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O14817

- TSN4_HUMAN

UniProt

O14817 - TSN4_HUMAN

Protein

Tetraspanin-4

Gene

TSPAN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB
    2. integrin binding Source: UniProtKB

    GO - Biological processi

    1. protein complex assembly Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-4
    Short name:
    Tspan-4
    Alternative name(s):
    Novel antigen 2
    Short name:
    NAG-2
    Transmembrane 4 superfamily member 7
    Gene namesi
    Name:TSPAN4
    Synonyms:NAG2, TM4SF7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11859. TSPAN4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB
    3. vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36560.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Tetraspanin-4PRO_0000219241Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO14817.
    PaxDbiO14817.
    PRIDEiO14817.

    Expressioni

    Tissue specificityi

    Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets.

    Gene expression databases

    ArrayExpressiO14817.
    BgeeiO14817.
    CleanExiHS_TSPAN4.
    GenevestigatoriO14817.

    Organism-specific databases

    HPAiHPA016435.

    Interactioni

    Subunit structurei

    Forms a complex with integrins.

    Protein-protein interaction databases

    BioGridi112961. 6 interactions.
    IntActiO14817. 1 interaction.
    STRINGi9606.ENSP00000324304.

    Structurei

    3D structure databases

    ProteinModelPortaliO14817.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 5521ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 859CytoplasmicSequence Analysis
    Topological domaini107 – 20195ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 23816CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290117.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiO14817.
    KOiK17294.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiO14817.
    TreeFamiTF352892.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14817-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARACLQAVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGS FATLSSSFPS    50
    LSAANLLIIT GAFVMAIGFV GCLGAIKENK CLLLTFFLLL LLVFLLEATI 100
    AILFFAYTDK IDRYAQQDLK KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV 150
    SNYTDWFEVY NATRVPDSCC LEFSESCGLH APGTWWKAPC YETVKVWLQE 200
    NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA 238
    Length:238
    Mass (Da):26,118
    Last modified:January 1, 1998 - v1
    Checksum:iA6B9A5633065A492
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671I → M in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036616

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022813 mRNA. Translation: AAC51864.1.
    AF054841 mRNA. Translation: AAC69717.1.
    AK291089 mRNA. Translation: BAF83778.1.
    BT006776 mRNA. Translation: AAP35422.1.
    CR457108 mRNA. Translation: CAG33389.1.
    CH471158 Genomic DNA. Translation: EAX02409.1.
    BC000389 mRNA. Translation: AAH00389.1.
    BC019314 mRNA. Translation: AAH19314.1.
    BC093031 mRNA. Translation: AAH93031.1.
    CCDSiCCDS7721.1.
    PIRiA59265.
    RefSeqiNP_001020405.1. NM_001025234.1.
    NP_001020406.1. NM_001025235.1.
    NP_001020407.1. NM_001025236.1.
    NP_001020408.1. NM_001025237.1.
    NP_001020409.1. NM_001025238.1.
    NP_001020410.1. NM_001025239.1.
    NP_003262.1. NM_003271.4.
    XP_005253159.1. XM_005253102.1.
    XP_006718350.1. XM_006718287.1.
    UniGeneiHs.654836.

    Genome annotation databases

    EnsembliENST00000397397; ENSP00000380552; ENSG00000214063.
    ENST00000397404; ENSP00000380553; ENSG00000214063.
    ENST00000397406; ENSP00000380554; ENSG00000214063.
    ENST00000397408; ENSP00000380555; ENSG00000214063.
    ENST00000397411; ENSP00000380558; ENSG00000214063.
    ENST00000409543; ENSP00000386513; ENSG00000214063.
    GeneIDi7106.
    KEGGihsa:7106.
    UCSCiuc001lsd.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022813 mRNA. Translation: AAC51864.1 .
    AF054841 mRNA. Translation: AAC69717.1 .
    AK291089 mRNA. Translation: BAF83778.1 .
    BT006776 mRNA. Translation: AAP35422.1 .
    CR457108 mRNA. Translation: CAG33389.1 .
    CH471158 Genomic DNA. Translation: EAX02409.1 .
    BC000389 mRNA. Translation: AAH00389.1 .
    BC019314 mRNA. Translation: AAH19314.1 .
    BC093031 mRNA. Translation: AAH93031.1 .
    CCDSi CCDS7721.1.
    PIRi A59265.
    RefSeqi NP_001020405.1. NM_001025234.1.
    NP_001020406.1. NM_001025235.1.
    NP_001020407.1. NM_001025236.1.
    NP_001020408.1. NM_001025237.1.
    NP_001020409.1. NM_001025238.1.
    NP_001020410.1. NM_001025239.1.
    NP_003262.1. NM_003271.4.
    XP_005253159.1. XM_005253102.1.
    XP_006718350.1. XM_006718287.1.
    UniGenei Hs.654836.

    3D structure databases

    ProteinModelPortali O14817.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112961. 6 interactions.
    IntActi O14817. 1 interaction.
    STRINGi 9606.ENSP00000324304.

    Proteomic databases

    MaxQBi O14817.
    PaxDbi O14817.
    PRIDEi O14817.

    Protocols and materials databases

    DNASUi 7106.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397397 ; ENSP00000380552 ; ENSG00000214063 .
    ENST00000397404 ; ENSP00000380553 ; ENSG00000214063 .
    ENST00000397406 ; ENSP00000380554 ; ENSG00000214063 .
    ENST00000397408 ; ENSP00000380555 ; ENSG00000214063 .
    ENST00000397411 ; ENSP00000380558 ; ENSG00000214063 .
    ENST00000409543 ; ENSP00000386513 ; ENSG00000214063 .
    GeneIDi 7106.
    KEGGi hsa:7106.
    UCSCi uc001lsd.1. human.

    Organism-specific databases

    CTDi 7106.
    GeneCardsi GC11P000843.
    HGNCi HGNC:11859. TSPAN4.
    HPAi HPA016435.
    MIMi 602644. gene.
    neXtProti NX_O14817.
    PharmGKBi PA36560.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290117.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi O14817.
    KOi K17294.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi O14817.
    TreeFami TF352892.

    Miscellaneous databases

    ChiTaRSi TSPAN4. human.
    GeneWikii TSPAN4.
    GenomeRNAii 7106.
    NextBioi 27801.
    PROi O14817.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14817.
    Bgeei O14817.
    CleanExi HS_TSPAN4.
    Genevestigatori O14817.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins."
      Tachibana I., Bodorova J., Berditchevski F., Zutter M.M., Hemler M.E.
      J. Biol. Chem. 272:29181-29189(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
      Todd S.C., Doctor V.S., Levy S.
      Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-161.
      Tissue: Liver.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-67.

    Entry informationi

    Entry nameiTSN4_HUMAN
    AccessioniPrimary (citable) accession number: O14817
    Secondary accession number(s): Q6IAP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3