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O14842

- FFAR1_HUMAN

UniProt

O14842 - FFAR1_HUMAN

Protein

Free fatty acid receptor 1

Gene

FFAR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. guanyl-nucleotide exchange factor activity Source: Reactome
    3. lipid binding Source: UniProtKB-KW

    GO - Biological processi

    1. energy reserve metabolic process Source: Reactome
    2. glucose homeostasis Source: Ensembl
    3. G-protein coupled receptor signaling pathway Source: ProtInc
    4. insulin secretion Source: Ensembl
    5. positive regulation of GTPase activity Source: GOC
    6. regulation of insulin secretion Source: Reactome
    7. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
    REACT_21268. Free fatty acid receptors.
    REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
    REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Free fatty acid receptor 1
    Alternative name(s):
    G-protein coupled receptor 40
    Gene namesi
    Name:FFAR1
    Synonyms:GPR40
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4498. FFAR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28887.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Free fatty acid receptor 1PRO_0000069567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO14842.
    PRIDEiO14842.

    PTM databases

    PhosphoSiteiO14842.

    Expressioni

    Tissue specificityi

    Expressed abundantly in pancreatic beta cells.1 Publication

    Gene expression databases

    BgeeiO14842.
    CleanExiHS_FFAR1.
    GenevestigatoriO14842.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000246553.

    Structurei

    3D structure databases

    ProteinModelPortaliO14842.
    SMRiO14842. Positions 13-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010ExtracellularSequence Analysis
    Topological domaini32 – 4211CytoplasmicAdd
    BLAST
    Topological domaini64 – 8118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 12321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini145 – 17834ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini198 – 22124CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini243 – 25816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 30021CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19719Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150822.
    HOGENOMiHOG000236290.
    HOVERGENiHBG080696.
    InParanoidiO14842.
    KOiK04325.
    OMAiLHLGCSD.
    OrthoDBiEOG7GQXWF.
    PhylomeDBiO14842.
    TreeFamiTF350010.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR013312. GPR40-rel_orph.
    IPR013313. GPR40_recept_FA.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01905. FATTYACIDR.
    PR00237. GPCRRHODOPSN.
    PR01904. GPR40FAMILY.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14842-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLPPQLSFG LYVAAFALGF PLNVLAIRGA TAHARLRLTP SLVYALNLGC    50
    SDLLLTVSLP LKAVEALASG AWPLPASLCP VFAVAHFFPL YAGGGFLAAL 100
    SAGRYLGAAF PLGYQAFRRP CYSWGVCAAI WALVLCHLGL VFGLEAPGGW 150
    LDHSNTSLGI NTPVNGSPVC LEAWDPASAG PARFSLSLLL FFLPLAITAF 200
    CYVGCLRALA RSGLTHRRKL RAAWVAGGAL LTLLLCVGPY NASNVASFLY 250
    PNLGGSWRKL GLITGAWSVV LNPLVTGYLG RGPGLKTVCA ARTQGGKSQK 300
    Length:300
    Mass (Da):31,457
    Last modified:January 1, 1998 - v1
    Checksum:i77EF27DACD93E80B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241V → A in AAH95536. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti211 – 2111R → H.1 Publication
    Corresponds to variant rs2301151 [ dbSNP | Ensembl ].
    VAR_020076

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024687 Genomic DNA. Translation: AAB86710.1.
    BC095536 mRNA. Translation: AAH95536.1.
    BC120944 mRNA. Translation: AAI20945.1.
    CCDSiCCDS12458.1.
    PIRiJC5714.
    RefSeqiNP_005294.1. NM_005303.2.
    UniGeneiHs.248127.

    Genome annotation databases

    EnsembliENST00000246553; ENSP00000246553; ENSG00000126266.
    GeneIDi2864.
    KEGGihsa:2864.
    UCSCiuc002nzc.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF024687 Genomic DNA. Translation: AAB86710.1 .
    BC095536 mRNA. Translation: AAH95536.1 .
    BC120944 mRNA. Translation: AAI20945.1 .
    CCDSi CCDS12458.1.
    PIRi JC5714.
    RefSeqi NP_005294.1. NM_005303.2.
    UniGenei Hs.248127.

    3D structure databases

    ProteinModelPortali O14842.
    SMRi O14842. Positions 13-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000246553.

    Chemistry

    BindingDBi O14842.
    ChEMBLi CHEMBL4422.
    DrugBanki DB00159. Icosapent.
    GuidetoPHARMACOLOGYi 225.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O14842.

    Proteomic databases

    PaxDbi O14842.
    PRIDEi O14842.

    Protocols and materials databases

    DNASUi 2864.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246553 ; ENSP00000246553 ; ENSG00000126266 .
    GeneIDi 2864.
    KEGGi hsa:2864.
    UCSCi uc002nzc.2. human.

    Organism-specific databases

    CTDi 2864.
    GeneCardsi GC19P035842.
    HGNCi HGNC:4498. FFAR1.
    MIMi 603820. gene.
    neXtProti NX_O14842.
    PharmGKBi PA28887.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150822.
    HOGENOMi HOG000236290.
    HOVERGENi HBG080696.
    InParanoidi O14842.
    KOi K04325.
    OMAi LHLGCSD.
    OrthoDBi EOG7GQXWF.
    PhylomeDBi O14842.
    TreeFami TF350010.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
    REACT_21268. Free fatty acid receptors.
    REACT_23824. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
    REACT_24019. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

    Miscellaneous databases

    GeneWikii Free_fatty_acid_receptor_1.
    GenomeRNAii 2864.
    NextBioi 11293.
    PROi O14842.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14842.
    CleanExi HS_FFAR1.
    Genevestigatori O14842.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR013312. GPR40-rel_orph.
    IPR013313. GPR40_recept_FA.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01905. FATTYACIDR.
    PR00237. GPCRRHODOPSN.
    PR01904. GPR40FAMILY.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
      Sawzdargo M., George S.R., Nguyen T., Xu S., Kolakowski L.F. Jr., O'Dowd B.F.
      Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-211.
    3. Cited for: FUNCTION.
    4. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFFAR1_HUMAN
    AccessioniPrimary (citable) accession number: O14842
    Secondary accession number(s): Q0VAS2, Q4VBL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3