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O14863

- ZNT4_HUMAN

UniProt

O14863 - ZNT4_HUMAN

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Protein
Zinc transporter 4
Gene
SLC30A4, ZNT4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. regulation of sequestering of zinc ion Source: BHF-UCL
  2. response to toxic substance Source: UniProtKB
  3. zinc ion homeostasis Source: Ensembl
  4. zinc ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.4.3.7. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 4
Short name:
ZnT-4
Alternative name(s):
Solute carrier family 30 member 4
Gene namesi
Name:SLC30A4
Synonyms:ZNT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:11015. SLC30A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 113113Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Topological domaini135 – 1439Vacuolar Reviewed prediction
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Topological domaini165 – 17814Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Topological domaini200 – 21617Vacuolar Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Reviewed prediction
Add
BLAST
Topological domaini238 – 27437Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei275 – 29521Helical; Reviewed prediction
Add
BLAST
Topological domaini296 – 31015Vacuolar Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST
Topological domaini332 – 42998Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. endosome membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. late endosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Zinc transporter 4
PRO_0000206099Add
BLAST

Proteomic databases

MaxQBiO14863.
PaxDbiO14863.
PRIDEiO14863.

PTM databases

PhosphoSiteiO14863.

Expressioni

Gene expression databases

BgeeiO14863.
CleanExiHS_SLC30A4.
GenevestigatoriO14863.

Organism-specific databases

HPAiHPA018178.

Interactioni

Protein-protein interaction databases

BioGridi113563. 1 interaction.
STRINGi9606.ENSP00000261867.

Structurei

3D structure databases

ProteinModelPortaliO14863.
SMRiO14863. Positions 114-209.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 9680Asp-rich (acidic)
Add
BLAST
Compositional biasi241 – 2477His-rich

Domaini

Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc (By similarity).

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiO14863.
KOiK14691.
OMAiMGRIMAR.
OrthoDBiEOG7S4X68.
PhylomeDBiO14863.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

O14863-1 [UniParc]FASTAAdd to Basket

« Hide

MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV    50
ADDGSEAPER PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK 100
QREILKQRKV KARLTIAAVL YLLFMIGELV GGYIANSLAI MTDALHMLTD 150
LSAIILTLLA LWLSSKSPTK RFTFGFHRLE VLSAMISVLL VYILMGFLLY 200
EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG HRHSHSHSLP 250
SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE 300
YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK 350
IEDVYSVEDL NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT 400
FGMYRCTIQL QSYRQEVDRT CANCQSSSP 429
Length:429
Mass (Da):47,483
Last modified:September 23, 2008 - v2
Checksum:i97B7FCBE881C8C32
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301D → E in AAB82561. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025409 mRNA. Translation: AAB82561.1.
AK290874 mRNA. Translation: BAF83563.1.
CH471082 Genomic DNA. Translation: EAW77316.1.
BC026089 mRNA. Translation: AAH26089.1.
CCDSiCCDS10125.1.
RefSeqiNP_037441.2. NM_013309.4.
UniGeneiHs.162989.

Genome annotation databases

EnsembliENST00000261867; ENSP00000261867; ENSG00000104154.
GeneIDi7782.
KEGGihsa:7782.
UCSCiuc001zvj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025409 mRNA. Translation: AAB82561.1 .
AK290874 mRNA. Translation: BAF83563.1 .
CH471082 Genomic DNA. Translation: EAW77316.1 .
BC026089 mRNA. Translation: AAH26089.1 .
CCDSi CCDS10125.1.
RefSeqi NP_037441.2. NM_013309.4.
UniGenei Hs.162989.

3D structure databases

ProteinModelPortali O14863.
SMRi O14863. Positions 114-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113563. 1 interaction.
STRINGi 9606.ENSP00000261867.

Protein family/group databases

TCDBi 2.A.4.3.7. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSitei O14863.

Proteomic databases

MaxQBi O14863.
PaxDbi O14863.
PRIDEi O14863.

Protocols and materials databases

DNASUi 7782.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261867 ; ENSP00000261867 ; ENSG00000104154 .
GeneIDi 7782.
KEGGi hsa:7782.
UCSCi uc001zvj.3. human.

Organism-specific databases

CTDi 7782.
GeneCardsi GC15M045771.
H-InvDB HIX0012212.
HGNCi HGNC:11015. SLC30A4.
HPAi HPA018178.
MIMi 602095. gene.
neXtProti NX_O14863.
PharmGKBi PA35885.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1230.
HOGENOMi HOG000079023.
HOVERGENi HBG003345.
InParanoidi O14863.
KOi K14691.
OMAi MGRIMAR.
OrthoDBi EOG7S4X68.
PhylomeDBi O14863.
TreeFami TF313382.

Miscellaneous databases

ChiTaRSi SLC30A4. human.
GeneWikii SLC30A4.
GenomeRNAii 7782.
NextBioi 30129.
PROi O14863.
SOURCEi Search...

Gene expression databases

Bgeei O14863.
CleanExi HS_SLC30A4.
Genevestigatori O14863.

Family and domain databases

Gene3Di 1.20.1510.10. 1 hit.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene involved in zinc transport is deficient in the lethal milk mouse."
    Huang L., Gitschier J.
    Nat. Genet. 17:292-297(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mesangial cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZNT4_HUMAN
AccessioniPrimary (citable) accession number: O14863
Secondary accession number(s): Q8TC39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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