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Protein

Ras-related protein M-Ras

Gene

MRAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: ProtInc
  • multicellular organism development Source: ProtInc
  • muscle organ development Source: ProtInc
  • Ras protein signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO14807.
SIGNORiO14807.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein M-Ras
Alternative name(s):
Ras-related protein R-Ras3
Gene namesi
Name:MRAS
Synonyms:RRAS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:7227. MRAS.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intracellular Source: GOC
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30932.

Polymorphism and mutation databases

BioMutaiMRAS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Ras-related protein M-RasPRO_0000082654Add
BLAST
Propeptidei206 – 2083Removed in mature formBy similarityPRO_0000281304

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei205 – 2051Cysteine methyl esterBy similarity
Lipidationi205 – 2051S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO14807.
PaxDbiO14807.
PeptideAtlasiO14807.
PRIDEiO14807.

PTM databases

iPTMnetiO14807.
PhosphoSiteiO14807.

Expressioni

Tissue specificityi

Expression highly restricted to the brain and heart.

Inductioni

By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4.

Gene expression databases

BgeeiENSG00000158186.
CleanExiHS_MRAS.
ExpressionAtlasiO14807. baseline and differential.
GenevisibleiO14807. HS.

Organism-specific databases

HPAiHPA042728.

Interactioni

Subunit structurei

Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC).By similarity1 Publication

GO - Molecular functioni

  • GTP-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116486. 11 interactions.
DIPiDIP-35406N.
IntActiO14807. 3 interactions.
MINTiMINT-101967.
STRINGi9606.ENSP00000289104.

Structurei

3D structure databases

ProteinModelPortaliO14807.
SMRiO14807. Positions 10-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 509Effector region

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 1917Poly-Lys

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO14807.
KOiK07831.
OMAiWVIMDVL.
OrthoDBiEOG091G0UAU.
PhylomeDBiO14807.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14807-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY
60 70 80 90 100
LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF
110 120 130 140 150
EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKITREQ GKEMATKHNI
160 170 180 190 200
PYIETSAKDP PLNVDKAFHD LVRVIRQQIP EKSQKKKKKT KWRGDRATGT

HKLQCVIL
Length:208
Mass (Da):23,846
Last modified:August 1, 1998 - v2
Checksum:i0B2B55AFA96B3EC4
GO
Isoform 2 (identifier: O14807-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:132
Mass (Da):15,542
Checksum:i4FC12B4978F7826D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7676Missing in isoform 2. 2 PublicationsVSP_044792Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022080 mRNA. Translation: AAC52085.1.
AF043938 mRNA. Translation: AAD02287.1.
AF493918 mRNA. Translation: AAM12632.1.
AK295640 mRNA. Translation: BAG58512.1.
AK316071 mRNA. Translation: BAH14442.1.
BT020057 mRNA. Translation: AAV38860.1.
AC022337 Genomic DNA. No translation available.
AC022497 Genomic DNA. No translation available.
BC047690 mRNA. No translation available.
CCDSiCCDS3100.1. [O14807-1]
CCDS58855.1. [O14807-2]
RefSeqiNP_001078518.1. NM_001085049.2. [O14807-1]
NP_001239019.1. NM_001252090.1. [O14807-1]
NP_001239020.1. NM_001252091.1. [O14807-2]
NP_001239021.1. NM_001252092.1. [O14807-2]
NP_001239022.1. NM_001252093.1. [O14807-2]
NP_036351.3. NM_012219.4. [O14807-1]
XP_005247285.1. XM_005247228.1. [O14807-1]
UniGeneiHs.527021.
Hs.735125.

Genome annotation databases

EnsembliENST00000289104; ENSP00000289104; ENSG00000158186. [O14807-1]
ENST00000423968; ENSP00000389682; ENSG00000158186. [O14807-1]
ENST00000464896; ENSP00000419582; ENSG00000158186. [O14807-2]
ENST00000474559; ENSP00000418356; ENSG00000158186. [O14807-1]
ENST00000614350; ENSP00000484586; ENSG00000158186. [O14807-2]
ENST00000621127; ENSP00000481637; ENSG00000158186. [O14807-2]
GeneIDi22808.
KEGGihsa:22808.
UCSCiuc011bmi.3. human. [O14807-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022080 mRNA. Translation: AAC52085.1.
AF043938 mRNA. Translation: AAD02287.1.
AF493918 mRNA. Translation: AAM12632.1.
AK295640 mRNA. Translation: BAG58512.1.
AK316071 mRNA. Translation: BAH14442.1.
BT020057 mRNA. Translation: AAV38860.1.
AC022337 Genomic DNA. No translation available.
AC022497 Genomic DNA. No translation available.
BC047690 mRNA. No translation available.
CCDSiCCDS3100.1. [O14807-1]
CCDS58855.1. [O14807-2]
RefSeqiNP_001078518.1. NM_001085049.2. [O14807-1]
NP_001239019.1. NM_001252090.1. [O14807-1]
NP_001239020.1. NM_001252091.1. [O14807-2]
NP_001239021.1. NM_001252092.1. [O14807-2]
NP_001239022.1. NM_001252093.1. [O14807-2]
NP_036351.3. NM_012219.4. [O14807-1]
XP_005247285.1. XM_005247228.1. [O14807-1]
UniGeneiHs.527021.
Hs.735125.

3D structure databases

ProteinModelPortaliO14807.
SMRiO14807. Positions 10-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116486. 11 interactions.
DIPiDIP-35406N.
IntActiO14807. 3 interactions.
MINTiMINT-101967.
STRINGi9606.ENSP00000289104.

PTM databases

iPTMnetiO14807.
PhosphoSiteiO14807.

Polymorphism and mutation databases

BioMutaiMRAS.

Proteomic databases

EPDiO14807.
PaxDbiO14807.
PeptideAtlasiO14807.
PRIDEiO14807.

Protocols and materials databases

DNASUi22808.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289104; ENSP00000289104; ENSG00000158186. [O14807-1]
ENST00000423968; ENSP00000389682; ENSG00000158186. [O14807-1]
ENST00000464896; ENSP00000419582; ENSG00000158186. [O14807-2]
ENST00000474559; ENSP00000418356; ENSG00000158186. [O14807-1]
ENST00000614350; ENSP00000484586; ENSG00000158186. [O14807-2]
ENST00000621127; ENSP00000481637; ENSG00000158186. [O14807-2]
GeneIDi22808.
KEGGihsa:22808.
UCSCiuc011bmi.3. human. [O14807-1]

Organism-specific databases

CTDi22808.
GeneCardsiMRAS.
HGNCiHGNC:7227. MRAS.
HPAiHPA042728.
MIMi608435. gene.
neXtProtiNX_O14807.
PharmGKBiPA30932.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO14807.
KOiK07831.
OMAiWVIMDVL.
OrthoDBiEOG091G0UAU.
PhylomeDBiO14807.
TreeFamiTF312796.

Enzyme and pathway databases

SignaLinkiO14807.
SIGNORiO14807.

Miscellaneous databases

ChiTaRSiMRAS. human.
GeneWikiiMRAS.
GenomeRNAii22808.
PROiO14807.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158186.
CleanExiHS_MRAS.
ExpressionAtlasiO14807. baseline and differential.
GenevisibleiO14807. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRASM_HUMAN
AccessioniPrimary (citable) accession number: O14807
Secondary accession number(s): B4DIK0, Q86WX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.