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O14863

- ZNT4_HUMAN

UniProt

O14863 - ZNT4_HUMAN

Protein

Zinc transporter 4

Gene

SLC30A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

    GO - Molecular functioni

    1. zinc ion transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. regulation of sequestering of zinc ion Source: BHF-UCL
    2. response to toxic substance Source: UniProtKB
    3. zinc ion homeostasis Source: Ensembl
    4. zinc ion transmembrane transport Source: GOC

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Protein family/group databases

    TCDBi2.A.4.3.7. the cation diffusion facilitator (cdf) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 4
    Short name:
    ZnT-4
    Alternative name(s):
    Solute carrier family 30 member 4
    Gene namesi
    Name:SLC30A4
    Synonyms:ZNT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:11015. SLC30A4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. endosome membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. late endosome Source: BHF-UCL

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35885.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Zinc transporter 4PRO_0000206099Add
    BLAST

    Proteomic databases

    MaxQBiO14863.
    PaxDbiO14863.
    PRIDEiO14863.

    PTM databases

    PhosphoSiteiO14863.

    Expressioni

    Gene expression databases

    BgeeiO14863.
    CleanExiHS_SLC30A4.
    GenevestigatoriO14863.

    Organism-specific databases

    HPAiHPA018178.

    Interactioni

    Protein-protein interaction databases

    BioGridi113563. 1 interaction.
    STRINGi9606.ENSP00000261867.

    Structurei

    3D structure databases

    ProteinModelPortaliO14863.
    SMRiO14863. Positions 114-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 113113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini135 – 1439VacuolarSequence Analysis
    Topological domaini165 – 17814CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini200 – 21617VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini238 – 27437CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini296 – 31015VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini332 – 42998CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi17 – 9680Asp-rich (acidic)Add
    BLAST
    Compositional biasi241 – 2477His-rich

    Domaini

    Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    HOGENOMiHOG000079023.
    HOVERGENiHBG003345.
    InParanoidiO14863.
    KOiK14691.
    OMAiMGRIMAR.
    OrthoDBiEOG7S4X68.
    PhylomeDBiO14863.
    TreeFamiTF313382.

    Family and domain databases

    Gene3Di1.20.1510.10. 1 hit.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O14863-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV    50
    ADDGSEAPER PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK 100
    QREILKQRKV KARLTIAAVL YLLFMIGELV GGYIANSLAI MTDALHMLTD 150
    LSAIILTLLA LWLSSKSPTK RFTFGFHRLE VLSAMISVLL VYILMGFLLY 200
    EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG HRHSHSHSLP 250
    SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE 300
    YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK 350
    IEDVYSVEDL NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT 400
    FGMYRCTIQL QSYRQEVDRT CANCQSSSP 429
    Length:429
    Mass (Da):47,483
    Last modified:September 23, 2008 - v2
    Checksum:i97B7FCBE881C8C32
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301D → E in AAB82561. (PubMed:9354792)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025409 mRNA. Translation: AAB82561.1.
    AK290874 mRNA. Translation: BAF83563.1.
    CH471082 Genomic DNA. Translation: EAW77316.1.
    BC026089 mRNA. Translation: AAH26089.1.
    CCDSiCCDS10125.1.
    RefSeqiNP_037441.2. NM_013309.4.
    UniGeneiHs.162989.

    Genome annotation databases

    EnsembliENST00000261867; ENSP00000261867; ENSG00000104154.
    GeneIDi7782.
    KEGGihsa:7782.
    UCSCiuc001zvj.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025409 mRNA. Translation: AAB82561.1 .
    AK290874 mRNA. Translation: BAF83563.1 .
    CH471082 Genomic DNA. Translation: EAW77316.1 .
    BC026089 mRNA. Translation: AAH26089.1 .
    CCDSi CCDS10125.1.
    RefSeqi NP_037441.2. NM_013309.4.
    UniGenei Hs.162989.

    3D structure databases

    ProteinModelPortali O14863.
    SMRi O14863. Positions 114-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113563. 1 interaction.
    STRINGi 9606.ENSP00000261867.

    Protein family/group databases

    TCDBi 2.A.4.3.7. the cation diffusion facilitator (cdf) family.

    PTM databases

    PhosphoSitei O14863.

    Proteomic databases

    MaxQBi O14863.
    PaxDbi O14863.
    PRIDEi O14863.

    Protocols and materials databases

    DNASUi 7782.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261867 ; ENSP00000261867 ; ENSG00000104154 .
    GeneIDi 7782.
    KEGGi hsa:7782.
    UCSCi uc001zvj.3. human.

    Organism-specific databases

    CTDi 7782.
    GeneCardsi GC15M045771.
    H-InvDB HIX0012212.
    HGNCi HGNC:11015. SLC30A4.
    HPAi HPA018178.
    MIMi 602095. gene.
    neXtProti NX_O14863.
    PharmGKBi PA35885.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1230.
    HOGENOMi HOG000079023.
    HOVERGENi HBG003345.
    InParanoidi O14863.
    KOi K14691.
    OMAi MGRIMAR.
    OrthoDBi EOG7S4X68.
    PhylomeDBi O14863.
    TreeFami TF313382.

    Miscellaneous databases

    ChiTaRSi SLC30A4. human.
    GeneWikii SLC30A4.
    GenomeRNAii 7782.
    NextBioi 30129.
    PROi O14863.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14863.
    CleanExi HS_SLC30A4.
    Genevestigatori O14863.

    Family and domain databases

    Gene3Di 1.20.1510.10. 1 hit.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene involved in zinc transport is deficient in the lethal milk mouse."
      Huang L., Gitschier J.
      Nat. Genet. 17:292-297(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mesangial cell.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiZNT4_HUMAN
    AccessioniPrimary (citable) accession number: O14863
    Secondary accession number(s): Q8TC39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3