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O14863 (ZNT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter 4

Short name=ZnT-4
Alternative name(s):
Solute carrier family 30 member 4
Gene names
Name:SLC30A4
Synonyms:ZNT4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

Subcellular location

Endosome membrane; Multi-pass membrane protein Probable.

Domain

Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc By similarity.

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Zinc transporter 4
PRO_0000206099

Regions

Topological domain1 – 113113Cytoplasmic Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 1439Vacuolar Potential
Transmembrane144 – 16421Helical; Potential
Topological domain165 – 17814Cytoplasmic Potential
Transmembrane179 – 19921Helical; Potential
Topological domain200 – 21617Vacuolar Potential
Transmembrane217 – 23721Helical; Potential
Topological domain238 – 27437Cytoplasmic Potential
Transmembrane275 – 29521Helical; Potential
Topological domain296 – 31015Vacuolar Potential
Transmembrane311 – 33121Helical; Potential
Topological domain332 – 42998Cytoplasmic Potential
Compositional bias17 – 9680Asp-rich (acidic)
Compositional bias241 – 2477His-rich

Experimental info

Sequence conflict301D → E in AAB82561. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O14863 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: 97B7FCBE881C8C32

FASTA42947,483
        10         20         30         40         50         60 
MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV ADDGSEAPER 

        70         80         90        100        110        120 
PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK QREILKQRKV KARLTIAAVL 

       130        140        150        160        170        180 
YLLFMIGELV GGYIANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTK RFTFGFHRLE 

       190        200        210        220        230        240 
VLSAMISVLL VYILMGFLLY EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG 

       250        260        270        280        290        300 
HRHSHSHSLP SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE 

       310        320        330        340        350        360 
YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK IEDVYSVEDL 

       370        380        390        400        410        420 
NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT FGMYRCTIQL QSYRQEVDRT 


CANCQSSSP 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene involved in zinc transport is deficient in the lethal milk mouse."
Huang L., Gitschier J.
Nat. Genet. 17:292-297(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mesangial cell.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF025409 mRNA. Translation: AAB82561.1.
AK290874 mRNA. Translation: BAF83563.1.
CH471082 Genomic DNA. Translation: EAW77316.1.
BC026089 mRNA. Translation: AAH26089.1.
CCDSCCDS10125.1.
RefSeqNP_037441.2. NM_013309.4.
UniGeneHs.162989.

3D structure databases

ProteinModelPortalO14863.
SMRO14863. Positions 114-209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113563. 1 interaction.
STRING9606.ENSP00000261867.

Protein family/group databases

TCDB2.A.4.3.7. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSiteO14863.

Proteomic databases

MaxQBO14863.
PaxDbO14863.
PRIDEO14863.

Protocols and materials databases

DNASU7782.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261867; ENSP00000261867; ENSG00000104154.
GeneID7782.
KEGGhsa:7782.
UCSCuc001zvj.3. human.

Organism-specific databases

CTD7782.
GeneCardsGC15M045771.
H-InvDBHIX0012212.
HGNCHGNC:11015. SLC30A4.
HPAHPA018178.
MIM602095. gene.
neXtProtNX_O14863.
PharmGKBPA35885.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1230.
HOGENOMHOG000079023.
HOVERGENHBG003345.
InParanoidO14863.
KOK14691.
OMAMGRIMAR.
OrthoDBEOG7S4X68.
PhylomeDBO14863.
TreeFamTF313382.

Gene expression databases

BgeeO14863.
CleanExHS_SLC30A4.
GenevestigatorO14863.

Family and domain databases

Gene3D1.20.1510.10. 1 hit.
InterProIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERPTHR11562. PTHR11562. 1 hit.
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC30A4. human.
GeneWikiSLC30A4.
GenomeRNAi7782.
NextBio30129.
PROO14863.
SOURCESearch...

Entry information

Entry nameZNT4_HUMAN
AccessionPrimary (citable) accession number: O14863
Secondary accession number(s): Q8TC39
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM