O14772 (FPGT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fucose-1-phosphate guanylyltransferase
EC=2.7.7.30

Alternative name(s):
GDP-L-fucose diphosphorylase
GDP-L-fucose pyrophosphorylase

Gene names

Name:	FPGT
Synonyms:	GFPP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	594 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.
Catalytic activity	GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.
Subcellular location	Cytoplasm.
Tissue specificity	Expressed in many tissues.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fucose metabolic process Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Traceable author statement. Source: ProtInc
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW fucose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: O14772-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q59H18-1)

The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

Isoform 3 (identifier: Q59H18-3)

The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

Isoform 4 (identifier: Q59H18-4)

The sequence of this isoform can be found in the external entry Q59H18.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 594	593	Fucose-1-phosphate guanylyltransferase		PRO_0000087327
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.3
Natural variations
	Natural variant	448	1	P → L. Corresponds to variant rs55882158 [ dbSNP | Ensembl ].		VAR_061650
Experimental info
	Sequence conflict	322	1	N → H in AAC73005. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 15BA9CB906C70CC7	FASTA	594	66,599
	10 20 30 40 50 60 MAAARDPPEV SLREATQRKL RRFSELRGKL VARGEFWDIV AITAADEKQE LAYNQQLSEK 70 80 90 100 110 120 LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSGGYSQR 130 140 150 160 170 180 LPNASALGKI FTALPLGNPI YQMLELKLAM YIDFPLNMNP GILVTCADDI ELYSIGEFEF 190 200 210 220 230 240 IRFDKPGFTA LAHPSSLTIG TTHGVFVLDP FDDLKHRDLE YRSCHRFLHK PSIEKMYQFN 250 260 270 280 290 300 AVCRPGNFCQ QDFAGGDIAD LKLDSDYVYT DSLFYMDHKS AKMLLAFYEK IGTLSCEIDA 310 320 330 340 350 360 YGDFLQALGP GATVEYTRNT SNVIKEESEL VEMRQRIFHL LKGTSLNVVV LNNSKFYHIG 370 380 390 400 410 420 TTEEYLFYFT SDNSLKSELG LQSITFSIFP DIPECSGKTS CIIQSILDSR CSVAPGSVVE 430 440 450 460 470 480 YSRLGPDVSV GENCIISGSY ILTKAALPAH SFVCSLSLKM NRCLKYATMA FGVQDNLKKS 490 500 510 520 530 540 VKTLSDIKLL QFFGVCFLSC LDVWNLKVTE ELFSGNKTCL SLWTARIFPV CSSLSDSVIT 550 560 570 580 590 SLKMLNAVKN KSAFSLNSYK LLSIEEMLIY KDVEDMITYR EQIFLEISLK SSLM
	Isoform 1 [UniParc]. See Q59H18.		–	–
	Isoform 3 [UniParc]. See Q59H18.		–	–
	Isoform 4 [UniParc]. See Q59H18.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme." Pastuszak I., Ketchum C., Hermanson G., Sjoberg E.J., Drake R., Elbein A.D. J. Biol. Chem. 273:30165-30174(1998) [PubMed: 9804772] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), CHARACTERIZATION.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon and Kidney.
[3]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF017445 mRNA. Translation: AAC73005.1. AF017446 Genomic DNA. Translation: AAC82511.1. BC032308 mRNA. Translation: AAH32308.1.
IPI	IPI00021943.
RefSeq	NP_003829.2. NM_003838.3.
UniGene	Hs.480085.
3D structure databases
ProteinModelPortal	O14772.
ModBase	Search...
Protein-protein interaction databases
STRING	O14772.
Proteomic databases
PRIDE	O14772.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370898; ENSP00000359935; ENSG00000116783.
GeneID	8790.
KEGG	hsa:8790.
UCSC	uc001dgb.1. human.
Organism-specific databases
CTD	8790.
GeneCards	GC01P074663.
HGNC	HGNC:3825. FPGT.
MIM	603609. gene.
neXtProt	NX_O14772.
PharmGKB	PA28243.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG025123.
OrthoDB	EOG4FFD1F.
PhylomeDB	O14772.
Gene expression databases
ArrayExpress	O14772.
Bgee	O14772.
CleanEx	HS_FPGT.
Genevestigator	O14772.
GermOnline	ENSG00000116783. Homo sapiens.
Family and domain databases
InterPro	IPR012887. Fucokinase. IPR012120. Fucose-1-phosphate_GuaTrfase. [Graphical view]
KO	K00976.
Pfam	PF07959. Fucokinase. 1 hit. [Graphical view]
PIRSF	PIRSF036640. FPGT. 1 hit.
ProtoNet	Search...
Other
NextBio	32968.
SOURCE	Search...

Entry information

Entry name

FPGT_HUMAN

Accession

Primary (citable) accession number: O14772
Secondary accession number(s): Q8N5J7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	February 20, 2007
Last modified:	November 16, 2011
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.