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O14798 (TR10C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 10C
Alternative name(s):
Antagonist decoy receptor for TRAIL/Apo-2L
Decoy TRAIL receptor without death domain
Decoy receptor 1
Short name=DcR1
Lymphocyte inhibitor of TRAIL
TNF-related apoptosis-inducing ligand receptor 3
Short name=TRAIL receptor 3
Short name=TRAIL-R3
TRAIL receptor without an intracellular domain
CD_antigen=CD263
Gene names
Name:TNFRSF10C
Synonyms:DCR1, LIT, TRAILR3, TRID
ORF Names:UNQ321/PRO366
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor.

Tissue specificity

Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Post-translational modification

N-glycosylated and O-glycosylated.

Sequence similarities

Contains 3 TNFR-Cys repeats.

Sequence caution

The sequence AAB71413.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAC05593.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAQ88648.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

signal transduction

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentanchored component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

integral component of plasma membrane

Traceable author statement Ref.2. Source: ProtInc

   Molecular_functiontransmembrane signaling receptor activity

Traceable author statement Ref.2. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.4 Ref.11
Chain26 – 236211Tumor necrosis factor receptor superfamily member 10C
PRO_0000034582
Propeptide237 – 25923Removed in mature form Potential
PRO_0000034583

Regions

Repeat29 – 6638TNFR-Cys 1
Repeat69 – 10941TNFR-Cys 2
Repeat110 – 14940TNFR-Cys 3
Repeat162 – 17615TAPE 1
Repeat177 – 19115TAPE 2
Repeat192 – 20615TAPE 3
Repeat207 – 22115TAPE 4
Repeat222 – 23615TAPE 5

Amino acid modifications

Lipidation2361GPI-anchor amidated alanine Potential
Glycosylation771N-linked (GlcNAc...) (high mannose) Potential
Glycosylation1401N-linked (GlcNAc...) (high mannose) Potential
Glycosylation1561N-linked (GlcNAc...) (high mannose) Potential
Disulfide bond53 ↔ 66 By similarity
Disulfide bond69 ↔ 85 By similarity
Disulfide bond88 ↔ 101 By similarity
Disulfide bond91 ↔ 109 By similarity
Disulfide bond111 ↔ 125 By similarity
Disulfide bond128 ↔ 141 By similarity
Disulfide bond131 ↔ 149 By similarity

Natural variations

Natural variant1991T → N.
Corresponds to variant rs12550828 [ dbSNP | Ensembl ].
VAR_046534
Natural variant2291I → T. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.10
Corresponds to variant rs9644063 [ dbSNP | Ensembl ].
VAR_046535

Experimental info

Sequence conflict1191E → V in AAB81181. Ref.5

Sequences

Sequence LengthMass (Da)Tools
O14798 [UniParc].

Last modified November 24, 2009. Version 3.
Checksum: 40CBF7FCEEAE4C69

FASTA25927,407
        10         20         30         40         50         60 
MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG EECPAGSHRS 

        70         80         90        100        110        120 
EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS CTMTRDTVCQ CKEGTFRNEN 

       130        140        150        160        170        180 
SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV EEFGANATVE TPAAEETMNT SPGTPAPAAE 

       190        200        210        220        230        240 
ETMNTSPGTP APAAEETMTT SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY 

       250 
LSCTIVGIIV LIVLLIVFV 

« Hide

References

« Hide 'large scale' references
[1]"Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL."
MacFarlane M., Ahmad M., Srinivasula S.M., Fernandes-Alnemri T., Cohen G.M., Alnemri E.S.
J. Biol. Chem. 272:25417-25420(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
[2]"Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family."
Degli-Esposti M.A., Smolak P.J., Walczak H., Waugh J., Huang C.-P., DuBose R.F., Goodwin R.G., Smith C.A.
J. Exp. Med. 186:1165-1170(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT THR-229.
Tissue: Foreskin fibroblast.
[3]"An antagonist decoy receptor and a death domain-containing receptor for TRAIL."
Pan G., Ni J., Wei Y.-F., Yu G.-L., Gentz R., Dixit V.M.
Science 277:815-818(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
[4]"Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors."
Sheridan J.P., Marsters S.A., Pitti R.M., Gurney A., Skubatch M., Baldwin D.T., Ramakrishnan L., Gray C.L., Baker K., Wood W.I., Goddard A.D., Godowski P.J., Ashkenazi A.
Science 277:818-821(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, VARIANT THR-229.
[5]"Characterization of two receptors for TRAIL."
Schneider P., Bodmer J.-L., Thome M., Hofmann K., Holler N., Tschopp J.
FEBS Lett. 416:329-334(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT THR-229.
Tissue: Liver and Spleen.
[6]"Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL."
Mongkolsapaya J., Cowper A.E., Xu X.-N., Morris G., McMichael A.J., Bell J.I., Screaton G.R.
J. Immunol. 160:3-6(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-229.
[7]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-229.
[8]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[9]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-229.
[11]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-40.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF020502 mRNA. Translation: AAB71413.1. Different initiation.
AF014794 mRNA. Translation: AAC05593.1. Different initiation.
AF012629 mRNA. Translation: AAB67110.1.
AF012536 mRNA. Translation: AAB67104.1.
AF016267 mRNA. Translation: AAB81181.1.
AF033854 mRNA. Translation: AAB87506.1.
AY358281 mRNA. Translation: AAQ88648.1. Different initiation.
CR541857 mRNA. Translation: CAG46655.1.
AC107959 Genomic DNA. No translation available.
BC125041 mRNA. Translation: AAI25042.1.
BC125042 mRNA. Translation: AAI25043.1.
RefSeqNP_003832.2. NM_003841.3.
UniGeneHs.655801.

3D structure databases

ProteinModelPortalO14798.
SMRO14798. Positions 35-161.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114322. 7 interactions.
DIPDIP-6242N.
IntActO14798. 8 interactions.
MINTMINT-1394827.
STRING9606.ENSP00000310908.

Proteomic databases

PaxDbO14798.
PRIDEO14798.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356864; ENSP00000349324; ENSG00000173535.
GeneID8794.
KEGGhsa:8794.

Organism-specific databases

CTD8794.
GeneCardsGC08P022997.
HGNCHGNC:11906. TNFRSF10C.
HPACAB025635.
MIM603613. gene.
neXtProtNX_O14798.
PharmGKBPA36599.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG253751.
HOVERGENHBG061470.
InParanoidO14798.
KOK04722.
OMANTSPGTP.
PhylomeDBO14798.
TreeFamTF333916.

Gene expression databases

ArrayExpressO14798.
BgeeO14798.
CleanExHS_TNFRSF10C.
GenevestigatorO14798.

Family and domain databases

InterProIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020465. TNFR_10.
[Graphical view]
PfamPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSPR01956. TNFACTORR10.
SMARTSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTNFRSF10C. human.
GeneWikiTNFRSF10C.
GenomeRNAi8794.
NextBio32980.
PROO14798.
SOURCESearch...

Entry information

Entry nameTR10C_HUMAN
AccessionPrimary (citable) accession number: O14798
Secondary accession number(s): O14755 expand/collapse secondary AC list , Q08AS6, Q6FH98, Q6UXM5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 24, 2009
Last modified: April 16, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries