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O14786

- NRP1_HUMAN

UniProt

O14786 - NRP1_HUMAN

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Protein

Neuropilin-1

Gene

NRP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi195 – 1951Calcium
Metal bindingi209 – 2091Calcium
Metal bindingi250 – 2501Calcium

GO - Molecular functioni

  1. coreceptor activity Source: BHF-UCL
  2. cytokine binding Source: BHF-UCL
  3. growth factor binding Source: UniProtKB
  4. heparin binding Source: UniProtKB-KW
  5. metal ion binding Source: UniProtKB-KW
  6. semaphorin receptor activity Source: BHF-UCL
  7. vascular endothelial growth factor-activated receptor activity Source: BHF-UCL
  8. vascular endothelial growth factor binding Source: BHF-UCL

GO - Biological processi

  1. angiogenesis Source: BHF-UCL
  2. angiogenesis involved in coronary vascular morphogenesis Source: BHF-UCL
  3. artery morphogenesis Source: BHF-UCL
  4. axonal fasciculation Source: Ensembl
  5. axon extension involved in axon guidance Source: BHF-UCL
  6. axon guidance Source: BHF-UCL
  7. axonogenesis involved in innervation Source: BHF-UCL
  8. branchiomotor neuron axon guidance Source: Ensembl
  9. cell adhesion Source: InterPro
  10. cell-cell signaling Source: ProtInc
  11. cell migration involved in sprouting angiogenesis Source: BHF-UCL
  12. cellular response to hepatocyte growth factor stimulus Source: BHF-UCL
  13. cellular response to vascular endothelial growth factor stimulus Source: BHF-UCL
  14. commissural neuron axon guidance Source: BHF-UCL
  15. coronary artery morphogenesis Source: Ensembl
  16. dendrite development Source: Ensembl
  17. dichotomous subdivision of terminal units involved in salivary gland branching Source: Ensembl
  18. endothelial cell chemotaxis Source: BHF-UCL
  19. endothelial tip cell fate specification Source: BHF-UCL
  20. facial nerve structural organization Source: Ensembl
  21. gonadotrophin-releasing hormone neuronal migration to the hypothalamus Source: Ensembl
  22. hepatocyte growth factor receptor signaling pathway Source: BHF-UCL
  23. negative regulation of axon extension involved in axon guidance Source: Ensembl
  24. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  25. negative regulation of neuron apoptotic process Source: Ensembl
  26. nerve development Source: BHF-UCL
  27. neural crest cell migration involved in autonomic nervous system development Source: BHF-UCL
  28. neuron migration Source: BHF-UCL
  29. organ morphogenesis Source: ProtInc
  30. patterning of blood vessels Source: BHF-UCL
  31. platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
  32. positive chemotaxis Source: BHF-UCL
  33. positive regulation of axon extension involved in axon guidance Source: BHF-UCL
  34. positive regulation of cytokine activity Source: BHF-UCL
  35. positive regulation of endothelial cell migration Source: BHF-UCL
  36. positive regulation of endothelial cell proliferation Source: BHF-UCL
  37. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  38. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  39. positive regulation of retinal ganglion cell axon guidance Source: BHF-UCL
  40. positive regulation of smooth muscle cell migration Source: BHF-UCL
  41. protein localization to early endosome Source: BHF-UCL
  42. regulation of retinal ganglion cell axon guidance Source: BHF-UCL
  43. regulation of vesicle-mediated transport Source: BHF-UCL
  44. renal artery morphogenesis Source: Ensembl
  45. response to wounding Source: Ensembl
  46. retinal ganglion cell axon guidance Source: BHF-UCL
  47. retina vasculature morphogenesis in camera-type eye Source: BHF-UCL
  48. semaphorin-plexin signaling pathway Source: BHF-UCL
  49. semaphorin-plexin signaling pathway involved in axon guidance Source: Ensembl
  50. semaphorin-plexin signaling pathway involved in neuron projection guidance Source: BHF-UCL
  51. signal transduction Source: ProtInc
  52. sprouting angiogenesis Source: BHF-UCL
  53. sympathetic ganglion development Source: BHF-UCL
  54. sympathetic neuron projection extension Source: BHF-UCL
  55. sympathetic neuron projection guidance Source: BHF-UCL
  56. trigeminal nerve structural organization Source: Ensembl
  57. vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  58. VEGF-activated neuropilin signaling pathway Source: BHF-UCL
  59. VEGF-activated neuropilin signaling pathway involved in axon guidance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Angiogenesis, Differentiation, Neurogenesis

Keywords - Ligandi

Calcium, Heparin-binding, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_12473. Neurophilin interactions with VEGF and VEGFR.
REACT_19199. CRMPs in Sema3A signaling.
REACT_19236. Sema3A PAK dependent Axon repulsion.
REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_22272. Signal transduction by L1.
REACT_22292. CHL1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin-1
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor
CD_antigen: CD304
Gene namesi
Name:NRP1
Synonyms:NRP, VEGF165R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:8004. NRP1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: BHF-UCL
  2. cell surface Source: Ensembl
  3. cytoplasmic vesicle Source: BHF-UCL
  4. cytosol Source: BHF-UCL
  5. early endosome Source: BHF-UCL
  6. extracellular space Source: UniProt
  7. focal adhesion Source: UniProtKB
  8. growth cone Source: Ensembl
  9. integral component of membrane Source: UniProtKB-KW
  10. neurofilament Source: Ensembl
  11. neuronal cell body Source: Ensembl
  12. plasma membrane Source: BHF-UCL
  13. receptor complex Source: BHF-UCL
  14. semaphorin receptor complex Source: BHF-UCL
  15. sorting endosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31783.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21212 PublicationsAdd
BLAST
Chaini22 – 923902Neuropilin-1PRO_0000021859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 541 Publication
Disulfide bondi82 ↔ 1041 Publication
Disulfide bondi147 ↔ 1731 Publication
Glycosylationi150 – 1501N-linked (GlcNAc...)3 Publications
Disulfide bondi206 ↔ 2281 Publication
Glycosylationi261 – 2611N-linked (GlcNAc...)2 Publications
Disulfide bondi275 ↔ 4241 Publication
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi431 ↔ 5831 Publication
Glycosylationi522 – 5221N-linked (GlcNAc...)1 Publication
Glycosylationi612 – 6121O-linked (Xyl...) (chondroitin sulfate); alternate1 Publication
Glycosylationi612 – 6121O-linked (Xyl...) (heparan sulfate); alternate1 Publication
Glycosylationi842 – 8421N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

MaxQBiO14786.
PaxDbiO14786.
PRIDEiO14786.

PTM databases

PhosphoSiteiO14786.

Miscellaneous databases

PMAP-CutDBB0LPG9.

Expressioni

Tissue specificityi

The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Gene expression databases

BgeeiO14786.
CleanExiHS_NRP1.
ExpressionAtlasiO14786. baseline and differential.
GenevestigatoriO14786.

Organism-specific databases

HPAiCAB004511.
HPA030278.

Interactioni

Subunit structurei

Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNAP213332EBI-1187100,EBI-350432
KDRP359682EBI-1187100,EBI-1005487
VEGFAP156924EBI-1187100,EBI-1026643
VEGFAP15692-44EBI-6285281,EBI-1026691

Protein-protein interaction databases

BioGridi114356. 21 interactions.
DIPiDIP-5743N.
IntActiO14786. 7 interactions.
MINTiMINT-2834207.
STRINGi9606.ENSP00000265371.

Structurei

Secondary structure

1
923
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi149 – 1513Combined sources
Beta strandi153 – 1597Combined sources
Turni161 – 1644Combined sources
Beta strandi172 – 1787Combined sources
Helixi180 – 1823Combined sources
Beta strandi185 – 1939Combined sources
Beta strandi208 – 21710Combined sources
Turni218 – 2203Combined sources
Beta strandi223 – 2275Combined sources
Beta strandi235 – 2384Combined sources
Beta strandi240 – 2489Combined sources
Beta strandi257 – 2648Combined sources
Turni281 – 2833Combined sources
Beta strandi284 – 2863Combined sources
Helixi288 – 2903Combined sources
Beta strandi291 – 2944Combined sources
Helixi299 – 3013Combined sources
Helixi303 – 3064Combined sources
Beta strandi318 – 3236Combined sources
Beta strandi326 – 34217Combined sources
Turni347 – 3493Combined sources
Beta strandi352 – 36817Combined sources
Beta strandi369 – 3713Combined sources
Beta strandi373 – 3786Combined sources
Beta strandi385 – 3895Combined sources
Beta strandi391 – 41424Combined sources
Beta strandi417 – 4248Combined sources
Helixi426 – 4283Combined sources
Turni437 – 4393Combined sources
Helixi444 – 4463Combined sources
Beta strandi447 – 4493Combined sources
Turni450 – 4534Combined sources
Helixi459 – 4624Combined sources
Turni464 – 4663Combined sources
Beta strandi471 – 4733Combined sources
Beta strandi485 – 50218Combined sources
Turni506 – 5083Combined sources
Beta strandi515 – 52511Combined sources
Beta strandi534 – 5374Combined sources
Beta strandi544 – 5474Combined sources
Beta strandi550 – 56617Combined sources
Beta strandi570 – 5723Combined sources
Beta strandi576 – 5849Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KEXX-ray1.90A273-427[»]
2QQIX-ray1.80A273-586[»]
2QQMX-ray2.00A141-586[»]
2QQNX-ray2.20A273-427[»]
3I97X-ray2.90A/B273-427[»]
4DEQX-ray2.65A/B274-429[»]
ProteinModelPortaliO14786.
SMRiO14786. Positions 25-612, 681-801.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14786.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 856835ExtracellularSequence AnalysisAdd
BLAST
Topological domaini880 – 92344CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei857 – 87923HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 141115CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini147 – 265119CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 424150F5/8 type C 1PROSITE-ProRule annotationAdd
BLAST
Domaini431 – 583153F5/8 type C 2PROSITE-ProRule annotationAdd
BLAST
Domaini645 – 811167MAMPROSITE-ProRule annotationAdd
BLAST

Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

Sequence similaritiesi

Belongs to the neuropilin family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150941.
GeneTreeiENSGT00760000119073.
HOVERGENiHBG000502.
InParanoidiO14786.
KOiK06724.
OMAiYCACWHN.
PhylomeDBiO14786.
TreeFamiTF316506.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin1_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF616. PTHR10127:SF616. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14786-1) [UniParc]FASTAAdd to Basket

Also known as: Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP
60 70 80 90 100
SEKCEWLIQA PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR
110 120 130 140 150
GKFCGKIAPP PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN
160 170 180 190 200
YTTPSGVIKS PGFPEKYPNS LECTYIVFVP KMSEIILEFE SFDLEPDSNP
210 220 230 240 250
PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS GILSMVFYTD
260 270 280 290 300
SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN
310 320 330 340 350
WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK
360 370 380 390 400
KKYYVKTYKI DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI
410 420 430 440 450
TRFVRIKPAT WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITSS
460 470 480 490 500
NQGDRNWMPE NIRLVTSRSG WALPPAPHSY INEWLQIDLG EEKIVRGIII
510 520 530 540 550
QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF EGNNNYDTPE
560 570 580 590 600
LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV
610 620 630 640 650
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC
660 670 680 690 700
EFGWGSHKTF CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN
710 720 730 740 750
QKGKVARLVS PVVYSQNSAH CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ
760 770 780 790 800
LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI
810 820 830 840 850
NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD KNISRKPGNV
860 870 880 890 900
LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN
910 920
FELVDGVKLK KDKLNTQSTY SEA
Length:923
Mass (Da):103,134
Last modified:September 23, 2008 - v3
Checksum:i1EAC2FA6C8FD6A0B
GO
Isoform 2 (identifier: O14786-2) [UniParc]FASTAAdd to Basket

Also known as: Soluble, SNRP1

The sequence of this isoform differs from the canonical sequence as follows:
     642-644: EFP → GIK
     645-923: Missing.

Show »
Length:644
Mass (Da):71,935
Checksum:i1F055D9E6DD9BE70
GO
Isoform 3 (identifier: O14786-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     587-621: Missing.
     642-644: EFP → GIK
     645-923: Missing.

Note: No experimental confirmation available.

Show »
Length:609
Mass (Da):68,376
Checksum:i5CE3CEAE3CAD8CB8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261K → E in AAC51759. (PubMed:9288753)Curated
Sequence conflicti219 – 2191D → G in CAD91133. (PubMed:17974005)Curated
Sequence conflicti749 – 7491D → H in AAC12921. (PubMed:9529250)Curated
Sequence conflicti855 – 8551D → E in AAC51759. (PubMed:9288753)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791V → A.8 Publications
Corresponds to variant rs7079053 [ dbSNP | Ensembl ].
VAR_046536
Natural varianti561 – 5611F → L.
Corresponds to variant rs2228637 [ dbSNP | Ensembl ].
VAR_046537
Natural varianti733 – 7331V → I.
Corresponds to variant rs2228638 [ dbSNP | Ensembl ].
VAR_056957

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei587 – 62135Missing in isoform 3. 1 PublicationVSP_053498Add
BLAST
Alternative sequencei642 – 6443EFP → GIK in isoform 2 and isoform 3. 3 PublicationsVSP_004339
Alternative sequencei645 – 923279Missing in isoform 2 and isoform 3. 3 PublicationsVSP_004340Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF018956 mRNA. Translation: AAC51759.1.
AF016050 mRNA. Translation: AAC12921.1.
AF145712 mRNA. Translation: AAF44344.1.
BT006995 mRNA. Translation: AAP35641.1.
BX510902 mRNA. Translation: CAD91133.1.
EU332859 Genomic DNA. Translation: ABY87548.1.
AL353600, AL121748 Genomic DNA. Translation: CAI16997.1.
AL353600, AL121748 Genomic DNA. Translation: CAI16998.1.
AL121748, AL353600 Genomic DNA. Translation: CAI40248.1.
AL121748, AL353600 Genomic DNA. Translation: CAI40250.1.
CH471072 Genomic DNA. Translation: EAW85942.1.
CH471072 Genomic DNA. Translation: EAW85944.1.
BC007533 mRNA. Translation: AAH07533.1.
BC007737 mRNA. Translation: AAH07737.1.
CCDSiCCDS31179.1. [O14786-3]
CCDS31180.1. [O14786-2]
CCDS7177.1. [O14786-1]
RefSeqiNP_001019799.1. NM_001024628.2.
NP_001019800.1. NM_001024629.2.
NP_003864.4. NM_003873.5.
UniGeneiHs.131704.
Hs.653996.

Genome annotation databases

EnsembliENST00000265371; ENSP00000265371; ENSG00000099250. [O14786-1]
ENST00000374821; ENSP00000363954; ENSG00000099250. [O14786-3]
ENST00000374822; ENSP00000363955; ENSG00000099250. [O14786-2]
ENST00000374867; ENSP00000364001; ENSG00000099250. [O14786-1]
GeneIDi8829.
KEGGihsa:8829.
UCSCiuc001iwx.4. human. [O14786-1]
uc001ixa.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF018956 mRNA. Translation: AAC51759.1 .
AF016050 mRNA. Translation: AAC12921.1 .
AF145712 mRNA. Translation: AAF44344.1 .
BT006995 mRNA. Translation: AAP35641.1 .
BX510902 mRNA. Translation: CAD91133.1 .
EU332859 Genomic DNA. Translation: ABY87548.1 .
AL353600 , AL121748 Genomic DNA. Translation: CAI16997.1 .
AL353600 , AL121748 Genomic DNA. Translation: CAI16998.1 .
AL121748 , AL353600 Genomic DNA. Translation: CAI40248.1 .
AL121748 , AL353600 Genomic DNA. Translation: CAI40250.1 .
CH471072 Genomic DNA. Translation: EAW85942.1 .
CH471072 Genomic DNA. Translation: EAW85944.1 .
BC007533 mRNA. Translation: AAH07533.1 .
BC007737 mRNA. Translation: AAH07737.1 .
CCDSi CCDS31179.1. [O14786-3 ]
CCDS31180.1. [O14786-2 ]
CCDS7177.1. [O14786-1 ]
RefSeqi NP_001019799.1. NM_001024628.2.
NP_001019800.1. NM_001024629.2.
NP_003864.4. NM_003873.5.
UniGenei Hs.131704.
Hs.653996.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KEX X-ray 1.90 A 273-427 [» ]
2QQI X-ray 1.80 A 273-586 [» ]
2QQM X-ray 2.00 A 141-586 [» ]
2QQN X-ray 2.20 A 273-427 [» ]
3I97 X-ray 2.90 A/B 273-427 [» ]
4DEQ X-ray 2.65 A/B 274-429 [» ]
ProteinModelPortali O14786.
SMRi O14786. Positions 25-612, 681-801.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114356. 21 interactions.
DIPi DIP-5743N.
IntActi O14786. 7 interactions.
MINTi MINT-2834207.
STRINGi 9606.ENSP00000265371.

Chemistry

BindingDBi O14786.
ChEMBLi CHEMBL5174.
DrugBanki DB00039. Palifermin.
DB04895. Pegaptanib.

PTM databases

PhosphoSitei O14786.

Proteomic databases

MaxQBi O14786.
PaxDbi O14786.
PRIDEi O14786.

Protocols and materials databases

DNASUi 8829.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265371 ; ENSP00000265371 ; ENSG00000099250 . [O14786-1 ]
ENST00000374821 ; ENSP00000363954 ; ENSG00000099250 . [O14786-3 ]
ENST00000374822 ; ENSP00000363955 ; ENSG00000099250 . [O14786-2 ]
ENST00000374867 ; ENSP00000364001 ; ENSG00000099250 . [O14786-1 ]
GeneIDi 8829.
KEGGi hsa:8829.
UCSCi uc001iwx.4. human. [O14786-1 ]
uc001ixa.2. human.

Organism-specific databases

CTDi 8829.
GeneCardsi GC10M033466.
HGNCi HGNC:8004. NRP1.
HPAi CAB004511.
HPA030278.
MIMi 602069. gene.
neXtProti NX_O14786.
PharmGKBi PA31783.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150941.
GeneTreei ENSGT00760000119073.
HOVERGENi HBG000502.
InParanoidi O14786.
KOi K06724.
OMAi YCACWHN.
PhylomeDBi O14786.
TreeFami TF316506.

Enzyme and pathway databases

Reactomei REACT_12473. Neurophilin interactions with VEGF and VEGFR.
REACT_19199. CRMPs in Sema3A signaling.
REACT_19236. Sema3A PAK dependent Axon repulsion.
REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_22272. Signal transduction by L1.
REACT_22292. CHL1 interactions.

Miscellaneous databases

ChiTaRSi NRP1. human.
EvolutionaryTracei O14786.
GeneWikii Neuropilin_1.
GenomeRNAii 8829.
NextBioi 33134.
PMAP-CutDB B0LPG9.
PROi O14786.
SOURCEi Search...

Gene expression databases

Bgeei O14786.
CleanExi HS_NRP1.
ExpressionAtlasi O14786. baseline and differential.
Genevestigatori O14786.

Family and domain databases

Gene3Di 2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin1_C.
IPR027146. NRP1.
[Graphical view ]
PANTHERi PTHR10127:SF616. PTHR10127:SF616. 1 hit.
Pfami PF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF036960. Neuropilin. 1 hit.
PRINTSi PR00020. MAMDOMAIN.
SMARTi SM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEi PS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neuropilin is a receptor for the axonal chemorepellent semaphorin III."
    He Z., Tessier-Lavigne M.
    Cell 90:739-751(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-179.
  2. "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."
    Soker S., Takashima S., Miao H.-Q., Neufeld G., Klagsbrun M.
    Cell 92:735-745(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-39, VARIANT ALA-179.
    Tissue: Mammary gland.
  3. "Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity."
    Gagnon M.L., Bielenberg D.R., Gechtman Z., Miao H.-Q., Takashima S., Soker S., Klagsbrun M.
    Proc. Natl. Acad. Sci. U.S.A. 97:2573-2578(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 22-31, VARIANT ALA-179.
    Tissue: Prostatic adenocarcinoma.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-179.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-179.
    Tissue: Skeletal muscle.
  6. SeattleSNPs variation discovery resource
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-179.
  7. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-179.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ALA-179.
    Tissue: Kidney and Muscle.
  10. "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
    Tamagnone L., Artigiani S., Chen H., He Z., Ming G.-L., Song H.-L., Chedotal A., Winberg M.L., Goodman C.S., Poo M.-M., Tessier-Lavigne M., Comoglio P.M.
    Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLXNB1.
  11. "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."
    Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G.
    J. Biol. Chem. 275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  12. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150.
    Tissue: Plasma.
  13. Cited for: GLYCOSYLATION AT SER-612.
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150; ASN-261 AND ASN-522.
    Tissue: Liver.
  15. "Crystal structure of the human neuropilin-1 b1 domain."
    Lee C.C., Kreusch A., McMullan D., Ng K., Spraggon G.
    Structure 11:99-108(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 273-427.
  16. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 141-586 ALONE AND IN COMPLEX WITH ANTIBODY, GLYCOSYLATION AT ASN-150 AND ASN-261, SUBUNIT, CALCIUM-BINDING SITES, HEPARIN-BINDING, DISULFIDE BONDS.

Entry informationi

Entry nameiNRP1_HUMAN
AccessioniPrimary (citable) accession number: O14786
Secondary accession number(s): B0LPG9
, O60461, Q5T7F1, Q5T7F2, Q5T7F3, Q86T59, Q96I90, Q96IH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 160 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3