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O14843

- FFAR3_HUMAN

UniProt

O14843 - FFAR3_HUMAN

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Protein
Free fatty acid receptor 3
Gene
FFAR3, GPR41
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5-trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate.2 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. lipid binding Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_21268. Free fatty acid receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Free fatty acid receptor 3
Alternative name(s):
G-protein coupled receptor 41
Gene namesi
Name:FFAR3
Synonyms:GPR41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4499. FFAR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Extracellular Reviewed prediction
Add
BLAST
Transmembranei20 – 4021Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini41 – 477Cytoplasmic
Transmembranei48 – 6821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini69 – 9022Extracellular Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini112 – 13221Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei133 – 15321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini154 – 17825Extracellular Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini200 – 22223Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei223 – 24321Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini244 – 25815Extracellular Reviewed prediction
Add
BLAST
Transmembranei259 – 27921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini280 – 34667Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28888.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Free fatty acid receptor 3
PRO_0000069569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO14843.
PRIDEiO14843.

Expressioni

Tissue specificityi

Highest level in adipose tissue, and lower expression across all tissues tested.1 Publication

Gene expression databases

BgeeiO14843.
CleanExiHS_FFAR3.
GenevestigatoriO14843.

Organism-specific databases

HPAiHPA044681.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000246538.

Structurei

3D structure databases

ProteinModelPortaliO14843.
SMRiO14843. Positions 6-295.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47521.
HOGENOMiHOG000026778.
HOVERGENiHBG051811.
InParanoidiO14843.
KOiK04326.
OMAiYVMEFSG.
OrthoDBiEOG7SFHXH.
PhylomeDBiO14843.
TreeFamiTF350010.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR013312. GPR40-rel_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01904. GPR40FAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14843-1 [UniParc]FASTAAdd to Basket

« Hide

MDTGPDQSYF SGNHWFVFSV YLLTFLVGLP LNLLALVVFV GKLQRRPVAV    50
DVLLLNLTAS DLLLLLFLPF RMVEAANGMH WPLPFILCPL SGFIFFTTIY 100
LTALFLAAVS IERFLSVAHP LWYKTRPRLG QAGLVSVACW LLASAHCSVV 150
YVIEFSGDIS HSQGTNGTCY LEFRKDQLAI LLPVRLEMAV VLFVVPLIIT 200
SYCYSRLVWI LGRGGSHRRQ RRVAGLLAAT LLNFLVCFGP YNVSHVVGYI 250
CGESPAWRIY VTLLSTLNSC VDPFVYYFSS SGFQADFHEL LRRLCGLWGQ 300
WQQESSMELK EQKGGEEQRA DRPAERKTSE HSQGCGTGGQ VACAES 346
Length:346
Mass (Da):38,649
Last modified:January 1, 1998 - v1
Checksum:iB3B19D62D11B6BA1
GO

Polymorphismi

Sequence differences between FFAR3 and GPR42 are due to polymorphisms. The consensus sequences within the coding regions are identical for the two genes.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441Q → R.1 Publication
VAR_062854
Natural varianti45 – 451R → C.1 Publication
Corresponds to variant rs423385 [ dbSNP | Ensembl ].
VAR_062855
Natural varianti174 – 1741R → W Abolishes activation by propionate. 2 Publications
VAR_062856
Natural varianti227 – 2271L → V.1 Publication
Corresponds to variant rs403989 [ dbSNP | Ensembl ].
VAR_062857
Natural varianti256 – 2561A → V.1 Publication
Corresponds to variant rs424715 [ dbSNP | Ensembl ].
VAR_062858
Natural varianti346 – 3461S → N.1 Publication
VAR_062962

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024688 Genomic DNA. Translation: AAB86711.1.
U62631 Genomic DNA. No translation available.
BC035657 mRNA. Translation: AAH35657.1.
BC113695 mRNA. Translation: AAI13696.1.
BC148269 mRNA. Translation: AAI48270.1.
CCDSiCCDS12459.1.
PIRiJC5715.
RefSeqiNP_005295.1. NM_005304.3.
UniGeneiHs.248055.

Genome annotation databases

EnsembliENST00000327809; ENSP00000328230; ENSG00000185897.
ENST00000594310; ENSP00000469522; ENSG00000185897.
GeneIDi2865.
KEGGihsa:2865.
UCSCiuc002nzd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024688 Genomic DNA. Translation: AAB86711.1 .
U62631 Genomic DNA. No translation available.
BC035657 mRNA. Translation: AAH35657.1 .
BC113695 mRNA. Translation: AAI13696.1 .
BC148269 mRNA. Translation: AAI48270.1 .
CCDSi CCDS12459.1.
PIRi JC5715.
RefSeqi NP_005295.1. NM_005304.3.
UniGenei Hs.248055.

3D structure databases

ProteinModelPortali O14843.
SMRi O14843. Positions 6-295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000246538.

Chemistry

ChEMBLi CHEMBL5201.
GuidetoPHARMACOLOGYi 227.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O14843.
PRIDEi O14843.

Protocols and materials databases

DNASUi 2865.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327809 ; ENSP00000328230 ; ENSG00000185897 .
ENST00000594310 ; ENSP00000469522 ; ENSG00000185897 .
GeneIDi 2865.
KEGGi hsa:2865.
UCSCi uc002nzd.3. human.

Organism-specific databases

CTDi 2865.
GeneCardsi GC19P035851.
HGNCi HGNC:4499. FFAR3.
HPAi HPA044681.
MIMi 603821. gene.
neXtProti NX_O14843.
PharmGKBi PA28888.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47521.
HOGENOMi HOG000026778.
HOVERGENi HBG051811.
InParanoidi O14843.
KOi K04326.
OMAi YVMEFSG.
OrthoDBi EOG7SFHXH.
PhylomeDBi O14843.
TreeFami TF350010.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_21268. Free fatty acid receptors.

Miscellaneous databases

GeneWikii Free_fatty_acid_receptor_3.
GenomeRNAii 2865.
NextBioi 11297.
PROi O14843.
SOURCEi Search...

Gene expression databases

Bgeei O14843.
CleanExi HS_FFAR3.
Genevestigatori O14843.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR013312. GPR40-rel_orph.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01904. GPR40FAMILY.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
    Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., O'Dowd B.F.
    Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.
  4. Cited for: FUNCTION, CHARACTERIZATION OF VARIANT TRP-174, TISSUE SPECIFICITY.
  5. "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation."
    Le Poul E., Loison C., Struyf S., Springael J.Y., Lannoy V., Decobecq M.E., Brezillon S., Dupriez V., Vassart G., Van Damme J., Parmentier M., Detheux M.
    J. Biol. Chem. 278:25481-25489(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CHARACTERIZATION.
  6. "Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42."
    Liaw C.W., Connolly D.T.
    DNA Cell Biol. 28:555-560(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM, VARIANTS ARG-44; CYS-45; TRP-174; VAL-227; VAL-256 AND ASN-346.

Entry informationi

Entry nameiFFAR3_HUMAN
AccessioniPrimary (citable) accession number: O14843
Secondary accession number(s): B2RWM8, Q14CM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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