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Protein

Secretory carrier-associated membrane protein 3

Gene

SCAMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • post-Golgi vesicle-mediated transport Source: ProtInc
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

SIGNORiO14828.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 3
Short name:
Secretory carrier membrane protein 3
Gene namesi
Name:SCAMP3
Synonyms:C1orf3, PROPIN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116521.10.
HGNCiHGNC:10565. SCAMP3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 170CytoplasmicSequence analysisAdd BLAST170
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 347CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi67P → L: Abolishes interaction with TSG101. 1 Publication1

Organism-specific databases

DisGeNETi10067.
OpenTargetsiENSG00000116521.
PharmGKBiPA34978.

Polymorphism and mutation databases

BioMutaiSCAMP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912571 – 347Secretory carrier-associated membrane protein 3Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei41PhosphotyrosineCombined sources1
Modified residuei53PhosphotyrosineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei83PhosphotyrosineBy similarity1
Modified residuei85PhosphoserineCombined sources1
Cross-linki313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

Post-translational modificationi

Monoubiquitinated.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO14828.
MaxQBiO14828.
PaxDbiO14828.
PeptideAtlasiO14828.
PRIDEiO14828.

PTM databases

iPTMnetiO14828.
PhosphoSitePlusiO14828.
SwissPalmiO14828.

Miscellaneous databases

PMAP-CutDBiO14828.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000116521.
CleanExiHS_SCAMP3.
GenevisibleiO14828. HS.

Organism-specific databases

HPAiHPA071167.

Interactioni

Subunit structurei

Interacts with NEDD4, NEDD4L and TSG101. Interacts with RNF126.2 Publications

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115378. 62 interactors.
CORUMiO14828.
ELMiO14828.
IntActiO14828. 44 interactors.
MINTiMINT-5003764.
STRINGi9606.ENSP00000307275.

Structurei

3D structure databases

ProteinModelPortaliO14828.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088. Eukaryota.
ENOG410XSJN. LUCA.
GeneTreeiENSGT00390000014393.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiO14828.
KOiK19995.
OMAiEPRNYGS.
OrthoDBiEOG091G0ID2.
PhylomeDBiO14828.
TreeFamiTF313797.

Family and domain databases

InterProiView protein in InterPro
IPR007273. SCAMP.
PANTHERiPTHR10687. PTHR10687. 1 hit.
PfamiView protein in Pfam
PF04144. SCAMP. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14828-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQSRDGGNP FAEPSELDNP FQDPAVIQHR PSRQYATLDV YNPFETREPP
60 70 80 90 100
PAYEPPAPAP LPPPSAPSLQ PSRKLSPTEP KNYGSYSTQA SAAAATAELL
110 120 130 140 150
KKQEELNRKA EELDRREREL QHAALGGTAT RQNNWPPLPS FCPVQPCFFQ
160 170 180 190 200
DISMEIPQEF QKTVSTMYYL WMCSTLALLL NFLACLASFC VETNNGAGFG
210 220 230 240 250
LSILWVLLFT PCSFVCWYRP MYKAFRSDSS FNFFVFFFIF FVQDVLFVLQ
260 270 280 290 300
AIGIPGWGFS GWISALVVPK GNTAVSVLML LVALLFTGIA VLGIVMLKRI
310 320 330 340
HSLYRRTGAS FQKAQQEFAA GVFSNPAVRT AAANAAAGAA ENAFRAP
Length:347
Mass (Da):38,287
Last modified:September 23, 2008 - v3
Checksum:iD5B0870C66B84F9F
GO
Isoform 2 (identifier: O14828-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-48: Missing.

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):35,202
Checksum:i4F1819F7430A70C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3Q → R in AAB62724 (PubMed:9378760).Curated1
Sequence conflicti74K → M in AAB62724 (PubMed:9378760).Curated1
Sequence conflicti331A → R in AAC51821 (PubMed:9331372).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01188538L → R1 PublicationCorresponds to variant dbSNP:rs760073Ensembl.1
Natural variantiVAR_011886235V → A1 PublicationCorresponds to variant dbSNP:rs1318328Ensembl.1
Natural variantiVAR_011887239I → N1 PublicationCorresponds to variant dbSNP:rs909106Ensembl.1
Natural variantiVAR_011888242V → D1 PublicationCorresponds to variant dbSNP:rs909107Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00438123 – 48Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023268 Genomic DNA. Translation: AAC51821.1.
AF005039 mRNA. Translation: AAB62724.1.
AL713999 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW53090.1.
CH471121 Genomic DNA. Translation: EAW53092.1.
BC000161 mRNA. Translation: AAH00161.1.
BC005135 mRNA. Translation: AAH05135.1.
BC010505 mRNA. Translation: AAH10505.1.
CCDSiCCDS1105.1. [O14828-1]
CCDS1106.1. [O14828-2]
PIRiT08826.
RefSeqiNP_005689.2. NM_005698.3. [O14828-1]
NP_443069.1. NM_052837.2. [O14828-2]
UniGeneiHs.200600.

Genome annotation databases

EnsembliENST00000302631; ENSP00000307275; ENSG00000116521. [O14828-1]
ENST00000355379; ENSP00000347540; ENSG00000116521. [O14828-2]
ENST00000570831; ENSP00000461521; ENSG00000263290. [O14828-1]
ENST00000573013; ENSP00000458542; ENSG00000263290. [O14828-2]
GeneIDi10067.
KEGGihsa:10067.
UCSCiuc001fjs.4. human. [O14828-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSCAM3_HUMAN
AccessioniPrimary (citable) accession number: O14828
Secondary accession number(s): A9Z1W6
, B1AVS6, O15128, Q96FR8, Q9BPY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 23, 2008
Last modified: November 22, 2017
This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families