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Protein

Kinesin-like protein KIF3C

Gene

KIF3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATP8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: GO_Central
  • motor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084731-MONOMER.
ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-5620924. Intraflagellar transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3C
Gene namesi
Name:KIF3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6321. KIF3C.

Subcellular locationi

GO - Cellular componenti

  • ciliary tip Source: Reactome
  • cytosol Source: Reactome
  • kinesin complex Source: ProtInc
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi3797.
PharmGKBiPA30104.

Chemistry databases

ChEMBLiCHEMBL1075196.

Polymorphism and mutation databases

BioMutaiKIF3C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253971 – 793Kinesin-like protein KIF3CAdd BLAST793

Proteomic databases

EPDiO14782.
MaxQBiO14782.
PaxDbiO14782.
PeptideAtlasiO14782.
PRIDEiO14782.

PTM databases

iPTMnetiO14782.
PhosphoSitePlusiO14782.

Expressioni

Gene expression databases

BgeeiENSG00000084731.
CleanExiHS_KIF3C.
ExpressionAtlasiO14782. baseline and differential.
GenevisibleiO14782. HS.

Organism-specific databases

HPAiHPA035755.

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3C.By similarity

Protein-protein interaction databases

BioGridi109998. 6 interactors.
IntActiO14782. 8 interactors.
STRINGi9606.ENSP00000264712.

Structurei

Secondary structure

1793
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 17Combined sources6
Helixi22 – 26Combined sources5
Beta strandi33 – 36Combined sources4
Turni37 – 40Combined sources4
Beta strandi41 – 44Combined sources4
Beta strandi56 – 59Combined sources4
Beta strandi61 – 64Combined sources4
Helixi70 – 77Combined sources8
Helixi79 – 86Combined sources8
Beta strandi91 – 97Combined sources7
Helixi103 – 107Combined sources5
Turni114 – 116Combined sources3
Helixi119 – 133Combined sources15
Beta strandi138 – 151Combined sources14
Beta strandi153 – 155Combined sources3
Beta strandi167 – 170Combined sources4
Turni171 – 173Combined sources3
Beta strandi174 – 177Combined sources4
Helixi188 – 201Combined sources14
Beta strandi215 – 227Combined sources13
Beta strandi237 – 246Combined sources10
Helixi295 – 307Combined sources13
Helixi317 – 319Combined sources3
Helixi321 – 325Combined sources5
Helixi326 – 329Combined sources4
Beta strandi332 – 342Combined sources11
Helixi346 – 348Combined sources3
Helixi349 – 362Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B6VX-ray2.70A/B7-383[»]
ProteinModelPortaliO14782.
SMRiO14782.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14782.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 365Kinesin motorPROSITE-ProRule annotationAdd BLAST356

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni630 – 793GlobularSequence analysisAdd BLAST164

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili376 – 629Sequence analysisAdd BLAST254

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi270 – 284Poly-GlyAdd BLAST15
Compositional biasi438 – 441Poly-Asn4

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO14782.
KOiK20197.
OrthoDBiEOG091G03RO.
PhylomeDBiO14782.
TreeFamiTF105223.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKTKASEA LKVVARCRPL SRKEEAAGHE QILTMDVKLG QVTLRNPRAA
60 70 80 90 100
PGELPKTFTF DAVYDASSKQ ADLYDETVRP LIDSVLQGFN GTVFAYGQTG
110 120 130 140 150
TGKTYTMQGT WVEPELRGVI PNAFEHIFTH ISRSQNQQYL VRASYLEIYQ
160 170 180 190 200
EEIRDLLSKE PGKRLELKEN PETGVYIKDL SSFVTKNVKE IEHVMNLGNQ
210 220 230 240 250
TRAVGSTHMN EVSSRSHAIF IITVECSERG SDGQDHIRVG KLNLVDLAGS
260 270 280 290 300
ERQNKAGPNT AGGAATPSSG GGGGGGGSGG GAGGERPKEA SKINLSLSAL
310 320 330 340 350
GNVIAALAGN RSTHIPYRDS KLTRLLQDSL GGNAKTIMVA TLGPASHSYD
360 370 380 390 400
ESLSTLRFAN RAKNIKNKPQ VNEDPKDTLL REFQEEIARL KAQLEKRGML
410 420 430 440 450
GKRPRRKSSR RKKAVSAPPG YPEGPVIEAW VAEEEDDNNN NHRPPQPILE
460 470 480 490 500
SALEKNMENY LQEQKERLEE EKAAIQDDRS LVSEEKQKLL EEKEKMLEDL
510 520 530 540 550
RREQQATELL AAKYKAMESK LLIGGRNIMD HTNEQQKMLE LKRQEIAEQK
560 570 580 590 600
RREREMQQEM MLRDEETMEL RGTYTSLQQE VEVKTKKLKK LYAKLQAVKA
610 620 630 640 650
EIQDQHDEYI RVRQDLEEAQ NEQTRELKLK YLIIENFIPP EEKNKIMNRL
660 670 680 690 700
FLDCEEEQWK FQPLVPAGVS SSQMKKRPTS AVGYKRPISQ YARVAMAMGS
710 720 730 740 750
HPRYRAENIM FLELDVSPPA VFEMEFSHDQ EQDPRALHME RLMRLDSFLE
760 770 780 790
RPSTSKVRKS RSWCQSPQRP PPSTTHASLA SASLRPATVA DHE
Length:793
Mass (Da):89,426
Last modified:October 5, 2010 - v3
Checksum:i9C6974265DE0A030
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77 – 79TVR → RE in AAC05302 (PubMed:9480755).Curated3
Sequence conflicti110 – 111TW → DL in AAC05302 (PubMed:9480755).Curated2
Sequence conflicti163K → R in AAC05302 (PubMed:9480755).Curated1
Sequence conflicti471E → D in AAC05302 (PubMed:9480755).Curated1
Sequence conflicti630K → G in AAC05302 (PubMed:9480755).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055120370Q → R.3 PublicationsCorresponds to variant rs1465878dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018164 mRNA. Translation: AAC05302.1.
AF035621 mRNA. Translation: AAC39562.1.
AJ002223 Genomic DNA. Translation: CAA05252.1.
AJ002224 Genomic DNA. Translation: CAA05253.1.
AJ002225 Genomic DNA. Translation: CAA05254.1.
AJ002226 Genomic DNA. Translation: CAA05255.1.
AJ002227 Genomic DNA. Translation: CAA05256.1.
AJ002228 Genomic DNA. Translation: CAA05257.1.
AJ002229 Genomic DNA. Translation: CAA05258.1.
AC013449 Genomic DNA. Translation: AAY24261.1.
AC064847 Genomic DNA. Translation: AAX88877.1.
BC092406 mRNA. Translation: AAH92406.1.
BC130423 mRNA. Translation: AAI30424.1.
CCDSiCCDS1719.1.
PIRiJC5831.
RefSeqiNP_002245.4. NM_002254.6.
UniGeneiHs.21611.

Genome annotation databases

EnsembliENST00000264712; ENSP00000264712; ENSG00000084731.
ENST00000405914; ENSP00000385030; ENSG00000084731.
GeneIDi3797.
KEGGihsa:3797.
UCSCiuc002rgu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018164 mRNA. Translation: AAC05302.1.
AF035621 mRNA. Translation: AAC39562.1.
AJ002223 Genomic DNA. Translation: CAA05252.1.
AJ002224 Genomic DNA. Translation: CAA05253.1.
AJ002225 Genomic DNA. Translation: CAA05254.1.
AJ002226 Genomic DNA. Translation: CAA05255.1.
AJ002227 Genomic DNA. Translation: CAA05256.1.
AJ002228 Genomic DNA. Translation: CAA05257.1.
AJ002229 Genomic DNA. Translation: CAA05258.1.
AC013449 Genomic DNA. Translation: AAY24261.1.
AC064847 Genomic DNA. Translation: AAX88877.1.
BC092406 mRNA. Translation: AAH92406.1.
BC130423 mRNA. Translation: AAI30424.1.
CCDSiCCDS1719.1.
PIRiJC5831.
RefSeqiNP_002245.4. NM_002254.6.
UniGeneiHs.21611.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B6VX-ray2.70A/B7-383[»]
ProteinModelPortaliO14782.
SMRiO14782.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109998. 6 interactors.
IntActiO14782. 8 interactors.
STRINGi9606.ENSP00000264712.

Chemistry databases

ChEMBLiCHEMBL1075196.

PTM databases

iPTMnetiO14782.
PhosphoSitePlusiO14782.

Polymorphism and mutation databases

BioMutaiKIF3C.

Proteomic databases

EPDiO14782.
MaxQBiO14782.
PaxDbiO14782.
PeptideAtlasiO14782.
PRIDEiO14782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264712; ENSP00000264712; ENSG00000084731.
ENST00000405914; ENSP00000385030; ENSG00000084731.
GeneIDi3797.
KEGGihsa:3797.
UCSCiuc002rgu.3. human.

Organism-specific databases

CTDi3797.
DisGeNETi3797.
GeneCardsiKIF3C.
HGNCiHGNC:6321. KIF3C.
HPAiHPA035755.
MIMi602845. gene.
neXtProtiNX_O14782.
PharmGKBiPA30104.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0240. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000116164.
HOVERGENiHBG052255.
InParanoidiO14782.
KOiK20197.
OrthoDBiEOG091G03RO.
PhylomeDBiO14782.
TreeFamiTF105223.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084731-MONOMER.
ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-5620924. Intraflagellar transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIF3C. human.
EvolutionaryTraceiO14782.
GeneWikiiKIF3C.
GenomeRNAii3797.
PROiO14782.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084731.
CleanExiHS_KIF3C.
ExpressionAtlasiO14782. baseline and differential.
GenevisibleiO14782. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 2 hits.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF3C_HUMAN
AccessioniPrimary (citable) accession number: O14782
Secondary accession number(s): O43544
, Q4ZG18, Q53SX5, Q562F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.