
110 120 130 140 150
ENVDEVCKCV EFLSVHNIEE SCFQFLKFKF LDSTADQQEC PRKKCFSSHC
160 170 180 190 200
QKTDLKLSLL DQRDLETDEV EEFLENKNVQ TPQCKLRRYQ GNAKASPPLQ
210 220 230 240 250
DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR TGESSVKDIH
260 270 280 290 300
ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP
310 320 330 340 350
TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP
360 370 380 390 400
LSGTDVQEKT FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG
410 420 430 440 450
FWSDICSTDT PCQMQLSPAV AKDGSEQISQ KRSECPWLGI RISESPEPGQ
460 470 480 490 500
RTFTTLSSVN CPFISTLSTE GCSSNLEIGN DDYVSEPQQE PCPYACVISL
510 520 530 540 550
GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND FQSLLKMHKL
560 570 580 590 600
TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL
610 620 630 640 650
KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF
660 670 680 690 700
LISEKDKSTP DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ
710 720 730
MSTATSEQAG PAEQCRQSGG ISDFCQQMTD KCTTDE
Length:736
Mass (Da):81,958
Last modified:May 30, 2000 - v2
Checksum:iCAAEECC63D46571B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158S → T in AAB84100 (PubMed:9544839).Curated1
Sequence conflicti171E → G in AAB84100 (PubMed:9544839).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048441314S → P.Corresponds to variant rs35474725dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026199 mRNA. Translation: AAB84100.1.
AF026200 mRNA. Translation: AAB84101.1.
AB002803 mRNA. Translation: BAA24932.1.
AF124731 Genomic DNA. Translation: AAD14689.1.
AK313791 mRNA. Translation: BAG36528.1.
CR450303 mRNA. Translation: CAG29299.1.
AL163249 Genomic DNA. Translation: CAB90435.1.
AP001705 Genomic DNA. Translation: BAA95505.1.
CH471079 Genomic DNA. Translation: EAX09913.1.
BC063307 mRNA. Translation: AAH63307.1.
CCDSiCCDS13585.1.
PIRiT00023.
RefSeqiNP_001177.1. NM_001186.3.
NP_996749.1. NM_206866.2.
UniGeneiHs.154276.

Genome annotation databases

EnsembliENST00000286800; ENSP00000286800; ENSG00000156273.
ENST00000399921; ENSP00000382805; ENSG00000156273.
GeneIDi571.
KEGGihsa:571.
UCSCiuc002ynj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026199 mRNA. Translation: AAB84100.1.
AF026200 mRNA. Translation: AAB84101.1.
AB002803 mRNA. Translation: BAA24932.1.
AF124731 Genomic DNA. Translation: AAD14689.1.
AK313791 mRNA. Translation: BAG36528.1.
CR450303 mRNA. Translation: CAG29299.1.
AL163249 Genomic DNA. Translation: CAB90435.1.
AP001705 Genomic DNA. Translation: BAA95505.1.
CH471079 Genomic DNA. Translation: EAX09913.1.
BC063307 mRNA. Translation: AAH63307.1.
CCDSiCCDS13585.1.
PIRiT00023.
RefSeqiNP_001177.1. NM_001186.3.
NP_996749.1. NM_206866.2.
UniGeneiHs.154276.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IHCX-ray2.44A/B/C/D7-128[»]
ProteinModelPortaliO14867.
SMRiO14867.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107047. 58 interactors.
DIPiDIP-24223N.
IntActiO14867. 30 interactors.
MINTiMINT-196655.
STRINGi9606.ENSP00000286800.

PTM databases

iPTMnetiO14867.
PhosphoSitePlusiO14867.

Polymorphism and mutation databases

BioMutaiBACH1.

Proteomic databases

EPDiO14867.
PaxDbiO14867.
PeptideAtlasiO14867.
PRIDEiO14867.

Protocols and materials databases

DNASUi571.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286800; ENSP00000286800; ENSG00000156273.
ENST00000399921; ENSP00000382805; ENSG00000156273.
GeneIDi571.
KEGGihsa:571.
UCSCiuc002ynj.4. human.

Organism-specific databases

CTDi571.
DisGeNETi571.
GeneCardsiBACH1.
GRIK1-AS2.
HGNCiHGNC:935. BACH1.
HPAiHPA003175.
HPA034949.
MalaCardsiBACH1.
MIMi602751. gene.
neXtProtiNX_O14867.
OpenTargetsiENSG00000156273.
PharmGKBiPA25234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISV2. Eukaryota.
ENOG410Z743. LUCA.
GeneTreeiENSGT00830000128250.
HOGENOMiHOG000231712.
HOVERGENiHBG099852.
InParanoidiO14867.
KOiK09042.
OMAiENKNVQT.
OrthoDBiEOG091G02EB.
PhylomeDBiO14867.
TreeFamiTF326681.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000156273-MONOMER.
BRENDAi3.6.4.12. 2681.
SIGNORiO14867.

Miscellaneous databases

ChiTaRSiBACH1. human.
EvolutionaryTraceiO14867.
GeneWikiiBACH1.
GenomeRNAii571.
PROiO14867.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156273.
CleanExiHS_BACH1.
ExpressionAtlasiO14867. baseline and differential.
GenevisibleiO14867. HS.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
1.20.5.370. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR011333. SKP1/BTB/POZ.
IPR008917. TF_DNA-bd.
IPR014751. XRCC4_C.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBACH1_HUMAN
AccessioniPrimary (citable) accession number: O14867
Secondary accession number(s): O43285, Q6ICU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 164 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.