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O14782 (KIF3C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF3C
Gene names
Name:KIF3C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length793 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Microtubule-based anterograde translocator for membranous organelles By similarity.

Subunit structure

Heterodimer of KIF3A and KIF3C By similarity.

Subcellular location

Cytoplasmcytoskeleton Probable.

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.

Contains 1 kinesin motor domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 793793Kinesin-like protein KIF3C
PRO_0000125397

Regions

Domain10 – 365356Kinesin motor
Nucleotide binding97 – 1048ATP
Region630 – 793164Globular Potential
Coiled coil376 – 629254 Potential
Compositional bias270 – 28415Poly-Gly
Compositional bias438 – 4414Poly-Asn

Natural variations

Natural variant3701Q → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs1465878 [ dbSNP | Ensembl ].
VAR_055120

Experimental info

Sequence conflict77 – 793TVR → RE in AAC05302. Ref.1
Sequence conflict110 – 1112TW → DL in AAC05302. Ref.1
Sequence conflict1631K → R in AAC05302. Ref.1
Sequence conflict4711E → D in AAC05302. Ref.1
Sequence conflict6301K → G in AAC05302. Ref.1

Secondary structure

................................................... 793
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O14782 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 9C6974265DE0A030

FASTA79389,426
        10         20         30         40         50         60 
MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA PGELPKTFTF 

        70         80         90        100        110        120 
DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG TGKTYTMQGT WVEPELRGVI 

       130        140        150        160        170        180 
PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ EEIRDLLSKE PGKRLELKEN PETGVYIKDL 

       190        200        210        220        230        240 
SSFVTKNVKE IEHVMNLGNQ TRAVGSTHMN EVSSRSHAIF IITVECSERG SDGQDHIRVG 

       250        260        270        280        290        300 
KLNLVDLAGS ERQNKAGPNT AGGAATPSSG GGGGGGGSGG GAGGERPKEA SKINLSLSAL 

       310        320        330        340        350        360 
GNVIAALAGN RSTHIPYRDS KLTRLLQDSL GGNAKTIMVA TLGPASHSYD ESLSTLRFAN 

       370        380        390        400        410        420 
RAKNIKNKPQ VNEDPKDTLL REFQEEIARL KAQLEKRGML GKRPRRKSSR RKKAVSAPPG 

       430        440        450        460        470        480 
YPEGPVIEAW VAEEEDDNNN NHRPPQPILE SALEKNMENY LQEQKERLEE EKAAIQDDRS 

       490        500        510        520        530        540 
LVSEEKQKLL EEKEKMLEDL RREQQATELL AAKYKAMESK LLIGGRNIMD HTNEQQKMLE 

       550        560        570        580        590        600 
LKRQEIAEQK RREREMQQEM MLRDEETMEL RGTYTSLQQE VEVKTKKLKK LYAKLQAVKA 

       610        620        630        640        650        660 
EIQDQHDEYI RVRQDLEEAQ NEQTRELKLK YLIIENFIPP EEKNKIMNRL FLDCEEEQWK 

       670        680        690        700        710        720 
FQPLVPAGVS SSQMKKRPTS AVGYKRPISQ YARVAMAMGS HPRYRAENIM FLELDVSPPA 

       730        740        750        760        770        780 
VFEMEFSHDQ EQDPRALHME RLMRLDSFLE RPSTSKVRKS RSWCQSPQRP PPSTTHASLA 

       790 
SASLRPATVA DHE 

« Hide

References

« Hide 'large scale' references
[1]"KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23."
Sardella M., Navone F., Rocchi M., Rubartelli A., Viggiano L., Vignali G., Consalez G.G., Sitia R., Cabibbo A.
Genomics 47:405-408(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-370.
[2]"cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C."
Telford E.A.R., Wightman P., Leek J., Markham A.F., Lench N.J., Bonthron D.T.
Biochem. Biophys. Res. Commun. 242:407-412(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ARG-370.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-370.
Tissue: Uterus.
[5]"Motor domain of human kinesin family member 3C in complex with ADP."
Structural genomics consortium (SGC)
Submitted (JAN-2008) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 7-383 IN COMPLEX WITH ADP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF018164 mRNA. Translation: AAC05302.1.
AF035621 mRNA. Translation: AAC39562.1.
AJ002223 Genomic DNA. Translation: CAA05252.1.
AJ002224 Genomic DNA. Translation: CAA05253.1.
AJ002225 Genomic DNA. Translation: CAA05254.1.
AJ002226 Genomic DNA. Translation: CAA05255.1.
AJ002227 Genomic DNA. Translation: CAA05256.1.
AJ002228 Genomic DNA. Translation: CAA05257.1.
AJ002229 Genomic DNA. Translation: CAA05258.1.
AC013449 Genomic DNA. Translation: AAY24261.1.
AC064847 Genomic DNA. Translation: AAX88877.1.
BC092406 mRNA. Translation: AAH92406.1.
BC130423 mRNA. Translation: AAI30424.1.
CCDSCCDS1719.1.
PIRJC5831.
RefSeqNP_002245.4. NM_002254.6.
UniGeneHs.21611.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3B6VX-ray2.70A/B7-383[»]
ProteinModelPortalO14782.
SMRO14782. Positions 7-372.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109998. 4 interactions.
IntActO14782. 3 interactions.
STRING9606.ENSP00000264712.

Chemistry

ChEMBLCHEMBL1075196.

PTM databases

PhosphoSiteO14782.

Proteomic databases

MaxQBO14782.
PaxDbO14782.
PRIDEO14782.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264712; ENSP00000264712; ENSG00000084731.
ENST00000405914; ENSP00000385030; ENSG00000084731.
GeneID3797.
KEGGhsa:3797.

Organism-specific databases

CTD3797.
GeneCardsGC02M026149.
HGNCHGNC:6321. KIF3C.
HPAHPA035755.
MIM602845. gene.
neXtProtNX_O14782.
PharmGKBPA30104.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5059.
HOGENOMHOG000116164.
HOVERGENHBG052255.
InParanoidO14782.
KOK10394.
OMAWVAEEED.
OrthoDBEOG7WX086.
PhylomeDBO14782.
TreeFamTF105223.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressO14782.
BgeeO14782.
CleanExHS_KIF3C.
GenevestigatorO14782.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKIF3C. human.
EvolutionaryTraceO14782.
GeneWikiKIF3C.
GenomeRNAi3797.
NextBio14909.
PROO14782.
SOURCESearch...

Entry information

Entry nameKIF3C_HUMAN
AccessionPrimary (citable) accession number: O14782
Secondary accession number(s): O43544 expand/collapse secondary AC list , Q4ZG18, Q53SX5, Q562F7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM