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O14782

- KIF3C_HUMAN

UniProt

O14782 - KIF3C_HUMAN

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Protein

Kinesin-like protein KIF3C

Gene
KIF3C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1048ATP

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: InterPro
  3. motor activity Source: ProtInc

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. blood coagulation Source: Reactome
  3. metabolic process Source: GOC
  4. microtubule-based movement Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_25201. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3C
Gene namesi
Name:KIF3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:6321. KIF3C.

Subcellular locationi

Cytoplasmcytoskeleton Inferred

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. kinesin complex Source: ProtInc
  3. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 793793Kinesin-like protein KIF3CPRO_0000125397Add
BLAST

Proteomic databases

MaxQBiO14782.
PaxDbiO14782.
PRIDEiO14782.

PTM databases

PhosphoSiteiO14782.

Expressioni

Gene expression databases

ArrayExpressiO14782.
BgeeiO14782.
CleanExiHS_KIF3C.
GenevestigatoriO14782.

Organism-specific databases

HPAiHPA035755.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3C By similarity.

Protein-protein interaction databases

BioGridi109998. 4 interactions.
IntActiO14782. 3 interactions.
STRINGi9606.ENSP00000264712.

Structurei

Secondary structure

1
793
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi12 – 176
Helixi22 – 265
Beta strandi33 – 364
Turni37 – 404
Beta strandi41 – 444
Beta strandi56 – 594
Beta strandi61 – 644
Helixi70 – 778
Helixi79 – 868
Beta strandi91 – 977
Helixi103 – 1075
Turni114 – 1163
Helixi119 – 13315
Beta strandi138 – 15114
Beta strandi153 – 1553
Beta strandi167 – 1704
Turni171 – 1733
Beta strandi174 – 1774
Helixi188 – 20114
Beta strandi215 – 22713
Beta strandi237 – 24610
Helixi295 – 30713
Helixi317 – 3193
Helixi321 – 3255
Helixi326 – 3294
Beta strandi332 – 34211
Helixi346 – 3483
Helixi349 – 36214

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B6VX-ray2.70A/B7-383[»]
ProteinModelPortaliO14782.
SMRiO14782. Positions 7-372.

Miscellaneous databases

EvolutionaryTraceiO14782.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 365356Kinesin motorAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni630 – 793164Globular Reviewed predictionAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili376 – 629254 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi270 – 28415Poly-GlyAdd
BLAST
Compositional biasi438 – 4414Poly-Asn

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO14782.
KOiK10394.
OMAiWVAEEED.
OrthoDBiEOG7WX086.
PhylomeDBiO14782.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14782-1 [UniParc]FASTAAdd to Basket

« Hide

MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA    50
PGELPKTFTF DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG 100
TGKTYTMQGT WVEPELRGVI PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ 150
EEIRDLLSKE PGKRLELKEN PETGVYIKDL SSFVTKNVKE IEHVMNLGNQ 200
TRAVGSTHMN EVSSRSHAIF IITVECSERG SDGQDHIRVG KLNLVDLAGS 250
ERQNKAGPNT AGGAATPSSG GGGGGGGSGG GAGGERPKEA SKINLSLSAL 300
GNVIAALAGN RSTHIPYRDS KLTRLLQDSL GGNAKTIMVA TLGPASHSYD 350
ESLSTLRFAN RAKNIKNKPQ VNEDPKDTLL REFQEEIARL KAQLEKRGML 400
GKRPRRKSSR RKKAVSAPPG YPEGPVIEAW VAEEEDDNNN NHRPPQPILE 450
SALEKNMENY LQEQKERLEE EKAAIQDDRS LVSEEKQKLL EEKEKMLEDL 500
RREQQATELL AAKYKAMESK LLIGGRNIMD HTNEQQKMLE LKRQEIAEQK 550
RREREMQQEM MLRDEETMEL RGTYTSLQQE VEVKTKKLKK LYAKLQAVKA 600
EIQDQHDEYI RVRQDLEEAQ NEQTRELKLK YLIIENFIPP EEKNKIMNRL 650
FLDCEEEQWK FQPLVPAGVS SSQMKKRPTS AVGYKRPISQ YARVAMAMGS 700
HPRYRAENIM FLELDVSPPA VFEMEFSHDQ EQDPRALHME RLMRLDSFLE 750
RPSTSKVRKS RSWCQSPQRP PPSTTHASLA SASLRPATVA DHE 793
Length:793
Mass (Da):89,426
Last modified:October 5, 2010 - v3
Checksum:i9C6974265DE0A030
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti370 – 3701Q → R.3 Publications
Corresponds to variant rs1465878 [ dbSNP | Ensembl ].
VAR_055120

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 793TVR → RE in AAC05302. 1 Publication
Sequence conflicti110 – 1112TW → DL in AAC05302. 1 Publication
Sequence conflicti163 – 1631K → R in AAC05302. 1 Publication
Sequence conflicti471 – 4711E → D in AAC05302. 1 Publication
Sequence conflicti630 – 6301K → G in AAC05302. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF018164 mRNA. Translation: AAC05302.1.
AF035621 mRNA. Translation: AAC39562.1.
AJ002223 Genomic DNA. Translation: CAA05252.1.
AJ002224 Genomic DNA. Translation: CAA05253.1.
AJ002225 Genomic DNA. Translation: CAA05254.1.
AJ002226 Genomic DNA. Translation: CAA05255.1.
AJ002227 Genomic DNA. Translation: CAA05256.1.
AJ002228 Genomic DNA. Translation: CAA05257.1.
AJ002229 Genomic DNA. Translation: CAA05258.1.
AC013449 Genomic DNA. Translation: AAY24261.1.
AC064847 Genomic DNA. Translation: AAX88877.1.
BC092406 mRNA. Translation: AAH92406.1.
BC130423 mRNA. Translation: AAI30424.1.
CCDSiCCDS1719.1.
PIRiJC5831.
RefSeqiNP_002245.4. NM_002254.6.
UniGeneiHs.21611.

Genome annotation databases

EnsembliENST00000264712; ENSP00000264712; ENSG00000084731.
ENST00000405914; ENSP00000385030; ENSG00000084731.
GeneIDi3797.
KEGGihsa:3797.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF018164 mRNA. Translation: AAC05302.1 .
AF035621 mRNA. Translation: AAC39562.1 .
AJ002223 Genomic DNA. Translation: CAA05252.1 .
AJ002224 Genomic DNA. Translation: CAA05253.1 .
AJ002225 Genomic DNA. Translation: CAA05254.1 .
AJ002226 Genomic DNA. Translation: CAA05255.1 .
AJ002227 Genomic DNA. Translation: CAA05256.1 .
AJ002228 Genomic DNA. Translation: CAA05257.1 .
AJ002229 Genomic DNA. Translation: CAA05258.1 .
AC013449 Genomic DNA. Translation: AAY24261.1 .
AC064847 Genomic DNA. Translation: AAX88877.1 .
BC092406 mRNA. Translation: AAH92406.1 .
BC130423 mRNA. Translation: AAI30424.1 .
CCDSi CCDS1719.1.
PIRi JC5831.
RefSeqi NP_002245.4. NM_002254.6.
UniGenei Hs.21611.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3B6V X-ray 2.70 A/B 7-383 [» ]
ProteinModelPortali O14782.
SMRi O14782. Positions 7-372.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109998. 4 interactions.
IntActi O14782. 3 interactions.
STRINGi 9606.ENSP00000264712.

Chemistry

ChEMBLi CHEMBL1075196.

PTM databases

PhosphoSitei O14782.

Proteomic databases

MaxQBi O14782.
PaxDbi O14782.
PRIDEi O14782.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264712 ; ENSP00000264712 ; ENSG00000084731 .
ENST00000405914 ; ENSP00000385030 ; ENSG00000084731 .
GeneIDi 3797.
KEGGi hsa:3797.

Organism-specific databases

CTDi 3797.
GeneCardsi GC02M026149.
HGNCi HGNC:6321. KIF3C.
HPAi HPA035755.
MIMi 602845. gene.
neXtProti NX_O14782.
PharmGKBi PA30104.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5059.
HOGENOMi HOG000116164.
HOVERGENi HBG052255.
InParanoidi O14782.
KOi K10394.
OMAi WVAEEED.
OrthoDBi EOG7WX086.
PhylomeDBi O14782.
TreeFami TF105223.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_25201. Kinesins.

Miscellaneous databases

ChiTaRSi KIF3C. human.
EvolutionaryTracei O14782.
GeneWikii KIF3C.
GenomeRNAii 3797.
NextBioi 14909.
PROi O14782.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14782.
Bgeei O14782.
CleanExi HS_KIF3C.
Genevestigatori O14782.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 2 hits.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23."
    Sardella M., Navone F., Rocchi M., Rubartelli A., Viggiano L., Vignali G., Consalez G.G., Sitia R., Cabibbo A.
    Genomics 47:405-408(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-370.
  2. "cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C."
    Telford E.A.R., Wightman P., Leek J., Markham A.F., Lench N.J., Bonthron D.T.
    Biochem. Biophys. Res. Commun. 242:407-412(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ARG-370.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-370.
    Tissue: Uterus.
  5. "Motor domain of human kinesin family member 3C in complex with ADP."
    Structural genomics consortium (SGC)
    Submitted (JAN-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 7-383 IN COMPLEX WITH ADP.

Entry informationi

Entry nameiKIF3C_HUMAN
AccessioniPrimary (citable) accession number: O14782
Secondary accession number(s): O43544
, Q4ZG18, Q53SX5, Q562F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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