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O14863

- ZNT4_HUMAN

UniProt

O14863 - ZNT4_HUMAN

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Protein

Zinc transporter 4

Gene

SLC30A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. regulation of sequestering of zinc ion Source: BHF-UCL
  2. response to toxic substance Source: UniProtKB
  3. zinc ion homeostasis Source: Ensembl
  4. zinc ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Protein family/group databases

TCDBi2.A.4.3.7. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 4
Short name:
ZnT-4
Alternative name(s):
Solute carrier family 30 member 4
Gene namesi
Name:SLC30A4
Synonyms:ZNT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:11015. SLC30A4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB-KW
  3. late endosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35885.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Zinc transporter 4PRO_0000206099Add
BLAST

Proteomic databases

MaxQBiO14863.
PaxDbiO14863.
PRIDEiO14863.

PTM databases

PhosphoSiteiO14863.

Expressioni

Gene expression databases

BgeeiO14863.
CleanExiHS_SLC30A4.
GenevestigatoriO14863.

Organism-specific databases

HPAiHPA018178.

Interactioni

Protein-protein interaction databases

BioGridi113563. 20 interactions.
STRINGi9606.ENSP00000261867.

Structurei

3D structure databases

ProteinModelPortaliO14863.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 113113CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini135 – 1439VacuolarSequence Analysis
Topological domaini165 – 17814CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini200 – 21617VacuolarSequence AnalysisAdd
BLAST
Topological domaini238 – 27437CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini296 – 31015VacuolarSequence AnalysisAdd
BLAST
Topological domaini332 – 42998CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Transmembranei275 – 29521HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 9680Asp-rich (acidic)Add
BLAST
Compositional biasi241 – 2477His-rich

Domaini

Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiO14863.
KOiK14691.
OMAiMGRIMAR.
OrthoDBiEOG7S4X68.
PhylomeDBiO14863.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

O14863-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV
60 70 80 90 100
ADDGSEAPER PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK
110 120 130 140 150
QREILKQRKV KARLTIAAVL YLLFMIGELV GGYIANSLAI MTDALHMLTD
160 170 180 190 200
LSAIILTLLA LWLSSKSPTK RFTFGFHRLE VLSAMISVLL VYILMGFLLY
210 220 230 240 250
EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG HRHSHSHSLP
260 270 280 290 300
SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE
310 320 330 340 350
YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK
360 370 380 390 400
IEDVYSVEDL NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT
410 420
FGMYRCTIQL QSYRQEVDRT CANCQSSSP
Length:429
Mass (Da):47,483
Last modified:September 23, 2008 - v2
Checksum:i97B7FCBE881C8C32
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301D → E in AAB82561. (PubMed:9354792)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025409 mRNA. Translation: AAB82561.1.
AK290874 mRNA. Translation: BAF83563.1.
CH471082 Genomic DNA. Translation: EAW77316.1.
BC026089 mRNA. Translation: AAH26089.1.
CCDSiCCDS10125.1.
RefSeqiNP_037441.2. NM_013309.4.
UniGeneiHs.162989.

Genome annotation databases

EnsembliENST00000261867; ENSP00000261867; ENSG00000104154.
GeneIDi7782.
KEGGihsa:7782.
UCSCiuc001zvj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025409 mRNA. Translation: AAB82561.1 .
AK290874 mRNA. Translation: BAF83563.1 .
CH471082 Genomic DNA. Translation: EAW77316.1 .
BC026089 mRNA. Translation: AAH26089.1 .
CCDSi CCDS10125.1.
RefSeqi NP_037441.2. NM_013309.4.
UniGenei Hs.162989.

3D structure databases

ProteinModelPortali O14863.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113563. 20 interactions.
STRINGi 9606.ENSP00000261867.

Protein family/group databases

TCDBi 2.A.4.3.7. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSitei O14863.

Proteomic databases

MaxQBi O14863.
PaxDbi O14863.
PRIDEi O14863.

Protocols and materials databases

DNASUi 7782.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261867 ; ENSP00000261867 ; ENSG00000104154 .
GeneIDi 7782.
KEGGi hsa:7782.
UCSCi uc001zvj.3. human.

Organism-specific databases

CTDi 7782.
GeneCardsi GC15M045771.
H-InvDB HIX0012212.
HGNCi HGNC:11015. SLC30A4.
HPAi HPA018178.
MIMi 602095. gene.
neXtProti NX_O14863.
PharmGKBi PA35885.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1230.
GeneTreei ENSGT00550000074381.
HOGENOMi HOG000079023.
HOVERGENi HBG003345.
InParanoidi O14863.
KOi K14691.
OMAi MGRIMAR.
OrthoDBi EOG7S4X68.
PhylomeDBi O14863.
TreeFami TF313382.

Miscellaneous databases

ChiTaRSi SLC30A4. human.
GeneWikii SLC30A4.
GenomeRNAii 7782.
NextBioi 30129.
PROi O14863.
SOURCEi Search...

Gene expression databases

Bgeei O14863.
CleanExi HS_SLC30A4.
Genevestigatori O14863.

Family and domain databases

Gene3Di 1.20.1510.10. 1 hit.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene involved in zinc transport is deficient in the lethal milk mouse."
    Huang L., Gitschier J.
    Nat. Genet. 17:292-297(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mesangial cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZNT4_HUMAN
AccessioniPrimary (citable) accession number: O14863
Secondary accession number(s): Q8TC39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3