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Protein

Tetraspanin-4

Gene

TSPAN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • integrin binding Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • protein complex assembly Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-4
Short name:
Tspan-4
Alternative name(s):
Novel antigen 2
Short name:
NAG-2
Transmembrane 4 superfamily member 7
Gene namesi
Name:TSPAN4
Synonyms:NAG2, TM4SF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11859. TSPAN4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 55ExtracellularSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 85CytoplasmicSequence analysis9
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 201ExtracellularSequence analysisAdd BLAST95
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 238CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: UniProtKB
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7106.
OpenTargetsiENSG00000214063.
PharmGKBiPA36560.

Polymorphism and mutation databases

BioMutaiTSPAN4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192411 – 238Tetraspanin-4Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO14817.
PaxDbiO14817.
PeptideAtlasiO14817.
PRIDEiO14817.

PTM databases

SwissPalmiO14817.

Expressioni

Tissue specificityi

Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets.

Gene expression databases

BgeeiENSG00000214063.
CleanExiHS_TSPAN4.
ExpressionAtlasiO14817. baseline and differential.
GenevisibleiO14817. HS.

Organism-specific databases

HPAiHPA016435.

Interactioni

Subunit structurei

Forms a complex with integrins.

Binary interactionsi

WithEntry#Exp.IntActNotes
NOTCH2NLQ7Z3S95EBI-8652667,EBI-945833

GO - Molecular functioni

  • integrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112961. 7 interactors.
IntActiO14817. 4 interactors.
STRINGi9606.ENSP00000380552.

Structurei

3D structure databases

ProteinModelPortaliO14817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO14817.
KOiK17294.
PhylomeDBiO14817.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARACLQAVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGS FATLSSSFPS
60 70 80 90 100
LSAANLLIIT GAFVMAIGFV GCLGAIKENK CLLLTFFLLL LLVFLLEATI
110 120 130 140 150
AILFFAYTDK IDRYAQQDLK KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV
160 170 180 190 200
SNYTDWFEVY NATRVPDSCC LEFSESCGLH APGTWWKAPC YETVKVWLQE
210 220 230
NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA
Length:238
Mass (Da):26,118
Last modified:January 1, 1998 - v1
Checksum:iA6B9A5633065A492
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03661667I → M in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022813 mRNA. Translation: AAC51864.1.
AF054841 mRNA. Translation: AAC69717.1.
AK291089 mRNA. Translation: BAF83778.1.
BT006776 mRNA. Translation: AAP35422.1.
CR457108 mRNA. Translation: CAG33389.1.
CH471158 Genomic DNA. Translation: EAX02409.1.
BC000389 mRNA. Translation: AAH00389.1.
BC019314 mRNA. Translation: AAH19314.1.
BC093031 mRNA. Translation: AAH93031.1.
CCDSiCCDS7721.1.
PIRiA59265.
RefSeqiNP_001020405.1. NM_001025234.1.
NP_001020406.1. NM_001025235.1.
NP_001020407.1. NM_001025236.1.
NP_001020408.1. NM_001025237.1.
NP_001020409.1. NM_001025238.1.
NP_001020410.1. NM_001025239.1.
NP_003262.1. NM_003271.4.
XP_005253159.1. XM_005253102.1.
UniGeneiHs.654836.

Genome annotation databases

EnsembliENST00000397397; ENSP00000380552; ENSG00000214063.
ENST00000397404; ENSP00000380553; ENSG00000214063.
ENST00000397406; ENSP00000380554; ENSG00000214063.
ENST00000397408; ENSP00000380555; ENSG00000214063.
ENST00000397411; ENSP00000380558; ENSG00000214063.
ENST00000409543; ENSP00000386513; ENSG00000214063.
GeneIDi7106.
KEGGihsa:7106.
UCSCiuc001lsd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022813 mRNA. Translation: AAC51864.1.
AF054841 mRNA. Translation: AAC69717.1.
AK291089 mRNA. Translation: BAF83778.1.
BT006776 mRNA. Translation: AAP35422.1.
CR457108 mRNA. Translation: CAG33389.1.
CH471158 Genomic DNA. Translation: EAX02409.1.
BC000389 mRNA. Translation: AAH00389.1.
BC019314 mRNA. Translation: AAH19314.1.
BC093031 mRNA. Translation: AAH93031.1.
CCDSiCCDS7721.1.
PIRiA59265.
RefSeqiNP_001020405.1. NM_001025234.1.
NP_001020406.1. NM_001025235.1.
NP_001020407.1. NM_001025236.1.
NP_001020408.1. NM_001025237.1.
NP_001020409.1. NM_001025238.1.
NP_001020410.1. NM_001025239.1.
NP_003262.1. NM_003271.4.
XP_005253159.1. XM_005253102.1.
UniGeneiHs.654836.

3D structure databases

ProteinModelPortaliO14817.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112961. 7 interactors.
IntActiO14817. 4 interactors.
STRINGi9606.ENSP00000380552.

PTM databases

SwissPalmiO14817.

Polymorphism and mutation databases

BioMutaiTSPAN4.

Proteomic databases

MaxQBiO14817.
PaxDbiO14817.
PeptideAtlasiO14817.
PRIDEiO14817.

Protocols and materials databases

DNASUi7106.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397397; ENSP00000380552; ENSG00000214063.
ENST00000397404; ENSP00000380553; ENSG00000214063.
ENST00000397406; ENSP00000380554; ENSG00000214063.
ENST00000397408; ENSP00000380555; ENSG00000214063.
ENST00000397411; ENSP00000380558; ENSG00000214063.
ENST00000409543; ENSP00000386513; ENSG00000214063.
GeneIDi7106.
KEGGihsa:7106.
UCSCiuc001lsd.2. human.

Organism-specific databases

CTDi7106.
DisGeNETi7106.
GeneCardsiTSPAN4.
HGNCiHGNC:11859. TSPAN4.
HPAiHPA016435.
MIMi602644. gene.
neXtProtiNX_O14817.
OpenTargetsiENSG00000214063.
PharmGKBiPA36560.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiO14817.
KOiK17294.
PhylomeDBiO14817.
TreeFamiTF352892.

Enzyme and pathway databases

BioCyciZFISH:G66-33050-MONOMER.

Miscellaneous databases

ChiTaRSiTSPAN4. human.
GeneWikiiTSPAN4.
GenomeRNAii7106.
PROiO14817.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214063.
CleanExiHS_TSPAN4.
ExpressionAtlasiO14817. baseline and differential.
GenevisibleiO14817. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN4_HUMAN
AccessioniPrimary (citable) accession number: O14817
Secondary accession number(s): Q6IAP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.