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O14782

- KIF3C_HUMAN

UniProt

O14782 - KIF3C_HUMAN

Protein

Kinesin-like protein KIF3C

Gene

KIF3C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Microtubule-based anterograde translocator for membranous organelles.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi97 – 1048ATP

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: InterPro
    3. motor activity Source: ProtInc

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. blood coagulation Source: Reactome
    3. metabolic process Source: GOC
    4. microtubule-based movement Source: Reactome

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_25201. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF3C
    Gene namesi
    Name:KIF3C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6321. KIF3C.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. kinesin complex Source: ProtInc
    3. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30104.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 793793Kinesin-like protein KIF3CPRO_0000125397Add
    BLAST

    Proteomic databases

    MaxQBiO14782.
    PaxDbiO14782.
    PRIDEiO14782.

    PTM databases

    PhosphoSiteiO14782.

    Expressioni

    Gene expression databases

    ArrayExpressiO14782.
    BgeeiO14782.
    CleanExiHS_KIF3C.
    GenevestigatoriO14782.

    Organism-specific databases

    HPAiHPA035755.

    Interactioni

    Subunit structurei

    Heterodimer of KIF3A and KIF3C.By similarity

    Protein-protein interaction databases

    BioGridi109998. 4 interactions.
    IntActiO14782. 3 interactions.
    STRINGi9606.ENSP00000264712.

    Structurei

    Secondary structure

    1
    793
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi12 – 176
    Helixi22 – 265
    Beta strandi33 – 364
    Turni37 – 404
    Beta strandi41 – 444
    Beta strandi56 – 594
    Beta strandi61 – 644
    Helixi70 – 778
    Helixi79 – 868
    Beta strandi91 – 977
    Helixi103 – 1075
    Turni114 – 1163
    Helixi119 – 13315
    Beta strandi138 – 15114
    Beta strandi153 – 1553
    Beta strandi167 – 1704
    Turni171 – 1733
    Beta strandi174 – 1774
    Helixi188 – 20114
    Beta strandi215 – 22713
    Beta strandi237 – 24610
    Helixi295 – 30713
    Helixi317 – 3193
    Helixi321 – 3255
    Helixi326 – 3294
    Beta strandi332 – 34211
    Helixi346 – 3483
    Helixi349 – 36214

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3B6VX-ray2.70A/B7-383[»]
    ProteinModelPortaliO14782.
    SMRiO14782. Positions 7-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14782.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 365356Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni630 – 793164GlobularSequence AnalysisAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili376 – 629254Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi270 – 28415Poly-GlyAdd
    BLAST
    Compositional biasi438 – 4414Poly-Asn

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOGENOMiHOG000116164.
    HOVERGENiHBG052255.
    InParanoidiO14782.
    KOiK10394.
    OMAiWVAEEED.
    OrthoDBiEOG7WX086.
    PhylomeDBiO14782.
    TreeFamiTF105223.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 2 hits.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14782-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA    50
    PGELPKTFTF DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG 100
    TGKTYTMQGT WVEPELRGVI PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ 150
    EEIRDLLSKE PGKRLELKEN PETGVYIKDL SSFVTKNVKE IEHVMNLGNQ 200
    TRAVGSTHMN EVSSRSHAIF IITVECSERG SDGQDHIRVG KLNLVDLAGS 250
    ERQNKAGPNT AGGAATPSSG GGGGGGGSGG GAGGERPKEA SKINLSLSAL 300
    GNVIAALAGN RSTHIPYRDS KLTRLLQDSL GGNAKTIMVA TLGPASHSYD 350
    ESLSTLRFAN RAKNIKNKPQ VNEDPKDTLL REFQEEIARL KAQLEKRGML 400
    GKRPRRKSSR RKKAVSAPPG YPEGPVIEAW VAEEEDDNNN NHRPPQPILE 450
    SALEKNMENY LQEQKERLEE EKAAIQDDRS LVSEEKQKLL EEKEKMLEDL 500
    RREQQATELL AAKYKAMESK LLIGGRNIMD HTNEQQKMLE LKRQEIAEQK 550
    RREREMQQEM MLRDEETMEL RGTYTSLQQE VEVKTKKLKK LYAKLQAVKA 600
    EIQDQHDEYI RVRQDLEEAQ NEQTRELKLK YLIIENFIPP EEKNKIMNRL 650
    FLDCEEEQWK FQPLVPAGVS SSQMKKRPTS AVGYKRPISQ YARVAMAMGS 700
    HPRYRAENIM FLELDVSPPA VFEMEFSHDQ EQDPRALHME RLMRLDSFLE 750
    RPSTSKVRKS RSWCQSPQRP PPSTTHASLA SASLRPATVA DHE 793
    Length:793
    Mass (Da):89,426
    Last modified:October 5, 2010 - v3
    Checksum:i9C6974265DE0A030
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 793TVR → RE in AAC05302. (PubMed:9480755)Curated
    Sequence conflicti110 – 1112TW → DL in AAC05302. (PubMed:9480755)Curated
    Sequence conflicti163 – 1631K → R in AAC05302. (PubMed:9480755)Curated
    Sequence conflicti471 – 4711E → D in AAC05302. (PubMed:9480755)Curated
    Sequence conflicti630 – 6301K → G in AAC05302. (PubMed:9480755)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti370 – 3701Q → R.3 Publications
    Corresponds to variant rs1465878 [ dbSNP | Ensembl ].
    VAR_055120

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018164 mRNA. Translation: AAC05302.1.
    AF035621 mRNA. Translation: AAC39562.1.
    AJ002223 Genomic DNA. Translation: CAA05252.1.
    AJ002224 Genomic DNA. Translation: CAA05253.1.
    AJ002225 Genomic DNA. Translation: CAA05254.1.
    AJ002226 Genomic DNA. Translation: CAA05255.1.
    AJ002227 Genomic DNA. Translation: CAA05256.1.
    AJ002228 Genomic DNA. Translation: CAA05257.1.
    AJ002229 Genomic DNA. Translation: CAA05258.1.
    AC013449 Genomic DNA. Translation: AAY24261.1.
    AC064847 Genomic DNA. Translation: AAX88877.1.
    BC092406 mRNA. Translation: AAH92406.1.
    BC130423 mRNA. Translation: AAI30424.1.
    CCDSiCCDS1719.1.
    PIRiJC5831.
    RefSeqiNP_002245.4. NM_002254.6.
    UniGeneiHs.21611.

    Genome annotation databases

    EnsembliENST00000264712; ENSP00000264712; ENSG00000084731.
    ENST00000405914; ENSP00000385030; ENSG00000084731.
    GeneIDi3797.
    KEGGihsa:3797.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018164 mRNA. Translation: AAC05302.1 .
    AF035621 mRNA. Translation: AAC39562.1 .
    AJ002223 Genomic DNA. Translation: CAA05252.1 .
    AJ002224 Genomic DNA. Translation: CAA05253.1 .
    AJ002225 Genomic DNA. Translation: CAA05254.1 .
    AJ002226 Genomic DNA. Translation: CAA05255.1 .
    AJ002227 Genomic DNA. Translation: CAA05256.1 .
    AJ002228 Genomic DNA. Translation: CAA05257.1 .
    AJ002229 Genomic DNA. Translation: CAA05258.1 .
    AC013449 Genomic DNA. Translation: AAY24261.1 .
    AC064847 Genomic DNA. Translation: AAX88877.1 .
    BC092406 mRNA. Translation: AAH92406.1 .
    BC130423 mRNA. Translation: AAI30424.1 .
    CCDSi CCDS1719.1.
    PIRi JC5831.
    RefSeqi NP_002245.4. NM_002254.6.
    UniGenei Hs.21611.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3B6V X-ray 2.70 A/B 7-383 [» ]
    ProteinModelPortali O14782.
    SMRi O14782. Positions 7-372.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109998. 4 interactions.
    IntActi O14782. 3 interactions.
    STRINGi 9606.ENSP00000264712.

    Chemistry

    ChEMBLi CHEMBL1075196.

    PTM databases

    PhosphoSitei O14782.

    Proteomic databases

    MaxQBi O14782.
    PaxDbi O14782.
    PRIDEi O14782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264712 ; ENSP00000264712 ; ENSG00000084731 .
    ENST00000405914 ; ENSP00000385030 ; ENSG00000084731 .
    GeneIDi 3797.
    KEGGi hsa:3797.

    Organism-specific databases

    CTDi 3797.
    GeneCardsi GC02M026149.
    HGNCi HGNC:6321. KIF3C.
    HPAi HPA035755.
    MIMi 602845. gene.
    neXtProti NX_O14782.
    PharmGKBi PA30104.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOGENOMi HOG000116164.
    HOVERGENi HBG052255.
    InParanoidi O14782.
    KOi K10394.
    OMAi WVAEEED.
    OrthoDBi EOG7WX086.
    PhylomeDBi O14782.
    TreeFami TF105223.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_25201. Kinesins.

    Miscellaneous databases

    ChiTaRSi KIF3C. human.
    EvolutionaryTracei O14782.
    GeneWikii KIF3C.
    GenomeRNAii 3797.
    NextBioi 14909.
    PROi O14782.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14782.
    Bgeei O14782.
    CleanExi HS_KIF3C.
    Genevestigatori O14782.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 2 hits.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23."
      Sardella M., Navone F., Rocchi M., Rubartelli A., Viggiano L., Vignali G., Consalez G.G., Sitia R., Cabibbo A.
      Genomics 47:405-408(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-370.
    2. "cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C."
      Telford E.A.R., Wightman P., Leek J., Markham A.F., Lench N.J., Bonthron D.T.
      Biochem. Biophys. Res. Commun. 242:407-412(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ARG-370.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-370.
      Tissue: Uterus.
    5. "Motor domain of human kinesin family member 3C in complex with ADP."
      Structural genomics consortium (SGC)
      Submitted (JAN-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 7-383 IN COMPLEX WITH ADP.

    Entry informationi

    Entry nameiKIF3C_HUMAN
    AccessioniPrimary (citable) accession number: O14782
    Secondary accession number(s): O43544
    , Q4ZG18, Q53SX5, Q562F7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3