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Protein

Tumor necrosis factor receptor superfamily member 10C

Gene

TNFRSF10C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-6803211. TP53 Regulates Transcription of Death Receptors and Ligands.
SIGNORiO14798.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 10C
Alternative name(s):
Antagonist decoy receptor for TRAIL/Apo-2L
Decoy TRAIL receptor without death domain
Decoy receptor 1
Short name:
DcR1
Lymphocyte inhibitor of TRAIL
TNF-related apoptosis-inducing ligand receptor 3
Short name:
TRAIL receptor 3
Short name:
TRAIL-R3
TRAIL receptor without an intracellular domain
CD_antigen: CD263
Gene namesi
Name:TNFRSF10C
Synonyms:DCR1, LIT, TRAILR3, TRID
ORF Names:UNQ321/PRO366
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:11906. TNFRSF10C.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8794.
OpenTargetsiENSG00000173535.
PharmGKBiPA36599.

Polymorphism and mutation databases

BioMutaiTNFRSF10C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 252 PublicationsAdd BLAST25
ChainiPRO_000003458226 – 236Tumor necrosis factor receptor superfamily member 10CAdd BLAST211
PropeptideiPRO_0000034583237 – 259Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 66PROSITE-ProRule annotation
Disulfide bondi69 ↔ 85PROSITE-ProRule annotation
Glycosylationi77N-linked (GlcNAc...) (high mannose) asparagineSequence analysis1
Disulfide bondi88 ↔ 101PROSITE-ProRule annotation
Disulfide bondi91 ↔ 109PROSITE-ProRule annotation
Disulfide bondi111 ↔ 125PROSITE-ProRule annotation
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi131 ↔ 149PROSITE-ProRule annotation
Glycosylationi140N-linked (GlcNAc...) (high mannose) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) (high mannose) asparagineSequence analysis1
Lipidationi236GPI-anchor amidated alanineSequence analysis1

Post-translational modificationi

N-glycosylated and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiO14798.
PaxDbiO14798.
PeptideAtlasiO14798.
PRIDEiO14798.

PTM databases

iPTMnetiO14798.
PhosphoSitePlusiO14798.

Expressioni

Tissue specificityi

Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Gene expression databases

BgeeiENSG00000173535.
CleanExiHS_TNFRSF10C.
ExpressionAtlasiO14798. baseline and differential.
GenevisibleiO14798. HS.

Organism-specific databases

HPAiCAB025635.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114322. 7 interactors.
DIPiDIP-6242N.
IntActiO14798. 11 interactors.
MINTiMINT-1394827.
STRINGi9606.ENSP00000349324.

Structurei

3D structure databases

ProteinModelPortaliO14798.
SMRiO14798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 66TNFR-Cys 1Add BLAST38
Repeati69 – 109TNFR-Cys 2Add BLAST41
Repeati110 – 149TNFR-Cys 3Add BLAST40
Repeati162 – 176TAPE 1Add BLAST15
Repeati177 – 191TAPE 2Add BLAST15
Repeati192 – 206TAPE 3Add BLAST15
Repeati207 – 221TAPE 4Add BLAST15
Repeati222 – 236TAPE 5Add BLAST15

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JFKD. Eukaryota.
ENOG410Y7QF. LUCA.
GeneTreeiENSGT00730000110985.
HOVERGENiHBG061470.
InParanoidiO14798.
KOiK04722.
OMAiHYLSCTI.
OrthoDBiEOG091G0MOV.
PhylomeDBiO14798.
TreeFamiTF333916.

Family and domain databases

CDDicd10580. TNFRSF10. 1 hit.
InterProiView protein in InterPro
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020465. TNFR_10.
IPR034024. TNFRSF10_N.
PfamiView protein in Pfam
PF00020. TNFR_c6. 2 hits.
PRINTSiPR01956. TNFACTORR10.
SMARTiView protein in SMART
SM00208. TNFR. 2 hits.
PROSITEiView protein in PROSITE
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG
60 70 80 90 100
EECPAGSHRS EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS
110 120 130 140 150
CTMTRDTVCQ CKEGTFRNEN SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV
160 170 180 190 200
EEFGANATVE TPAAEETMNT SPGTPAPAAE ETMNTSPGTP APAAEETMTT
210 220 230 240 250
SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY LSCTIVGIIV

LIVLLIVFV
Length:259
Mass (Da):27,407
Last modified:November 24, 2009 - v3
Checksum:i40CBF7FCEEAE4C69
GO

Sequence cautioni

The sequence AAB71413 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC05593 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAQ88648 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119E → V in AAB81181 (PubMed:9373179).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046534199T → N. Corresponds to variant dbSNP:rs12550828Ensembl.1
Natural variantiVAR_046535229I → T8 PublicationsCorresponds to variant dbSNP:rs9644063Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020502 mRNA. Translation: AAB71413.1. Different initiation.
AF014794 mRNA. Translation: AAC05593.1. Different initiation.
AF012629 mRNA. Translation: AAB67110.1.
AF012536 mRNA. Translation: AAB67104.1.
AF016267 mRNA. Translation: AAB81181.1.
AF033854 mRNA. Translation: AAB87506.1.
AY358281 mRNA. Translation: AAQ88648.1. Different initiation.
CR541857 mRNA. Translation: CAG46655.1.
AC107959 Genomic DNA. No translation available.
BC125041 mRNA. Translation: AAI25042.1.
BC125042 mRNA. Translation: AAI25043.1.
CCDSiCCDS6037.1.
RefSeqiNP_003832.2. NM_003841.4.
UniGeneiHs.655801.

Genome annotation databases

EnsembliENST00000356864; ENSP00000349324; ENSG00000173535.
GeneIDi8794.
KEGGihsa:8794.
UCSCiuc003xcy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTR10C_HUMAN
AccessioniPrimary (citable) accession number: O14798
Secondary accession number(s): O14755
, Q08AS6, Q6FH98, Q6UXM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 24, 2009
Last modified: July 5, 2017
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot