Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kinesin-like protein KIF3C

Gene

KIF3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048ATP

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: GO_Central
  • motor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_25201. Kinesins.
REACT_268024. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3C
Gene namesi
Name:KIF3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6321. KIF3C.

Subcellular locationi

GO - Cellular componenti

  • ciliary tip Source: Reactome
  • cytosol Source: Reactome
  • kinesin complex Source: ProtInc
  • microtubule Source: UniProtKB-KW
  • primary cilium Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30104.

Polymorphism and mutation databases

BioMutaiKIF3C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 793793Kinesin-like protein KIF3CPRO_0000125397Add
BLAST

Proteomic databases

MaxQBiO14782.
PaxDbiO14782.
PRIDEiO14782.

PTM databases

PhosphoSiteiO14782.

Expressioni

Gene expression databases

BgeeiO14782.
CleanExiHS_KIF3C.
ExpressionAtlasiO14782. baseline and differential.
GenevisibleiO14782. HS.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3C.By similarity

Protein-protein interaction databases

BioGridi109998. 5 interactions.
IntActiO14782. 3 interactions.
STRINGi9606.ENSP00000264712.

Structurei

Secondary structure

1
793
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 176Combined sources
Helixi22 – 265Combined sources
Beta strandi33 – 364Combined sources
Turni37 – 404Combined sources
Beta strandi41 – 444Combined sources
Beta strandi56 – 594Combined sources
Beta strandi61 – 644Combined sources
Helixi70 – 778Combined sources
Helixi79 – 868Combined sources
Beta strandi91 – 977Combined sources
Helixi103 – 1075Combined sources
Turni114 – 1163Combined sources
Helixi119 – 13315Combined sources
Beta strandi138 – 15114Combined sources
Beta strandi153 – 1553Combined sources
Beta strandi167 – 1704Combined sources
Turni171 – 1733Combined sources
Beta strandi174 – 1774Combined sources
Helixi188 – 20114Combined sources
Beta strandi215 – 22713Combined sources
Beta strandi237 – 24610Combined sources
Helixi295 – 30713Combined sources
Helixi317 – 3193Combined sources
Helixi321 – 3255Combined sources
Helixi326 – 3294Combined sources
Beta strandi332 – 34211Combined sources
Helixi346 – 3483Combined sources
Helixi349 – 36214Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B6VX-ray2.70A/B7-383[»]
ProteinModelPortaliO14782.
SMRiO14782. Positions 7-372.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14782.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 365356Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni630 – 793164GlobularSequence AnalysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili376 – 629254Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi270 – 28415Poly-GlyAdd
BLAST
Compositional biasi438 – 4414Poly-Asn

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO14782.
KOiK10394.
OMAiNMENYLQ.
OrthoDBiEOG7WX086.
PhylomeDBiO14782.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA
60 70 80 90 100
PGELPKTFTF DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG
110 120 130 140 150
TGKTYTMQGT WVEPELRGVI PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ
160 170 180 190 200
EEIRDLLSKE PGKRLELKEN PETGVYIKDL SSFVTKNVKE IEHVMNLGNQ
210 220 230 240 250
TRAVGSTHMN EVSSRSHAIF IITVECSERG SDGQDHIRVG KLNLVDLAGS
260 270 280 290 300
ERQNKAGPNT AGGAATPSSG GGGGGGGSGG GAGGERPKEA SKINLSLSAL
310 320 330 340 350
GNVIAALAGN RSTHIPYRDS KLTRLLQDSL GGNAKTIMVA TLGPASHSYD
360 370 380 390 400
ESLSTLRFAN RAKNIKNKPQ VNEDPKDTLL REFQEEIARL KAQLEKRGML
410 420 430 440 450
GKRPRRKSSR RKKAVSAPPG YPEGPVIEAW VAEEEDDNNN NHRPPQPILE
460 470 480 490 500
SALEKNMENY LQEQKERLEE EKAAIQDDRS LVSEEKQKLL EEKEKMLEDL
510 520 530 540 550
RREQQATELL AAKYKAMESK LLIGGRNIMD HTNEQQKMLE LKRQEIAEQK
560 570 580 590 600
RREREMQQEM MLRDEETMEL RGTYTSLQQE VEVKTKKLKK LYAKLQAVKA
610 620 630 640 650
EIQDQHDEYI RVRQDLEEAQ NEQTRELKLK YLIIENFIPP EEKNKIMNRL
660 670 680 690 700
FLDCEEEQWK FQPLVPAGVS SSQMKKRPTS AVGYKRPISQ YARVAMAMGS
710 720 730 740 750
HPRYRAENIM FLELDVSPPA VFEMEFSHDQ EQDPRALHME RLMRLDSFLE
760 770 780 790
RPSTSKVRKS RSWCQSPQRP PPSTTHASLA SASLRPATVA DHE
Length:793
Mass (Da):89,426
Last modified:October 5, 2010 - v3
Checksum:i9C6974265DE0A030
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 793TVR → RE in AAC05302 (PubMed:9480755).Curated
Sequence conflicti110 – 1112TW → DL in AAC05302 (PubMed:9480755).Curated
Sequence conflicti163 – 1631K → R in AAC05302 (PubMed:9480755).Curated
Sequence conflicti471 – 4711E → D in AAC05302 (PubMed:9480755).Curated
Sequence conflicti630 – 6301K → G in AAC05302 (PubMed:9480755).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti370 – 3701Q → R.3 Publications
Corresponds to variant rs1465878 [ dbSNP | Ensembl ].
VAR_055120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018164 mRNA. Translation: AAC05302.1.
AF035621 mRNA. Translation: AAC39562.1.
AJ002223 Genomic DNA. Translation: CAA05252.1.
AJ002224 Genomic DNA. Translation: CAA05253.1.
AJ002225 Genomic DNA. Translation: CAA05254.1.
AJ002226 Genomic DNA. Translation: CAA05255.1.
AJ002227 Genomic DNA. Translation: CAA05256.1.
AJ002228 Genomic DNA. Translation: CAA05257.1.
AJ002229 Genomic DNA. Translation: CAA05258.1.
AC013449 Genomic DNA. Translation: AAY24261.1.
AC064847 Genomic DNA. Translation: AAX88877.1.
BC092406 mRNA. Translation: AAH92406.1.
BC130423 mRNA. Translation: AAI30424.1.
CCDSiCCDS1719.1.
PIRiJC5831.
RefSeqiNP_002245.4. NM_002254.6.
UniGeneiHs.21611.

Genome annotation databases

EnsembliENST00000264712; ENSP00000264712; ENSG00000084731.
ENST00000405914; ENSP00000385030; ENSG00000084731.
GeneIDi3797.
KEGGihsa:3797.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018164 mRNA. Translation: AAC05302.1.
AF035621 mRNA. Translation: AAC39562.1.
AJ002223 Genomic DNA. Translation: CAA05252.1.
AJ002224 Genomic DNA. Translation: CAA05253.1.
AJ002225 Genomic DNA. Translation: CAA05254.1.
AJ002226 Genomic DNA. Translation: CAA05255.1.
AJ002227 Genomic DNA. Translation: CAA05256.1.
AJ002228 Genomic DNA. Translation: CAA05257.1.
AJ002229 Genomic DNA. Translation: CAA05258.1.
AC013449 Genomic DNA. Translation: AAY24261.1.
AC064847 Genomic DNA. Translation: AAX88877.1.
BC092406 mRNA. Translation: AAH92406.1.
BC130423 mRNA. Translation: AAI30424.1.
CCDSiCCDS1719.1.
PIRiJC5831.
RefSeqiNP_002245.4. NM_002254.6.
UniGeneiHs.21611.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B6VX-ray2.70A/B7-383[»]
ProteinModelPortaliO14782.
SMRiO14782. Positions 7-372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109998. 5 interactions.
IntActiO14782. 3 interactions.
STRINGi9606.ENSP00000264712.

Chemistry

ChEMBLiCHEMBL1075196.

PTM databases

PhosphoSiteiO14782.

Polymorphism and mutation databases

BioMutaiKIF3C.

Proteomic databases

MaxQBiO14782.
PaxDbiO14782.
PRIDEiO14782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264712; ENSP00000264712; ENSG00000084731.
ENST00000405914; ENSP00000385030; ENSG00000084731.
GeneIDi3797.
KEGGihsa:3797.

Organism-specific databases

CTDi3797.
GeneCardsiGC02M026149.
HGNCiHGNC:6321. KIF3C.
MIMi602845. gene.
neXtProtiNX_O14782.
PharmGKBiPA30104.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5059.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO14782.
KOiK10394.
OMAiNMENYLQ.
OrthoDBiEOG7WX086.
PhylomeDBiO14782.
TreeFamiTF105223.

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_25201. Kinesins.
REACT_268024. Intraflagellar transport.

Miscellaneous databases

ChiTaRSiKIF3C. human.
EvolutionaryTraceiO14782.
GeneWikiiKIF3C.
GenomeRNAii3797.
NextBioi14909.
PROiO14782.
SOURCEiSearch...

Gene expression databases

BgeeiO14782.
CleanExiHS_KIF3C.
ExpressionAtlasiO14782. baseline and differential.
GenevisibleiO14782. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23."
    Sardella M., Navone F., Rocchi M., Rubartelli A., Viggiano L., Vignali G., Consalez G.G., Sitia R., Cabibbo A.
    Genomics 47:405-408(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-370.
  2. "cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C."
    Telford E.A.R., Wightman P., Leek J., Markham A.F., Lench N.J., Bonthron D.T.
    Biochem. Biophys. Res. Commun. 242:407-412(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ARG-370.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-370.
    Tissue: Uterus.
  5. "Motor domain of human kinesin family member 3C in complex with ADP."
    Structural genomics consortium (SGC)
    Submitted (JAN-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 7-383 IN COMPLEX WITH ADP.

Entry informationi

Entry nameiKIF3C_HUMAN
AccessioniPrimary (citable) accession number: O14782
Secondary accession number(s): O43544
, Q4ZG18, Q53SX5, Q562F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 5, 2010
Last modified: June 24, 2015
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.