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Protein

Complexin-1

Gene

CPLX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • exocytosis Source: ProtInc
  • insulin secretion Source: Ensembl
  • regulation of exocytosis Source: ParkinsonsUK-UCL
  • synaptic vesicle exocytosis Source: Ensembl

Keywordsi

Biological processExocytosis, Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-1
Alternative name(s):
Complexin I
Short name:
CPX I
Synaphin-2
Gene namesi
Name:CPLX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168993.14
HGNCiHGNC:2309 CPLX1
MIMi605032 gene
neXtProtiNX_O14810

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10815
MalaCardsiCPLX1
OpenTargetsiENSG00000168993
PharmGKBiPA26826

Polymorphism and mutation databases

BioMutaiCPLX1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448701 – 134Complexin-1Add BLAST134

Proteomic databases

MaxQBiO14810
PaxDbiO14810
PeptideAtlasiO14810
PRIDEiO14810

PTM databases

iPTMnetiO14810
PhosphoSitePlusiO14810

Expressioni

Tissue specificityi

Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.3 Publications

Gene expression databases

BgeeiENSG00000168993
CleanExiHS_CPLX1
ExpressionAtlasiO14810 baseline and differential
GenevisibleiO14810 HS

Organism-specific databases

HPAiHPA071191

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNAP25P60880-26EBI-2691813,EBI-12177361

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116028, 37 interactors
CORUMiO14810
DIPiDIP-56109N
IntActiO14810, 5 interactors
STRINGi9606.ENSP00000305613

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 70Combined sources42

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RK3X-ray3.50E26-83[»]
3RL0X-ray3.80g/h/i/j/k/l/m/n26-83[»]
ProteinModelPortaliO14810
SMRiO14810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 70Interaction with the SNARE complexBy similarityAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 69Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWGS Eukaryota
ENOG4111MX0 LUCA
GeneTreeiENSGT00490000043416
HOGENOMiHOG000017716
HOVERGENiHBG062792
InParanoidiO14810
KOiK15294
OMAiTVMKFIP
OrthoDBiEOG091G0WGX
PhylomeDBiO14810
TreeFamiTF315172

Family and domain databases

InterProiView protein in InterPro
IPR008849 Synaphin
PANTHERiPTHR16705 PTHR16705, 1 hit
PfamiView protein in Pfam
PF05835 Synaphin, 1 hit

Sequencei

Sequence statusi: Complete.

O14810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA
60 70 80 90 100
KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA
110 120 130
IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK
Length:134
Mass (Da):15,030
Last modified:January 1, 1998 - v1
Checksum:iA7A52F17F10D28A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022383 mRNA Translation: AAB72108.1
KJ534815 mRNA Translation: AHW56455.1
BT007029 mRNA Translation: AAP35676.1
AB593095 mRNA Translation: BAJ84035.1
AK311921 mRNA Translation: BAG34862.1
AC139887 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82648.1
CH471131 Genomic DNA Translation: EAW82649.1
BC002471 mRNA Translation: AAH02471.1
CCDSiCCDS46995.1
RefSeqiNP_006642.1, NM_006651.3
UniGeneiHs.478930

Genome annotation databases

EnsembliENST00000304062; ENSP00000305613; ENSG00000168993
GeneIDi10815
KEGGihsa:10815
UCSCiuc003gbi.4 human

Similar proteinsi

Entry informationi

Entry nameiCPLX1_HUMAN
AccessioniPrimary (citable) accession number: O14810
Secondary accession number(s): A6NI80
, B2R4R5, D3DVN3, F1T0G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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