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O14787

- TNPO2_HUMAN

UniProt

O14787 - TNPO2_HUMAN

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Protein

Transportin-2

Gene

TNPO2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

  1. nuclear localization sequence binding Source: ProtInc

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transportin-2
Alternative name(s):
Karyopherin beta-2b
Gene namesi
Name:TNPO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:19998. TNPO2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 897897Transportin-2PRO_0000120767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei862 – 8621N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO14787.
PaxDbiO14787.
PRIDEiO14787.

PTM databases

PhosphoSiteiO14787.

Expressioni

Gene expression databases

BgeeiO14787.
CleanExiHS_TNPO2.
ExpressionAtlasiO14787. baseline and differential.
GenevestigatoriO14787.

Organism-specific databases

HPAiCAB046446.

Interactioni

Protein-protein interaction databases

BioGridi119024. 29 interactions.
IntActiO14787. 5 interactions.
MINTiMINT-2998321.
STRINGi9606.ENSP00000397379.

Structurei

3D structure databases

ProteinModelPortaliO14787.
SMRiO14787. Positions 3-896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 9969Importin N-terminalAdd
BLAST
Repeati121 – 15939HEAT 1Add
BLAST
Repeati167 – 20539HEAT 2Add
BLAST
Repeati208 – 24639HEAT 3Add
BLAST
Repeati249 – 28739HEAT 4Add
BLAST
Repeati292 – 33039HEAT 5Add
BLAST
Repeati389 – 42739HEAT 6Add
BLAST
Repeati430 – 46839HEAT 7Add
BLAST
Repeati472 – 51039HEAT 8Add
BLAST
Repeati513 – 55139HEAT 9Add
BLAST
Repeati556 – 59641HEAT 10Add
BLAST
Repeati659 – 69739HEAT 11Add
BLAST
Repeati700 – 73839HEAT 12Add
BLAST
Repeati741 – 78040HEAT 13Add
BLAST

Sequence similaritiesi

Belongs to the importin beta family.Curated
Contains 13 HEAT repeats.Curated
Contains 1 importin N-terminal domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5215.
GeneTreeiENSGT00550000074720.
HOGENOMiHOG000203940.
HOVERGENiHBG058963.
InParanoidiO14787.
OMAiVRRHVCQ.
OrthoDBiEOG7XM2X0.
PhylomeDBiO14787.
TreeFamiTF300825.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14787-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDWQPDEQGL QQVLQLLKDS QSPNTATQRI VQDKLKQLNQ FPDFNNYLIF
60 70 80 90 100
VLTRLKSEDE PTRSLSGLIL KNNVKAHYQS FPPPVADFIK QECLNNIGDA
110 120 130 140 150
SSLIRATIGI LITTIASKGE LQMWPELLPQ LCNLLNSEDY NTCEGAFGAL
160 170 180 190 200
QKICEDSSEL LDSDALNRPL NIMIPKFLQF FKHCSPKIRS HAIACVNQFI
210 220 230 240 250
MDRAQALMDN IDTFIEHLFA LAVDDDPEVR KNVCRALVML LEVRIDRLIP
260 270 280 290 300
HMHSIIQYML QRTQDHDENV ALEACEFWLT LAEQPICKEV LASHLVQLIP
310 320 330 340 350
ILVNGMKYSE IDIILLKGDV EEDEAVPDSE QDIKPRFHKS RTVTLPHEAE
360 370 380 390 400
RPDGSEDAED DDDDDALSDW NLRKCSAAAL DVLANVFREE LLPHLLPLLK
410 420 430 440 450
GLLFHPEWVV KESGILVLGA IAEGCMQGMV PYLPELIPHL IQCLSDKKAL
460 470 480 490 500
VRSIACWTLS RYAHWVVSQP PDMHLKPLMT ELLKRILDGN KRVQEAACSA
510 520 530 540 550
FATLEEEACT ELVPYLSYIL DTLVFAFGKY QHKNLLILYD AIGTLADSVG
560 570 580 590 600
HHLNQPEYIQ KLMPPLIQKW NELKDEDKDL FPLLECLSSV ATALQSGFLP
610 620 630 640 650
YCEPVYQRCV TLVQKTLAQA MMYTQHPEQY EAPDKDFMIV ALDLLSGLAE
660 670 680 690 700
GLGGHVEQLV ARSNIMTLLF QCMQDSMPEV RQSSFALLGD LTKACFIHVK
710 720 730 740 750
PCIAEFMPIL GTNLNPEFIS VCNNATWAIG EICMQMGAEM QPYVQMVLNN
760 770 780 790 800
LVEIINRPNT PKTLLENTGR LTSPSAIPAI TIGRLGYVCP QEVAPMLQQF
810 820 830 840 850
IRPWCTSLRN IRDNEEKDSA FRGICMMIGV NPGGVVQDFI FFCDAVASWV
860 870 880 890
SPKDDLRDMF YKILHGFKDQ VGEDNWQQFS EQFPPLLKER LAAFYGV
Length:897
Mass (Da):101,388
Last modified:November 24, 2009 - v3
Checksum:i26FE455583D7D35F
GO
Isoform 2 (identifier: O14787-2) [UniParc]FASTAAdd to Basket

Also known as: beta2b

The sequence of this isoform differs from the canonical sequence as follows:
     769-778: Missing.

Note: No experimental confirmation available.

Show »
Length:887
Mass (Da):100,408
Checksum:iAE64FDCE4DA901DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281Q → H in AAB71349. 1 PublicationCurated
Sequence conflicti32 – 321Q → R in AAB71349. 1 PublicationCurated
Sequence conflicti194 – 1941A → G in AAB71349. 1 PublicationCurated
Sequence conflicti398 – 4014LLKG → YQS in AAB83973. (PubMed:9298975)Curated
Sequence conflicti492 – 4921R → K in AAB71349. 1 PublicationCurated
Sequence conflicti499 – 4991S → I in AAB71349. 1 PublicationCurated
Sequence conflicti507 – 5071E → K in AAB71349. 1 PublicationCurated
Sequence conflicti608 – 6081R → C in AAB71349. 1 PublicationCurated
Sequence conflicti645 – 6451L → F in AAB71349. 1 PublicationCurated
Sequence conflicti646 – 6461S → T in AAB83973. (PubMed:9298975)Curated
Sequence conflicti656 – 6561V → L in AAB83973. (PubMed:9298975)Curated
Sequence conflicti687 – 6871L → F in AAB71349. 1 PublicationCurated
Sequence conflicti691 – 6911L → F in AAB71349. 1 PublicationCurated
Sequence conflicti696 – 6972FI → SS in AAB71349. 1 PublicationCurated
Sequence conflicti717 – 7171E → K in AAB83973. (PubMed:9298975)Curated
Sequence conflicti812 – 8121R → Q in AAB83973. (PubMed:9298975)Curated
Sequence conflicti841 – 8411F → L in AAB71349. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti370 – 3701W → C Found in a patient with severely delayed development, autism, myopia, strabismus and some dysmorphisms. 1 Publication
VAR_069373

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei769 – 77810Missing in isoform 2. 2 PublicationsVSP_009657

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019039 mRNA. Translation: AAB83973.1.
AF007748 mRNA. Translation: AAB71349.1.
AC018761 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84300.1.
BC072420 mRNA. Translation: AAH72420.1.
CCDSiCCDS45991.1. [O14787-1]
CCDS45992.1. [O14787-2]
RefSeqiNP_001129667.1. NM_001136195.1. [O14787-2]
NP_001129668.1. NM_001136196.1. [O14787-1]
NP_038461.2. NM_013433.4. [O14787-2]
UniGeneiHs.416049.
Hs.714402.

Genome annotation databases

EnsembliENST00000356861; ENSP00000349321; ENSG00000105576. [O14787-2]
ENST00000425528; ENSP00000407182; ENSG00000105576. [O14787-1]
ENST00000450764; ENSP00000397379; ENSG00000105576. [O14787-2]
ENST00000588216; ENSP00000465625; ENSG00000105576. [O14787-2]
ENST00000592287; ENSP00000468434; ENSG00000105576. [O14787-1]
GeneIDi30000.
KEGGihsa:30000.
UCSCiuc002muo.3. human. [O14787-1]
uc002muq.3. human. [O14787-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019039 mRNA. Translation: AAB83973.1 .
AF007748 mRNA. Translation: AAB71349.1 .
AC018761 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84300.1 .
BC072420 mRNA. Translation: AAH72420.1 .
CCDSi CCDS45991.1. [O14787-1 ]
CCDS45992.1. [O14787-2 ]
RefSeqi NP_001129667.1. NM_001136195.1. [O14787-2 ]
NP_001129668.1. NM_001136196.1. [O14787-1 ]
NP_038461.2. NM_013433.4. [O14787-2 ]
UniGenei Hs.416049.
Hs.714402.

3D structure databases

ProteinModelPortali O14787.
SMRi O14787. Positions 3-896.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119024. 29 interactions.
IntActi O14787. 5 interactions.
MINTi MINT-2998321.
STRINGi 9606.ENSP00000397379.

PTM databases

PhosphoSitei O14787.

Proteomic databases

MaxQBi O14787.
PaxDbi O14787.
PRIDEi O14787.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356861 ; ENSP00000349321 ; ENSG00000105576 . [O14787-2 ]
ENST00000425528 ; ENSP00000407182 ; ENSG00000105576 . [O14787-1 ]
ENST00000450764 ; ENSP00000397379 ; ENSG00000105576 . [O14787-2 ]
ENST00000588216 ; ENSP00000465625 ; ENSG00000105576 . [O14787-2 ]
ENST00000592287 ; ENSP00000468434 ; ENSG00000105576 . [O14787-1 ]
GeneIDi 30000.
KEGGi hsa:30000.
UCSCi uc002muo.3. human. [O14787-1 ]
uc002muq.3. human. [O14787-2 ]

Organism-specific databases

CTDi 30000.
GeneCardsi GC19M012810.
HGNCi HGNC:19998. TNPO2.
HPAi CAB046446.
MIMi 603002. gene.
neXtProti NX_O14787.
PharmGKBi PA134921349.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5215.
GeneTreei ENSGT00550000074720.
HOGENOMi HOG000203940.
HOVERGENi HBG058963.
InParanoidi O14787.
OMAi VRRHVCQ.
OrthoDBi EOG7XM2X0.
PhylomeDBi O14787.
TreeFami TF300825.

Miscellaneous databases

ChiTaRSi TNPO2. human.
GeneWikii TNPO2.
GenomeRNAii 30000.
NextBioi 52812.
PROi O14787.
SOURCEi Search...

Gene expression databases

Bgeei O14787.
CleanExi HS_TNPO2.
ExpressionAtlasi O14787. baseline and differential.
Genevestigatori O14787.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR001494. Importin-beta_N.
[Graphical view ]
Pfami PF02985. HEAT. 1 hit.
PF03810. IBN_N. 1 hit.
[Graphical view ]
SMARTi SM00913. IBN_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins."
    Siomi M.C., Eder P.S., Kataoka N., Wan L., Liu Q., Dreyfuss G.
    J. Cell Biol. 138:1181-1192(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Human karyopherin beta2b: an homolog of human karyopherin beta2."
    Bonifaci N., Radu A., Blobel G.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: PNS.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-862, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT CYS-370.

Entry informationi

Entry nameiTNPO2_HUMAN
AccessioniPrimary (citable) accession number: O14787
Secondary accession number(s): O14655, Q6IN77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 24, 2009
Last modified: October 29, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3