O14863 (ZNT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc transporter 4
Short name=ZnT-4

Alternative name(s):
Solute carrier family 30 member 4

Gene names

Name:	SLC30A4
Synonyms:	ZNT4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.
Subcellular location	Endosome membrane; Multi-pass membrane protein Probable.
Domain	Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc By similarity.
Sequence similarities	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport Zinc transport
Cellular component	Endosome Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of sequestering of zinc ion Inferred from direct assay PubMed 17349999. Source: BHF-UCL response to toxin Inferred from direct assay PubMed 17575980. Source: UniProtKB zinc ion homeostasis Inferred from electronic annotation. Source: Compara
Cellular_component	endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW late endosome Inferred from direct assay PubMed 17349999. Source: BHF-UCL
Molecular_function	zinc ion transmembrane transporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Zinc transporter 4		PRO_0000206099
Regions
	Topological domain	1 – 113	113	Cytoplasmic Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Topological domain	135 – 143	9	Vacuolar Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Topological domain	165 – 178	14	Cytoplasmic Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Topological domain	200 – 216	17	Vacuolar Potential
	Transmembrane	217 – 237	21	Helical; Potential
	Topological domain	238 – 274	37	Cytoplasmic Potential
	Transmembrane	275 – 295	21	Helical; Potential
	Topological domain	296 – 310	15	Vacuolar Potential
	Transmembrane	311 – 331	21	Helical; Potential
	Topological domain	332 – 429	98	Cytoplasmic Potential
	Compositional bias	17 – 96	80	Asp-rich (acidic)
	Compositional bias	241 – 247	7	His-rich
Experimental info
	Sequence conflict	30	1	D → E in AAB82561. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O14863 [UniParc]. Last modified September 23, 2008. Version 2. Checksum: 97B7FCBE881C8C32	FASTA	429	47,483
	10 20 30 40 50 60 MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV ADDGSEAPER 70 80 90 100 110 120 PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK QREILKQRKV KARLTIAAVL 130 140 150 160 170 180 YLLFMIGELV GGYIANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTK RFTFGFHRLE 190 200 210 220 230 240 VLSAMISVLL VYILMGFLLY EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG 250 260 270 280 290 300 HRHSHSHSLP SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE 310 320 330 340 350 360 YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK IEDVYSVEDL 370 380 390 400 410 420 NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT FGMYRCTIQL QSYRQEVDRT CANCQSSSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene involved in zinc transport is deficient in the lethal milk mouse." Huang L., Gitschier J. Nat. Genet. 17:292-297(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mesangial cell.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF025409 mRNA. Translation: AAB82561.1. AK290874 mRNA. Translation: BAF83563.1. CH471082 Genomic DNA. Translation: EAW77316.1. BC026089 mRNA. Translation: AAH26089.1.
IPI	IPI00152263.
RefSeq	NP_037441.2. NM_013309.4.
UniGene	Hs.162989.
3D structure databases
ProteinModelPortal	O14863.
SMR	O14863. Positions 115-208.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000261867.
PTM databases
PhosphoSite	O14863.
Proteomic databases
PaxDb	O14863.
PRIDE	O14863.
Protocols and materials databases
DNASU	7782.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261867; ENSP00000261867; ENSG00000104154.
GeneID	7782.
KEGG	hsa:7782.
UCSC	uc001zvj.3. human.
Organism-specific databases
CTD	7782.
GeneCards	GC15M045771.
H-InvDB	HIX0012212.
HGNC	HGNC:11015. SLC30A4.
HPA	HPA018178.
MIM	602095. gene.
neXtProt	NX_O14863.
PharmGKB	PA35885.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1230.
HOGENOM	HOG000079023.
HOVERGEN	HBG003345.
InParanoid	O14863.
KO	K14691.
OMA	PEVRNIH.
OrthoDB	EOG4NCMDC.
PhylomeDB	O14863.
Gene expression databases
Bgee	O14863.
CleanEx	HS_SLC30A4.
Genevestigator	O14863.
GermOnline	ENSG00000104154. Homo sapiens.
Family and domain databases
InterPro	IPR002524. Cation_efflux. [Graphical view]
PANTHER	PTHR11562. PTHR11562. 1 hit.
Pfam	PF01545. Cation_efflux. 1 hit. [Graphical view]
TIGRFAMs	TIGR01297. CDF. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	SLC30A4. human.
GenomeRNAi	7782.
NextBio	30129.
SOURCE	Search...

Entry information

Entry name

ZNT4_HUMAN

Accession

Primary (citable) accession number: O14863
Secondary accession number(s): Q8TC39

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.