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O14772

- FPGT_HUMAN

UniProt

O14772 - FPGT_HUMAN

Protein

Fucose-1-phosphate guanylyltransferase

Gene

FPGT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

    Catalytic activityi

    GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.

    GO - Molecular functioni

    1. catalytic activity Source: ProtInc
    2. fucose-1-phosphate guanylyltransferase activity Source: UniProtKB-EC
    3. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. fucose metabolic process Source: ProtInc

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)
    Alternative name(s):
    GDP-L-fucose diphosphorylase
    GDP-L-fucose pyrophosphorylase
    Gene namesi
    Name:FPGT
    Synonyms:GFPP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3825. FPGT.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28243.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594Fucose-1-phosphate guanylyltransferasePRO_0000087327Add
    BLAST

    Proteomic databases

    MaxQBiO14772.
    PaxDbiO14772.
    PRIDEiO14772.

    Expressioni

    Tissue specificityi

    Expressed in many tissues.

    Gene expression databases

    ArrayExpressiO14772.
    BgeeiO14772.
    CleanExiHS_FPGT.
    GenevestigatoriO14772.

    Interactioni

    Protein-protein interaction databases

    BioGridi114318. 2 interactions.
    STRINGi9606.ENSP00000359928.

    Structurei

    3D structure databases

    ProteinModelPortaliO14772.
    SMRiO14772. Positions 109-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000067964.
    HOVERGENiHBG025123.
    KOiK00976.
    OMAiKLAMYVD.
    OrthoDBiEOG7SFHW9.
    PhylomeDBiO14772.
    TreeFamiTF328750.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR012887. Fucokinase.
    IPR012120. Fucose-1-phosphate_GuaTrfase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF07959. Fucokinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036640. FPGT. 1 hit.
    SUPFAMiSSF51161. SSF51161. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: O14772-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAARDPPEV SLREATQRKL RRFSELRGKL VARGEFWDIV AITAADEKQE    50
    LAYNQQLSEK LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY 100
    GDKWNSFTIL LIHSGGYSQR LPNASALGKI FTALPLGNPI YQMLELKLAM 150
    YIDFPLNMNP GILVTCADDI ELYSIGEFEF IRFDKPGFTA LAHPSSLTIG 200
    TTHGVFVLDP FDDLKHRDLE YRSCHRFLHK PSIEKMYQFN AVCRPGNFCQ 250
    QDFAGGDIAD LKLDSDYVYT DSLFYMDHKS AKMLLAFYEK IGTLSCEIDA 300
    YGDFLQALGP GATVEYTRNT SNVIKEESEL VEMRQRIFHL LKGTSLNVVV 350
    LNNSKFYHIG TTEEYLFYFT SDNSLKSELG LQSITFSIFP DIPECSGKTS 400
    CIIQSILDSR CSVAPGSVVE YSRLGPDVSV GENCIISGSY ILTKAALPAH 450
    SFVCSLSLKM NRCLKYATMA FGVQDNLKKS VKTLSDIKLL QFFGVCFLSC 500
    LDVWNLKVTE ELFSGNKTCL SLWTARIFPV CSSLSDSVIT SLKMLNAVKN 550
    KSAFSLNSYK LLSIEEMLIY KDVEDMITYR EQIFLEISLK SSLM 594
    Length:594
    Mass (Da):66,599
    Last modified:February 20, 2007 - v2
    Checksum:i15BA9CB906C70CC7
    GO
    Isoform 1 (identifier: Q59H18-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q59H18.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

    Length:936
    Mass (Da):104,179
    GO
    Isoform 3 (identifier: Q59H18-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q59H18.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

    Length:697
    Mass (Da):77,957
    GO
    Isoform 4 (identifier: Q59H18-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q59H18.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

    Length:843
    Mass (Da):94,517
    GO
    Isoform 5 (identifier: O14772-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         137-390: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:340
    Mass (Da):37,631
    Checksum:i804504F161653FD2
    GO
    Isoform 6 (identifier: O14772-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         115-594: GGYSQRLPNA...LEISLKSSLM → VSFQIYQNAL...KTALLVVLTS

    Note: No experimental confirmation available.

    Show »
    Length:169
    Mass (Da):19,170
    Checksum:iE8D68424A3C4D277
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441A → T in BAG61434. (PubMed:14702039)Curated
    Sequence conflicti322 – 3221N → H in AAC73005. (PubMed:9804772)Curated
    Sequence conflicti549 – 5491K → R in BAG61434. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti448 – 4481P → L.
    Corresponds to variant rs55882158 [ dbSNP | Ensembl ].
    VAR_061650

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei115 – 594480GGYSQ…KSSLM → VSFQIYQNALAKHPVSFKAY WIQDVLWHLAQLWSIPDWGL MFQLGKTALLVVLTS in isoform 6. 1 PublicationVSP_046460Add
    BLAST
    Alternative sequencei137 – 390254Missing in isoform 5. 1 PublicationVSP_045076Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017445 mRNA. Translation: AAC73005.1.
    AF017446 Genomic DNA. Translation: AAC82511.1.
    AK299468 mRNA. Translation: BAG61434.1.
    AK304490 mRNA. Translation: BAG65299.1. Sequence problems.
    AC098692 Genomic DNA. No translation available.
    BC032308 mRNA. Translation: AAH32308.1.
    RefSeqiNP_001186257.2. NM_001199328.2.
    NP_001186258.2. NM_001199329.2.
    NP_003829.3. NM_003838.4.
    UniGeneiHs.480085.

    Genome annotation databases

    EnsembliENST00000370894; ENSP00000359931; ENSG00000254685. [O14772-3]
    ENST00000534056; ENSP00000432819; ENSG00000254685. [O14772-2]
    GeneIDi8790.
    KEGGihsa:8790.
    UCSCiuc001dgb.2. human. [O14772-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017445 mRNA. Translation: AAC73005.1 .
    AF017446 Genomic DNA. Translation: AAC82511.1 .
    AK299468 mRNA. Translation: BAG61434.1 .
    AK304490 mRNA. Translation: BAG65299.1 . Sequence problems.
    AC098692 Genomic DNA. No translation available.
    BC032308 mRNA. Translation: AAH32308.1 .
    RefSeqi NP_001186257.2. NM_001199328.2.
    NP_001186258.2. NM_001199329.2.
    NP_003829.3. NM_003838.4.
    UniGenei Hs.480085.

    3D structure databases

    ProteinModelPortali O14772.
    SMRi O14772. Positions 109-168.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114318. 2 interactions.
    STRINGi 9606.ENSP00000359928.

    Proteomic databases

    MaxQBi O14772.
    PaxDbi O14772.
    PRIDEi O14772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370894 ; ENSP00000359931 ; ENSG00000254685 . [O14772-3 ]
    ENST00000534056 ; ENSP00000432819 ; ENSG00000254685 . [O14772-2 ]
    GeneIDi 8790.
    KEGGi hsa:8790.
    UCSCi uc001dgb.2. human. [O14772-1 ]

    Organism-specific databases

    CTDi 8790.
    GeneCardsi GC01P074663.
    HGNCi HGNC:3825. FPGT.
    MIMi 603609. gene.
    neXtProti NX_O14772.
    PharmGKBi PA28243.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000067964.
    HOVERGENi HBG025123.
    KOi K00976.
    OMAi KLAMYVD.
    OrthoDBi EOG7SFHW9.
    PhylomeDBi O14772.
    TreeFami TF328750.

    Miscellaneous databases

    GeneWikii FPGT.
    GenomeRNAii 8790.
    NextBioi 32968.
    PROi O14772.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14772.
    Bgeei O14772.
    CleanExi HS_FPGT.
    Genevestigatori O14772.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR012887. Fucokinase.
    IPR012120. Fucose-1-phosphate_GuaTrfase.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF07959. Fucokinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036640. FPGT. 1 hit.
    SUPFAMi SSF51161. SSF51161. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme."
      Pastuszak I., Ketchum C., Hermanson G., Sjoberg E.J., Drake R., Elbein A.D.
      J. Biol. Chem. 273:30165-30174(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), CHARACTERIZATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6).
      Tissue: Tongue and Uterus.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Colon and Kidney.

    Entry informationi

    Entry nameiFPGT_HUMAN
    AccessioniPrimary (citable) accession number: O14772
    Secondary accession number(s): A6NMH3
    , B4DRX2, B4E2Y7, E9PNQ2, Q8N5J7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3