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O14798

- TR10C_HUMAN

UniProt

O14798 - TR10C_HUMAN

Protein

Tumor necrosis factor receptor superfamily member 10C

Gene

TNFRSF10C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 3 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10C
    Alternative name(s):
    Antagonist decoy receptor for TRAIL/Apo-2L
    Decoy TRAIL receptor without death domain
    Decoy receptor 1
    Short name:
    DcR1
    Lymphocyte inhibitor of TRAIL
    TNF-related apoptosis-inducing ligand receptor 3
    Short name:
    TRAIL receptor 3
    Short name:
    TRAIL-R3
    TRAIL receptor without an intracellular domain
    CD_antigen: CD263
    Gene namesi
    Name:TNFRSF10C
    Synonyms:DCR1, LIT, TRAILR3, TRID
    ORF Names:UNQ321/PRO366
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:11906. TNFRSF10C.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36599.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 25252 PublicationsAdd
    BLAST
    Chaini26 – 236211Tumor necrosis factor receptor superfamily member 10CPRO_0000034582Add
    BLAST
    Propeptidei237 – 25923Removed in mature formSequence AnalysisPRO_0000034583Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi69 ↔ 85PROSITE-ProRule annotation
    Glycosylationi77 – 771N-linked (GlcNAc...) (high mannose)Sequence Analysis
    Disulfide bondi88 ↔ 101PROSITE-ProRule annotation
    Disulfide bondi91 ↔ 109PROSITE-ProRule annotation
    Disulfide bondi111 ↔ 125PROSITE-ProRule annotation
    Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
    Disulfide bondi131 ↔ 149PROSITE-ProRule annotation
    Glycosylationi140 – 1401N-linked (GlcNAc...) (high mannose)Sequence Analysis
    Glycosylationi156 – 1561N-linked (GlcNAc...) (high mannose)Sequence Analysis
    Lipidationi236 – 2361GPI-anchor amidated alanineSequence Analysis

    Post-translational modificationi

    N-glycosylated and O-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiO14798.
    PRIDEiO14798.

    Expressioni

    Tissue specificityi

    Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

    Gene expression databases

    ArrayExpressiO14798.
    BgeeiO14798.
    CleanExiHS_TNFRSF10C.
    GenevestigatoriO14798.

    Organism-specific databases

    HPAiCAB025635.

    Interactioni

    Protein-protein interaction databases

    BioGridi114322. 7 interactions.
    DIPiDIP-6242N.
    IntActiO14798. 8 interactions.
    MINTiMINT-1394827.
    STRINGi9606.ENSP00000310908.

    Structurei

    3D structure databases

    ProteinModelPortaliO14798.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 6638TNFR-Cys 1Add
    BLAST
    Repeati69 – 10941TNFR-Cys 2Add
    BLAST
    Repeati110 – 14940TNFR-Cys 3Add
    BLAST
    Repeati162 – 17615TAPE 1Add
    BLAST
    Repeati177 – 19115TAPE 2Add
    BLAST
    Repeati192 – 20615TAPE 3Add
    BLAST
    Repeati207 – 22115TAPE 4Add
    BLAST
    Repeati222 – 23615TAPE 5Add
    BLAST

    Sequence similaritiesi

    Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG253751.
    HOVERGENiHBG061470.
    InParanoidiO14798.
    KOiK04722.
    PhylomeDBiO14798.
    TreeFamiTF333916.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020465. TNFR_10.
    [Graphical view]
    PfamiPF00020. TNFR_c6. 2 hits.
    [Graphical view]
    PRINTSiPR01956. TNFACTORR10.
    SMARTiSM00208. TNFR. 2 hits.
    [Graphical view]
    PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14798-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG    50
    EECPAGSHRS EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS 100
    CTMTRDTVCQ CKEGTFRNEN SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV 150
    EEFGANATVE TPAAEETMNT SPGTPAPAAE ETMNTSPGTP APAAEETMTT 200
    SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY LSCTIVGIIV 250
    LIVLLIVFV 259
    Length:259
    Mass (Da):27,407
    Last modified:November 24, 2009 - v3
    Checksum:i40CBF7FCEEAE4C69
    GO

    Sequence cautioni

    The sequence AAB71413.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAC05593.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAQ88648.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191E → V in AAB81181. (PubMed:9373179)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti199 – 1991T → N.
    Corresponds to variant rs12550828 [ dbSNP | Ensembl ].
    VAR_046534
    Natural varianti229 – 2291I → T.8 Publications
    Corresponds to variant rs9644063 [ dbSNP | Ensembl ].
    VAR_046535

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020502 mRNA. Translation: AAB71413.1. Different initiation.
    AF014794 mRNA. Translation: AAC05593.1. Different initiation.
    AF012629 mRNA. Translation: AAB67110.1.
    AF012536 mRNA. Translation: AAB67104.1.
    AF016267 mRNA. Translation: AAB81181.1.
    AF033854 mRNA. Translation: AAB87506.1.
    AY358281 mRNA. Translation: AAQ88648.1. Different initiation.
    CR541857 mRNA. Translation: CAG46655.1.
    AC107959 Genomic DNA. No translation available.
    BC125041 mRNA. Translation: AAI25042.1.
    BC125042 mRNA. Translation: AAI25043.1.
    CCDSiCCDS6037.1.
    RefSeqiNP_003832.2. NM_003841.3.
    UniGeneiHs.655801.

    Genome annotation databases

    EnsembliENST00000356864; ENSP00000349324; ENSG00000173535.
    GeneIDi8794.
    KEGGihsa:8794.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020502 mRNA. Translation: AAB71413.1 . Different initiation.
    AF014794 mRNA. Translation: AAC05593.1 . Different initiation.
    AF012629 mRNA. Translation: AAB67110.1 .
    AF012536 mRNA. Translation: AAB67104.1 .
    AF016267 mRNA. Translation: AAB81181.1 .
    AF033854 mRNA. Translation: AAB87506.1 .
    AY358281 mRNA. Translation: AAQ88648.1 . Different initiation.
    CR541857 mRNA. Translation: CAG46655.1 .
    AC107959 Genomic DNA. No translation available.
    BC125041 mRNA. Translation: AAI25042.1 .
    BC125042 mRNA. Translation: AAI25043.1 .
    CCDSi CCDS6037.1.
    RefSeqi NP_003832.2. NM_003841.3.
    UniGenei Hs.655801.

    3D structure databases

    ProteinModelPortali O14798.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114322. 7 interactions.
    DIPi DIP-6242N.
    IntActi O14798. 8 interactions.
    MINTi MINT-1394827.
    STRINGi 9606.ENSP00000310908.

    Proteomic databases

    PaxDbi O14798.
    PRIDEi O14798.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356864 ; ENSP00000349324 ; ENSG00000173535 .
    GeneIDi 8794.
    KEGGi hsa:8794.

    Organism-specific databases

    CTDi 8794.
    GeneCardsi GC08P022997.
    HGNCi HGNC:11906. TNFRSF10C.
    HPAi CAB025635.
    MIMi 603613. gene.
    neXtProti NX_O14798.
    PharmGKBi PA36599.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253751.
    HOVERGENi HBG061470.
    InParanoidi O14798.
    KOi K04722.
    PhylomeDBi O14798.
    TreeFami TF333916.

    Miscellaneous databases

    ChiTaRSi TNFRSF10C. human.
    GeneWikii TNFRSF10C.
    GenomeRNAii 8794.
    NextBioi 32980.
    PROi O14798.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14798.
    Bgeei O14798.
    CleanExi HS_TNFRSF10C.
    Genevestigatori O14798.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020465. TNFR_10.
    [Graphical view ]
    Pfami PF00020. TNFR_c6. 2 hits.
    [Graphical view ]
    PRINTSi PR01956. TNFACTORR10.
    SMARTi SM00208. TNFR. 2 hits.
    [Graphical view ]
    PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL."
      MacFarlane M., Ahmad M., Srinivasula S.M., Fernandes-Alnemri T., Cohen G.M., Alnemri E.S.
      J. Biol. Chem. 272:25417-25420(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
    2. "Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family."
      Degli-Esposti M.A., Smolak P.J., Walczak H., Waugh J., Huang C.-P., DuBose R.F., Goodwin R.G., Smith C.A.
      J. Exp. Med. 186:1165-1170(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT THR-229.
      Tissue: Foreskin fibroblast.
    3. "An antagonist decoy receptor and a death domain-containing receptor for TRAIL."
      Pan G., Ni J., Wei Y.-F., Yu G.-L., Gentz R., Dixit V.M.
      Science 277:815-818(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, VARIANT THR-229.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT THR-229.
      Tissue: Liver and Spleen.
    6. "Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL."
      Mongkolsapaya J., Cowper A.E., Xu X.-N., Morris G., McMichael A.J., Bell J.I., Screaton G.R.
      J. Immunol. 160:3-6(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-229.
    8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-229.
    11. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-40.

    Entry informationi

    Entry nameiTR10C_HUMAN
    AccessioniPrimary (citable) accession number: O14798
    Secondary accession number(s): O14755
    , Q08AS6, Q6FH98, Q6UXM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 123 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3