ID   TR10C_HUMAN             Reviewed;         259 AA.
AC   O14798; O14755; Q08AS6; Q6FH98; Q6UXM5;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 3.
DT   24-JAN-2024, entry version 184.
DE   RecName: Full=Tumor necrosis factor receptor superfamily member 10C;
DE   AltName: Full=Antagonist decoy receptor for TRAIL/Apo-2L;
DE   AltName: Full=Decoy TRAIL receptor without death domain;
DE   AltName: Full=Decoy receptor 1;
DE            Short=DcR1;
DE   AltName: Full=Lymphocyte inhibitor of TRAIL;
DE   AltName: Full=TNF-related apoptosis-inducing ligand receptor 3;
DE            Short=TRAIL receptor 3;
DE            Short=TRAIL-R3;
DE   AltName: Full=TRAIL receptor without an intracellular domain;
DE   AltName: CD_antigen=CD263;
DE   Flags: Precursor;
GN   Name=TNFRSF10C; Synonyms=DCR1, LIT, TRAILR3, TRID;
GN   ORFNames=UNQ321/PRO366;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-229.
RX   PubMed=9325248; DOI=10.1074/jbc.272.41.25417;
RA   MacFarlane M., Ahmad M., Srinivasula S.M., Fernandes-Alnemri T.,
RA   Cohen G.M., Alnemri E.S.;
RT   "Identification and molecular cloning of two novel receptors for the
RT   cytotoxic ligand TRAIL.";
RL   J. Biol. Chem. 272:25417-25420(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND VARIANT THR-229.
RC   TISSUE=Foreskin fibroblast;
RX   PubMed=9314565; DOI=10.1084/jem.186.7.1165;
RA   Degli-Esposti M.A., Smolak P.J., Walczak H., Waugh J., Huang C.-P.,
RA   DuBose R.F., Goodwin R.G., Smith C.A.;
RT   "Cloning and characterization of TRAIL-R3, a novel member of the emerging
RT   TRAIL receptor family.";
RL   J. Exp. Med. 186:1165-1170(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-229.
RX   PubMed=9242610; DOI=10.1126/science.277.5327.815;
RA   Pan G., Ni J., Wei Y.-F., Yu G.-L., Gentz R., Dixit V.M.;
RT   "An antagonist decoy receptor and a death domain-containing receptor for
RT   TRAIL.";
RL   Science 277:815-818(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, AND VARIANT
RP   THR-229.
RX   PubMed=9242611; DOI=10.1126/science.277.5327.818;
RA   Sheridan J.P., Marsters S.A., Pitti R.M., Gurney A., Skubatch M.,
RA   Baldwin D.T., Ramakrishnan L., Gray C.L., Baker K., Wood W.I.,
RA   Goddard A.D., Godowski P.J., Ashkenazi A.;
RT   "Control of TRAIL-induced apoptosis by a family of signaling and decoy
RT   receptors.";
RL   Science 277:818-821(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND VARIANT THR-229.
RC   TISSUE=Liver, and Spleen;
RX   PubMed=9373179; DOI=10.1016/s0014-5793(97)01231-3;
RA   Schneider P., Bodmer J.-L., Thome M., Hofmann K., Holler N., Tschopp J.;
RT   "Characterization of two receptors for TRAIL.";
RL   FEBS Lett. 416:329-334(1997).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-229.
RX   PubMed=9551946;
RA   Mongkolsapaya J., Cowper A.E., Xu X.-N., Morris G., McMichael A.J.,
RA   Bell J.I., Screaton G.R.;
RT   "Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a
RT   new receptor protecting lymphocytes from the death ligand TRAIL.";
RL   J. Immunol. 160:3-6(1998).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-229.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-229.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [11]
RP   PROTEIN SEQUENCE OF 26-40.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally verified
RT   cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic
CC       death domain and hence is not capable of inducing apoptosis. May
CC       protect cells against TRAIL mediated apoptosis by competing with TRAIL-
CC       R1 and R2 for binding to the ligand.
CC   -!- INTERACTION:
CC       O14798; Q13520: AQP6; NbExp=3; IntAct=EBI-717441, EBI-13059134;
CC       O14798; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-717441, EBI-11343438;
CC       O14798; Q8WWH4: ASZ1; NbExp=3; IntAct=EBI-717441, EBI-12239061;
CC       O14798; P11912: CD79A; NbExp=3; IntAct=EBI-717441, EBI-7797864;
CC       O14798; O75208: COQ9; NbExp=3; IntAct=EBI-717441, EBI-724524;
CC       O14798; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-717441, EBI-6942903;
CC       O14798; P00387: CYB5R3; NbExp=3; IntAct=EBI-717441, EBI-1046040;
CC       O14798; Q96KC8: DNAJC1; NbExp=3; IntAct=EBI-717441, EBI-296550;
CC       O14798; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-717441, EBI-781551;
CC       O14798; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-717441, EBI-18304435;
CC       O14798; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-717441, EBI-13345167;
CC       O14798; O60883: GPR37L1; NbExp=3; IntAct=EBI-717441, EBI-2927498;
CC       O14798; P48051: KCNJ6; NbExp=3; IntAct=EBI-717441, EBI-12017638;
CC       O14798; O95279: KCNK5; NbExp=3; IntAct=EBI-717441, EBI-3934936;
CC       O14798; P10620: MGST1; NbExp=3; IntAct=EBI-717441, EBI-2691601;
CC       O14798; Q9Y676: MRPS18B; NbExp=3; IntAct=EBI-717441, EBI-750085;
CC       O14798; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-717441, EBI-716063;
CC       O14798; O43765: SGTA; NbExp=3; IntAct=EBI-717441, EBI-347996;
CC       O14798; O14863: SLC30A4; NbExp=3; IntAct=EBI-717441, EBI-13918058;
CC       O14798; P27105: STOM; NbExp=3; IntAct=EBI-717441, EBI-1211440;
CC       O14798; Q96A49: SYAP1; NbExp=3; IntAct=EBI-717441, EBI-10770179;
CC       O14798; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-717441, EBI-3923061;
CC       O14798; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-717441, EBI-11742770;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- TISSUE SPECIFICITY: Higher expression in normal tissues than in tumor
CC       cell lines. Highly expressed in peripheral blood lymphocytes, spleen,
CC       skeletal muscle, placenta, lung and heart.
CC   -!- PTM: N-glycosylated and O-glycosylated.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB71413.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAC05593.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAQ88648.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF020502; AAB71413.1; ALT_INIT; mRNA.
DR   EMBL; AF014794; AAC05593.1; ALT_INIT; mRNA.
DR   EMBL; AF012629; AAB67110.1; -; mRNA.
DR   EMBL; AF012536; AAB67104.1; -; mRNA.
DR   EMBL; AF016267; AAB81181.1; -; mRNA.
DR   EMBL; AF033854; AAB87506.1; -; mRNA.
DR   EMBL; AY358281; AAQ88648.1; ALT_INIT; mRNA.
DR   EMBL; CR541857; CAG46655.1; -; mRNA.
DR   EMBL; AC107959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC125041; AAI25042.1; -; mRNA.
DR   EMBL; BC125042; AAI25043.1; -; mRNA.
DR   CCDS; CCDS6037.1; -.
DR   RefSeq; NP_003832.2; NM_003841.4.
DR   AlphaFoldDB; O14798; -.
DR   SMR; O14798; -.
DR   BioGRID; 114322; 101.
DR   DIP; DIP-6242N; -.
DR   IntAct; O14798; 31.
DR   STRING; 9606.ENSP00000349324; -.
DR   GlyCosmos; O14798; 4 sites, 1 glycan.
DR   GlyGen; O14798; 4 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; O14798; -.
DR   PhosphoSitePlus; O14798; -.
DR   BioMuta; TNFRSF10C; -.
DR   MassIVE; O14798; -.
DR   PaxDb; 9606-ENSP00000349324; -.
DR   PeptideAtlas; O14798; -.
DR   ProteomicsDB; 48247; -.
DR   Antibodypedia; 9707; 739 antibodies from 39 providers.
DR   DNASU; 8794; -.
DR   Ensembl; ENST00000356864.4; ENSP00000349324.4; ENSG00000173535.15.
DR   GeneID; 8794; -.
DR   KEGG; hsa:8794; -.
DR   MANE-Select; ENST00000356864.4; ENSP00000349324.4; NM_003841.5; NP_003832.3.
DR   UCSC; uc003xcy.4; human.
DR   AGR; HGNC:11906; -.
DR   CTD; 8794; -.
DR   DisGeNET; 8794; -.
DR   GeneCards; TNFRSF10C; -.
DR   HGNC; HGNC:11906; TNFRSF10C.
DR   HPA; ENSG00000173535; Tissue enhanced (bone marrow, lymphoid tissue).
DR   MIM; 603613; gene.
DR   neXtProt; NX_O14798; -.
DR   OpenTargets; ENSG00000173535; -.
DR   PharmGKB; PA36599; -.
DR   VEuPathDB; HostDB:ENSG00000173535; -.
DR   eggNOG; ENOG502RBEC; Eukaryota.
DR   GeneTree; ENSGT00940000165140; -.
DR   HOGENOM; CLU_930534_0_0_1; -.
DR   InParanoid; O14798; -.
DR   OMA; QVSNCTS; -.
DR   OrthoDB; 4604019at2759; -.
DR   PhylomeDB; O14798; -.
DR   TreeFam; TF333916; -.
DR   PathwayCommons; O14798; -.
DR   Reactome; R-HSA-6803211; TP53 Regulates Transcription of Death Receptors and Ligands.
DR   SignaLink; O14798; -.
DR   SIGNOR; O14798; -.
DR   BioGRID-ORCS; 8794; 11 hits in 1149 CRISPR screens.
DR   ChiTaRS; TNFRSF10C; human.
DR   GeneWiki; TNFRSF10C; -.
DR   GenomeRNAi; 8794; -.
DR   Pharos; O14798; Tbio.
DR   PRO; PR:O14798; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; O14798; Protein.
DR   Bgee; ENSG00000173535; Expressed in blood and 126 other cell types or tissues.
DR   ExpressionAtlas; O14798; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045569; F:TRAIL binding; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0036462; P:TRAIL-activated apoptotic signaling pathway; IBA:GO_Central.
DR   CDD; cd10580; TNFRSF10; 1.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR020465; TNFR_10.
DR   InterPro; IPR034024; TNFRSF10_N.
DR   PANTHER; PTHR46330; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; 1.
DR   PANTHER; PTHR46330:SF13; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10C; 1.
DR   Pfam; PF00020; TNFR_c6; 2.
DR   PRINTS; PR01956; TNFACTORR10.
DR   SMART; SM00208; TNFR; 2.
DR   SUPFAM; SSF57586; TNF receptor-like; 3.
DR   PROSITE; PS00652; TNFR_NGFR_1; 2.
DR   PROSITE; PS50050; TNFR_NGFR_2; 2.
DR   Genevisible; O14798; HS.
PE   1: Evidence at protein level;
KW   Apoptosis; Cell membrane; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Receptor;
KW   Reference proteome; Repeat; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000269|PubMed:15340161,
FT                   ECO:0000269|PubMed:9242611"
FT   CHAIN           26..236
FT                   /note="Tumor necrosis factor receptor superfamily member
FT                   10C"
FT                   /id="PRO_0000034582"
FT   PROPEP          237..259
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000034583"
FT   REPEAT          29..66
FT                   /note="TNFR-Cys 1"
FT   REPEAT          69..109
FT                   /note="TNFR-Cys 2"
FT   REPEAT          110..149
FT                   /note="TNFR-Cys 3"
FT   REPEAT          162..176
FT                   /note="TAPE 1"
FT   REPEAT          177..191
FT                   /note="TAPE 2"
FT   REPEAT          192..206
FT                   /note="TAPE 3"
FT   REPEAT          207..221
FT                   /note="TAPE 4"
FT   REPEAT          222..236
FT                   /note="TAPE 5"
FT   REGION          30..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           236
FT                   /note="GPI-anchor amidated alanine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) (high mannose) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        140
FT                   /note="N-linked (GlcNAc...) (high mannose) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) (high mannose) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        53..66
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        69..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        88..101
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        91..109
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        111..125
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        128..141
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        131..149
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   VARIANT         199
FT                   /note="T -> N (in dbSNP:rs12550828)"
FT                   /id="VAR_046534"
FT   VARIANT         229
FT                   /note="I -> T (in dbSNP:rs9644063)"
FT                   /evidence="ECO:0000269|PubMed:12975309,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9242610,
FT                   ECO:0000269|PubMed:9242611, ECO:0000269|PubMed:9314565,
FT                   ECO:0000269|PubMed:9325248, ECO:0000269|PubMed:9373179,
FT                   ECO:0000269|PubMed:9551946"
FT                   /id="VAR_046535"
FT   CONFLICT        119
FT                   /note="E -> V (in Ref. 5; AAB81181)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   259 AA;  27407 MW;  40CBF7FCEEAE4C69 CRC64;
     MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG EECPAGSHRS
     EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS CTMTRDTVCQ CKEGTFRNEN
     SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV EEFGANATVE TPAAEETMNT SPGTPAPAAE
     ETMNTSPGTP APAAEETMTT SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY
     LSCTIVGIIV LIVLLIVFV
//