O14791 (APOL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein L1

Alternative name(s):
Apolipoprotein L
Short name=Apo-L
Short name=ApoL
Apolipoprotein L-I
Short name=ApoL-I

Gene names

Name:	APOL1
Synonyms:	APOL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
Subunit structure	In plasma, interacts with APOA1 and mainly associated with large high density lipoprotein particles.
Subcellular location	Secreted.
Tissue specificity	Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.
Post-translational modification	Phosphorylation sites are present in the extracellular medium.
Involvement in disease	Focal segmental glomerulosclerosis 4 (FSGS4) [MIM:612551]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11
Sequence similarities	Belongs to the apolipoprotein L family.
Sequence caution	The sequence AAB81218.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cholesterol metabolism Lipid metabolism Lipid transport Steroid metabolism Sterol metabolism Transport
Cellular component	HDL Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Signal
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cholesterol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW cytolysis Inferred from direct assay PubMed 12621437PubMed 17192540. Source: BHF-UCL innate immune response Inferred from direct assay PubMed 17192540. Source: BHF-UCL killing of cells of other organism Inferred from direct assay PubMed 12621437PubMed 17192540. Source: BHF-UCL lipid transport Inferred from electronic annotation. Source: UniProtKB-KW lipoprotein metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	high-density lipoprotein particle Inferred from direct assay Ref.1. Source: BHF-UCL intrinsic to membrane Inferred by curator PubMed 16020735. Source: BHF-UCL very-low-density lipoprotein particle Inferred from direct assay PubMed 17154273. Source: BHF-UCL
Molecular_function	chloride channel activity Inferred from direct assay PubMed 16020735. Source: BHF-UCL lipid binding Inferred from direct assay PubMed 16020735. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14791-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Major isoform.

Isoform 2 (identifier: O14791-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRFKSHTVELRRPCSDM

Isoform 3 (identifier: O14791-3)

The sequence of this isoform differs from the canonical sequence as follows:
     16-33: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Ref.1
	Chain	28 – 398	371	Apolipoprotein L1		PRO_0000002040
Amino acid modifications
	Glycosylation	261	1	N-linked (GlcNAc...) Ref.8
Natural variations
	Alternative sequence	1	1	M → MRFKSHTVELRRPCSDM in isoform 2.		VSP_000292
	Alternative sequence	16 – 33	18	Missing in isoform 3.		VSP_045077
	Natural variant	150	1	E → K. Ref.1 Ref.2 Ref.5 Corresponds to variant rs2239785 [ dbSNP | Ensembl ].		VAR_011383
	Natural variant	188	1	I → T in a breast cancer sample; somatic mutation. Ref.9		VAR_036568
	Natural variant	228	1	M → I. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs136175 [ dbSNP | Ensembl ].		VAR_011384
	Natural variant	255	1	R → K. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs136176 [ dbSNP | Ensembl ].		VAR_011385
	Natural variant	337	1	D → N. Corresponds to variant rs16996616 [ dbSNP | Ensembl ].		VAR_046641
	Natural variant	342	1	S → G in FSGS4. Ref.4 Ref.10 Ref.11 Corresponds to variant rs73885319 [ dbSNP | Ensembl ].		VAR_063598
	Natural variant	384	1	I → M in FSGS4. Ref.4 Ref.10 Ref.11 Corresponds to variant rs60910145 [ dbSNP | Ensembl ].		VAR_061995
Experimental info
	Sequence conflict	24	1	G → R in AAG53690. Ref.1
	Sequence conflict	24	1	G → R in AAK11591. Ref.2
	Sequence conflict	256	1	E → G in AAK20210. Ref.3
	Sequence conflict	346	1	V → A in AAK20210. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified September 23, 2008. Version 5. Checksum: BD1A8F1D7C5A889F	FASTA	398	43,974
	10 20 30 40 50 60 MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS GTDTGDPQSK PLGDWAAGTM 70 80 90 100 110 120 DPESSIFIED AIKYFKEKVS TQNLLLLLTD NEAWNGFVAA AELPRNEADE LRKALDNLAR 130 140 150 160 170 180 QMIMKDKNWH DKGQQYRNWF LKEFPRLKSE LEDNIRRLRA LADGVQKVHK GTTIANVVSG 190 200 210 220 230 240 SLSISSGILT LVGMGLAPFT EGGSLVLLEP GMELGITAAL TGITSSTMDY GKKWWTQAQA 250 260 270 280 290 300 HDLVIKSLDK LKEVREFLGE NISNFLSLAG NTYQLTRGIG KDIRALRRAR ANLQSVPHAS 310 320 330 340 350 360 ASRPRVTEPI SAESGEQVER VNEPSILEMS RGVKLTDVAP VSFFLVLDVV YLVYESKHLH 370 380 390 EGAKSETAEE LKKVAQELEE KLNILNNNYK ILQADQEL
	Isoform 2 (B) [UniParc]. Checksum: FFB6B4E66BA3F953	FASTA	414	45,918
	10 20 30 40 50 60 MRFKSHTVEL RRPCSDMEGA ALLRVSVLCI WMSALFLGVG VRAEEAGARV QQNVPSGTDT 70 80 90 100 110 120 GDPQSKPLGD WAAGTMDPES SIFIEDAIKY FKEKVSTQNL LLLLTDNEAW NGFVAAAELP 130 140 150 160 170 180 RNEADELRKA LDNLARQMIM KDKNWHDKGQ QYRNWFLKEF PRLKSELEDN IRRLRALADG 190 200 210 220 230 240 VQKVHKGTTI ANVVSGSLSI SSGILTLVGM GLAPFTEGGS LVLLEPGMEL GITAALTGIT 250 260 270 280 290 300 SSTMDYGKKW WTQAQAHDLV IKSLDKLKEV REFLGENISN FLSLAGNTYQ LTRGIGKDIR 310 320 330 340 350 360 ALRRARANLQ SVPHASASRP RVTEPISAES GEQVERVNEP SILEMSRGVK LTDVAPVSFF 370 380 390 400 410 LVLDVVYLVY ESKHLHEGAK SETAEELKKV AQELEEKLNI LNNNYKILQA DQEL
	Isoform 3 [UniParc]. Checksum: C87A9934630D7744	FASTA	380	42,158
	10 20 30 40 50 60 MEGAALLRVS VLCIWVQQNV PSGTDTGDPQ SKPLGDWAAG TMDPESSIFI EDAIKYFKEK 70 80 90 100 110 120 VSTQNLLLLL TDNEAWNGFV AAAELPRNEA DELRKALDNL ARQMIMKDKN WHDKGQQYRN 130 140 150 160 170 180 WFLKEFPRLK SELEDNIRRL RALADGVQKV HKGTTIANVV SGSLSISSGI LTLVGMGLAP 190 200 210 220 230 240 FTEGGSLVLL EPGMELGITA ALTGITSSTM DYGKKWWTQA QAHDLVIKSL DKLKEVREFL 250 260 270 280 290 300 GENISNFLSL AGNTYQLTRG IGKDIRALRR ARANLQSVPH ASASRPRVTE PISAESGEQV 310 320 330 340 350 360 ERVNEPSILE MSRGVKLTDV APVSFFLVLD VVYLVYESKH LHEGAKSETA EELKKVAQEL 370 380 EEKLNILNNN YKILQADQEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L." Duchateau P.N., Pullinger C.R., Orellana R.E., Kunitake S.T., Naya-Vigne J., O'Connor P.M., Malloy M.J., Kane J.P. J. Biol. Chem. 272:25576-25582(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 28-63, VARIANTS LYS-150; ILE-228 AND LYS-255. Tissue: Pancreas.
[2]	"Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene." Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P. J. Lipid Res. 42:620-630(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SEQUENCE REVISION TO 155 AND 346, VARIANTS LYS-150; ILE-228 AND LYS-255. Tissue: Pancreas.
[3]	"The human apolipoprotein L gene cluster: identification, classification, and sites of distribution." Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J. Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta.
[4]	"The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue." Monajemi H., Fontijn R.D., Pannekoek H., Horrevoets A.J.G. Genomics 79:539-546(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-228; LYS-255; GLY-342 AND MET-384.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS LYS-150; ILE-228 AND LYS-255. Tissue: Placenta.
[6]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261, MASS SPECTROMETRY. Tissue: Plasma.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-188.
[10]	"Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene." Tzur S., Rosset S., Shemer R., Yudkovsky G., Selig S., Tarekegn A., Bekele E., Bradman N., Wasser W.G., Behar D.M., Skorecki K. Hum. Genet. 128:345-350(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS FSGS4 GLY-342 AND MET-384.
[11]	"Association of trypanolytic ApoL1 variants with kidney disease in African Americans." Genovese G., Friedman D.J., Ross M.D., Lecordier L., Uzureau P., Freedman B.I., Bowden D.W., Langefeld C.D., Oleksyk T.K., Uscinski Knob A.L., Bernhardy A.J., Hicks P.J., Nelson G.W., Vanhollebeke B., Winkler C.A., Kopp J.B., Pays E., Pollak M.R. Science 329:841-845(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS FSGS4 GLY-342 AND MET-384.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF019225 mRNA. Translation: AAB81218.2. Different initiation. AF323540 mRNA. Translation: AAG53690.1. AF323548 , AF323543, AF323544, AF323545, AF323546, AF323547 Genomic DNA. Translation: AAK11591.1. AF305224 mRNA. Translation: AAK20210.1. AF305428 mRNA. Translation: AAL09358.1. AK300454 mRNA. Translation: BAG62174.1. Z82215 Genomic DNA. Translation: CAI22438.1. Z82215 Genomic DNA. Translation: CAQ09089.1. BC143039 mRNA. Translation: AAI43040.1.
IPI	IPI00186903. IPI00514475. IPI00914948.
RefSeq	NP_001130012.1. NM_001136540.1. NP_001130013.1. NM_001136541.1. NP_003652.2. NM_003661.3. NP_663318.1. NM_145343.2.
UniGene	Hs.114309.
3D structure databases
ProteinModelPortal	O14791.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14791. 1 interaction.
STRING	9606.ENSP00000317674.
PTM databases
PhosphoSite	O14791.
Proteomic databases
PaxDb	O14791.
PRIDE	O14791.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000319136; ENSP00000317674; ENSG00000100342. ENST00000397278; ENSP00000380448; ENSG00000100342. ENST00000397279; ENSP00000380449; ENSG00000100342. ENST00000422706; ENSP00000411507; ENSG00000100342. ENST00000426053; ENSP00000388477; ENSG00000100342.
GeneID	8542.
KEGG	hsa:8542.
UCSC	uc003ape.3. human. uc003apf.3. human.
Organism-specific databases
CTD	8542.
GeneCards	GC22P036649.
H-InvDB	HIX0016423.
HGNC	HGNC:618. APOL1.
HPA	CAB056156. HPA018885.
MIM	603743. gene. 612551. phenotype.
neXtProt	NX_O14791.
Orphanet	93218. Sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis.
PharmGKB	PA24904.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG125779.
HOVERGEN	HBG074468.
InParanoid	O14791.
KO	K14480.
OMA	KGTTIAN.
OrthoDB	EOG49ZXPX.
Gene expression databases
ArrayExpress	O14791.
Bgee	O14791.
CleanEx	HS_APOL1.
Genevestigator	O14791.
GermOnline	ENSG00000100342. Homo sapiens.
Family and domain databases
InterPro	IPR008405. ApoL. [Graphical view]
PANTHER	PTHR14096. PTHR14096. 1 hit.
Pfam	PF05461. ApoL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	APOL1. human.
GenomeRNAi	8542.
NextBio	31996.
SOURCE	Search...

Entry information

Entry name

APOL1_HUMAN

Accession

Primary (citable) accession number: O14791
Secondary accession number(s): A5PLQ4 , B4DU12, E9PF24, O60804, Q5R3P7, Q5R3P8, Q96AB8, Q96PM4, Q9BQ03

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	September 23, 2008
Last modified:	May 1, 2013
This is version 120 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.