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O14804 (TAAR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trace amine-associated receptor 5
Short name=TaR-5
Short name=Trace amine receptor 5
Alternative name(s):
Putative neurotransmitter receptor
Gene names
Name:TAAR5
Synonyms:PNR
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed almost exclusively in skeletal muscle and selected areas of the brain, such amygdala, hippocampus, caudate nucleus, thalamus and hypothalamus. Weak expression is also find in substantia nigra. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processsynaptic transmission

Traceable author statement. Source: ProtInc

   Cellular componentintegral to plasma membrane

Traceable author statement. Source: ProtInc

   Molecular functionG-protein coupled receptor activity

Traceable author statement Ref.2. Source: GDB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Trace amine-associated receptor 5
PRO_0000070154

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 5521Helical; Name=1; Potential
Topological domain56 – 7015Cytoplasmic Potential
Transmembrane71 – 9121Helical; Name=2; Potential
Topological domain92 – 10918Extracellular Potential
Transmembrane110 – 13021Helical; Name=3; Potential
Topological domain131 – 15424Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 20429Extracellular Potential
Transmembrane205 – 22521Helical; Name=5; Potential
Topological domain226 – 25328Cytoplasmic Potential
Transmembrane254 – 27421Helical; Name=6; Potential
Topological domain275 – 28410Extracellular Potential
Transmembrane285 – 30723Helical; Name=7; Potential
Topological domain308 – 33730Cytoplasmic Potential

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 192 By similarity

Natural variations

Natural variant2721T → M.
Corresponds to variant rs34746740 [ dbSNP | Ensembl ].
VAR_055923
Natural variant3301R → C.
Corresponds to variant rs35839363 [ dbSNP | Ensembl ].
VAR_055924

Experimental info

Sequence conflict161F → L in AAH95541. Ref.4
Sequence conflict401A → T in AAC39581. Ref.1
Sequence conflict801D → N in AAH69171. Ref.4
Sequence conflict2571A → V in AAC39581. Ref.1
Sequence conflict3321V → A in AAH95541. Ref.4

Sequences

Sequence LengthMass (Da)Tools
O14804 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: 251DB41A13A5535A

FASTA33738,242
        10         20         30         40         50         60 
MRAVFIQGAE EHPAAFCYQV NGSCPRTVHT LGIQLVIYLA CAAGMLIIVL GNVFVAFAVS 

        70         80         90        100        110        120 
YFKALHTPTN FLLLSLALAD MFLGLLVLPL STIRSVESCW FFGDFLCRLH TYLDTLFCLT 

       130        140        150        160        170        180 
SIFHLCFISI DRHCAICDPL LYPSKFTVRV ALRYILAGWG VPAAYTSLFL YTDVVETRLS 

       190        200        210        220        230        240 
QWLEEMPCVG SCQLLLNKFW GWLNFPLFFV PCLIMISLYV KIFVVATRQA QQITTLSKSL 

       250        260        270        280        290        300 
AGAAKHERKA AKTLGIAVGI YLLCWLPFTI DTMVDSLLHF ITPPLVFDIF IWFAYFNSAC 

       310        320        330 
NPIIYVFSYQ WFRKALKLTL SQKVFSPQTR TVDLYQE

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain."
Zeng Z., Fan P., Rand E., Kyaw H., Su K., Madike V., Carter K.C., Li Y.
Biochem. Biophys. Res. Commun. 242:575-578(1998) [PubMed: 9464258] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors."
Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K., Hoener M.C.
Genomics 85:372-385(2005) [PubMed: 15718104] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF021818 mRNA. Translation: AAC39581.1.
AY702306 Genomic DNA. Translation: AAV70123.1.
AL513524 Genomic DNA. Translation: CAH72100.1.
BC069171 mRNA. Translation: AAH69171.1.
BC095541 mRNA. Translation: AAH95541.1.
BC112209 mRNA. Translation: AAI12210.1.
BC112211 mRNA. Translation: AAI12212.1.
IPIIPI00022579.
PIRJC5832.
RefSeqNP_003958.2. NM_003967.2.
UniGeneHs.248198.

3D structure databases

ProteinModelPortalO14804.
SMRO14804. Positions 31-321.
ModBaseSearch...

Protein-protein interaction databases

STRINGO14804.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEO14804.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258034; ENSP00000258034; ENSG00000135569.
GeneID9038.
KEGGhsa:9038.
UCSCuc003qdk.1. human.

Organism-specific databases

CTD9038.
GeneCardsGC06M132910.
H-InvDBHIX0032758.
HGNCHGNC:30236. TAAR5.
MIM607405. gene.
neXtProtNX_O14804.
PharmGKBPA142670843.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG16188.
GeneTreeENSGT00550000074214.
HOGENOMHBG445348.
HOVERGENHBG106962.
InParanoidO14804.
OMAAFCYQVN.
OrthoDBEOG495ZS8.
PhylomeDBO14804.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO14804.
BgeeO14804.
CleanExHS_TAAR5.
GenevestigatorO14804.
GermOnlineENSG00000135569. Homo sapiens.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR009132. Trace_amine_rcpt.
[Graphical view]
KOK05051.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01830. TRACEAMINER.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio33855.
SOURCESearch...

Entry information

Entry nameTAAR5_HUMAN
AccessionPrimary (citable) accession number: O14804
Secondary accession number(s): Q2M1V1 expand/collapse secondary AC list , Q4VBL1, Q5VUQ3, Q6NTA8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: January 25, 2012
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents