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Protein

Transportin-2

Gene

TNPO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

  • nuclear localization sequence binding Source: ProtInc
  • protein transporter activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105576-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transportin-2
Alternative name(s):
Karyopherin beta-2b
Gene namesi
Name:TNPO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19998. TNPO2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • nuclear membrane Source: GO_Central
  • nuclear periphery Source: GO_Central
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi30000.
OpenTargetsiENSG00000105576.
PharmGKBiPA134921349.

Polymorphism and mutation databases

BioMutaiTNPO2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207671 – 897Transportin-2Add BLAST897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei862N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO14787.
PaxDbiO14787.
PeptideAtlasiO14787.
PRIDEiO14787.

PTM databases

iPTMnetiO14787.
PhosphoSitePlusiO14787.

Expressioni

Gene expression databases

BgeeiENSG00000105576.
CleanExiHS_TNPO2.
ExpressionAtlasiO14787. baseline and differential.
GenevisibleiO14787. HS.

Organism-specific databases

HPAiCAB046446.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APIPQ96GX93EBI-431907,EBI-359248
C1orf94Q6P1W53EBI-431907,EBI-946029
CAMK2DQ135573EBI-431907,EBI-351018
EXOC5Q8IW243EBI-431907,EBI-10171392
HEL-S-101V9HW273EBI-431907,EBI-10178933
KLHL2O951983EBI-431907,EBI-746999
NME1P155313EBI-431907,EBI-741141
PNMA5Q96PV43EBI-431907,EBI-10171633
TERF1P542742EBI-431907,EBI-710997

Protein-protein interaction databases

BioGridi119024. 62 interactors.
IntActiO14787. 19 interactors.
MINTiMINT-2998321.
STRINGi9606.ENSP00000407182.

Structurei

3D structure databases

ProteinModelPortaliO14787.
SMRiO14787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 36HEAT 1By similarityAdd BLAST28
Domaini31 – 99Importin N-terminalAdd BLAST69
Repeati41 – 79HEAT 2By similarityAdd BLAST39
Repeati88 – 121HEAT 3By similarityAdd BLAST34
Repeati127 – 164HEAT 4By similarityAdd BLAST38
Repeati171 – 201HEAT 5By similarityAdd BLAST31
Repeati214 – 241HEAT 6By similarityAdd BLAST28
Repeati253 – 280HEAT 7By similarityAdd BLAST28
Repeati296 – 386HEAT 8By similarityAdd BLAST91
Repeati394 – 422HEAT 9By similarityAdd BLAST29
Repeati434 – 461HEAT 10By similarityAdd BLAST28
Repeati475 – 508HEAT 11By similarityAdd BLAST34
Repeati516 – 549HEAT 12By similarityAdd BLAST34
Repeati557 – 595HEAT 13By similarityAdd BLAST39
Repeati603 – 654HEAT 14By similarityAdd BLAST52
Repeati665 – 696HEAT 15By similarityAdd BLAST32
Repeati704 – 737HEAT 16By similarityAdd BLAST34
Repeati745 – 790HEAT 17By similarityAdd BLAST46
Repeati798 – 831HEAT 18By similarityAdd BLAST34
Repeati840 – 871HEAT 19By similarityAdd BLAST32
Repeati874 – 894HEAT 20By similarityAdd BLAST21

Sequence similaritiesi

Contains 20 HEAT repeats.By similarity
Contains 1 importin N-terminal domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2023. Eukaryota.
ENOG410XPK2. LUCA.
GeneTreeiENSGT00550000074720.
HOGENOMiHOG000203940.
HOVERGENiHBG058963.
InParanoidiO14787.
KOiK18727.
OMAiCAMDWQP.
OrthoDBiEOG091G01O2.
PhylomeDBiO14787.
TreeFamiTF300825.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14787-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDWQPDEQGL QQVLQLLKDS QSPNTATQRI VQDKLKQLNQ FPDFNNYLIF
60 70 80 90 100
VLTRLKSEDE PTRSLSGLIL KNNVKAHYQS FPPPVADFIK QECLNNIGDA
110 120 130 140 150
SSLIRATIGI LITTIASKGE LQMWPELLPQ LCNLLNSEDY NTCEGAFGAL
160 170 180 190 200
QKICEDSSEL LDSDALNRPL NIMIPKFLQF FKHCSPKIRS HAIACVNQFI
210 220 230 240 250
MDRAQALMDN IDTFIEHLFA LAVDDDPEVR KNVCRALVML LEVRIDRLIP
260 270 280 290 300
HMHSIIQYML QRTQDHDENV ALEACEFWLT LAEQPICKEV LASHLVQLIP
310 320 330 340 350
ILVNGMKYSE IDIILLKGDV EEDEAVPDSE QDIKPRFHKS RTVTLPHEAE
360 370 380 390 400
RPDGSEDAED DDDDDALSDW NLRKCSAAAL DVLANVFREE LLPHLLPLLK
410 420 430 440 450
GLLFHPEWVV KESGILVLGA IAEGCMQGMV PYLPELIPHL IQCLSDKKAL
460 470 480 490 500
VRSIACWTLS RYAHWVVSQP PDMHLKPLMT ELLKRILDGN KRVQEAACSA
510 520 530 540 550
FATLEEEACT ELVPYLSYIL DTLVFAFGKY QHKNLLILYD AIGTLADSVG
560 570 580 590 600
HHLNQPEYIQ KLMPPLIQKW NELKDEDKDL FPLLECLSSV ATALQSGFLP
610 620 630 640 650
YCEPVYQRCV TLVQKTLAQA MMYTQHPEQY EAPDKDFMIV ALDLLSGLAE
660 670 680 690 700
GLGGHVEQLV ARSNIMTLLF QCMQDSMPEV RQSSFALLGD LTKACFIHVK
710 720 730 740 750
PCIAEFMPIL GTNLNPEFIS VCNNATWAIG EICMQMGAEM QPYVQMVLNN
760 770 780 790 800
LVEIINRPNT PKTLLENTGR LTSPSAIPAI TIGRLGYVCP QEVAPMLQQF
810 820 830 840 850
IRPWCTSLRN IRDNEEKDSA FRGICMMIGV NPGGVVQDFI FFCDAVASWV
860 870 880 890
SPKDDLRDMF YKILHGFKDQ VGEDNWQQFS EQFPPLLKER LAAFYGV
Length:897
Mass (Da):101,388
Last modified:November 24, 2009 - v3
Checksum:i26FE455583D7D35F
GO
Isoform 2 (identifier: O14787-2) [UniParc]FASTAAdd to basket
Also known as: beta2b

The sequence of this isoform differs from the canonical sequence as follows:
     769-778: Missing.

Note: No experimental confirmation available.
Show »
Length:887
Mass (Da):100,408
Checksum:iAE64FDCE4DA901DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28Q → H in AAB71349 (Ref. 2) Curated1
Sequence conflicti32Q → R in AAB71349 (Ref. 2) Curated1
Sequence conflicti194A → G in AAB71349 (Ref. 2) Curated1
Sequence conflicti398 – 401LLKG → YQS in AAB83973 (PubMed:9298975).Curated4
Sequence conflicti492R → K in AAB71349 (Ref. 2) Curated1
Sequence conflicti499S → I in AAB71349 (Ref. 2) Curated1
Sequence conflicti507E → K in AAB71349 (Ref. 2) Curated1
Sequence conflicti608R → C in AAB71349 (Ref. 2) Curated1
Sequence conflicti645L → F in AAB71349 (Ref. 2) Curated1
Sequence conflicti646S → T in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti656V → L in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti687L → F in AAB71349 (Ref. 2) Curated1
Sequence conflicti691L → F in AAB71349 (Ref. 2) Curated1
Sequence conflicti696 – 697FI → SS in AAB71349 (Ref. 2) Curated2
Sequence conflicti717E → K in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti812R → Q in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti841F → L in AAB71349 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069373370W → C Found in a patient with severely delayed development, autism, myopia, strabismus and some dysmorphisms. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009657769 – 778Missing in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019039 mRNA. Translation: AAB83973.1.
AF007748 mRNA. Translation: AAB71349.1.
AC018761 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84300.1.
BC072420 mRNA. Translation: AAH72420.1.
CCDSiCCDS45991.1. [O14787-1]
CCDS45992.1. [O14787-2]
RefSeqiNP_001129667.1. NM_001136195.1. [O14787-2]
NP_001129668.1. NM_001136196.1. [O14787-1]
NP_038461.2. NM_013433.4. [O14787-2]
UniGeneiHs.416049.
Hs.714402.

Genome annotation databases

EnsembliENST00000356861; ENSP00000349321; ENSG00000105576. [O14787-2]
ENST00000425528; ENSP00000407182; ENSG00000105576. [O14787-1]
ENST00000450764; ENSP00000397379; ENSG00000105576. [O14787-2]
ENST00000588216; ENSP00000465625; ENSG00000105576. [O14787-2]
ENST00000592287; ENSP00000468434; ENSG00000105576. [O14787-1]
GeneIDi30000.
KEGGihsa:30000.
UCSCiuc002muo.4. human. [O14787-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019039 mRNA. Translation: AAB83973.1.
AF007748 mRNA. Translation: AAB71349.1.
AC018761 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84300.1.
BC072420 mRNA. Translation: AAH72420.1.
CCDSiCCDS45991.1. [O14787-1]
CCDS45992.1. [O14787-2]
RefSeqiNP_001129667.1. NM_001136195.1. [O14787-2]
NP_001129668.1. NM_001136196.1. [O14787-1]
NP_038461.2. NM_013433.4. [O14787-2]
UniGeneiHs.416049.
Hs.714402.

3D structure databases

ProteinModelPortaliO14787.
SMRiO14787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119024. 62 interactors.
IntActiO14787. 19 interactors.
MINTiMINT-2998321.
STRINGi9606.ENSP00000407182.

Protein family/group databases

TCDBi1.I.1.1.3. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiO14787.
PhosphoSitePlusiO14787.

Polymorphism and mutation databases

BioMutaiTNPO2.

Proteomic databases

MaxQBiO14787.
PaxDbiO14787.
PeptideAtlasiO14787.
PRIDEiO14787.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356861; ENSP00000349321; ENSG00000105576. [O14787-2]
ENST00000425528; ENSP00000407182; ENSG00000105576. [O14787-1]
ENST00000450764; ENSP00000397379; ENSG00000105576. [O14787-2]
ENST00000588216; ENSP00000465625; ENSG00000105576. [O14787-2]
ENST00000592287; ENSP00000468434; ENSG00000105576. [O14787-1]
GeneIDi30000.
KEGGihsa:30000.
UCSCiuc002muo.4. human. [O14787-1]

Organism-specific databases

CTDi30000.
DisGeNETi30000.
GeneCardsiTNPO2.
HGNCiHGNC:19998. TNPO2.
HPAiCAB046446.
MIMi603002. gene.
neXtProtiNX_O14787.
OpenTargetsiENSG00000105576.
PharmGKBiPA134921349.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2023. Eukaryota.
ENOG410XPK2. LUCA.
GeneTreeiENSGT00550000074720.
HOGENOMiHOG000203940.
HOVERGENiHBG058963.
InParanoidiO14787.
KOiK18727.
OMAiCAMDWQP.
OrthoDBiEOG091G01O2.
PhylomeDBiO14787.
TreeFamiTF300825.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105576-MONOMER.

Miscellaneous databases

ChiTaRSiTNPO2. human.
GeneWikiiTNPO2.
GenomeRNAii30000.
PROiO14787.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105576.
CleanExiHS_TNPO2.
ExpressionAtlasiO14787. baseline and differential.
GenevisibleiO14787. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTNPO2_HUMAN
AccessioniPrimary (citable) accession number: O14787
Secondary accession number(s): O14655, Q6IN77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.