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O14772 (FPGT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fucose-1-phosphate guanylyltransferase

EC=2.7.7.30
Alternative name(s):
GDP-L-fucose diphosphorylase
GDP-L-fucose pyrophosphorylase
Gene names
Name:FPGT
Synonyms:GFPP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

Catalytic activity

GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in many tissues.

Sequence caution

The sequence BAG65299.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandGTP-binding
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfucose metabolic process

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentcytoplasm

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

catalytic activity

Traceable author statement Ref.1. Source: ProtInc

fucose-1-phosphate guanylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: O14772-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: Q59H18-1)

The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.
Isoform 3 (identifier: Q59H18-3)

The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.
Isoform 4 (identifier: Q59H18-4)

The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.
Isoform 5 (identifier: O14772-2)

The sequence of this isoform differs from the canonical sequence as follows:
     137-390: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: O14772-3)

The sequence of this isoform differs from the canonical sequence as follows:
     115-594: GGYSQRLPNA...LEISLKSSLM → VSFQIYQNAL...KTALLVVLTS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594Fucose-1-phosphate guanylyltransferase
PRO_0000087327

Natural variations

Alternative sequence115 – 594480GGYSQ…KSSLM → VSFQIYQNALAKHPVSFKAY WIQDVLWHLAQLWSIPDWGL MFQLGKTALLVVLTS in isoform 6.
VSP_046460
Alternative sequence137 – 390254Missing in isoform 5.
VSP_045076
Natural variant4481P → L.
Corresponds to variant rs55882158 [ dbSNP | Ensembl ].
VAR_061650

Experimental info

Sequence conflict441A → T in BAG61434. Ref.2
Sequence conflict3221N → H in AAC73005. Ref.1
Sequence conflict5491K → R in BAG61434. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 15BA9CB906C70CC7

FASTA59466,599
        10         20         30         40         50         60 
MAAARDPPEV SLREATQRKL RRFSELRGKL VARGEFWDIV AITAADEKQE LAYNQQLSEK 

        70         80         90        100        110        120 
LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSGGYSQR 

       130        140        150        160        170        180 
LPNASALGKI FTALPLGNPI YQMLELKLAM YIDFPLNMNP GILVTCADDI ELYSIGEFEF 

       190        200        210        220        230        240 
IRFDKPGFTA LAHPSSLTIG TTHGVFVLDP FDDLKHRDLE YRSCHRFLHK PSIEKMYQFN 

       250        260        270        280        290        300 
AVCRPGNFCQ QDFAGGDIAD LKLDSDYVYT DSLFYMDHKS AKMLLAFYEK IGTLSCEIDA 

       310        320        330        340        350        360 
YGDFLQALGP GATVEYTRNT SNVIKEESEL VEMRQRIFHL LKGTSLNVVV LNNSKFYHIG 

       370        380        390        400        410        420 
TTEEYLFYFT SDNSLKSELG LQSITFSIFP DIPECSGKTS CIIQSILDSR CSVAPGSVVE 

       430        440        450        460        470        480 
YSRLGPDVSV GENCIISGSY ILTKAALPAH SFVCSLSLKM NRCLKYATMA FGVQDNLKKS 

       490        500        510        520        530        540 
VKTLSDIKLL QFFGVCFLSC LDVWNLKVTE ELFSGNKTCL SLWTARIFPV CSSLSDSVIT 

       550        560        570        580        590 
SLKMLNAVKN KSAFSLNSYK LLSIEEMLIY KDVEDMITYR EQIFLEISLK SSLM 

« Hide

Isoform 1 [UniParc].

See Q59H18.

Isoform 3 [UniParc].

See Q59H18.

Isoform 4 [UniParc].

See Q59H18.

Isoform 5 [UniParc].

Checksum: 804504F161653FD2
Show »

FASTA34037,631
Isoform 6 [UniParc].

Checksum: E8D68424A3C4D277
Show »

FASTA16919,170

References

« Hide 'large scale' references
[1]"GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme."
Pastuszak I., Ketchum C., Hermanson G., Sjoberg E.J., Drake R., Elbein A.D.
J. Biol. Chem. 273:30165-30174(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), CHARACTERIZATION.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6).
Tissue: Tongue and Uterus.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Colon and Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017445 mRNA. Translation: AAC73005.1.
AF017446 Genomic DNA. Translation: AAC82511.1.
AK299468 mRNA. Translation: BAG61434.1.
AK304490 mRNA. Translation: BAG65299.1. Sequence problems.
AC098692 Genomic DNA. No translation available.
BC032308 mRNA. Translation: AAH32308.1.
RefSeqNP_001186257.2. NM_001199328.2.
NP_001186258.2. NM_001199329.2.
NP_003829.3. NM_003838.4.
UniGeneHs.480085.

3D structure databases

ProteinModelPortalO14772.
SMRO14772. Positions 109-168.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114318. 2 interactions.
STRING9606.ENSP00000359928.

Proteomic databases

MaxQBO14772.
PaxDbO14772.
PRIDEO14772.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370894; ENSP00000359931; ENSG00000254685. [O14772-3]
ENST00000534056; ENSP00000432819; ENSG00000254685. [O14772-2]
ENST00000609362; ENSP00000476680; ENSG00000254685. [O14772-1]
GeneID8790.
KEGGhsa:8790.
UCSCuc001dgb.2. human. [O14772-1]

Organism-specific databases

CTD8790.
GeneCardsGC01P074663.
HGNCHGNC:3825. FPGT.
MIM603609. gene.
neXtProtNX_O14772.
PharmGKBPA28243.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000067964.
HOVERGENHBG025123.
KOK00976.
OMAKLAMYVD.
OrthoDBEOG7SFHW9.
PhylomeDBO14772.
TreeFamTF328750.

Gene expression databases

ArrayExpressO14772.
BgeeO14772.
CleanExHS_FPGT.
GenevestigatorO14772.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
InterProIPR012887. Fucokinase.
IPR012120. Fucose-1-phosphate_GuaTrfase.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamPF07959. Fucokinase. 1 hit.
[Graphical view]
PIRSFPIRSF036640. FPGT. 1 hit.
SUPFAMSSF51161. SSF51161. 1 hit.
ProtoNetSearch...

Other

GeneWikiFPGT.
GenomeRNAi8790.
NextBio32968.
PROO14772.
SOURCESearch...

Entry information

Entry nameFPGT_HUMAN
AccessionPrimary (citable) accession number: O14772
Secondary accession number(s): A6NMH3 expand/collapse secondary AC list , B4DRX2, B4E2Y7, E9PNQ2, Q8N5J7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: February 20, 2007
Last modified: June 11, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM