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O14802

- RPC1_HUMAN

UniProt

O14802 - RPC1_HUMAN

Protein

DNA-directed RNA polymerase III subunit RPC1

Gene

POLR3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition By similarity. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.By similarity2 Publications

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi69 – 691Zinc 1By similarity
    Metal bindingi72 – 721Zinc 1By similarity
    Metal bindingi79 – 791Zinc 1By similarity
    Metal bindingi82 – 821Zinc 1By similarity
    Metal bindingi109 – 1091Zinc 2By similarity
    Metal bindingi112 – 1121Zinc 2By similarity
    Metal bindingi156 – 1561Zinc 2By similarity
    Metal bindingi499 – 4991Magnesium; catalyticBy similarity
    Metal bindingi501 – 5011Magnesium; catalyticBy similarity
    Metal bindingi503 – 5031Magnesium; catalyticBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: InterPro
    3. DNA-directed RNA polymerase activity Source: UniProtKB
    4. ribonucleoside binding Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. defense response to virus Source: UniProtKB-KW
    2. gene expression Source: Reactome
    3. innate immune response Source: UniProtKB
    4. positive regulation of interferon-beta production Source: UniProtKB
    5. positive regulation of type I interferon production Source: Reactome
    6. termination of RNA polymerase III transcription Source: Reactome
    7. transcription, DNA-templated Source: UniProtKB
    8. transcription elongation from RNA polymerase III promoter Source: Reactome
    9. transcription from RNA polymerase III promoter Source: Reactome

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Antiviral defense, Immunity, Innate immunity, Transcription

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    REACT_63. RNA Polymerase III Transcription Termination.
    REACT_756. RNA Polymerase III Chain Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC1 (EC:2.7.7.6)
    Short name:
    RNA polymerase III subunit C1
    Alternative name(s):
    DNA-directed RNA polymerase III largest subunit
    DNA-directed RNA polymerase III subunit A
    RNA polymerase III 155 kDa subunit
    Short name:
    RPC155
    RNA polymerase III subunit C160
    Gene namesi
    Name:POLR3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:30074. POLR3A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. DNA-directed RNA polymerase III complex Source: MGI
    3. membrane Source: UniProtKB
    4. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism (HLD7) [MIM:607694]: An autosomal recessive neurodegenerative disorder characterized by childhood onset of progressive motor decline manifest as spasticity, ataxia, tremor, and cerebellar signs, as well as mild cognitive regression. Other features may include hypodontia or oligodontia and hypogonadotropic hypogonadism. There is considerable inter- and intrafamilial variability.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti372 – 3721D → N in HLD7. 1 Publication
    VAR_066516
    Natural varianti558 – 5581F → L in HLD7. 1 Publication
    VAR_066517
    Natural varianti636 – 6361S → Y in HLD7. 1 Publication
    VAR_066518
    Natural varianti672 – 6721G → E in HLD7. 1 Publication
    VAR_066519
    Natural varianti724 – 7241C → Y in HLD7. 1 Publication
    VAR_066520
    Natural varianti775 – 7751N → I in HLD7. 1 Publication
    VAR_066521
    Natural varianti852 – 8521M → V in HLD7. 1 Publication
    VAR_066522
    Natural varianti897 – 8971I → N in HLD7. 1 Publication
    VAR_067004
    Natural varianti1005 – 10051R → C in HLD7. 1 Publication
    VAR_066523
    Natural varianti1247 – 12471T → TT in HLD7. 1 Publication
    VAR_066524

    Keywords - Diseasei

    Leukodystrophy

    Organism-specific databases

    MIMi607694. phenotype.
    Orphaneti88637. Hypomyelination - hypogonadotropic hypogonadism - hypodontia.
    77295. Odontoleukodystrophy.
    PharmGKBiPA134900426.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13901390DNA-directed RNA polymerase III subunit RPC1PRO_0000073947Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei445 – 4451N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO14802.
    PaxDbiO14802.
    PRIDEiO14802.

    PTM databases

    PhosphoSiteiO14802.

    Expressioni

    Tissue specificityi

    Expressed in the brain, in the cortex and the white matter (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiO14802.
    BgeeiO14802.
    CleanExiHS_POLR3A.
    GenevestigatoriO14802.

    Organism-specific databases

    HPAiHPA037926.
    HPA037927.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.By similarity

    Protein-protein interaction databases

    BioGridi116301. 26 interactions.
    IntActiO14802. 10 interactions.
    STRINGi9606.ENSP00000361446.

    Structurei

    3D structure databases

    ProteinModelPortaliO14802.
    SMRiO14802. Positions 13-1363.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni844 – 85613Bridging helixBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RNA polymerase beta' chain family.Curated

    Phylogenomic databases

    eggNOGiCOG0086.
    HOGENOMiHOG000222974.
    HOVERGENiHBG004339.
    InParanoidiO14802.
    KOiK03018.
    OMAiHKADRDP.
    OrthoDBiEOG761BSV.
    PhylomeDBiO14802.
    TreeFamiTF103054.

    Family and domain databases

    InterProiIPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    IPR015700. RPC1.
    [Graphical view]
    PANTHERiPTHR19376:SF31. PTHR19376:SF31. 1 hit.
    PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
    PF00623. RNA_pol_Rpb1_2. 1 hit.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view]
    SMARTiSM00663. RPOLA_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14802-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKEQFRETD VAKKISHICF GMKSPEEMRQ QAHIQVVSKN LYSQDNQHAP     50
    LLYGVLDHRM GTSEKDRPCE TCGKNLADCL GHYGYIDLEL PCFHVGYFRA 100
    VIGILQMICK TCCHIMLSQE EKKQFLDYLK RPGLTYLQKR GLKKKISDKC 150
    RKKNICHHCG AFNGTVKKCG LLKIIHEKYK TNKKVVDPIV SNFLQSFETA 200
    IEHNKEVEPL LGRAQENLNP LVVLNLFKRI PAEDVPLLLM NPEAGKPSDL 250
    ILTRLLVPPL CIRPSVVSDL KSGTNEDDLT MKLTEIIFLN DVIKKHRISG 300
    AKTQMIMEDW DFLQLQCALY INSELSGIPL NMAPKKWTRG FVQRLKGKQG 350
    RFRGNLSGKR VDFSGRTVIS PDPNLRIDEV AVPVHVAKIL TFPEKVNKAN 400
    INFLRKLVQN GPEVHPGANF IQQRHTQMKR FLKYGNREKM AQELKYGDIV 450
    ERHLIDGDVV LFNRQPSLHK LSIMAHLARV KPHRTFRFNE CVCTPYNADF 500
    DGDEMNLHLP QTEEAKAEAL VLMGTKANLV TPRNGEPLIA AIQDFLTGAY 550
    LLTLKDTFFD RAKACQIIAS ILVGKDEKIK VRLPPPTILK PVTLWTGKQI 600
    FSVILRPSDD NPVRANLRTK GKQYCGKGED LCANDSYVTI QNSELMSGSM 650
    DKGTLGSGSK NNIFYILLRD WGQNEAADAM SRLARLAPVY LSNRGFSIGI 700
    GDVTPGQGLL KAKYELLNAG YKKCDEYIEA LNTGKLQQQP GCTAEETLEA 750
    LILKELSVIR DHAGSACLRE LDKSNSPLTM ALCGSKGSFI NISQMIACVG 800
    QQAISGSRVP DGFENRSLPH FEKHSKLPAA KGFVANSFYS GLTPTEFFFH 850
    TMAGREGLVD TAVKTAETGY MQRRLVKSLE DLCSQYDLTV RSSTGDIIQF 900
    IYGGDGLDPA AMEGKDEPLE FKRVLDNIKA VFPCPSEPAL SKNELILTTE 950
    SIMKKSEFLC CQDSFLQEIK KFIKGVSEKI KKTRDKYGIN DNGTTEPRVL 1000
    YQLDRITPTQ VEKFLETCRD KYMRAQMEPG SAVGALCAQS IGEPGTQMTL 1050
    KTFHFAGVAS MNITLGVPRI KEIINASKAI STPIITAQLD KDDDADYARL 1100
    VKGRIEKTLL GEISEYIEEV FLPDDCFILV KLSLERIRLL RLEVNAETVR 1150
    YSICTSKLRV KPGDVAVHGE AVVCVTPREN SKSSMYYVLQ FLKEDLPKVV 1200
    VQGIPEVSRA VIHIDEQSGK EKYKLLVEGD NLRAVMATHG VKGTRTTSNN 1250
    TYEVEKTLGI EAARTTIINE IQYTMVNHGM SIDRRHVMLL SDLMTYKGEV 1300
    LGITRFGLAK MKESVLMLAS FEKTADHLFD AAYFGQKDSV CGVSECIIMG 1350
    IPMNIGTGLF KLLHKADRDP NPPKRPLIFD TNEFHIPLVT 1390
    Length:1,390
    Mass (Da):155,641
    Last modified:September 23, 2008 - v2
    Checksum:i56F30900848E3DB9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151I → T in AAB86536. (PubMed:9331371)Curated
    Sequence conflicti262 – 2621I → F in AAB86536. (PubMed:9331371)Curated
    Sequence conflicti283 – 2831L → P in AAM12029. (PubMed:12384934)Curated
    Sequence conflicti1056 – 10561A → G in AAB86536. (PubMed:9331371)Curated
    Sequence conflicti1275 – 12751M → MV in AAB86536. (PubMed:9331371)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti372 – 3721D → N in HLD7. 1 Publication
    VAR_066516
    Natural varianti558 – 5581F → L in HLD7. 1 Publication
    VAR_066517
    Natural varianti582 – 5821R → L.
    Corresponds to variant rs34588967 [ dbSNP | Ensembl ].
    VAR_051873
    Natural varianti636 – 6361S → Y in HLD7. 1 Publication
    VAR_066518
    Natural varianti672 – 6721G → E in HLD7. 1 Publication
    VAR_066519
    Natural varianti713 – 7131K → N.
    Corresponds to variant rs35354908 [ dbSNP | Ensembl ].
    VAR_051874
    Natural varianti724 – 7241C → Y in HLD7. 1 Publication
    VAR_066520
    Natural varianti775 – 7751N → I in HLD7. 1 Publication
    VAR_066521
    Natural varianti852 – 8521M → V in HLD7. 1 Publication
    VAR_066522
    Natural varianti897 – 8971I → N in HLD7. 1 Publication
    VAR_067004
    Natural varianti1005 – 10051R → C in HLD7. 1 Publication
    VAR_066523
    Natural varianti1247 – 12471T → TT in HLD7. 1 Publication
    VAR_066524

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF021351 mRNA. Translation: AAB86536.1.
    AL512628 Genomic DNA. Translation: CAI16466.1.
    CH471083 Genomic DNA. Translation: EAW54617.1.
    BC041089 mRNA. Translation: AAH41089.1.
    AY091459 mRNA. Translation: AAM12029.1.
    CCDSiCCDS7354.1.
    RefSeqiNP_008986.2. NM_007055.3.
    UniGeneiHs.436896.

    Genome annotation databases

    EnsembliENST00000372371; ENSP00000361446; ENSG00000148606.
    GeneIDi11128.
    KEGGihsa:11128.
    UCSCiuc001jzn.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF021351 mRNA. Translation: AAB86536.1 .
    AL512628 Genomic DNA. Translation: CAI16466.1 .
    CH471083 Genomic DNA. Translation: EAW54617.1 .
    BC041089 mRNA. Translation: AAH41089.1 .
    AY091459 mRNA. Translation: AAM12029.1 .
    CCDSi CCDS7354.1.
    RefSeqi NP_008986.2. NM_007055.3.
    UniGenei Hs.436896.

    3D structure databases

    ProteinModelPortali O14802.
    SMRi O14802. Positions 13-1363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116301. 26 interactions.
    IntActi O14802. 10 interactions.
    STRINGi 9606.ENSP00000361446.

    PTM databases

    PhosphoSitei O14802.

    Proteomic databases

    MaxQBi O14802.
    PaxDbi O14802.
    PRIDEi O14802.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372371 ; ENSP00000361446 ; ENSG00000148606 .
    GeneIDi 11128.
    KEGGi hsa:11128.
    UCSCi uc001jzn.3. human.

    Organism-specific databases

    CTDi 11128.
    GeneCardsi GC10M079729.
    GeneReviewsi POLR3A.
    HGNCi HGNC:30074. POLR3A.
    HPAi HPA037926.
    HPA037927.
    MIMi 607694. phenotype.
    614258. gene.
    neXtProti NX_O14802.
    Orphaneti 88637. Hypomyelination - hypogonadotropic hypogonadism - hypodontia.
    77295. Odontoleukodystrophy.
    PharmGKBi PA134900426.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0086.
    HOGENOMi HOG000222974.
    HOVERGENi HBG004339.
    InParanoidi O14802.
    KOi K03018.
    OMAi HKADRDP.
    OrthoDBi EOG761BSV.
    PhylomeDBi O14802.
    TreeFami TF103054.

    Enzyme and pathway databases

    Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    REACT_63. RNA Polymerase III Transcription Termination.
    REACT_756. RNA Polymerase III Chain Elongation.

    Miscellaneous databases

    ChiTaRSi POLR3A. human.
    GenomeRNAii 11128.
    NextBioi 42292.
    PROi O14802.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14802.
    Bgeei O14802.
    CleanExi HS_POLR3A.
    Genevestigatori O14802.

    Family and domain databases

    InterProi IPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    IPR015700. RPC1.
    [Graphical view ]
    PANTHERi PTHR19376:SF31. PTHR19376:SF31. 1 hit.
    Pfami PF04997. RNA_pol_Rpb1_1. 1 hit.
    PF00623. RNA_pol_Rpb1_2. 1 hit.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view ]
    SMARTi SM00663. RPOLA_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The largest subunit of human RNA polymerase III is closely related to the largest subunit of yeast and trypanosome RNA polymerase III."
      Sepehri S., Hernandez N.
      Genome Res. 7:1006-1019(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. "Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay."
      Kuwana M., Kimura K., Kawakami Y.
      Arthritis Rheum. 46:2742-2747(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-374.
    6. "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits."
      Hu P., Wu S., Sun Y., Yuan C.-C., Kobayashi R., Myers M.P., Hernandez N.
      Mol. Cell. Biol. 22:8044-8055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNA POL III COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway."
      Chiu Y.-H., Macmillan J.B., Chen Z.J.
      Cell 138:576-591(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate."
      Ablasser A., Bauernfeind F., Hartmann G., Latz E., Fitzgerald K.A., Hornung V.
      Nat. Immunol. 10:1065-1072(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-445, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: VARIANTS HLD7 ASN-372; LEU-558; TYR-636; GLU-672; TYR-724; ILE-775; VAL-852 AND THR-1247 INS, TISSUE SPECIFICITY.
    12. "Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy."
      Saitsu H., Osaka H., Sasaki M., Takanashi J., Hamada K., Yamashita A., Shibayama H., Shiina M., Kondo Y., Nishiyama K., Tsurusaki Y., Miyake N., Doi H., Ogata K., Inoue K., Matsumoto N.
      Am. J. Hum. Genet. 89:644-651(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HLD7 ASN-897 AND CYS-1005.

    Entry informationi

    Entry nameiRPC1_HUMAN
    AccessioniPrimary (citable) accession number: O14802
    Secondary accession number(s): Q8IW34, Q8TCW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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