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Protein

Neuropilin-1

Gene

NRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi195CalciumCombined sources1 Publication1
Metal bindingi209CalciumCombined sources1 Publication1
Metal bindingi250CalciumCombined sources1 Publication1

GO - Molecular functioni

  • coreceptor activity Source: BHF-UCL
  • cytokine binding Source: BHF-UCL
  • growth factor binding Source: UniProtKB
  • heparin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • semaphorin receptor activity Source: BHF-UCL
  • vascular endothelial growth factor-activated receptor activity Source: BHF-UCL
  • vascular endothelial growth factor binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Angiogenesis, Differentiation, Neurogenesis

Keywords - Ligandi

Calcium, Heparin-binding, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099250-MONOMER.
ReactomeiR-HSA-194306. Neurophilin interactions with VEGF and VEGFR.
R-HSA-399954. Sema3A PAK dependent Axon repulsion.
R-HSA-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-HSA-399956. CRMPs in Sema3A signaling.
R-HSA-445144. Signal transduction by L1.
R-HSA-447041. CHL1 interactions.
SIGNORiO14786.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin-1
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor
CD_antigen: CD304
Gene namesi
Name:NRP1
Synonyms:NRP, VEGF165R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:8004. NRP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 856ExtracellularSequence analysisAdd BLAST835
Transmembranei857 – 879HelicalSequence analysisAdd BLAST23
Topological domaini880 – 923CytoplasmicSequence analysisAdd BLAST44

GO - Cellular componenti

  • axon Source: BHF-UCL
  • cell surface Source: Ensembl
  • cytoplasmic vesicle Source: BHF-UCL
  • cytosol Source: BHF-UCL
  • early endosome Source: BHF-UCL
  • extracellular space Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • growth cone Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • neurofilament Source: Ensembl
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: BHF-UCL
  • receptor complex Source: BHF-UCL
  • semaphorin receptor complex Source: BHF-UCL
  • sorting endosome Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8829.
OpenTargetsiENSG00000099250.
PharmGKBiPA31783.

Chemistry databases

ChEMBLiCHEMBL5174.
DrugBankiDB00039. Palifermin.
DB04895. Pegaptanib.

Polymorphism and mutation databases

BioMutaiNRP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 212 PublicationsAdd BLAST21
ChainiPRO_000002185922 – 923Neuropilin-1Add BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 541 Publication
Disulfide bondi82 ↔ 1041 Publication
Disulfide bondi147 ↔ 1731 Publication
Glycosylationi150N-linked (GlcNAc...)3 Publications1
Disulfide bondi206 ↔ 2281 Publication
Glycosylationi261N-linked (GlcNAc...)2 Publications1
Disulfide bondi275 ↔ 4241 Publication
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi431 ↔ 5831 Publication
Glycosylationi522N-linked (GlcNAc...)1 Publication1
Glycosylationi612O-linked (Xyl...) (chondroitin sulfate); alternate1 Publication1
Glycosylationi612O-linked (Xyl...) (heparan sulfate); alternate1 Publication1
Glycosylationi842N-linked (GlcNAc...)Sequence analysis1
Modified residuei894PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

EPDiO14786.
MaxQBiO14786.
PaxDbiO14786.
PeptideAtlasiO14786.
PRIDEiO14786.

PTM databases

iPTMnetiO14786.
PhosphoSitePlusiO14786.
SwissPalmiO14786.

Miscellaneous databases

PMAP-CutDBB0LPG9.

Expressioni

Tissue specificityi

The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Gene expression databases

BgeeiENSG00000099250.
CleanExiHS_NRP1.
ExpressionAtlasiO14786. baseline and differential.
GenevisibleiO14786. HS.

Organism-specific databases

HPAiCAB004511.
HPA030278.

Interactioni

Subunit structurei

Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNAP213332EBI-1187100,EBI-350432
KDRP359682EBI-1187100,EBI-1005487
VEGFAP156924EBI-1187100,EBI-1026643
VEGFAP15692-44EBI-6285281,EBI-1026691

GO - Molecular functioni

  • cytokine binding Source: BHF-UCL
  • growth factor binding Source: UniProtKB
  • vascular endothelial growth factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114356. 42 interactors.
DIPiDIP-5743N.
IntActiO14786. 7 interactors.
MINTiMINT-2834207.
STRINGi9606.ENSP00000265371.

Chemistry databases

BindingDBiO14786.

Structurei

Secondary structure

1923
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi149 – 151Combined sources3
Beta strandi153 – 159Combined sources7
Turni161 – 164Combined sources4
Beta strandi172 – 178Combined sources7
Helixi180 – 182Combined sources3
Beta strandi185 – 193Combined sources9
Beta strandi208 – 217Combined sources10
Turni218 – 220Combined sources3
Beta strandi223 – 227Combined sources5
Beta strandi235 – 238Combined sources4
Beta strandi240 – 248Combined sources9
Beta strandi257 – 264Combined sources8
Turni273 – 275Combined sources3
Turni281 – 283Combined sources3
Beta strandi284 – 286Combined sources3
Helixi288 – 290Combined sources3
Beta strandi291 – 294Combined sources4
Helixi299 – 301Combined sources3
Helixi303 – 306Combined sources4
Beta strandi318 – 323Combined sources6
Beta strandi326 – 342Combined sources17
Turni347 – 349Combined sources3
Beta strandi352 – 367Combined sources16
Beta strandi369 – 371Combined sources3
Beta strandi373 – 378Combined sources6
Beta strandi385 – 389Combined sources5
Beta strandi391 – 414Combined sources24
Beta strandi417 – 424Combined sources8
Helixi426 – 428Combined sources3
Turni437 – 439Combined sources3
Helixi444 – 446Combined sources3
Beta strandi447 – 449Combined sources3
Turni450 – 453Combined sources4
Helixi459 – 462Combined sources4
Turni464 – 466Combined sources3
Beta strandi471 – 473Combined sources3
Beta strandi485 – 502Combined sources18
Turni506 – 508Combined sources3
Beta strandi515 – 525Combined sources11
Beta strandi534 – 537Combined sources4
Beta strandi544 – 547Combined sources4
Beta strandi550 – 566Combined sources17
Beta strandi570 – 572Combined sources3
Beta strandi576 – 584Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KEXX-ray1.90A273-427[»]
2QQIX-ray1.80A273-586[»]
2QQMX-ray2.00A141-586[»]
2QQNX-ray2.20A273-427[»]
3I97X-ray2.90A/B273-427[»]
4DEQX-ray2.65A/B274-429[»]
4RN5X-ray1.73A273-427[»]
5C7GX-ray1.45A273-427[»]
ProteinModelPortaliO14786.
SMRiO14786.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14786.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 141CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini147 – 265CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini275 – 424F5/8 type C 1PROSITE-ProRule annotationAdd BLAST150
Domaini431 – 583F5/8 type C 2PROSITE-ProRule annotationAdd BLAST153
Domaini645 – 811MAMPROSITE-ProRule annotationAdd BLAST167

Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

Sequence similaritiesi

Belongs to the neuropilin family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8T. Eukaryota.
ENOG410YRBE. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000039978.
HOVERGENiHBG000502.
InParanoidiO14786.
KOiK06724.
OMAiYCACWHN.
OrthoDBiEOG091G017M.
PhylomeDBiO14786.
TreeFamiTF316506.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF654. PTHR10127:SF654. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14786-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP
60 70 80 90 100
SEKCEWLIQA PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR
110 120 130 140 150
GKFCGKIAPP PVVSSGPFLF IKFVSDYETH GAGFSIRYEI FKRGPECSQN
160 170 180 190 200
YTTPSGVIKS PGFPEKYPNS LECTYIVFVP KMSEIILEFE SFDLEPDSNP
210 220 230 240 250
PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS GILSMVFYTD
260 270 280 290 300
SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN
310 320 330 340 350
WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK
360 370 380 390 400
KKYYVKTYKI DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI
410 420 430 440 450
TRFVRIKPAT WETGISMRFE VYGCKITDYP CSGMLGMVSG LISDSQITSS
460 470 480 490 500
NQGDRNWMPE NIRLVTSRSG WALPPAPHSY INEWLQIDLG EEKIVRGIII
510 520 530 540 550
QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF EGNNNYDTPE
560 570 580 590 600
LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV
610 620 630 640 650
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC
660 670 680 690 700
EFGWGSHKTF CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN
710 720 730 740 750
QKGKVARLVS PVVYSQNSAH CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ
760 770 780 790 800
LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI FEGEIGKGNL GGIAVDDISI
810 820 830 840 850
NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD KNISRKPGNV
860 870 880 890 900
LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN
910 920
FELVDGVKLK KDKLNTQSTY SEA
Length:923
Mass (Da):103,134
Last modified:September 23, 2008 - v3
Checksum:i1EAC2FA6C8FD6A0B
GO
Isoform 2 (identifier: O14786-2) [UniParc]FASTAAdd to basket
Also known as: Soluble, SNRP1

The sequence of this isoform differs from the canonical sequence as follows:
     642-644: EFP → GIK
     645-923: Missing.

Show »
Length:644
Mass (Da):71,935
Checksum:i1F055D9E6DD9BE70
GO
Isoform 3 (identifier: O14786-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     587-621: Missing.
     642-644: EFP → GIK
     645-923: Missing.

Note: No experimental confirmation available.
Show »
Length:609
Mass (Da):68,376
Checksum:i5CE3CEAE3CAD8CB8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26K → E in AAC51759 (PubMed:9288753).Curated1
Sequence conflicti219D → G in CAD91133 (PubMed:17974005).Curated1
Sequence conflicti749D → H in AAC12921 (PubMed:9529250).Curated1
Sequence conflicti855D → E in AAC51759 (PubMed:9288753).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046536179V → A.8 PublicationsCorresponds to variant rs7079053dbSNPEnsembl.1
Natural variantiVAR_046537561F → L.Corresponds to variant rs2228637dbSNPEnsembl.1
Natural variantiVAR_056957733V → I.Corresponds to variant rs2228638dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053498587 – 621Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_004339642 – 644EFP → GIK in isoform 2 and isoform 3. 3 Publications3
Alternative sequenceiVSP_004340645 – 923Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST279

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018956 mRNA. Translation: AAC51759.1.
AF016050 mRNA. Translation: AAC12921.1.
AF145712 mRNA. Translation: AAF44344.1.
BT006995 mRNA. Translation: AAP35641.1.
BX510902 mRNA. Translation: CAD91133.1.
EU332859 Genomic DNA. Translation: ABY87548.1.
AL353600, AL121748 Genomic DNA. Translation: CAI16997.1.
AL353600, AL121748 Genomic DNA. Translation: CAI16998.1.
AL121748, AL353600 Genomic DNA. Translation: CAI40248.1.
AL121748, AL353600 Genomic DNA. Translation: CAI40250.1.
CH471072 Genomic DNA. Translation: EAW85942.1.
CH471072 Genomic DNA. Translation: EAW85944.1.
BC007533 mRNA. Translation: AAH07533.1.
BC007737 mRNA. Translation: AAH07737.1.
CCDSiCCDS31179.1. [O14786-3]
CCDS31180.1. [O14786-2]
CCDS7177.1. [O14786-1]
RefSeqiNP_001019799.1. NM_001024628.2.
NP_001019800.1. NM_001024629.2.
NP_001316997.1. NM_001330068.1.
NP_003864.4. NM_003873.5.
UniGeneiHs.131704.
Hs.653996.

Genome annotation databases

EnsembliENST00000265371; ENSP00000265371; ENSG00000099250. [O14786-1]
ENST00000374821; ENSP00000363954; ENSG00000099250. [O14786-3]
ENST00000374822; ENSP00000363955; ENSG00000099250. [O14786-2]
ENST00000374867; ENSP00000364001; ENSG00000099250. [O14786-1]
GeneIDi8829.
KEGGihsa:8829.
UCSCiuc001iwx.5. human. [O14786-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018956 mRNA. Translation: AAC51759.1.
AF016050 mRNA. Translation: AAC12921.1.
AF145712 mRNA. Translation: AAF44344.1.
BT006995 mRNA. Translation: AAP35641.1.
BX510902 mRNA. Translation: CAD91133.1.
EU332859 Genomic DNA. Translation: ABY87548.1.
AL353600, AL121748 Genomic DNA. Translation: CAI16997.1.
AL353600, AL121748 Genomic DNA. Translation: CAI16998.1.
AL121748, AL353600 Genomic DNA. Translation: CAI40248.1.
AL121748, AL353600 Genomic DNA. Translation: CAI40250.1.
CH471072 Genomic DNA. Translation: EAW85942.1.
CH471072 Genomic DNA. Translation: EAW85944.1.
BC007533 mRNA. Translation: AAH07533.1.
BC007737 mRNA. Translation: AAH07737.1.
CCDSiCCDS31179.1. [O14786-3]
CCDS31180.1. [O14786-2]
CCDS7177.1. [O14786-1]
RefSeqiNP_001019799.1. NM_001024628.2.
NP_001019800.1. NM_001024629.2.
NP_001316997.1. NM_001330068.1.
NP_003864.4. NM_003873.5.
UniGeneiHs.131704.
Hs.653996.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KEXX-ray1.90A273-427[»]
2QQIX-ray1.80A273-586[»]
2QQMX-ray2.00A141-586[»]
2QQNX-ray2.20A273-427[»]
3I97X-ray2.90A/B273-427[»]
4DEQX-ray2.65A/B274-429[»]
4RN5X-ray1.73A273-427[»]
5C7GX-ray1.45A273-427[»]
ProteinModelPortaliO14786.
SMRiO14786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114356. 42 interactors.
DIPiDIP-5743N.
IntActiO14786. 7 interactors.
MINTiMINT-2834207.
STRINGi9606.ENSP00000265371.

Chemistry databases

BindingDBiO14786.
ChEMBLiCHEMBL5174.
DrugBankiDB00039. Palifermin.
DB04895. Pegaptanib.

PTM databases

iPTMnetiO14786.
PhosphoSitePlusiO14786.
SwissPalmiO14786.

Polymorphism and mutation databases

BioMutaiNRP1.

Proteomic databases

EPDiO14786.
MaxQBiO14786.
PaxDbiO14786.
PeptideAtlasiO14786.
PRIDEiO14786.

Protocols and materials databases

DNASUi8829.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265371; ENSP00000265371; ENSG00000099250. [O14786-1]
ENST00000374821; ENSP00000363954; ENSG00000099250. [O14786-3]
ENST00000374822; ENSP00000363955; ENSG00000099250. [O14786-2]
ENST00000374867; ENSP00000364001; ENSG00000099250. [O14786-1]
GeneIDi8829.
KEGGihsa:8829.
UCSCiuc001iwx.5. human. [O14786-1]

Organism-specific databases

CTDi8829.
DisGeNETi8829.
GeneCardsiNRP1.
HGNCiHGNC:8004. NRP1.
HPAiCAB004511.
HPA030278.
MIMi602069. gene.
neXtProtiNX_O14786.
OpenTargetsiENSG00000099250.
PharmGKBiPA31783.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8T. Eukaryota.
ENOG410YRBE. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000039978.
HOVERGENiHBG000502.
InParanoidiO14786.
KOiK06724.
OMAiYCACWHN.
OrthoDBiEOG091G017M.
PhylomeDBiO14786.
TreeFamiTF316506.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000099250-MONOMER.
ReactomeiR-HSA-194306. Neurophilin interactions with VEGF and VEGFR.
R-HSA-399954. Sema3A PAK dependent Axon repulsion.
R-HSA-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-HSA-399956. CRMPs in Sema3A signaling.
R-HSA-445144. Signal transduction by L1.
R-HSA-447041. CHL1 interactions.
SIGNORiO14786.

Miscellaneous databases

ChiTaRSiNRP1. human.
EvolutionaryTraceiO14786.
GeneWikiiNeuropilin_1.
GenomeRNAii8829.
PMAP-CutDBB0LPG9.
PROiO14786.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099250.
CleanExiHS_NRP1.
ExpressionAtlasiO14786. baseline and differential.
GenevisibleiO14786. HS.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF654. PTHR10127:SF654. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]
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Entry informationi

Entry nameiNRP1_HUMAN
AccessioniPrimary (citable) accession number: O14786
Secondary accession number(s): B0LPG9
, O60461, Q5T7F1, Q5T7F2, Q5T7F3, Q86T59, Q96I90, Q96IH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 181 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.