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O14810

- CPLX1_HUMAN

UniProt

O14810 - CPLX1_HUMAN

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Protein
Complexin-1
Gene
CPLX1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells By similarity.1 Publication

GO - Molecular functioni

  1. neurotransmitter transporter activity Source: Ensembl

GO - Biological processi

  1. exocytosis Source: ProtInc
  2. glutamate secretion Source: Reactome
  3. insulin secretion Source: Ensembl
  4. neurotransmitter secretion Source: Reactome
  5. synaptic transmission Source: Reactome
  6. synaptic vesicle exocytosis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_15293. Dopamine Neurotransmitter Release Cycle.
REACT_15309. Acetylcholine Neurotransmitter Release Cycle.
REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
REACT_15425. Serotonin Neurotransmitter Release Cycle.
REACT_23947. GABA synthesis, release, reuptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-1
Alternative name(s):
Complexin I
Short name:
CPX I
Synaphin-2
Gene namesi
Name:CPLX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:2309. CPLX1.

Subcellular locationi

Cytoplasmcytosol By similarity
Note: Enriched at synaptic-releasing sites in mature neurons By similarity.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. dendrite Source: Ensembl
  3. neuronal cell body Source: Ensembl
  4. synapse Source: Ensembl
  5. synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Complexin-1
PRO_0000144870Add
BLAST

Proteomic databases

MaxQBiO14810.
PaxDbiO14810.
PeptideAtlasiO14810.
PRIDEiO14810.

PTM databases

PhosphoSiteiO14810.

Expressioni

Tissue specificityi

Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.3 Publications

Gene expression databases

ArrayExpressiO14810.
BgeeiO14810.
CleanExiHS_CPLX1.
GenevestigatoriO14810.

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.1 Publication

Protein-protein interaction databases

BioGridi116028. 32 interactions.
DIPiDIP-56109N.
IntActiO14810. 2 interactions.
STRINGi9606.ENSP00000305613.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 7042

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RK3X-ray3.50E26-83[»]
3RL0X-ray3.80g/h/i/j/k/l/m/n26-83[»]
ProteinModelPortaliO14810.
SMRiO14810. Positions 32-72.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 7023Interaction with the SNARE complex By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili29 – 6941 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG85303.
HOGENOMiHOG000017716.
HOVERGENiHBG062792.
KOiK15294.
OMAiKYARMEA.
OrthoDBiEOG71G9XG.
PhylomeDBiO14810.
TreeFamiTF315172.

Family and domain databases

InterProiIPR008849. Synaphin.
[Graphical view]
PANTHERiPTHR16705. PTHR16705. 1 hit.
PfamiPF05835. Synaphin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14810-1 [UniParc]FASTAAdd to Basket

« Hide

MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA    50
KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA 100
IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK 134
Length:134
Mass (Da):15,030
Last modified:January 1, 1998 - v1
Checksum:iA7A52F17F10D28A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022383 mRNA. Translation: AAB72108.1.
KJ534815 mRNA. Translation: AHW56455.1.
BT007029 mRNA. Translation: AAP35676.1.
AB593095 mRNA. Translation: BAJ84035.1.
AK311921 mRNA. Translation: BAG34862.1.
AC139887 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82648.1.
CH471131 Genomic DNA. Translation: EAW82649.1.
BC002471 mRNA. Translation: AAH02471.1.
CCDSiCCDS46995.1.
RefSeqiNP_006642.1. NM_006651.3.
UniGeneiHs.478930.

