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O14786 (NRP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 154. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropilin-1
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor
CD_antigen=CD304
Gene names
Name:NRP1
Synonyms:NRP, VEGF165R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length923 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform ofPGF, The VEGF-165 isoform ofVEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.

The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Subunit structure

Homodimer, and heterodimer with NRP2. Interacts with FER By similarity. Binds PLXNB1. Ref.10 Ref.16

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Isoform 2: Secreted.

Tissue specificity

The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Domain

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

Sequence similarities

Belongs to the neuropilin family.

Contains 2 CUB domains.

Contains 2 F5/8 type C domains.

Contains 1 MAM domain.

Ontologies

Keywords
   Biological processAngiogenesis
Differentiation
Neurogenesis
   Cellular componentCell membrane
Membrane
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Heparin-binding
Metal-binding
   Molecular functionDevelopmental protein
Receptor
   PTMDisulfide bond
Glycoprotein
Heparan sulfate
Proteoglycan
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processaxon extension involved in axon guidance

Inferred from sequence or structural similarity. Source: BHF-UCL

axon guidance

Non-traceable author statement PubMed 19909241. Source: BHF-UCL

axonal fasciculation

Inferred from electronic annotation. Source: Ensembl

axonogenesis involved in innervation

Inferred from sequence or structural similarity. Source: BHF-UCL

cell adhesion

Inferred from electronic annotation. Source: InterPro

cell migration involved in sprouting angiogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

cell-cell signaling

Traceable author statement Ref.1. Source: ProtInc

cellular response to hepatocyte growth factor stimulus

Inferred from mutant phenotype PubMed 21245381. Source: BHF-UCL

commissural neuron axon guidance

Inferred from sequence or structural similarity. Source: BHF-UCL

dendrite development

Inferred from electronic annotation. Source: Ensembl

dichotomous subdivision of terminal units involved in salivary gland branching

Inferred from electronic annotation. Source: Ensembl

endothelial cell chemotaxis

Inferred from mutant phenotype PubMed 21245381. Source: BHF-UCL

endothelial tip cell fate specification

Inferred from sequence or structural similarity. Source: BHF-UCL

heart development

Inferred from electronic annotation. Source: Ensembl

hepatocyte growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 21245381. Source: BHF-UCL

negative regulation of axon extension involved in axon guidance

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

nerve development

Inferred from sequence or structural similarity. Source: BHF-UCL

neuron migration

Inferred from sequence or structural similarity. Source: BHF-UCL

organ morphogenesis

Traceable author statement Ref.2. Source: ProtInc

patterning of blood vessels

Inferred from sequence or structural similarity. Source: BHF-UCL

platelet-derived growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 21245381. Source: BHF-UCL

positive chemotaxis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of axon extension involved in axon guidance

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of cytokine activity

Traceable author statement PubMed 21245381. Source: BHF-UCL

positive regulation of endothelial cell migration

Traceable author statement PubMed 21245381. Source: BHF-UCL

positive regulation of endothelial cell proliferation

Traceable author statement PubMed 21245381. Source: BHF-UCL

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from mutant phenotype PubMed 21245381. Source: BHF-UCL

positive regulation of retinal ganglion cell axon guidance

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of smooth muscle cell migration

Traceable author statement PubMed 21245381. Source: BHF-UCL

regulation of retinal ganglion cell axon guidance

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of vesicle-mediated transport

Traceable author statement PubMed 21245381. Source: BHF-UCL

response to wounding

Inferred from electronic annotation. Source: Ensembl

retinal ganglion cell axon guidance

Inferred from sequence or structural similarity. Source: BHF-UCL

semaphorin-plexin signaling pathway

Non-traceable author statement PubMed 19909241. Source: BHF-UCL

semaphorin-plexin signaling pathway involved in neuron projection guidance

Inferred from sequence or structural similarity. Source: BHF-UCL

signal transduction

Traceable author statement Ref.1. Source: ProtInc

sympathetic ganglion development

Inferred from sequence or structural similarity. Source: BHF-UCL

sympathetic neuron projection extension

Inferred from sequence or structural similarity. Source: BHF-UCL

sympathetic neuron projection guidance

Inferred from sequence or structural similarity. Source: BHF-UCL

trigeminal nerve morphogenesis

Inferred from electronic annotation. Source: Ensembl

vascular endothelial growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 21245381. Source: BHF-UCL

   Cellular_componentaxon

Inferred from sequence or structural similarity. Source: BHF-UCL

cell surface

Inferred from electronic annotation. Source: Ensembl

cytoplasmic vesicle

Traceable author statement PubMed 21245381. Source: BHF-UCL

cytosol

Inferred from direct assay PubMed 21245381. Source: BHF-UCL

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

growth cone

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neurofilament

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 21245381. Source: BHF-UCL

receptor complex

Traceable author statement PubMed 21245381. Source: BHF-UCL

semaphorin receptor complex

Non-traceable author statement PubMed 19909241. Source: BHF-UCL

   Molecular_functioncoreceptor activity

Traceable author statement PubMed 21245381. Source: BHF-UCL

cytokine binding

Non-traceable author statement PubMed 19909241. Source: BHF-UCL

growth factor binding

Inferred from physical interaction Ref.2. Source: UniProtKB

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

semaphorin receptor activity

Non-traceable author statement PubMed 19909241. Source: BHF-UCL

vascular endothelial growth factor-activated receptor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O14786-1)

Also known as: Membrane-bound;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O14786-2)

Also known as: Soluble; SNRP1;

The sequence of this isoform differs from the canonical sequence as follows:
     642-644: EFP → GIK
     645-923: Missing.
Isoform 3 (identifier: O14786-3)

The sequence of this isoform differs from the canonical sequence as follows:
     587-621: Missing.
     642-644: EFP → GIK
     645-923: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.2 Ref.3
Chain22 – 923902Neuropilin-1
PRO_0000021859

Regions

Topological domain22 – 856835Extracellular Potential
Transmembrane857 – 87923Helical; Potential
Topological domain880 – 92344Cytoplasmic Potential
Domain27 – 141115CUB 1
Domain147 – 265119CUB 2
Domain275 – 424150F5/8 type C 1
Domain431 – 583153F5/8 type C 2
Domain645 – 811167MAM

Sites

Metal binding1951Calcium
Metal binding2091Calcium
Metal binding2501Calcium

Amino acid modifications

Glycosylation1501N-linked (GlcNAc...) Ref.12 Ref.14 Ref.16
Glycosylation2611N-linked (GlcNAc...) Ref.14 Ref.16
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation5221N-linked (GlcNAc...) Ref.14
Glycosylation6121O-linked (Xyl...) (chondroitin sulfate); alternate Ref.13
Glycosylation6121O-linked (Xyl...) (heparan sulfate); alternate Ref.13
Glycosylation8421N-linked (GlcNAc...) Potential
Disulfide bond27 ↔ 54 Probable
Disulfide bond82 ↔ 104 Probable
Disulfide bond147 ↔ 173 Ref.16
Disulfide bond206 ↔ 228 Ref.16
Disulfide bond275 ↔ 424 Ref.16
Disulfide bond431 ↔ 583 Ref.16

Natural variations

Alternative sequence587 – 62135Missing in isoform 3.
VSP_053498
Alternative sequence642 – 6443EFP → GIK in isoform 2 and isoform 3.
VSP_004339
Alternative sequence645 – 923279Missing in isoform 2 and isoform 3.
VSP_004340
Natural variant1791V → A. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.8 Ref.9
Corresponds to variant rs7079053 [ dbSNP | Ensembl ].
VAR_046536
Natural variant5611F → L.
Corresponds to variant rs2228637 [ dbSNP | Ensembl ].
VAR_046537
Natural variant7331V → I.
Corresponds to variant rs2228638 [ dbSNP | Ensembl ].
VAR_056957

Experimental info

Sequence conflict261K → E in AAC51759. Ref.1
Sequence conflict2191D → G in CAD91133. Ref.5
Sequence conflict7491D → H in AAC12921. Ref.2
Sequence conflict8551D → E in AAC51759. Ref.1

Secondary structure

................................................................................. 923
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Membrane-bound) [UniParc].

Last modified September 23, 2008. Version 3.
Checksum: 1EAC2FA6C8FD6A0B

FASTA923103,134
        10         20         30         40         50         60 
MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA 

        70         80         90        100        110        120 
PDPYQRIMIN FNPHFDLEDR DCKYDYVEVF DGENENGHFR GKFCGKIAPP PVVSSGPFLF 

       130        140        150        160        170        180 
IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTTPSGVIKS PGFPEKYPNS LECTYIVFVP 

       190        200        210        220        230        240 
KMSEIILEFE SFDLEPDSNP PGGMFCRYDR LEIWDGFPDV GPHIGRYCGQ KTPGRIRSSS 

       250        260        270        280        290        300 
GILSMVFYTD SAIAKEGFSA NYSVLQSSVS EDFKCMEALG MESGEIHSDQ ITASSQYSTN 

       310        320        330        340        350        360 
WSAERSRLNY PENGWTPGED SYREWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYKI 

       370        380        390        400        410        420 
DVSSNGEDWI TIKEGNKPVL FQGNTNPTDV VVAVFPKPLI TRFVRIKPAT WETGISMRFE 

       430        440        450        460        470        480 
VYGCKITDYP CSGMLGMVSG LISDSQITSS NQGDRNWMPE NIRLVTSRSG WALPPAPHSY 

       490        500        510        520        530        540 
INEWLQIDLG EEKIVRGIII QGGKHRENKV FMRKFKIGYS NNGSDWKMIM DDSKRKAKSF 

       550        560        570        580        590        600 
EGNNNYDTPE LRTFPALSTR FIRIYPERAT HGGLGLRMEL LGCEVEAPTA GPTTPNGNLV 

       610        620        630        640        650        660 
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTVIDSTIQ SEFPTYGFNC EFGWGSHKTF 

       670        680        690        700        710        720 
CHWEHDNHVQ LKWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQNSAH 

       730        740        750        760        770        780 
CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMAIGHQG DHWKEGRVLL HKSLKLYQVI 

       790        800        810        820        830        840 
FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPADLDKKNP EIKIDETGST PGYEGEGEGD 

       850        860        870        880        890        900 
KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 

       910        920 
FELVDGVKLK KDKLNTQSTY SEA 

« Hide

Isoform 2 (Soluble) (SNRP1) [UniParc].

Checksum: 1F055D9E6DD9BE70
Show »

FASTA64471,935
Isoform 3 [UniParc].

Checksum: 5CE3CEAE3CAD8CB8
Show »

FASTA60968,376

References

« Hide 'large scale' references
[1]"Neuropilin is a receptor for the axonal chemorepellent semaphorin III."
He Z., Tessier-Lavigne M.
Cell 90:739-751(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-179.
[2]"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."
Soker S., Takashima S., Miao H.-Q., Neufeld G., Klagsbrun M.
Cell 92:735-745(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-39, VARIANT ALA-179.
Tissue: Mammary gland.
[3]"Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity."
Gagnon M.L., Bielenberg D.R., Gechtman Z., Miao H.-Q., Takashima S., Soker S., Klagsbrun M.
Proc. Natl. Acad. Sci. U.S.A. 97:2573-2578(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 22-31, VARIANT ALA-179.
Tissue: Prostatic adenocarcinoma.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-179.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-179.
Tissue: Skeletal muscle.
[6]SeattleSNPs variation discovery resource
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-179.
[7]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-179.
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ALA-179.
Tissue: Kidney and Muscle.
[10]"Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
Tamagnone L., Artigiani S., Chen H., He Z., Ming G.-L., Song H.-L., Chedotal A., Winberg M.L., Goodman C.S., Poo M.-M., Tessier-Lavigne M., Comoglio P.M.
Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PLXNB1.
[11]"Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."
Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G.
J. Biol. Chem. 275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[12]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150.
Tissue: Plasma.
[13]"Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling."
Shintani Y., Takashima S., Asano Y., Kato H., Liao Y., Yamazaki S., Tsukamoto O., Seguchi O., Yamamoto H., Fukushima T., Sugahara K., Kitakaze M., Hori M.
EMBO J. 25:3045-3055(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT SER-612.
[14]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150; ASN-261 AND ASN-522.
Tissue: Liver.
[15]"Crystal structure of the human neuropilin-1 b1 domain."
Lee C.C., Kreusch A., McMullan D., Ng K., Spraggon G.
Structure 11:99-108(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 273-427.
[16]"Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding."
Appleton B.A., Wu P., Maloney J., Yin J., Liang W.C., Stawicki S., Mortara K., Bowman K.K., Elliott J.M., Desmarais W., Bazan J.F., Bagri A., Tessier-Lavigne M., Koch A.W., Wu Y., Watts R.J., Wiesmann C.
EMBO J. 26:4902-4912(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 141-586 ALONE AND IN COMPLEX WITH ANTIBODY, GLYCOSYLATION AT ASN-150 AND ASN-261, SUBUNIT, CALCIUM-BINDING SITES, HEPARIN-BINDING, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF018956 mRNA. Translation: AAC51759.1.
AF016050 mRNA. Translation: AAC12921.1.
AF145712 mRNA. Translation: AAF44344.1.
BT006995 mRNA. Translation: AAP35641.1.
BX510902 mRNA. Translation: CAD91133.1.
EU332859 Genomic DNA. Translation: ABY87548.1.
AL353600, AL121748 Genomic DNA. Translation: CAI16997.1.
AL353600, AL121748 Genomic DNA. Translation: CAI16998.1.
AL121748, AL353600 Genomic DNA. Translation: CAI40248.1.
AL121748, AL353600 Genomic DNA. Translation: CAI40250.1.
CH471072 Genomic DNA. Translation: EAW85942.1.
CH471072 Genomic DNA. Translation: EAW85944.1.
BC007533 mRNA. Translation: AAH07533.1.
BC007737 mRNA. Translation: AAH07737.1.
RefSeqNP_001019799.1. NM_001024628.2.
NP_001019800.1. NM_001024629.2.
NP_003864.4. NM_003873.5.
UniGeneHs.131704.
Hs.653996.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1KEXX-ray1.90A273-427[»]
2QQIX-ray1.80A273-586[»]
2QQMX-ray2.00A141-586[»]
2QQNX-ray2.20A273-427[»]
3I97X-ray2.90A/B273-427[»]
4DEQX-ray2.65A/B274-429[»]
ProteinModelPortalO14786.
SMRO14786. Positions 25-612, 647-847.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114356. 13 interactions.
DIPDIP-5743N.
IntActO14786. 7 interactions.
MINTMINT-2834207.
STRING9606.ENSP00000265371.

Chemistry

BindingDBO14786.
ChEMBLCHEMBL5174.
DrugBankDB00039. Palifermin.
DB04895. Pegaptanib.

PTM databases

PhosphoSiteO14786.

Proteomic databases

PaxDbO14786.
PRIDEO14786.

Protocols and materials databases

DNASU8829.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265371; ENSP00000265371; ENSG00000099250. [O14786-1]
ENST00000374821; ENSP00000363954; ENSG00000099250. [O14786-3]
ENST00000374822; ENSP00000363955; ENSG00000099250. [O14786-2]
ENST00000374867; ENSP00000364001; ENSG00000099250. [O14786-1]
GeneID8829.
KEGGhsa:8829.
UCSCuc001iwx.4. human. [O14786-1]
uc001ixa.2. human.

Organism-specific databases

CTD8829.
GeneCardsGC10M033506.
HGNCHGNC:8004. NRP1.
HPACAB004511.
HPA030278.
MIM602069. gene.
neXtProtNX_O14786.
PharmGKBPA31783.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150941.
HOVERGENHBG000502.
InParanoidO14786.
KOK06724.
OMAYCACWHN.
PhylomeDBO14786.
TreeFamTF316506.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO14786.
BgeeO14786.
CleanExHS_NRP1.
GenevestigatorO14786.

Family and domain databases

Gene3D2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR000859. CUB_dom.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin1_C.
IPR027146. NRP1.
[Graphical view]
PANTHERPTHR10127:SF84. PTHR10127:SF84. 1 hit.
PfamPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFPIRSF036960. Neuropilin. 1 hit.
PRINTSPR00020. MAMDOMAIN.
SMARTSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNRP1. human.
EvolutionaryTraceO14786.
GeneWikiNeuropilin_1.
GenomeRNAi8829.
NextBio33134.
PMAP-CutDBB0LPG9.
PROO14786.
SOURCESearch...

Entry information

Entry nameNRP1_HUMAN
AccessionPrimary (citable) accession number: O14786
Secondary accession number(s): B0LPG9 expand/collapse secondary AC list , O60461, Q5T7F1, Q5T7F2, Q5T7F3, Q86T59, Q96I90, Q96IH5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries