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Protein

Ras-related protein M-Ras

Gene

MRAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: ProtInc
  • cellular response to leukemia inhibitory factor Source: Ensembl
  • multicellular organism development Source: ProtInc
  • muscle organ development Source: ProtInc
  • Ras protein signal transduction Source: ProtInc

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO14807.
SIGNORiO14807.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein M-Ras
Alternative name(s):
Ras-related protein R-Ras3
Gene namesi
Name:MRAS
Synonyms:RRAS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000158186.12.
HGNCiHGNC:7227. MRAS.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22808.
OpenTargetsiENSG00000158186.
PharmGKBiPA30932.

Polymorphism and mutation databases

BioMutaiMRAS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826541 – 205Ras-related protein M-RasAdd BLAST205
PropeptideiPRO_0000281304206 – 208Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205Cysteine methyl esterBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO14807.
PaxDbiO14807.
PeptideAtlasiO14807.
PRIDEiO14807.

PTM databases

iPTMnetiO14807.
PhosphoSitePlusiO14807.

Expressioni

Tissue specificityi

Expression highly restricted to the brain and heart.

Inductioni

By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4.

Gene expression databases

BgeeiENSG00000158186.
CleanExiHS_MRAS.
ExpressionAtlasiO14807. baseline and differential.
GenevisibleiO14807. HS.

Organism-specific databases

HPAiHPA042728.

Interactioni

Subunit structurei

Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC).By similarity1 Publication

GO - Molecular functioni

  • GTP-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116486. 12 interactors.
DIPiDIP-35406N.
IntActiO14807. 4 interactors.
MINTiMINT-101967.
STRINGi9606.ENSP00000289104.

Structurei

3D structure databases

ProteinModelPortaliO14807.
SMRiO14807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector region9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 191Poly-Lys7

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO14807.
KOiK07831.
OMAiFHEVVRI.
OrthoDBiEOG091G0UAU.
PhylomeDBiO14807.
TreeFamiTF312796.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51421. RAS. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14807-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY
60 70 80 90 100
LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF
110 120 130 140 150
EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKITREQ GKEMATKHNI
160 170 180 190 200
PYIETSAKDP PLNVDKAFHD LVRVIRQQIP EKSQKKKKKT KWRGDRATGT

HKLQCVIL
Length:208
Mass (Da):23,846
Last modified:August 1, 1998 - v2
Checksum:i0B2B55AFA96B3EC4
GO
Isoform 2 (identifier: O14807-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:132
Mass (Da):15,542
Checksum:i4FC12B4978F7826D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0447921 – 76Missing in isoform 2. 2 PublicationsAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022080 mRNA. Translation: AAC52085.1.
AF043938 mRNA. Translation: AAD02287.1.
AF493918 mRNA. Translation: AAM12632.1.
AK295640 mRNA. Translation: BAG58512.1.
AK316071 mRNA. Translation: BAH14442.1.
BT020057 mRNA. Translation: AAV38860.1.
AC022337 Genomic DNA. No translation available.
AC022497 Genomic DNA. No translation available.
BC047690 mRNA. No translation available.
CCDSiCCDS3100.1. [O14807-1]
CCDS58855.1. [O14807-2]
RefSeqiNP_001078518.1. NM_001085049.2. [O14807-1]
NP_001239019.1. NM_001252090.1. [O14807-1]
NP_001239020.1. NM_001252091.1. [O14807-2]
NP_001239021.1. NM_001252092.1. [O14807-2]
NP_001239022.1. NM_001252093.1. [O14807-2]
NP_036351.3. NM_012219.4. [O14807-1]
XP_005247285.1. XM_005247228.1. [O14807-1]
XP_016861376.1. XM_017005887.1. [O14807-1]
UniGeneiHs.527021.
Hs.735125.

Genome annotation databases

EnsembliENST00000289104; ENSP00000289104; ENSG00000158186. [O14807-1]
ENST00000423968; ENSP00000389682; ENSG00000158186. [O14807-1]
ENST00000464896; ENSP00000419582; ENSG00000158186. [O14807-2]
ENST00000474559; ENSP00000418356; ENSG00000158186. [O14807-1]
ENST00000614350; ENSP00000484586; ENSG00000158186. [O14807-2]
ENST00000621127; ENSP00000481637; ENSG00000158186. [O14807-2]
GeneIDi22808.
KEGGihsa:22808.
UCSCiuc011bmi.3. human. [O14807-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRASM_HUMAN
AccessioniPrimary (citable) accession number: O14807
Secondary accession number(s): B4DIK0, Q86WX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families