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O14798

- TR10C_HUMAN

UniProt

O14798 - TR10C_HUMAN

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Protein

Tumor necrosis factor receptor superfamily member 10C

Gene

TNFRSF10C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 10C
Alternative name(s):
Antagonist decoy receptor for TRAIL/Apo-2L
Decoy TRAIL receptor without death domain
Decoy receptor 1
Short name:
DcR1
Lymphocyte inhibitor of TRAIL
TNF-related apoptosis-inducing ligand receptor 3
Short name:
TRAIL receptor 3
Short name:
TRAIL-R3
TRAIL receptor without an intracellular domain
CD_antigen: CD263
Gene namesi
Name:TNFRSF10C
Synonyms:DCR1, LIT, TRAILR3, TRID
ORF Names:UNQ321/PRO366
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:11906. TNFRSF10C.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25252 PublicationsAdd
BLAST
Chaini26 – 236211Tumor necrosis factor receptor superfamily member 10CPRO_0000034582Add
BLAST
Propeptidei237 – 25923Removed in mature formSequence AnalysisPRO_0000034583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 66PROSITE-ProRule annotation
Disulfide bondi69 ↔ 85PROSITE-ProRule annotation
Glycosylationi77 – 771N-linked (GlcNAc...) (high mannose)Sequence Analysis
Disulfide bondi88 ↔ 101PROSITE-ProRule annotation
Disulfide bondi91 ↔ 109PROSITE-ProRule annotation
Disulfide bondi111 ↔ 125PROSITE-ProRule annotation
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi131 ↔ 149PROSITE-ProRule annotation
Glycosylationi140 – 1401N-linked (GlcNAc...) (high mannose)Sequence Analysis
Glycosylationi156 – 1561N-linked (GlcNAc...) (high mannose)Sequence Analysis
Lipidationi236 – 2361GPI-anchor amidated alanineSequence Analysis

Post-translational modificationi

N-glycosylated and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO14798.
PRIDEiO14798.

Expressioni

Tissue specificityi

Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Gene expression databases

BgeeiO14798.
CleanExiHS_TNFRSF10C.
ExpressionAtlasiO14798. baseline and differential.
GenevestigatoriO14798.

Organism-specific databases

HPAiCAB025635.

Interactioni

Protein-protein interaction databases

BioGridi114322. 7 interactions.
DIPiDIP-6242N.
IntActiO14798. 8 interactions.
MINTiMINT-1394827.
STRINGi9606.ENSP00000310908.

Structurei

3D structure databases

ProteinModelPortaliO14798.
SMRiO14798. Positions 53-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 6638TNFR-Cys 1Add
BLAST
Repeati69 – 10941TNFR-Cys 2Add
BLAST
Repeati110 – 14940TNFR-Cys 3Add
BLAST
Repeati162 – 17615TAPE 1Add
BLAST
Repeati177 – 19115TAPE 2Add
BLAST
Repeati192 – 20615TAPE 3Add
BLAST
Repeati207 – 22115TAPE 4Add
BLAST
Repeati222 – 23615TAPE 5Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG253751.
GeneTreeiENSGT00730000110985.
HOVERGENiHBG061470.
InParanoidiO14798.
KOiK04722.
PhylomeDBiO14798.
TreeFamiTF333916.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020465. TNFR_10.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01956. TNFACTORR10.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14798-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG
60 70 80 90 100
EECPAGSHRS EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS
110 120 130 140 150
CTMTRDTVCQ CKEGTFRNEN SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV
160 170 180 190 200
EEFGANATVE TPAAEETMNT SPGTPAPAAE ETMNTSPGTP APAAEETMTT
210 220 230 240 250
SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY LSCTIVGIIV

LIVLLIVFV
Length:259
Mass (Da):27,407
Last modified:November 24, 2009 - v3
Checksum:i40CBF7FCEEAE4C69
GO

Sequence cautioni

The sequence AAB71413.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC05593.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAQ88648.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191E → V in AAB81181. (PubMed:9373179)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti199 – 1991T → N.
Corresponds to variant rs12550828 [ dbSNP | Ensembl ].
VAR_046534
Natural varianti229 – 2291I → T.8 Publications
Corresponds to variant rs9644063 [ dbSNP | Ensembl ].
VAR_046535

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020502 mRNA. Translation: AAB71413.1. Different initiation.
AF014794 mRNA. Translation: AAC05593.1. Different initiation.
AF012629 mRNA. Translation: AAB67110.1.
AF012536 mRNA. Translation: AAB67104.1.
AF016267 mRNA. Translation: AAB81181.1.
AF033854 mRNA. Translation: AAB87506.1.
AY358281 mRNA. Translation: AAQ88648.1. Different initiation.
CR541857 mRNA. Translation: CAG46655.1.
AC107959 Genomic DNA. No translation available.
BC125041 mRNA. Translation: AAI25042.1.
BC125042 mRNA. Translation: AAI25043.1.
CCDSiCCDS6037.1.
RefSeqiNP_003832.2. NM_003841.3.
UniGeneiHs.655801.

Genome annotation databases

EnsembliENST00000356864; ENSP00000349324; ENSG00000173535.
GeneIDi8794.
KEGGihsa:8794.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020502 mRNA. Translation: AAB71413.1 . Different initiation.
AF014794 mRNA. Translation: AAC05593.1 . Different initiation.
AF012629 mRNA. Translation: AAB67110.1 .
AF012536 mRNA. Translation: AAB67104.1 .
AF016267 mRNA. Translation: AAB81181.1 .
AF033854 mRNA. Translation: AAB87506.1 .
AY358281 mRNA. Translation: AAQ88648.1 . Different initiation.
CR541857 mRNA. Translation: CAG46655.1 .
AC107959 Genomic DNA. No translation available.
BC125041 mRNA. Translation: AAI25042.1 .
BC125042 mRNA. Translation: AAI25043.1 .
CCDSi CCDS6037.1.
RefSeqi NP_003832.2. NM_003841.3.
UniGenei Hs.655801.

3D structure databases

ProteinModelPortali O14798.
SMRi O14798. Positions 53-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114322. 7 interactions.
DIPi DIP-6242N.
IntActi O14798. 8 interactions.
MINTi MINT-1394827.
STRINGi 9606.ENSP00000310908.

Proteomic databases

PaxDbi O14798.
PRIDEi O14798.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356864 ; ENSP00000349324 ; ENSG00000173535 .
GeneIDi 8794.
KEGGi hsa:8794.

Organism-specific databases

CTDi 8794.
GeneCardsi GC08P022997.
HGNCi HGNC:11906. TNFRSF10C.
HPAi CAB025635.
MIMi 603613. gene.
neXtProti NX_O14798.
PharmGKBi PA36599.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253751.
GeneTreei ENSGT00730000110985.
HOVERGENi HBG061470.
InParanoidi O14798.
KOi K04722.
PhylomeDBi O14798.
TreeFami TF333916.

Miscellaneous databases

ChiTaRSi TNFRSF10C. human.
GeneWikii TNFRSF10C.
GenomeRNAii 8794.
NextBioi 32980.
PROi O14798.
SOURCEi Search...

Gene expression databases

Bgeei O14798.
CleanExi HS_TNFRSF10C.
ExpressionAtlasi O14798. baseline and differential.
Genevestigatori O14798.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020465. TNFR_10.
[Graphical view ]
Pfami PF00020. TNFR_c6. 2 hits.
[Graphical view ]
PRINTSi PR01956. TNFACTORR10.
SMARTi SM00208. TNFR. 2 hits.
[Graphical view ]
PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL."
    MacFarlane M., Ahmad M., Srinivasula S.M., Fernandes-Alnemri T., Cohen G.M., Alnemri E.S.
    J. Biol. Chem. 272:25417-25420(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
  2. "Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family."
    Degli-Esposti M.A., Smolak P.J., Walczak H., Waugh J., Huang C.-P., DuBose R.F., Goodwin R.G., Smith C.A.
    J. Exp. Med. 186:1165-1170(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT THR-229.
    Tissue: Foreskin fibroblast.
  3. "An antagonist decoy receptor and a death domain-containing receptor for TRAIL."
    Pan G., Ni J., Wei Y.-F., Yu G.-L., Gentz R., Dixit V.M.
    Science 277:815-818(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, VARIANT THR-229.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT THR-229.
    Tissue: Liver and Spleen.
  6. "Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL."
    Mongkolsapaya J., Cowper A.E., Xu X.-N., Morris G., McMichael A.J., Bell J.I., Screaton G.R.
    J. Immunol. 160:3-6(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-229.
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-229.
  11. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-40.

Entry informationi

Entry nameiTR10C_HUMAN
AccessioniPrimary (citable) accession number: O14798
Secondary accession number(s): O14755
, Q08AS6, Q6FH98, Q6UXM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 24, 2009
Last modified: October 29, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3