Genome annotation databases

EnsembliENST00000304062; ENSP00000305613; ENSG00000168993.
GeneIDi10815.
KEGGihsa:10815.
UCSCiuc003gbi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022383 mRNA. Translation: AAB72108.1 .
KJ534815 mRNA. Translation: AHW56455.1 .
BT007029 mRNA. Translation: AAP35676.1 .
AB593095 mRNA. Translation: BAJ84035.1 .
AK311921 mRNA. Translation: BAG34862.1 .
AC139887 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82648.1 .
CH471131 Genomic DNA. Translation: EAW82649.1 .
BC002471 mRNA. Translation: AAH02471.1 .
CCDSi CCDS46995.1.
RefSeqi NP_006642.1. NM_006651.3.
UniGenei Hs.478930.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RK3 X-ray 3.50 E 26-83 [» ]
3RL0 X-ray 3.80 g/h/i/j/k/l/m/n 26-83 [» ]
ProteinModelPortali O14810.
SMRi O14810. Positions 32-72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116028. 32 interactions.
DIPi DIP-56109N.
IntActi O14810. 2 interactions.
STRINGi 9606.ENSP00000305613.

PTM databases

PhosphoSitei O14810.

Proteomic databases

MaxQBi O14810.
PaxDbi O14810.
PeptideAtlasi O14810.
PRIDEi O14810.

Protocols and materials databases

DNASUi 10815.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304062 ; ENSP00000305613 ; ENSG00000168993 .
GeneIDi 10815.
KEGGi hsa:10815.
UCSCi uc003gbi.3. human.

Organism-specific databases

CTDi 10815.
GeneCardsi GC04M000778.
HGNCi HGNC:2309. CPLX1.
MIMi 605032. gene.
neXtProti NX_O14810.
PharmGKBi PA26826.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85303.
HOGENOMi HOG000017716.
HOVERGENi HBG062792.
KOi K15294.
OMAi KYARMEA.
OrthoDBi EOG71G9XG.
PhylomeDBi O14810.
TreeFami TF315172.

Enzyme and pathway databases

Reactomei REACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_15293. Dopamine Neurotransmitter Release Cycle.
REACT_15309. Acetylcholine Neurotransmitter Release Cycle.
REACT_15418. Norepinephrine Neurotransmitter Release Cycle.
REACT_15425. Serotonin Neurotransmitter Release Cycle.
REACT_23947. GABA synthesis, release, reuptake and degradation.

Miscellaneous databases

GeneWikii CPLX1.
GenomeRNAii 10815.
NextBioi 41085.
PROi O14810.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14810.
Bgeei O14810.
CleanExi HS_CPLX1.
Genevestigatori O14810.

Family and domain databases

InterProi IPR008849. Synaphin.
[Graphical view ]
PANTHERi PTHR16705. PTHR16705. 1 hit.
Pfami PF05835. Synaphin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complexins: cytosolic proteins that regulate SNAP receptor function."
    McMahon H.T., Missler M., Li C., Suedhof T.C.
    Cell 83:111-119(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
    Corominas R., Yang X., Lin G.N., Kang S., Shen Y., Ghamsari L., Broly M., Rodriguez M., Tam S., Wanamaker S.A., Fan C., Yi S., Tasan M., Lemmens I., Kuang X., Zhao N., Malhotra D., Michaelson J.J.
    , Vacic V., Calderwood M.A., Roth F.P., Tavernier J., Horvath S., Salehi-Ashtiani K., Korkin D., Sebat J., Hill D.E., Hao T., Vidal M., Iakoucheva L.M.
    Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
    Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
    Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  9. "Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia."
    Harrison P.J., Eastwood S.L.
    Lancet 352:1669-1673(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Cerebellar synaptic protein expression in schizophrenia."
    Eastwood S.L., Cotter D., Harrison P.J.
    Neuroscience 105:219-229(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Proteome analysis of human substantia nigra in Parkinson's disease."
    Basso M., Giraudo S., Corpillo D., Bergamasco B., Lopiano L., Fasano M.
    Proteomics 4:3943-3952(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 28-83 ALONE AND IN COMPLEX WITH SNAP25; VAMP2 AND RAT STX1A, SUBUNIT, FUNCTION.

Entry informationi

Entry nameiCPLX1_HUMAN
AccessioniPrimary (citable) accession number: O14810
Secondary accession number(s): A6NI80
, B2R4R5, D3DVN3, F1T0G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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