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Reviewed, UniProtKB/Swiss-Prot O14863 (ZNT4_HUMAN)

Last modified June 16, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Zinc transporter 4
      Short name=ZnT-4
Alternative name(s):
    Solute carrier family 30 member 4
Gene names
Name: SLC30A4
Synonyms: ZNT4
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

Subcellular location

Endosome membrane; Multi-pass membrane protein Probable.

Domain

Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc By similarity.

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

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Ontologies

Keywords
   Biological processIon transport
Transport
Zinc transport
   Cellular componentEndosome
Membrane
   DomainTransmembrane
   LigandZinc
Gene Ontology (GO)
   Biological processzinc ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentendosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionzinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion transmembrane transporter activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Zinc transporter 4
PRO_0000206099

Regions

Topological domain1 – 113113Cytoplasmic Potential
Transmembrane114 – 13421 Potential
Topological domain135 – 1439Vacuolar Potential
Transmembrane144 – 16421 Potential
Topological domain165 – 17814Cytoplasmic Potential
Transmembrane179 – 19921 Potential
Topological domain200 – 21617Vacuolar Potential
Transmembrane217 – 23721 Potential
Topological domain238 – 27437Cytoplasmic Potential
Transmembrane275 – 29521 Potential
Topological domain296 – 31015Vacuolar Potential
Transmembrane311 – 33121 Potential
Topological domain332 – 42998Cytoplasmic Potential
Compositional bias17 – 9680Asp-rich (acidic)
Compositional bias241 – 2477His-rich

Experimental info

Sequence conflict301D → E in AAB82561. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
O14863-1 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: 97B7FCBE881C8C32

FASTA42947,483
        10         20         30         40         50         60 
MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV ADDGSEAPER 

        70         80         90        100        110        120 
PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK QREILKQRKV KARLTIAAVL 

       130        140        150        160        170        180 
YLLFMIGELV GGYIANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTK RFTFGFHRLE 

       190        200        210        220        230        240 
VLSAMISVLL VYILMGFLLY EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG 

       250        260        270        280        290        300 
HRHSHSHSLP SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE 

       310        320        330        340        350        360 
YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK IEDVYSVEDL 

       370        380        390        400        410        420 
NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT FGMYRCTIQL QSYRQEVDRT 


CANCQSSSP

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References

« Hide 'large scale' references
[1]"A novel gene involved in zinc transport is deficient in the lethal milk mouse."
Huang L., Gitschier J.
Nat. Genet. 17:292-297(1997) [PubMed: 9354792] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mesangial cell.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF025409 mRNA. Translation: AAB82561.1.
AK290874 mRNA. Translation: BAF83563.1.
CH471082 Genomic DNA. Translation: EAW77316.1.
BC026089 mRNA. Translation: AAH26089.1.
IPIIPI00152263.
RefSeqNP_037441.2.
UniGeneHs.162989

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSG00000104154. Homo sapiens. [Contig view]
GeneID7782.
KEGGhsa:7782.

Organism-specific databases

GeneCardsGC15M043564.
HGNCHGNC:11015. SLC30A4.
HPAHPA018178.
MIM602095. gene.
PharmGKBPA35885.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO14863.
HOVERGENO14863.
OMAO14863. KEPVEIA.

Gene expression databases

ArrayExpressO14863.
BgeeO14863.
CleanExHS_SLC30A4.
GermOnlineENSG00000104154. Homo sapiens.

Family and domain databases

InterProIPR002524. Cation_efflux.
[Graphical view]
PANTHERPTHR11562. Cation_efflux. 1 hit.
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameZNT4_HUMAN
AccessionPrimary (citable) accession number: O14863
Secondary accession number(s): Q8TC39
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: June 16, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents