O14798 (TR10C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor receptor superfamily member 10C

Alternative name(s):
Antagonist decoy receptor for TRAIL/Apo-2L
Decoy TRAIL receptor without death domain
Decoy receptor 1
Short name=DcR1
Lymphocyte inhibitor of TRAIL
TNF-related apoptosis-inducing ligand receptor 3
Short name=TRAIL receptor 3
Short name=TRAIL-R3
TRAIL receptor without an intracellular domain
CD_antigen=CD263

Gene names

Name:	TNFRSF10C
Synonyms:	DCR1, LIT, TRAILR3, TRID
ORF Names:	UNQ321/PRO366

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity	Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
Post-translational modification	N-glycosylated and O-glycosylated.
Sequence similarities	Contains 3 TNFR-Cys repeats.
Sequence caution	The sequence AAB71413.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAC05593.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAQ88648.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal
Molecular function	Receptor
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	transmembrane signaling receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Ref.4 Ref.11
	Chain	26 – 236	211	Tumor necrosis factor receptor superfamily member 10C		PRO_0000034582
	Propeptide	237 – 259	23	Removed in mature form Potential		PRO_0000034583
Regions
	Repeat	29 – 66	38	TNFR-Cys 1
	Repeat	69 – 109	41	TNFR-Cys 2
	Repeat	110 – 149	40	TNFR-Cys 3
	Repeat	162 – 176	15	TAPE 1
	Repeat	177 – 191	15	TAPE 2
	Repeat	192 – 206	15	TAPE 3
	Repeat	207 – 221	15	TAPE 4
	Repeat	222 – 236	15	TAPE 5
Amino acid modifications
	Lipidation	236	1	GPI-anchor amidated alanine Potential
	Glycosylation	77	1	N-linked (GlcNAc...) (high mannose) Potential
	Glycosylation	140	1	N-linked (GlcNAc...) (high mannose) Potential
	Glycosylation	156	1	N-linked (GlcNAc...) (high mannose) Potential
	Disulfide bond	53 ↔ 66		By similarity
	Disulfide bond	69 ↔ 85		By similarity
	Disulfide bond	88 ↔ 101		By similarity
	Disulfide bond	91 ↔ 109		By similarity
	Disulfide bond	111 ↔ 125		By similarity
	Disulfide bond	128 ↔ 141		By similarity
	Disulfide bond	131 ↔ 149		By similarity
Natural variations
	Natural variant	199	1	T → N. Corresponds to variant rs12550828 [ dbSNP | Ensembl ].		VAR_046534
	Natural variant	229	1	I → T. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.10 Corresponds to variant rs9644063 [ dbSNP | Ensembl ].		VAR_046535
Experimental info
	Sequence conflict	119	1	E → V in AAB81181. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O14798 [UniParc]. Last modified November 24, 2009. Version 3. Checksum: 40CBF7FCEEAE4C69	FASTA	259	27,407
	10 20 30 40 50 60 MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG EECPAGSHRS 70 80 90 100 110 120 EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS CTMTRDTVCQ CKEGTFRNEN 130 140 150 160 170 180 SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV EEFGANATVE TPAAEETMNT SPGTPAPAAE 190 200 210 220 230 240 ETMNTSPGTP APAAEETMTT SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY 250 LSCTIVGIIV LIVLLIVFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL." MacFarlane M., Ahmad M., Srinivasula S.M., Fernandes-Alnemri T., Cohen G.M., Alnemri E.S. J. Biol. Chem. 272:25417-25420(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
[2]	"Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family." Degli-Esposti M.A., Smolak P.J., Walczak H., Waugh J., Huang C.-P., DuBose R.F., Goodwin R.G., Smith C.A. J. Exp. Med. 186:1165-1170(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT THR-229. Tissue: Foreskin fibroblast.
[3]	"An antagonist decoy receptor and a death domain-containing receptor for TRAIL." Pan G., Ni J., Wei Y.-F., Yu G.-L., Gentz R., Dixit V.M. Science 277:815-818(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
[4]	"Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors." Sheridan J.P., Marsters S.A., Pitti R.M., Gurney A., Skubatch M., Baldwin D.T., Ramakrishnan L., Gray C.L., Baker K., Wood W.I., Goddard A.D., Godowski P.J., Ashkenazi A. Science 277:818-821(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, VARIANT THR-229.
[5]	"Characterization of two receptors for TRAIL." Schneider P., Bodmer J.-L., Thome M., Hofmann K., Holler N., Tschopp J. FEBS Lett. 416:329-334(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT THR-229. Tissue: Liver and Spleen.
[6]	"Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL." Mongkolsapaya J., Cowper A.E., Xu X.-N., Morris G., McMichael A.J., Bell J.I., Screaton G.R. J. Immunol. 160:3-6(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
[7]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-229.
[8]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[9]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-229.
[11]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 26-40.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF020502 mRNA. Translation: AAB71413.1. Different initiation. AF014794 mRNA. Translation: AAC05593.1. Different initiation. AF012629 mRNA. Translation: AAB67110.1. AF012536 mRNA. Translation: AAB67104.1. AF016267 mRNA. Translation: AAB81181.1. AF033854 mRNA. Translation: AAB87506.1. AY358281 mRNA. Translation: AAQ88648.1. Different initiation. CR541857 mRNA. Translation: CAG46655.1. AC107959 Genomic DNA. No translation available. BC125041 mRNA. Translation: AAI25042.1. BC125042 mRNA. Translation: AAI25043.1.
IPI	IPI00021970.
RefSeq	NP_003832.2. NM_003841.3.
UniGene	Hs.655801.
3D structure databases
ProteinModelPortal	O14798.
SMR	O14798. Positions 53-150.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6242N.
IntAct	O14798. 6 interactions.
MINT	MINT-1394827.
STRING	9606.ENSP00000310908.
Proteomic databases
PaxDb	O14798.
PRIDE	O14798.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356864; ENSP00000349324; ENSG00000173535.
GeneID	8794.
KEGG	hsa:8794.
Organism-specific databases
CTD	8794.
GeneCards	GC08P022997.
HGNC	HGNC:11906. TNFRSF10C.
HPA	CAB025635.
MIM	603613. gene.
neXtProt	NX_O14798.
PharmGKB	PA36599.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253751.
HOVERGEN	HBG061470.
InParanoid	O14798.
KO	K04722.
OrthoDB	EOG43TZWC.
PhylomeDB	O14798.
Enzyme and pathway databases
Pathway_Interaction_DB	trail_pathway. TRAIL signaling pathway.
Gene expression databases
ArrayExpress	O14798.
Bgee	O14798.
CleanEx	HS_TNFRSF10C.
Genevestigator	O14798.
GermOnline	ENSG00000173535. Homo sapiens.
Family and domain databases
InterPro	IPR001368. TNFR/NGFR_Cys_rich_reg. IPR020465. TNFR_10. [Graphical view]
Pfam	PF00020. TNFR_c6. 2 hits. [Graphical view]
PRINTS	PR01956. TNFACTORR10.
SMART	SM00208. TNFR. 2 hits. [Graphical view]
PROSITE	PS00652. TNFR_NGFR_1. 2 hits. PS50050. TNFR_NGFR_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TNFRSF10C. human.
GenomeRNAi	8794.
NextBio	32980.
SOURCE	Search...

Entry information

Entry name

TR10C_HUMAN

Accession

Primary (citable) accession number: O14798
Secondary accession number(s): O14755 , Q08AS6, Q6FH98, Q6UXM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 110 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.