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O14786

- NRP1_HUMAN

UniProt

O14786 - NRP1_HUMAN

Protein

Neuropilin-1

Gene

NRP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 3 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
    The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi195 – 1951Calcium
    Metal bindingi209 – 2091Calcium
    Metal bindingi250 – 2501Calcium

    GO - Molecular functioni

    1. coreceptor activity Source: BHF-UCL
    2. cytokine binding Source: BHF-UCL
    3. growth factor binding Source: UniProtKB
    4. heparin binding Source: UniProtKB-KW
    5. metal ion binding Source: UniProtKB-KW
    6. protein binding Source: IntAct
    7. semaphorin receptor activity Source: BHF-UCL
    8. vascular endothelial growth factor-activated receptor activity Source: BHF-UCL
    9. vascular endothelial growth factor binding Source: BHF-UCL

    GO - Biological processi

    1. angiogenesis Source: BHF-UCL
    2. angiogenesis involved in coronary vascular morphogenesis Source: BHF-UCL
    3. artery morphogenesis Source: BHF-UCL
    4. axonal fasciculation Source: Ensembl
    5. axon extension involved in axon guidance Source: BHF-UCL
    6. axon guidance Source: BHF-UCL
    7. axonogenesis involved in innervation Source: BHF-UCL
    8. cell adhesion Source: InterPro
    9. cell-cell signaling Source: ProtInc
    10. cell migration involved in sprouting angiogenesis Source: BHF-UCL
    11. cellular response to hepatocyte growth factor stimulus Source: BHF-UCL
    12. cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
    13. commissural neuron axon guidance Source: BHF-UCL
    14. dendrite development Source: Ensembl
    15. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
    16. endothelial cell chemotaxis Source: BHF-UCL
    17. endothelial tip cell fate specification Source: BHF-UCL
    18. hepatocyte growth factor receptor signaling pathway Source: BHF-UCL
    19. negative regulation of axon extension involved in axon guidance Source: Ensembl
    20. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    21. negative regulation of neuron apoptotic process Source: Ensembl
    22. nerve development Source: BHF-UCL
    23. neural crest cell migration involved in autonomic nervous system development Source: BHF-UCL
    24. neuron migration Source: BHF-UCL
    25. organ morphogenesis Source: ProtInc
    26. patterning of blood vessels Source: BHF-UCL
    27. platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
    28. positive chemotaxis Source: BHF-UCL
    29. positive regulation of axon extension involved in axon guidance Source: BHF-UCL
    30. positive regulation of cytokine activity Source: BHF-UCL
    31. positive regulation of endothelial cell migration Source: BHF-UCL
    32. positive regulation of endothelial cell proliferation Source: BHF-UCL
    33. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
    34. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
    35. positive regulation of retinal ganglion cell axon guidance Source: BHF-UCL
    36. positive regulation of smooth muscle cell migration Source: BHF-UCL
    37. protein localization to early endosome Source: BHF-UCL
    38. regulation of retinal ganglion cell axon guidance Source: BHF-UCL
    39. regulation of vesicle-mediated transport Source: BHF-UCL
    40. response to wounding Source: Ensembl
    41. retinal ganglion cell axon guidance Source: BHF-UCL
    42. retina vasculature morphogenesis in camera-type eye Source: BHF-UCL
    43. semaphorin-plexin signaling pathway Source: BHF-UCL
    44. semaphorin-plexin signaling pathway involved in neuron projection guidance Source: BHF-UCL
    45. signal transduction Source: ProtInc
    46. sprouting angiogenesis Source: BHF-UCL
    47. sympathetic ganglion development Source: BHF-UCL
    48. sympathetic neuron projection extension Source: BHF-UCL
    49. sympathetic neuron projection guidance Source: BHF-UCL
    50. trigeminal nerve morphogenesis Source: Ensembl
    51. vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
    52. VEGF-activated neuropilin signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Angiogenesis, Differentiation, Neurogenesis

    Keywords - Ligandi

    Calcium, Heparin-binding, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_12473. Neurophilin interactions with VEGF and VEGFR.
    REACT_19199. CRMPs in Sema3A signaling.
    REACT_19236. Sema3A PAK dependent Axon repulsion.
    REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
    REACT_22272. Signal transduction by L1.
    REACT_22292. CHL1 interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropilin-1
    Alternative name(s):
    Vascular endothelial cell growth factor 165 receptor
    CD_antigen: CD304
    Gene namesi
    Name:NRP1
    Synonyms:NRP, VEGF165R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:8004. NRP1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: BHF-UCL
    2. cell surface Source: Ensembl
    3. cytoplasmic vesicle Source: BHF-UCL
    4. cytosol Source: BHF-UCL
    5. early endosome Source: BHF-UCL
    6. extracellular space Source: UniProt
    7. growth cone Source: Ensembl
    8. integral component of membrane Source: UniProtKB-KW
    9. neurofilament Source: Ensembl
    10. neuronal cell body Source: Ensembl
    11. plasma membrane Source: BHF-UCL
    12. receptor complex Source: BHF-UCL
    13. semaphorin receptor complex Source: BHF-UCL
    14. sorting endosome Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31783.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21212 PublicationsAdd
    BLAST
    Chaini22 – 923902Neuropilin-1PRO_0000021859Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 541 Publication
    Disulfide bondi82 ↔ 1041 Publication
    Disulfide bondi147 ↔ 1731 Publication
    Glycosylationi150 – 1501N-linked (GlcNAc...)3 Publications
    Disulfide bondi206 ↔ 2281 Publication
    Glycosylationi261 – 2611N-linked (GlcNAc...)2 Publications
    Disulfide bondi275 ↔ 4241 Publication
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi431 ↔ 5831 Publication
    Glycosylationi522 – 5221N-linked (GlcNAc...)1 Publication
    Glycosylationi612 – 6121O-linked (Xyl...) (chondroitin sulfate); alternate1 Publication
    Glycosylationi612 – 6121O-linked (Xyl...) (heparan sulfate); alternate1 Publication
    Glycosylationi842 – 8421N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

    Proteomic databases

    MaxQBiO14786.
    PaxDbiO14786.
    PRIDEiO14786.

    PTM databases

    PhosphoSiteiO14786.

    Miscellaneous databases

    PMAP-CutDBB0LPG9.

    Expressioni

    Tissue specificityi

    The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

    Gene expression databases

    ArrayExpressiO14786.
    BgeeiO14786.
    CleanExiHS_NRP1.
    GenevestigatoriO14786.

    Organism-specific databases

    HPAiCAB004511.
    HPA030278.

    Interactioni

    Subunit structurei

    Homodimer, and heterodimer with NRP2. Interacts with FER By similarity. Binds PLXNB1.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FLNAP213332EBI-1187100,EBI-350432
    KDRP359682EBI-1187100,EBI-1005487
    VEGFAP156924EBI-1187100,EBI-1026643
    VEGFAP15692-44EBI-6285281,EBI-1026691

    Protein-protein interaction databases

    BioGridi114356. 13 interactions.
    DIPiDIP-5743N.
    IntActiO14786. 7 interactions.
    MINTiMINT-2834207.
    STRINGi9606.ENSP00000265371.

    Structurei

    Secondary structure

    1
    923
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi149 – 1513
    Beta strandi153 – 1597
    Turni161 – 1644
    Beta strandi172 – 1787
    Helixi180 – 1823
    Beta strandi185 – 1939
    Beta strandi208 – 21710
    Turni218 – 2203
    Beta strandi223 – 2275
    Beta strandi235 – 2384
    Beta strandi240 – 2489
    Beta strandi257 – 2648
    Turni281 – 2833
    Beta strandi284 – 2863
    Helixi288 – 2903
    Beta strandi291 – 2944
    Helixi299 – 3013
    Helixi303 – 3064
    Beta strandi318 – 3236
    Beta strandi326 – 34217
    Turni347 – 3493
    Beta strandi352 – 36817
    Beta strandi369 – 3713
    Beta strandi373 – 3786
    Beta strandi385 – 3895
    Beta strandi391 – 41424
    Beta strandi417 – 4248
    Helixi426 – 4283
    Turni437 – 4393
    Helixi444 – 4463
    Beta strandi447 – 4493
    Turni450 – 4534
    Helixi459 – 4624
    Turni464 – 4663
    Beta strandi471 – 4733
    Beta strandi485 – 50218
    Turni506 – 5083
    Beta strandi515 – 52511
    Beta strandi534 – 5374
    Beta strandi544 – 5474
    Beta strandi550 – 56617
    Beta strandi570 – 5723
    Beta strandi576 – 5849

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KEXX-ray1.90A273-427[»]
    2QQIX-ray1.80A273-586[»]
    2QQMX-ray2.00A141-586[»]
    2QQNX-ray2.20A273-427[»]
    3I97X-ray2.90A/B273-427[»]
    4DEQX-ray2.65A/B274-429[»]
    ProteinModelPortaliO14786.
    SMRiO14786. Positions 25-612, 681-801.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14786.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 856835ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini880 – 92344CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei857 – 87923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 141115CUB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini147 – 265119CUB 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 424150F5/8 type C 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini431 – 583153F5/8 type C 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini645 – 811167MAMPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

    Sequence similaritiesi

    Belongs to the neuropilin family.Curated
    Contains 2 CUB domains.PROSITE-ProRule annotation
    Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
    Contains 1 MAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150941.
    HOVERGENiHBG000502.
    InParanoidiO14786.
    KOiK06724.
    OMAiYCACWHN.
    PhylomeDBiO14786.
    TreeFamiTF316506.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    2.60.120.290. 2 hits.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000859. CUB_dom.
    IPR008979. Galactose-bd-like.
    IPR000998. MAM_dom.
    IPR014648. Neuropilin.
    IPR022579. Neuropilin1_C.
    IPR027146. NRP1.
    [Graphical view]
    PANTHERiPTHR10127:SF616. PTHR10127:SF616. 1 hit.
    PfamiPF00431. CUB. 2 hits.
    PF11980. DUF3481. 1 hit.
    PF00754. F5_F8_type_C. 2 hits.
    PF00629. MAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036960. Neuropilin. 1 hit.
    PRINTSiPR00020. MAMDOMAIN.
    SMARTiSM00042. CUB. 2 hits.
    SM00231. FA58C. 2 hits.
    SM00137. MAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 2 hits.
    SSF49854. SSF49854. 2 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS01180. CUB. 2 hits.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14786-1) [UniParc]FASTAAdd to Basket

    Also known as: Membrane-bound

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP    50
    SEKCEWLIQA PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR 100
    GKFCGKIAPP PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN 150
    YTTPSGVIKS PGFPEKYPNS LECTYIVFVP KMSEIILEFE SFDLEPDSNP 200
    PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS GILSMVFYTD 250
    SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN 300
    WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK 350
    KKYYVKTYKI DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI 400
    TRFVRIKPAT WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITSS 450
    NQGDRNWMPE NIRLVTSRSG WALPPAPHSY INEWLQIDLG EEKIVRGIII 500
    QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF EGNNNYDTPE 550
    LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV 600
    DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC 650
    EFGWGSHKTF CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN 700
    QKGKVARLVS PVVYSQNSAH CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ 750
    LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI 800
    NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD KNISRKPGNV 850
    LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 900
    FELVDGVKLK KDKLNTQSTY SEA 923
    Length:923
    Mass (Da):103,134
    Last modified:September 23, 2008 - v3
    Checksum:i1EAC2FA6C8FD6A0B
    GO
    Isoform 2 (identifier: O14786-2) [UniParc]FASTAAdd to Basket

    Also known as: Soluble, SNRP1

    The sequence of this isoform differs from the canonical sequence as follows:
         642-644: EFP → GIK
         645-923: Missing.

    Show »
    Length:644
    Mass (Da):71,935
    Checksum:i1F055D9E6DD9BE70
    GO
    Isoform 3 (identifier: O14786-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         587-621: Missing.
         642-644: EFP → GIK
         645-923: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:609
    Mass (Da):68,376
    Checksum:i5CE3CEAE3CAD8CB8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261K → E in AAC51759. (PubMed:9288753)Curated
    Sequence conflicti219 – 2191D → G in CAD91133. (PubMed:17974005)Curated
    Sequence conflicti749 – 7491D → H in AAC12921. (PubMed:9529250)Curated
    Sequence conflicti855 – 8551D → E in AAC51759. (PubMed:9288753)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti179 – 1791V → A.8 Publications
    Corresponds to variant rs7079053 [ dbSNP | Ensembl ].
    VAR_046536
    Natural varianti561 – 5611F → L.
    Corresponds to variant rs2228637 [ dbSNP | Ensembl ].
    VAR_046537
    Natural varianti733 – 7331V → I.
    Corresponds to variant rs2228638 [ dbSNP | Ensembl ].
    VAR_056957

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei587 – 62135Missing in isoform 3. 1 PublicationVSP_053498Add
    BLAST
    Alternative sequencei642 – 6443EFP → GIK in isoform 2 and isoform 3. 3 PublicationsVSP_004339
    Alternative sequencei645 – 923279Missing in isoform 2 and isoform 3. 3 PublicationsVSP_004340Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018956 mRNA. Translation: AAC51759.1.
    AF016050 mRNA. Translation: AAC12921.1.
    AF145712 mRNA. Translation: AAF44344.1.
    BT006995 mRNA. Translation: AAP35641.1.
    BX510902 mRNA. Translation: CAD91133.1.
    EU332859 Genomic DNA. Translation: ABY87548.1.
    AL353600, AL121748 Genomic DNA. Translation: CAI16997.1.
    AL353600, AL121748 Genomic DNA. Translation: CAI16998.1.
    AL121748, AL353600 Genomic DNA. Translation: CAI40248.1.
    AL121748, AL353600 Genomic DNA. Translation: CAI40250.1.
    CH471072 Genomic DNA. Translation: EAW85942.1.
    CH471072 Genomic DNA. Translation: EAW85944.1.
    BC007533 mRNA. Translation: AAH07533.1.
    BC007737 mRNA. Translation: AAH07737.1.
    CCDSiCCDS31179.1. [O14786-3]
    CCDS31180.1. [O14786-2]
    CCDS7177.1. [O14786-1]
    RefSeqiNP_001019799.1. NM_001024628.2.
    NP_001019800.1. NM_001024629.2.
    NP_003864.4. NM_003873.5.
    UniGeneiHs.131704.
    Hs.653996.

    Genome annotation databases

    EnsembliENST00000265371; ENSP00000265371; ENSG00000099250. [O14786-1]
    ENST00000374821; ENSP00000363954; ENSG00000099250. [O14786-3]
    ENST00000374822; ENSP00000363955; ENSG00000099250. [O14786-2]
    ENST00000374867; ENSP00000364001; ENSG00000099250. [O14786-1]
    GeneIDi8829.
    KEGGihsa:8829.
    UCSCiuc001iwx.4. human. [O14786-1]
    uc001ixa.2. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018956 mRNA. Translation: AAC51759.1 .
    AF016050 mRNA. Translation: AAC12921.1 .
    AF145712 mRNA. Translation: AAF44344.1 .
    BT006995 mRNA. Translation: AAP35641.1 .
    BX510902 mRNA. Translation: CAD91133.1 .
    EU332859 Genomic DNA. Translation: ABY87548.1 .
    AL353600 , AL121748 Genomic DNA. Translation: CAI16997.1 .
    AL353600 , AL121748 Genomic DNA. Translation: CAI16998.1 .
    AL121748 , AL353600 Genomic DNA. Translation: CAI40248.1 .
    AL121748 , AL353600 Genomic DNA. Translation: CAI40250.1 .
    CH471072 Genomic DNA. Translation: EAW85942.1 .
    CH471072 Genomic DNA. Translation: EAW85944.1 .
    BC007533 mRNA. Translation: AAH07533.1 .
    BC007737 mRNA. Translation: AAH07737.1 .
    CCDSi CCDS31179.1. [O14786-3 ]
    CCDS31180.1. [O14786-2 ]
    CCDS7177.1. [O14786-1 ]
    RefSeqi NP_001019799.1. NM_001024628.2.
    NP_001019800.1. NM_001024629.2.
    NP_003864.4. NM_003873.5.
    UniGenei Hs.131704.
    Hs.653996.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KEX X-ray 1.90 A 273-427 [» ]
    2QQI X-ray 1.80 A 273-586 [» ]
    2QQM X-ray 2.00 A 141-586 [» ]
    2QQN X-ray 2.20 A 273-427 [» ]
    3I97 X-ray 2.90 A/B 273-427 [» ]
    4DEQ X-ray 2.65 A/B 274-429 [» ]
    ProteinModelPortali O14786.
    SMRi O14786. Positions 25-612, 681-801.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114356. 13 interactions.
    DIPi DIP-5743N.
    IntActi O14786. 7 interactions.
    MINTi MINT-2834207.
    STRINGi 9606.ENSP00000265371.

    Chemistry

    BindingDBi O14786.
    ChEMBLi CHEMBL5174.
    DrugBanki DB00039. Palifermin.
    DB04895. Pegaptanib.

    PTM databases

    PhosphoSitei O14786.

    Proteomic databases

    MaxQBi O14786.
    PaxDbi O14786.
    PRIDEi O14786.

    Protocols and materials databases

    DNASUi 8829.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265371 ; ENSP00000265371 ; ENSG00000099250 . [O14786-1 ]
    ENST00000374821 ; ENSP00000363954 ; ENSG00000099250 . [O14786-3 ]
    ENST00000374822 ; ENSP00000363955 ; ENSG00000099250 . [O14786-2 ]
    ENST00000374867 ; ENSP00000364001 ; ENSG00000099250 . [O14786-1 ]
    GeneIDi 8829.
    KEGGi hsa:8829.
    UCSCi uc001iwx.4. human. [O14786-1 ]
    uc001ixa.2. human.

    Organism-specific databases

    CTDi 8829.
    GeneCardsi GC10M033506.
    HGNCi HGNC:8004. NRP1.
    HPAi CAB004511.
    HPA030278.
    MIMi 602069. gene.
    neXtProti NX_O14786.
    PharmGKBi PA31783.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150941.
    HOVERGENi HBG000502.
    InParanoidi O14786.
    KOi K06724.
    OMAi YCACWHN.
    PhylomeDBi O14786.
    TreeFami TF316506.

    Enzyme and pathway databases

    Reactomei REACT_12473. Neurophilin interactions with VEGF and VEGFR.
    REACT_19199. CRMPs in Sema3A signaling.
    REACT_19236. Sema3A PAK dependent Axon repulsion.
    REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
    REACT_22272. Signal transduction by L1.
    REACT_22292. CHL1 interactions.

    Miscellaneous databases

    ChiTaRSi NRP1. human.
    EvolutionaryTracei O14786.
    GeneWikii Neuropilin_1.
    GenomeRNAii 8829.
    NextBioi 33134.
    PMAP-CutDB B0LPG9.
    PROi O14786.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14786.
    Bgeei O14786.
    CleanExi HS_NRP1.
    Genevestigatori O14786.

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    2.60.120.290. 2 hits.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR000859. CUB_dom.
    IPR008979. Galactose-bd-like.
    IPR000998. MAM_dom.
    IPR014648. Neuropilin.
    IPR022579. Neuropilin1_C.
    IPR027146. NRP1.
    [Graphical view ]
    PANTHERi PTHR10127:SF616. PTHR10127:SF616. 1 hit.
    Pfami PF00431. CUB. 2 hits.
    PF11980. DUF3481. 1 hit.
    PF00754. F5_F8_type_C. 2 hits.
    PF00629. MAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036960. Neuropilin. 1 hit.
    PRINTSi PR00020. MAMDOMAIN.
    SMARTi SM00042. CUB. 2 hits.
    SM00231. FA58C. 2 hits.
    SM00137. MAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 2 hits.
    SSF49854. SSF49854. 2 hits.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS01180. CUB. 2 hits.
    PS01285. FA58C_1. 2 hits.
    PS01286. FA58C_2. 2 hits.
    PS50022. FA58C_3. 2 hits.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neuropilin is a receptor for the axonal chemorepellent semaphorin III."
      He Z., Tessier-Lavigne M.
      Cell 90:739-751(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-179.
    2. "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."
      Soker S., Takashima S., Miao H.-Q., Neufeld G., Klagsbrun M.
      Cell 92:735-745(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-39, VARIANT ALA-179.
      Tissue: Mammary gland.
    3. "Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity."
      Gagnon M.L., Bielenberg D.R., Gechtman Z., Miao H.-Q., Takashima S., Soker S., Klagsbrun M.
      Proc. Natl. Acad. Sci. U.S.A. 97:2573-2578(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 22-31, VARIANT ALA-179.
      Tissue: Prostatic adenocarcinoma.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-179.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-179.
      Tissue: Skeletal muscle.
    6. SeattleSNPs variation discovery resource
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-179.
    7. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-179.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ALA-179.
      Tissue: Kidney and Muscle.
    10. "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
      Tamagnone L., Artigiani S., Chen H., He Z., Ming G.-L., Song H.-L., Chedotal A., Winberg M.L., Goodman C.S., Poo M.-M., Tessier-Lavigne M., Comoglio P.M.
      Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLXNB1.
    11. "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."
      Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G.
      J. Biol. Chem. 275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    12. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150.
      Tissue: Plasma.
    13. Cited for: GLYCOSYLATION AT SER-612.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150; ASN-261 AND ASN-522.
      Tissue: Liver.
    15. "Crystal structure of the human neuropilin-1 b1 domain."
      Lee C.C., Kreusch A., McMullan D., Ng K., Spraggon G.
      Structure 11:99-108(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 273-427.
    16. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 141-586 ALONE AND IN COMPLEX WITH ANTIBODY, GLYCOSYLATION AT ASN-150 AND ASN-261, SUBUNIT, CALCIUM-BINDING SITES, HEPARIN-BINDING, DISULFIDE BONDS.

    Entry informationi

    Entry nameiNRP1_HUMAN
    AccessioniPrimary (citable) accession number: O14786
    Secondary accession number(s): B0LPG9
    , O60461, Q5T7F1, Q5T7F2, Q5T7F3, Q86T59, Q96I90, Q96IH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 159 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3