ID APOL1_HUMAN Reviewed; 398 AA. AC O14791; A5PLQ4; B4DU12; E9PF24; O60804; Q5R3P7; Q5R3P8; Q96AB8; Q96PM4; AC Q9BQ03; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 5. DT 27-MAR-2024, entry version 194. DE RecName: Full=Apolipoprotein L1; DE AltName: Full=Apolipoprotein L; DE Short=Apo-L; DE Short=ApoL; DE AltName: Full=Apolipoprotein L-I; DE Short=ApoL-I; DE Flags: Precursor; GN Name=APOL1; Synonyms=APOL; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 28-63, AND RP VARIANTS LYS-150; ILE-228 AND LYS-255. RC TISSUE=Pancreas; RX PubMed=9325276; DOI=10.1074/jbc.272.41.25576; RA Duchateau P.N., Pullinger C.R., Orellana R.E., Kunitake S.T., RA Naya-Vigne J., O'Connor P.M., Malloy M.J., Kane J.P.; RT "Apolipoprotein L, a new human high density lipoprotein apolipoprotein RT expressed by the pancreas. Identification, cloning, characterization, and RT plasma distribution of apolipoprotein L."; RL J. Biol. Chem. 272:25576-25582(1997). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), RP SEQUENCE REVISION TO 155 AND 346, AND VARIANTS LYS-150; ILE-228 AND RP LYS-255. RC TISSUE=Pancreas; RX PubMed=11290834; RA Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P.; RT "Apolipoprotein L gene family: tissue-specific expression, splicing, RT promoter regions; discovery of a new gene."; RL J. Lipid Res. 42:620-630(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=11374903; DOI=10.1006/geno.2001.6534; RA Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.; RT "The human apolipoprotein L gene cluster: identification, classification, RT and sites of distribution."; RL Genomics 74:71-78(2001). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ILE-228; LYS-255; RP GLY-342 AND MET-384. RX PubMed=11944986; DOI=10.1006/geno.2002.6729; RA Monajemi H., Fontijn R.D., Pannekoek H., Horrevoets A.J.G.; RT "The apolipoprotein L gene cluster has emerged recently in evolution and is RT expressed in human vascular tissue."; RL Genomics 79:539-546(2002). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANTS LYS-150; RP ILE-228 AND LYS-255. RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., RA Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261. RC TISSUE=Plasma; RX PubMed=16335952; DOI=10.1021/pr0502065; RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., RA Smith R.D.; RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, RT hydrazide chemistry, and mass spectrometry."; RL J. Proteome Res. 4:2070-2080(2005). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311 AND SER-314, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [10] RP PHOSPHORYLATION AT SER-311 AND SER-314. RX PubMed=26091039; DOI=10.1016/j.cell.2015.05.028; RA Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J., RA Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N., RA Pinna L.A., Pagliarini D.J., Dixon J.E.; RT "A single kinase generates the majority of the secreted phosphoproteome."; RL Cell 161:1619-1632(2015). RN [11] RP VARIANT [LARGE SCALE ANALYSIS] THR-188. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). RN [12] RP VARIANTS GLY-342 AND MET-384, AND INVOLVEMENT IN FSGS4. RX PubMed=20635188; DOI=10.1007/s00439-010-0861-0; RA Tzur S., Rosset S., Shemer R., Yudkovsky G., Selig S., Tarekegn A., RA Bekele E., Bradman N., Wasser W.G., Behar D.M., Skorecki K.; RT "Missense mutations in the APOL1 gene are highly associated with end stage RT kidney disease risk previously attributed to the MYH9 gene."; RL Hum. Genet. 128:345-350(2010). RN [13] RP VARIANTS GLY-342 AND MET-384, AND INVOLVEMENT IN FSGS4. RX PubMed=20647424; DOI=10.1126/science.1193032; RA Genovese G., Friedman D.J., Ross M.D., Lecordier L., Uzureau P., RA Freedman B.I., Bowden D.W., Langefeld C.D., Oleksyk T.K., RA Uscinski Knob A.L., Bernhardy A.J., Hicks P.J., Nelson G.W., RA Vanhollebeke B., Winkler C.A., Kopp J.B., Pays E., Pollak M.R.; RT "Association of trypanolytic ApoL1 variants with kidney disease in African RT Americans."; RL Science 329:841-845(2010). CC -!- FUNCTION: May play a role in lipid exchange and transport throughout CC the body. May participate in reverse cholesterol transport from CC peripheral cells to the liver. CC -!- SUBUNIT: In plasma, interacts with APOA1 and mainly associated with CC large high density lipoprotein particles. CC -!- INTERACTION: CC O14791; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-1221934, EBI-396137; CC O14791; Q8IXL6: FAM20C; NbExp=2; IntAct=EBI-1221934, EBI-7147442; CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; Synonyms=A; CC IsoId=O14791-1; Sequence=Displayed; CC Name=2; Synonyms=B; CC IsoId=O14791-2; Sequence=VSP_000292; CC Name=3; CC IsoId=O14791-3; Sequence=VSP_045077; CC -!- TISSUE SPECIFICITY: Plasma. Found on APOA-I-containing high density CC lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, CC placenta and spleen. CC -!- PTM: Phosphorylated by FAM20C in the extracellular medium. CC {ECO:0000269|PubMed:26091039}. CC -!- DISEASE: Focal segmental glomerulosclerosis 4 (FSGS4) [MIM:612551]: A CC renal pathology defined by the presence of segmental sclerosis in CC glomeruli and resulting in proteinuria, reduced glomerular filtration CC rate and progressive decline in renal function. Renal insufficiency CC often progresses to end-stage renal disease, a highly morbid state CC requiring either dialysis therapy or kidney transplantation. CC {ECO:0000269|PubMed:20635188, ECO:0000269|PubMed:20647424}. CC Note=Disease susceptibility is associated with variants affecting the CC gene represented in this entry. CC -!- MISCELLANEOUS: [Isoform 1]: Major isoform. CC -!- SIMILARITY: Belongs to the apolipoprotein L family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAB81218.2; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF019225; AAB81218.2; ALT_INIT; mRNA. DR EMBL; AF323540; AAG53690.1; -; mRNA. DR EMBL; AF323548; AAK11591.1; -; Genomic_DNA. DR EMBL; AF323543; AAK11591.1; JOINED; Genomic_DNA. DR EMBL; AF323544; AAK11591.1; JOINED; Genomic_DNA. DR EMBL; AF323545; AAK11591.1; JOINED; Genomic_DNA. DR EMBL; AF323546; AAK11591.1; JOINED; Genomic_DNA. DR EMBL; AF323547; AAK11591.1; JOINED; Genomic_DNA. DR EMBL; AF305224; AAK20210.1; -; mRNA. DR EMBL; AF305428; AAL09358.1; -; mRNA. DR EMBL; AK300454; BAG62174.1; -; mRNA. DR EMBL; Z82215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC143039; AAI43040.1; -; mRNA. DR CCDS; CCDS13925.1; -. [O14791-2] DR CCDS; CCDS13926.1; -. [O14791-1] DR CCDS; CCDS46702.1; -. [O14791-3] DR RefSeq; NP_001130012.1; NM_001136540.1. [O14791-1] DR RefSeq; NP_001130013.1; NM_001136541.1. [O14791-3] DR RefSeq; NP_003652.2; NM_003661.3. [O14791-1] DR RefSeq; XP_005261853.1; XM_005261796.3. DR PDB; 7L6K; NMR; -; A=61-172. DR PDB; 7LF7; X-ray; 2.03 A; K/M=61-172. DR PDB; 7LFA; X-ray; 1.86 A; A/C=61-172. DR PDB; 7LFB; X-ray; 1.91 A; X=61-172. DR PDB; 7LFD; X-ray; 2.16 A; A=152-168. DR PDBsum; 7L6K; -. DR PDBsum; 7LF7; -. DR PDBsum; 7LFA; -. DR PDBsum; 7LFB; -. DR PDBsum; 7LFD; -. DR AlphaFoldDB; O14791; -. DR SMR; O14791; -. DR BioGRID; 114112; 3. DR CORUM; O14791; -. DR IntAct; O14791; 3. DR STRING; 9606.ENSP00000317674; -. DR BindingDB; O14791; -. DR ChEMBL; CHEMBL4680021; -. DR DrugBank; DB11886; Infigratinib. DR DrugBank; DB00877; Sirolimus. DR DrugBank; DB01593; Zinc. DR DrugBank; DB14487; Zinc acetate. DR DrugBank; DB14533; Zinc chloride. DR DrugBank; DB14548; Zinc sulfate, unspecified form. DR TCDB; 1.C.127.1.1; the pore-forming trypanolytic apolipoprotein a1 factor (apol1) family. DR GlyCosmos; O14791; 2 sites, 2 glycans. DR GlyGen; O14791; 4 sites, 3 O-linked glycans (3 sites). DR iPTMnet; O14791; -. DR PhosphoSitePlus; O14791; -. DR BioMuta; APOL1; -. DR CPTAC; non-CPTAC-2628; -. DR jPOST; O14791; -. DR MassIVE; O14791; -. DR MaxQB; O14791; -. DR PaxDb; 9606-ENSP00000317674; -. DR PeptideAtlas; O14791; -. DR ProteomicsDB; 20010; -. DR ProteomicsDB; 48240; -. [O14791-1] DR ProteomicsDB; 48241; -. [O14791-2] DR Pumba; O14791; -. DR Antibodypedia; 875; 527 antibodies from 36 providers. DR DNASU; 8542; -. DR Ensembl; ENST00000319136.8; ENSP00000317674.4; ENSG00000100342.22. [O14791-2] DR Ensembl; ENST00000397278.8; ENSP00000380448.4; ENSG00000100342.22. [O14791-1] DR Ensembl; ENST00000426053.5; ENSP00000388477.1; ENSG00000100342.22. [O14791-3] DR Ensembl; ENST00000427990.6; ENSP00000391302.2; ENSG00000100342.22. [O14791-1] DR GeneID; 8542; -. DR KEGG; hsa:8542; -. DR MANE-Select; ENST00000397278.8; ENSP00000380448.4; NM_003661.4; NP_003652.2. DR UCSC; uc003ape.4; human. [O14791-1] DR AGR; HGNC:618; -. DR DisGeNET; 8542; -. DR GeneCards; APOL1; -. DR HGNC; HGNC:618; APOL1. DR HPA; ENSG00000100342; Tissue enhanced (liver). DR MalaCards; APOL1; -. DR MIM; 603743; gene. DR MIM; 612551; phenotype. DR neXtProt; NX_O14791; -. DR OpenTargets; ENSG00000100342; -. DR Orphanet; 656; Genetic steroid-resistant nephrotic syndrome. DR PharmGKB; PA24904; -. DR VEuPathDB; HostDB:ENSG00000100342; -. DR eggNOG; ENOG502RZGU; Eukaryota. DR GeneTree; ENSGT01030000234599; -. DR HOGENOM; CLU_046288_1_0_1; -. DR InParanoid; O14791; -. DR OrthoDB; 5323587at2759; -. DR PhylomeDB; O14791; -. DR TreeFam; TF334681; -. DR PathwayCommons; O14791; -. DR Reactome; R-HSA-2168880; Scavenging of heme from plasma. DR Reactome; R-HSA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). DR Reactome; R-HSA-8957275; Post-translational protein phosphorylation. DR SignaLink; O14791; -. DR BioGRID-ORCS; 8542; 13 hits in 1164 CRISPR screens. DR ChiTaRS; APOL1; human. DR GeneWiki; APOL1; -. DR GenomeRNAi; 8542; -. DR Pharos; O14791; Tbio. DR PRO; PR:O14791; -. DR Proteomes; UP000005640; Chromosome 22. DR RNAct; O14791; Protein. DR Bgee; ENSG00000100342; Expressed in gall bladder and 179 other cell types or tissues. DR ExpressionAtlas; O14791; baseline and differential. DR GO; GO:0072562; C:blood microparticle; HDA:UniProtKB. DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IDA:BHF-UCL. DR GO; GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL. DR GO; GO:0016020; C:membrane; IC:BHF-UCL. DR GO; GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL. DR GO; GO:0005254; F:chloride channel activity; IDA:BHF-UCL. DR GO; GO:0008289; F:lipid binding; IDA:BHF-UCL. DR GO; GO:1902476; P:chloride transmembrane transport; IDA:BHF-UCL. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR GO; GO:0051838; P:cytolysis by host of symbiont cells; IDA:BHF-UCL. DR GO; GO:0045087; P:innate immune response; IDA:BHF-UCL. DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW. DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro. DR InterPro; IPR008405; ApoL. DR PANTHER; PTHR14096; APOLIPOPROTEIN L; 1. DR PANTHER; PTHR14096:SF55; APOLIPOPROTEIN L1; 1. DR Pfam; PF05461; ApoL; 1. DR Genevisible; O14791; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cholesterol metabolism; KW Direct protein sequencing; Disease variant; Glycoprotein; HDL; KW Lipid metabolism; Lipid transport; Phosphoprotein; Reference proteome; KW Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport. FT SIGNAL 1..27 FT /evidence="ECO:0000269|PubMed:9325276" FT CHAIN 28..398 FT /note="Apolipoprotein L1" FT /id="PRO_0000002040" FT REGION 35..55 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 297..317 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 311 FT /note="Phosphoserine; by FAM20C" FT /evidence="ECO:0000269|PubMed:26091039, FT ECO:0007744|PubMed:24275569" FT MOD_RES 314 FT /note="Phosphoserine; by FAM20C" FT /evidence="ECO:0000269|PubMed:26091039, FT ECO:0007744|PubMed:24275569" FT CARBOHYD 261 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16335952" FT VAR_SEQ 1 FT /note="M -> MRFKSHTVELRRPCSDM (in isoform 2)" FT /evidence="ECO:0000303|PubMed:11290834" FT /id="VSP_000292" FT VAR_SEQ 16..33 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_045077" FT VARIANT 150 FT /note="E -> K (in dbSNP:rs2239785)" FT /evidence="ECO:0000269|PubMed:11290834, FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:9325276" FT /id="VAR_011383" FT VARIANT 188 FT /note="I -> T (in a breast cancer sample; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_036568" FT VARIANT 228 FT /note="M -> I (in dbSNP:rs136175)" FT /evidence="ECO:0000269|PubMed:11290834, FT ECO:0000269|PubMed:11944986, ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:9325276" FT /id="VAR_011384" FT VARIANT 255 FT /note="R -> K (in dbSNP:rs136176)" FT /evidence="ECO:0000269|PubMed:11290834, FT ECO:0000269|PubMed:11944986, ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:9325276" FT /id="VAR_011385" FT VARIANT 337 FT /note="D -> N (in dbSNP:rs16996616)" FT /id="VAR_046641" FT VARIANT 342 FT /note="S -> G (risk factor for FSGS4; when associated in FT cis with M-384; dbSNP:rs73885319)" FT /evidence="ECO:0000269|PubMed:11944986, FT ECO:0000269|PubMed:20635188, ECO:0000269|PubMed:20647424" FT /id="VAR_063598" FT VARIANT 384 FT /note="I -> M (risk factor for FSGS4; when associated in FT cis with G-342; dbSNP:rs60910145)" FT /evidence="ECO:0000269|PubMed:11944986, FT ECO:0000269|PubMed:20635188, ECO:0000269|PubMed:20647424" FT /id="VAR_061995" FT CONFLICT 24 FT /note="G -> R (in Ref. 1; AAG53690 and 2; AAK11591)" FT /evidence="ECO:0000305" FT CONFLICT 256 FT /note="E -> G (in Ref. 3; AAK20210)" FT /evidence="ECO:0000305" FT CONFLICT 346 FT /note="V -> A (in Ref. 3; AAK20210)" FT /evidence="ECO:0000305" FT HELIX 67..75 FT /evidence="ECO:0007829|PDB:7LFA" FT HELIX 81..89 FT /evidence="ECO:0007829|PDB:7LFA" FT HELIX 91..100 FT /evidence="ECO:0007829|PDB:7LFA" FT HELIX 105..125 FT /evidence="ECO:0007829|PDB:7LFA" FT HELIX 127..129 FT /evidence="ECO:0007829|PDB:7LFA" FT STRAND 130..132 FT /evidence="ECO:0007829|PDB:7L6K" FT HELIX 134..158 FT /evidence="ECO:0007829|PDB:7LFA" FT HELIX 162..167 FT /evidence="ECO:0007829|PDB:7LFA" SQ SEQUENCE 398 AA; 43974 MW; BD1A8F1D7C5A889F CRC64; MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS GTDTGDPQSK PLGDWAAGTM DPESSIFIED AIKYFKEKVS TQNLLLLLTD NEAWNGFVAA AELPRNEADE LRKALDNLAR QMIMKDKNWH DKGQQYRNWF LKEFPRLKSE LEDNIRRLRA LADGVQKVHK GTTIANVVSG SLSISSGILT LVGMGLAPFT EGGSLVLLEP GMELGITAAL TGITSSTMDY GKKWWTQAQA HDLVIKSLDK LKEVREFLGE NISNFLSLAG NTYQLTRGIG KDIRALRRAR ANLQSVPHAS ASRPRVTEPI SAESGEQVER VNEPSILEMS RGVKLTDVAP VSFFLVLDVV YLVYESKHLH EGAKSETAEE LKKVAQELEE KLNILNNNYK ILQADQEL //