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O14772 (FPGT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fucose-1-phosphate guanylyltransferase

EC=2.7.7.30
Alternative name(s):
GDP-L-fucose diphosphorylase
GDP-L-fucose pyrophosphorylase
Gene names
Name:FPGT
Synonyms:GFPP
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

Catalytic activity

GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in many tissues.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandGTP-binding
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processfucose metabolic process

Traceable author statement. Source: ProtInc

   Cellular componentcytoplasm

Traceable author statement. Source: ProtInc

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

fucose-1-phosphate guanylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: O14772-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: Q59H18-1)

The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.
Isoform 3 (identifier: Q59H18-3)

The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.
Isoform 4 (identifier: Q59H18-4)

The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 594593Fucose-1-phosphate guanylyltransferase
PRO_0000087327

Amino acid modifications

Modified residue21N-acetylalanine Ref.3

Natural variations

Natural variant4481P → L.
Corresponds to variant rs55882158 [ dbSNP | Ensembl ].
VAR_061650

Experimental info

Sequence conflict3221N → H in AAC73005. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 15BA9CB906C70CC7

FASTA59466,599
        10         20         30         40         50         60 
MAAARDPPEV SLREATQRKL RRFSELRGKL VARGEFWDIV AITAADEKQE LAYNQQLSEK 

        70         80         90        100        110        120 
LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSGGYSQR 

       130        140        150        160        170        180 
LPNASALGKI FTALPLGNPI YQMLELKLAM YIDFPLNMNP GILVTCADDI ELYSIGEFEF 

       190        200        210        220        230        240 
IRFDKPGFTA LAHPSSLTIG TTHGVFVLDP FDDLKHRDLE YRSCHRFLHK PSIEKMYQFN 

       250        260        270        280        290        300 
AVCRPGNFCQ QDFAGGDIAD LKLDSDYVYT DSLFYMDHKS AKMLLAFYEK IGTLSCEIDA 

       310        320        330        340        350        360 
YGDFLQALGP GATVEYTRNT SNVIKEESEL VEMRQRIFHL LKGTSLNVVV LNNSKFYHIG 

       370        380        390        400        410        420 
TTEEYLFYFT SDNSLKSELG LQSITFSIFP DIPECSGKTS CIIQSILDSR CSVAPGSVVE 

       430        440        450        460        470        480 
YSRLGPDVSV GENCIISGSY ILTKAALPAH SFVCSLSLKM NRCLKYATMA FGVQDNLKKS 

       490        500        510        520        530        540 
VKTLSDIKLL QFFGVCFLSC LDVWNLKVTE ELFSGNKTCL SLWTARIFPV CSSLSDSVIT 

       550        560        570        580        590 
SLKMLNAVKN KSAFSLNSYK LLSIEEMLIY KDVEDMITYR EQIFLEISLK SSLM 

« Hide

Isoform 1 [UniParc].

See Q59H18.

Isoform 3 [UniParc].

See Q59H18.

Isoform 4 [UniParc].

See Q59H18.

References

« Hide 'large scale' references
[1]"GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme."
Pastuszak I., Ketchum C., Hermanson G., Sjoberg E.J., Drake R., Elbein A.D.
J. Biol. Chem. 273:30165-30174(1998) [PubMed: 9804772] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), CHARACTERIZATION.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Colon and Kidney.
[3]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY.
Tissue: Embryonic kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017445 mRNA. Translation: AAC73005.1.
AF017446 Genomic DNA. Translation: AAC82511.1.
BC032308 mRNA. Translation: AAH32308.1.
IPIIPI00021943.
RefSeqNP_003829.2. NM_003838.3.
UniGeneHs.480085.

3D structure databases

ProteinModelPortalO14772.
ModBaseSearch...

Protein-protein interaction databases

STRINGO14772.

Proteomic databases

PRIDEO14772.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370898; ENSP00000359935; ENSG00000116783.
GeneID8790.
KEGGhsa:8790.
UCSCuc001dgb.1. human.

Organism-specific databases

CTD8790.
GeneCardsGC01P074663.
HGNCHGNC:3825. FPGT.
MIM603609. gene.
neXtProtNX_O14772.
PharmGKBPA28243.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG025123.
OrthoDBEOG4FFD1F.
PhylomeDBO14772.

Gene expression databases

ArrayExpressO14772.
BgeeO14772.
CleanExHS_FPGT.
GenevestigatorO14772.
GermOnlineENSG00000116783. Homo sapiens.

Family and domain databases

InterProIPR012887. Fucokinase.
IPR012120. Fucose-1-phosphate_GuaTrfase.
[Graphical view]
KOK00976.
PfamPF07959. Fucokinase. 1 hit.
[Graphical view]
PIRSFPIRSF036640. FPGT. 1 hit.
ProtoNetSearch...

Other

NextBio32968.
SOURCESearch...

Entry information

Entry nameFPGT_HUMAN
AccessionPrimary (citable) accession number: O14772
Secondary accession number(s): Q8N5J7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: February 20, 2007
Last modified: November 16, 2011
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot