O14782 (KIF3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF3C

Gene names

Name:

KIF3C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	793 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Microtubule-based anterograde translocator for membranous organelles By similarity.
Subunit structure	Heterodimer of KIF3A and KIF3C By similarity.
Subcellular location	Cytoplasm › cytoskeleton Probable.
Sequence similarities	Belongs to the kinesin-like protein family. Kinesin II subfamily. Contains 1 kinesin-motor domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II Traceable author statement. Source: Reactome blood coagulation Traceable author statement. Source: Reactome microtubule-based movement Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome kinesin complex Traceable author statement Ref.1. Source: ProtInc microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro motor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 793

793

Kinesin-like protein KIF3C

PRO_0000125397

Regions

Domain

1 – 375

375

Kinesin-motor

Nucleotide binding

97 – 104

8

ATP

Region

630 – 793

164

Globular Potential

Coiled coil

376 – 629

254

Potential

Compositional bias

270 – 284

15

Poly-Gly

Compositional bias

438 – 441

4

Poly-Asn

Natural variations

Natural variant

370

1

Q → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs1465878 [ dbSNP | Ensembl ].

VAR_055120

Experimental info

Sequence conflict

77 – 79

3

TVR → RE in AAC05302. Ref.1

Sequence conflict

110 – 111

2

TW → DL in AAC05302. Ref.1

Sequence conflict

163

1

K → R in AAC05302. Ref.1

Sequence conflict

471

1

E → D in AAC05302. Ref.1

Sequence conflict

630

1

K → G in AAC05302. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

793

Helix Strand Turn

Details...

Beta strand

12 – 17

6

Helix

22 – 26

5

Beta strand

33 – 36

4

Turn

37 – 40

4

Beta strand

41 – 44

4

Beta strand

56 – 59

4

Beta strand

61 – 64

4

Helix

70 – 77

8

Helix

79 – 86

8

Beta strand

91 – 97

7

Helix

103 – 107

5

Turn

114 – 116

3

Helix

119 – 133

15

Beta strand

138 – 151

14

Beta strand

153 – 155

3

Beta strand

167 – 170

4

Turn

171 – 173

3

Beta strand

174 – 177

4

Helix

188 – 201

14

Beta strand

215 – 227

13

Beta strand

237 – 246

10

Helix

295 – 307

13

Helix

317 – 319

3

Helix

321 – 325

5

Helix

326 – 329

4

Beta strand

332 – 342

11

Helix

346 – 348

3

Helix

349 – 362

14

Sequences

	Sequence		Length	Mass (Da)
	O14782 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 9C6974265DE0A030	FASTA	793	89,426
	10 20 30 40 50 60 MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA PGELPKTFTF 70 80 90 100 110 120 DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG TGKTYTMQGT WVEPELRGVI 130 140 150 160 170 180 PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ EEIRDLLSKE PGKRLELKEN PETGVYIKDL 190 200 210 220 230 240 SSFVTKNVKE IEHVMNLGNQ TRAVGSTHMN EVSSRSHAIF IITVECSERG SDGQDHIRVG 250 260 270 280 290 300 KLNLVDLAGS ERQNKAGPNT AGGAATPSSG GGGGGGGSGG GAGGERPKEA SKINLSLSAL 310 320 330 340 350 360 GNVIAALAGN RSTHIPYRDS KLTRLLQDSL GGNAKTIMVA TLGPASHSYD ESLSTLRFAN 370 380 390 400 410 420 RAKNIKNKPQ VNEDPKDTLL REFQEEIARL KAQLEKRGML GKRPRRKSSR RKKAVSAPPG 430 440 450 460 470 480 YPEGPVIEAW VAEEEDDNNN NHRPPQPILE SALEKNMENY LQEQKERLEE EKAAIQDDRS 490 500 510 520 530 540 LVSEEKQKLL EEKEKMLEDL RREQQATELL AAKYKAMESK LLIGGRNIMD HTNEQQKMLE 550 560 570 580 590 600 LKRQEIAEQK RREREMQQEM MLRDEETMEL RGTYTSLQQE VEVKTKKLKK LYAKLQAVKA 610 620 630 640 650 660 EIQDQHDEYI RVRQDLEEAQ NEQTRELKLK YLIIENFIPP EEKNKIMNRL FLDCEEEQWK 670 680 690 700 710 720 FQPLVPAGVS SSQMKKRPTS AVGYKRPISQ YARVAMAMGS HPRYRAENIM FLELDVSPPA 730 740 750 760 770 780 VFEMEFSHDQ EQDPRALHME RLMRLDSFLE RPSTSKVRKS RSWCQSPQRP PPSTTHASLA 790 SASLRPATVA DHE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23." Sardella M., Navone F., Rocchi M., Rubartelli A., Viggiano L., Vignali G., Consalez G.G., Sitia R., Cabibbo A. Genomics 47:405-408(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-370.
[2]	"cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C." Telford E.A.R., Wightman P., Leek J., Markham A.F., Lench N.J., Bonthron D.T. Biochem. Biophys. Res. Commun. 242:407-412(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ARG-370.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-370. Tissue: Uterus.
[5]	"Motor domain of human kinesin family member 3C in complex with ADP." Structural genomics consortium (SGC) Submitted (JAN-2008) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 7-383 IN COMPLEX WITH ADP.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF018164 mRNA. Translation: AAC05302.1.
AF035621 mRNA. Translation: AAC39562.1.
AJ002223 Genomic DNA. Translation: CAA05252.1.
AJ002224 Genomic DNA. Translation: CAA05253.1.
AJ002225 Genomic DNA. Translation: CAA05254.1.
AJ002226 Genomic DNA. Translation: CAA05255.1.
AJ002227 Genomic DNA. Translation: CAA05256.1.
AJ002228 Genomic DNA. Translation: CAA05257.1.
AJ002229 Genomic DNA. Translation: CAA05258.1.
AC013449 Genomic DNA. Translation: AAY24261.1.
AC064847 Genomic DNA. Translation: AAX88877.1.
BC092406 mRNA. Translation: AAH92406.1.
BC130423 mRNA. Translation: AAI30424.1.

IPI

IPI00023727.

PIR

JC5831.

RefSeq

NP_002245.4. NM_002254.6.

UniGene

Hs.21611.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3B6V	X-ray	2.70	A/B	7-383	[»]

ProteinModelPortal

O14782.

SMR

O14782. Positions 7-372.

ModBase

Search...

Protein-protein interaction databases

IntAct

O14782. 3 interactions.

STRING

9606.ENSP00000264712.

PTM databases

PhosphoSite

O14782.

Proteomic databases

PaxDb

O14782.

PRIDE

O14782.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000264712; ENSP00000264712; ENSG00000084731.
ENST00000405914; ENSP00000385030; ENSG00000084731.

GeneID

3797.

KEGG

hsa:3797.

Organism-specific databases

CTD

3797.

GeneCards

GC02M026149.

HGNC

HGNC:6321. KIF3C.

HPA

HPA035755.

MIM

602845. gene.

neXtProt

NX_O14782.

PharmGKB

PA30104.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5059.

HOGENOM

HOG000116164.

HOVERGEN

HBG052255.

InParanoid

O14782.

KO

K10394.

OMA

MLLRDEE.

PhylomeDB

O14782.

Enzyme and pathway databases

Reactome

REACT_604. Hemostasis.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

O14782.

Bgee

O14782.

CleanEx

HS_KIF3C.

Genevestigator

O14782.

GermOnline

ENSG00000084731. Homo sapiens.

Family and domain databases

Gene3D

3.40.850.10. 1 hit.

InterPro

IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
[Graphical view]

Pfam

PF00225. Kinesin. 2 hits.
[Graphical view]

PRINTS

PR00380. KINESINHEAVY.

SMART

SM00129. KISc. 1 hit.
[Graphical view]

PROSITE

PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL1075196.

ChiTaRS

KIF3C. human.

EvolutionaryTrace

O14782.

GenomeRNAi

3797.

NextBio

14909.

SOURCE

Search...

Entry information

Entry name

KIF3C_HUMAN

Accession

Primary (citable) accession number: O14782
Secondary accession number(s): O43544 , Q4ZG18, Q53SX5, Q562F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	October 5, 2010
Last modified:	April 3, 2013
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.