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O14829

- PPE1_HUMAN

UniProt

O14829 - PPE1_HUMAN

Protein

Serine/threonine-protein phosphatase with EF-hands 1

Gene

PPEF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May have a role in the recovery or adaptation response of photoreceptors. May have a role in development.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity
    Magnesium.By similarity

    Enzyme regulationi

    Activated by calcium.

    pH dependencei

    Optimum pH is 8.0.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi172 – 1721Manganese 1By similarity
    Metal bindingi174 – 1741Manganese 1By similarity
    Metal bindingi201 – 2011Manganese 1By similarity
    Metal bindingi201 – 2011Manganese 2By similarity
    Metal bindingi233 – 2331Manganese 2By similarity
    Active sitei234 – 2341Proton donorBy similarity
    Metal bindingi285 – 2851Manganese 2By similarity
    Metal bindingi403 – 4031Manganese 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi579 – 590121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi619 – 630122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. manganese ion binding Source: InterPro
    4. protein binding Source: IntAct
    5. protein serine/threonine phosphatase activity Source: Reactome

    GO - Biological processi

    1. detection of stimulus involved in sensory perception Source: InterPro
    2. phototransduction, visible light Source: Reactome
    3. protein dephosphorylation Source: ProtInc
    4. regulation of rhodopsin mediated signaling pathway Source: Reactome
    5. rhodopsin mediated signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Calcium, Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase with EF-hands 1 (EC:3.1.3.16)
    Short name:
    PPEF-1
    Alternative name(s):
    Protein phosphatase with EF calcium-binding domain
    Short name:
    PPEF
    Serine/threonine-protein phosphatase 7
    Short name:
    PP7
    Gene namesi
    Name:PPEF1
    Synonyms:PPEF, PPP7C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:9243. PPEF1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33564.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 653653Serine/threonine-protein phosphatase with EF-hands 1PRO_0000058899Add
    BLAST

    Proteomic databases

    PaxDbiO14829.
    PRIDEiO14829.

    PTM databases

    PhosphoSiteiO14829.

    Expressioni

    Tissue specificityi

    Detected in retina and retinal derived Y-79 retinoblastoma cells. Also found in fetal brain.

    Gene expression databases

    ArrayExpressiO14829.
    BgeeiO14829.
    CleanExiHS_PPEF1.
    GenevestigatoriO14829.

    Organism-specific databases

    HPAiHPA034577.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Calm3P622042EBI-2931238,EBI-397460From a different organism.

    Protein-protein interaction databases

    BioGridi111471. 1 interaction.
    IntActiO14829. 1 interaction.
    STRINGi9606.ENSP00000354871.

    Structurei

    3D structure databases

    ProteinModelPortaliO14829.
    SMRiO14829. Positions 107-451, 483-639.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 4530IQPROSITE-ProRule annotationAdd
    BLAST
    Domaini483 – 51836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini566 – 60136EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini606 – 64136EF-hand 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni121 – 455335CatalyticAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PPP phosphatase family.Curated
    Contains 3 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 IQ domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000006820.
    HOVERGENiHBG008238.
    InParanoidiO14829.
    KOiK13807.
    OMAiMMNLRYG.
    OrthoDBiEOG7KH9J7.
    PhylomeDBiO14829.
    TreeFamiTF313342.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    3.60.21.10. 2 hits.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR029052. Metallo-depent_PP-like.
    IPR013235. PPP_dom.
    IPR012008. Ser/Thr-Pase_EF-hand_contain.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00036. EF-hand_1. 1 hit.
    PF00612. IQ. 1 hit.
    PF00149. Metallophos. 1 hit.
    PF08321. PPP5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000912. PPEF. 1 hit.
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00054. EFh. 3 hits.
    SM00015. IQ. 1 hit.
    SM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 2 hits.
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS50096. IQ. 1 hit.
    PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14829-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGCSSSSTKT RRSDTSLRAA LIIQNWYRGY KARLKARQHY ALTIFQSIEY    50
    ADEQGQMQLS TFFSFMLENY THIHKEELEL RNQSLESEQD MRDRWDYVDS 100
    IDVPDSYNGP RLQFPLTCTD IDLLLEAFKE QQILHAHYVL EVLFETKKVL 150
    KQMPNFTHIQ TSPSKEVTIC GDLHGKLDDL FLIFYKNGLP SERNPYVFNG 200
    DFVDRGKNSI EILMILCVSF LVYPNDLHLN RGNHEDFMMN LRYGFTKEIL 250
    HKYKLHGKRI LQILEEFYAW LPIGTIVDNE ILVIHGGISE TTDLNLLHRV 300
    ERNKMKSVLI PPTETNRDHD TDSKHNKVGV TFNAHGRIKT NGSPTEHLTE 350
    HEWEQIIDIL WSDPRGKNGC FPNTCRGGGC YFGPDVTSKI LNKYQLKMLI 400
    RSHECKPEGY EICHDGKVVT IFSASNYYEE GSNRGAYIKL CSGTTPRFFQ 450
    YQVTKATCFQ PLRQRVDTME NSAIKILRER VISRKSDLTR AFQLQDHRKS 500
    GKLSVSQWAF CMENILGLNL PWRSLSSNLV NIDQNGNVEY MSSFQNIRIE 550
    KPVQEAHSTL VETLYRYRSD LEIIFNAIDT DHSGLISVEE FRAMWKLFSS 600
    HYNVHIDDSQ VNKLANIMDL NKDGSIDFNE FLKAFYVVHR YEDLMKPDVT 650
    NLG 653
    Length:653
    Mass (Da):75,792
    Last modified:January 1, 1998 - v1
    Checksum:iDF7B78C444EE6484
    GO
    Isoform 1A (identifier: O14829-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         79-132: Missing.

    Show »
    Length:599
    Mass (Da):69,376
    Checksum:iCA3972CC029AE822
    GO
    Isoform 1B (identifier: O14829-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         328-355: Missing.

    Show »
    Length:625
    Mass (Da):72,635
    Checksum:iDF86ABE8D0433ECE
    GO
    Isoform 2 (identifier: O14829-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         356-376: IIDILWSDPRGKNGCFPNTCR → SGYYGKQRHQDIKRESDFTKK
         377-653: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:376
    Mass (Da):44,019
    Checksum:i0C0E1B327FC8C000
    GO
    Isoform 3 (identifier: O14829-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         356-417: Missing.

    Note: May have no functional significance.

    Show »
    Length:591
    Mass (Da):68,806
    Checksum:i920657F8E80D2C8B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti367 – 3671K → T.1 Publication
    Corresponds to variant rs1065074 [ dbSNP | Ensembl ].
    VAR_051736
    Natural varianti443 – 4431G → S.
    Corresponds to variant rs11796620 [ dbSNP | Ensembl ].
    VAR_051737

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei79 – 13254Missing in isoform 1A. CuratedVSP_005098Add
    BLAST
    Alternative sequencei328 – 35528Missing in isoform 1B. CuratedVSP_005099Add
    BLAST
    Alternative sequencei356 – 41762Missing in isoform 3. CuratedVSP_005102Add
    BLAST
    Alternative sequencei356 – 37621IIDIL…PNTCR → SGYYGKQRHQDIKRESDFTK K in isoform 2. CuratedVSP_005100Add
    BLAST
    Alternative sequencei377 – 653277Missing in isoform 2. CuratedVSP_005101Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF023455 mRNA. Translation: AAB82795.1.
    X97867 mRNA. Translation: CAA66461.1.
    AF027977 mRNA. Translation: AAC05825.1.
    AK290463 mRNA. Translation: BAF83152.1.
    AL096700, Z94056 Genomic DNA. Translation: CAI42857.1.
    Z94056, AL096700 Genomic DNA. Translation: CAI42777.1.
    CH471074 Genomic DNA. Translation: EAW98944.1.
    BC036026 mRNA. Translation: AAH36026.1.
    CCDSiCCDS14188.1. [O14829-1]
    CCDS43920.1. [O14829-5]
    RefSeqiNP_006231.2. NM_006240.2. [O14829-1]
    NP_689410.1. NM_152224.1. [O14829-3]
    NP_689412.1. NM_152226.1. [O14829-5]
    XP_005274610.1. XM_005274553.1. [O14829-1]
    UniGeneiHs.211589.

    Genome annotation databases

    EnsembliENST00000349874; ENSP00000341892; ENSG00000086717. [O14829-5]
    ENST00000361511; ENSP00000354871; ENSG00000086717. [O14829-1]
    GeneIDi5475.
    KEGGihsa:5475.
    UCSCiuc004cyp.3. human. [O14829-3]
    uc004cyq.3. human. [O14829-1]
    uc004cyr.3. human. [O14829-5]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF023455 mRNA. Translation: AAB82795.1 .
    X97867 mRNA. Translation: CAA66461.1 .
    AF027977 mRNA. Translation: AAC05825.1 .
    AK290463 mRNA. Translation: BAF83152.1 .
    AL096700 , Z94056 Genomic DNA. Translation: CAI42857.1 .
    Z94056 , AL096700 Genomic DNA. Translation: CAI42777.1 .
    CH471074 Genomic DNA. Translation: EAW98944.1 .
    BC036026 mRNA. Translation: AAH36026.1 .
    CCDSi CCDS14188.1. [O14829-1 ]
    CCDS43920.1. [O14829-5 ]
    RefSeqi NP_006231.2. NM_006240.2. [O14829-1 ]
    NP_689410.1. NM_152224.1. [O14829-3 ]
    NP_689412.1. NM_152226.1. [O14829-5 ]
    XP_005274610.1. XM_005274553.1. [O14829-1 ]
    UniGenei Hs.211589.

    3D structure databases

    ProteinModelPortali O14829.
    SMRi O14829. Positions 107-451, 483-639.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111471. 1 interaction.
    IntActi O14829. 1 interaction.
    STRINGi 9606.ENSP00000354871.

    PTM databases

    PhosphoSitei O14829.

    Proteomic databases

    PaxDbi O14829.
    PRIDEi O14829.

    Protocols and materials databases

    DNASUi 5475.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349874 ; ENSP00000341892 ; ENSG00000086717 . [O14829-5 ]
    ENST00000361511 ; ENSP00000354871 ; ENSG00000086717 . [O14829-1 ]
    GeneIDi 5475.
    KEGGi hsa:5475.
    UCSCi uc004cyp.3. human. [O14829-3 ]
    uc004cyq.3. human. [O14829-1 ]
    uc004cyr.3. human. [O14829-5 ]

    Organism-specific databases

    CTDi 5475.
    GeneCardsi GC0XP018694.
    HGNCi HGNC:9243. PPEF1.
    HPAi HPA034577.
    MIMi 300109. gene.
    neXtProti NX_O14829.
    PharmGKBi PA33564.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000006820.
    HOVERGENi HBG008238.
    InParanoidi O14829.
    KOi K13807.
    OMAi MMNLRYG.
    OrthoDBi EOG7KH9J7.
    PhylomeDBi O14829.
    TreeFami TF313342.

    Enzyme and pathway databases

    Reactomei REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

    Miscellaneous databases

    GeneWikii PPEF1.
    GenomeRNAii 5475.
    NextBioi 21194.
    PROi O14829.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14829.
    Bgeei O14829.
    CleanExi HS_PPEF1.
    Genevestigatori O14829.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    3.60.21.10. 2 hits.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR029052. Metallo-depent_PP-like.
    IPR013235. PPP_dom.
    IPR012008. Ser/Thr-Pase_EF-hand_contain.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00036. EF-hand_1. 1 hit.
    PF00612. IQ. 1 hit.
    PF00149. Metallophos. 1 hit.
    PF08321. PPP5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000912. PPEF. 1 hit.
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00054. EFh. 3 hits.
    SM00015. IQ. 1 hit.
    SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 2 hits.
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS50096. IQ. 1 hit.
    PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C."
      Sherman P.M., Sun H., Macke J.P., Williams J., Smallwood P.M., Nathans J.
      Proc. Natl. Acad. Sci. U.S.A. 94:11639-11644(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. "A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin."
      Montini E., Rugarli E.I., van de Vosse E., Andolfi G., Mariani M., Puca A.A., Consales G.G., den Dunnen J.T., Ballabio A., Franco B.
      Hum. Mol. Genet. 6:1137-1145(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, VARIANT THR-367.
      Tissue: Fetal brain.
    3. "Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)."
      Huang X., Honkanen R.E.
      J. Biol. Chem. 273:1462-1468(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    8. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

    Entry informationi

    Entry nameiPPE1_HUMAN
    AccessioniPrimary (citable) accession number: O14829
    Secondary accession number(s): A6NHP4
    , A8K348, O15253, Q9NU21, Q9UJH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 154 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3