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O14775

- GBB5_HUMAN

UniProt

O14775 - GBB5_HUMAN

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Protein

Guanine nucleotide-binding protein subunit beta-5

Gene

GNB5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. chaperone binding Source: UniProt
  2. G-protein gamma-subunit binding Source: UniProt
  3. GTPase activity Source: UniProtKB
  4. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. negative regulation of voltage-gated calcium channel activity Source: UniProt
  3. phototransduction, visible light Source: Reactome
  4. regulation of rhodopsin mediated signaling pathway Source: Reactome
  5. rhodopsin mediated signaling pathway Source: Reactome
  6. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
SignaLinkiO14775.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-5
Alternative name(s):
Gbeta5
Transducin beta chain 5
Gene namesi
Name:GNB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:4401. GNB5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Guanine nucleotide-binding protein subunit beta-5PRO_0000127705Add
BLAST

Proteomic databases

MaxQBiO14775.
PaxDbiO14775.
PRIDEiO14775.

PTM databases

PhosphoSiteiO14775.

Expressioni

Tissue specificityi

Expressed in multiple tissues.

Gene expression databases

BgeeiO14775.
CleanExiHS_GNB5.
ExpressionAtlasiO14775. baseline and differential.
GenevestigatoriO14775.

Organism-specific databases

HPAiCAB032353.
HPA041942.
HPA044198.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Component of the RGS9-1-Gbeta5 complex composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) and RGS9BP (By similarity).By similarity

Protein-protein interaction databases

BioGridi115920. 33 interactions.
IntActiO14775. 27 interactions.
MINTiMINT-1399610.
STRINGi9606.ENSP00000261837.

Structurei

3D structure databases

ProteinModelPortaliO14775.
SMRiO14775. Positions 43-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati103 – 14240WD 1Add
BLAST
Repeati145 – 18440WD 2Add
BLAST
Repeati193 – 23442WD 3Add
BLAST
Repeati236 – 27843WD 4Add
BLAST
Repeati279 – 31840WD 5Add
BLAST
Repeati320 – 36243WD 6Add
BLAST
Repeati365 – 39430WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119239.
HOGENOMiHOG000176356.
HOVERGENiHBG000188.
InParanoidiO14775.
KOiK04539.
OMAiDQTFLVN.
OrthoDBiEOG7GN2N5.
PhylomeDBiO14775.
TreeFamiTF106149.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PIRSFiPIRSF002394. GN-bd_beta. 1 hit.
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14775-1) [UniParc]FASTAAdd to Basket

Also known as: Long, Beta-5L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCDQTFLVNV FGSCDKCFKQ RALRPVFKKS QQLSYCSTCA EIMATEGLHE
60 70 80 90 100
NETLASLKSE AESLKGKLEE ERAKLHDVEL HQVAERVEAL GQFVMKTRRT
110 120 130 140 150
LKGHGNKVLC MDWCKDKRRI VSSSQDGKVI VWDSFTTNKE HAVTMPCTWV
160 170 180 190 200
MACAYAPSGC AIACGGLDNK CSVYPLTFDK NENMAAKKKS VAMHTNYLSA
210 220 230 240 250
CSFTNSDMQI LTASGDGTCA LWDVESGQLL QSFHGHGADV LCLDLAPSET
260 270 280 290 300
GNTFVSGGCD KKAMVWDMRS GQCVQAFETH ESDINSVRYY PSGDAFASGS
310 320 330 340 350
DDATCRLYDL RADREVAIYS KESIIFGASS VDFSLSGRLL FAGYNDYTIN
360 370 380 390
VWDVLKGSRV SILFGHENRV STLRVSPDGT AFCSGSWDHT LRVWA
Length:395
Mass (Da):43,566
Last modified:October 31, 2003 - v2
Checksum:iE001B07FCFA587AD
GO
Isoform 2 (identifier: O14775-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:353
Mass (Da):38,760
Checksum:i982B08C9F2B9976B
GO
Isoform 3 (identifier: O14775-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     140-209: Missing.

Show »
Length:283
Mass (Da):31,247
Checksum:iBC7C4F15B805825B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231D → G in BAG37312. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131A → V.
Corresponds to variant rs34637551 [ dbSNP | Ensembl ].
VAR_049270

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 2 and isoform 3. 5 PublicationsVSP_008765Add
BLAST
Alternative sequencei140 – 20970Missing in isoform 3. 1 PublicationVSP_039101Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017656 mRNA. Translation: AAC63826.1.
AL117471 mRNA. Translation: CAB55946.1.
AF501885 mRNA. Translation: AAM15921.1.
AF300650 mRNA. Translation: AAG18444.1.
AK314775 mRNA. Translation: BAG37312.1.
BC013997 mRNA. Translation: AAH13997.1.
CCDSiCCDS10149.1. [O14775-1]
CCDS45261.1. [O14775-2]
PIRiT17256.
RefSeqiNP_006569.1. NM_006578.3. [O14775-2]
NP_057278.2. NM_016194.3. [O14775-1]
UniGeneiHs.155090.

Genome annotation databases

EnsembliENST00000261837; ENSP00000261837; ENSG00000069966. [O14775-1]
ENST00000358784; ENSP00000351635; ENSG00000069966. [O14775-2]
ENST00000396335; ENSP00000379626; ENSG00000069966. [O14775-3]
GeneIDi10681.
KEGGihsa:10681.
UCSCiuc002abr.1. human. [O14775-1]
uc002abs.1. human. [O14775-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017656 mRNA. Translation: AAC63826.1 .
AL117471 mRNA. Translation: CAB55946.1 .
AF501885 mRNA. Translation: AAM15921.1 .
AF300650 mRNA. Translation: AAG18444.1 .
AK314775 mRNA. Translation: BAG37312.1 .
BC013997 mRNA. Translation: AAH13997.1 .
CCDSi CCDS10149.1. [O14775-1 ]
CCDS45261.1. [O14775-2 ]
PIRi T17256.
RefSeqi NP_006569.1. NM_006578.3. [O14775-2 ]
NP_057278.2. NM_016194.3. [O14775-1 ]
UniGenei Hs.155090.

3D structure databases

ProteinModelPortali O14775.
SMRi O14775. Positions 43-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115920. 33 interactions.
IntActi O14775. 27 interactions.
MINTi MINT-1399610.
STRINGi 9606.ENSP00000261837.

PTM databases

PhosphoSitei O14775.

Proteomic databases

MaxQBi O14775.
PaxDbi O14775.
PRIDEi O14775.

Protocols and materials databases

DNASUi 10681.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261837 ; ENSP00000261837 ; ENSG00000069966 . [O14775-1 ]
ENST00000358784 ; ENSP00000351635 ; ENSG00000069966 . [O14775-2 ]
ENST00000396335 ; ENSP00000379626 ; ENSG00000069966 . [O14775-3 ]
GeneIDi 10681.
KEGGi hsa:10681.
UCSCi uc002abr.1. human. [O14775-1 ]
uc002abs.1. human. [O14775-3 ]

Organism-specific databases

CTDi 10681.
GeneCardsi GC15M052413.
HGNCi HGNC:4401. GNB5.
HPAi CAB032353.
HPA041942.
HPA044198.
MIMi 604447. gene.
neXtProti NX_O14775.
PharmGKBi PA28780.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000119239.
HOGENOMi HOG000176356.
HOVERGENi HBG000188.
InParanoidi O14775.
KOi K04539.
OMAi DQTFLVN.
OrthoDBi EOG7GN2N5.
PhylomeDBi O14775.
TreeFami TF106149.

Enzyme and pathway databases

Reactomei REACT_15457. G-protein activation.
REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
SignaLinki O14775.

Miscellaneous databases

ChiTaRSi GNB5. human.
GeneWikii GNB5.
GenomeRNAii 10681.
NextBioi 35468110.
PROi O14775.
SOURCEi Search...

Gene expression databases

Bgeei O14775.
CleanExi HS_GNB5.
ExpressionAtlasi O14775. baseline and differential.
Genevestigatori O14775.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 7 hits.
[Graphical view ]
PIRSFi PIRSF002394. GN-bd_beta. 1 hit.
PRINTSi PR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and tissue distribution of the human G protein beta 5 cDNA."
    Jones P.G., Lombardi S.J., Cockett M.I.
    Biochim. Biophys. Acta 1402:288-291(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Uterus.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lymph.

Entry informationi

Entry nameiGBB5_HUMAN
AccessioniPrimary (citable) accession number: O14775
Secondary accession number(s): B2RBR5, Q9HAU9, Q9UFT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 31, 2003
Last modified: November 26, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3