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Protein

Zinc finger protein 213

Gene

ZNF213

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 33923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 213
Alternative name(s):
Putative transcription factor CR53
Zinc finger protein with KRAB and SCAN domains 21
Gene namesi
Name:ZNF213
Synonyms:ZKSCAN21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13005. ZNF213.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37584.

Polymorphism and mutation databases

BioMutaiZNF213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Zinc finger protein 213PRO_0000047457Add
BLAST

Proteomic databases

PaxDbiO14771.
PRIDEiO14771.

PTM databases

PhosphoSiteiO14771.

Expressioni

Tissue specificityi

Widely expressed with highest levels in testis.1 Publication

Gene expression databases

BgeeiO14771.
CleanExiHS_ZNF213.
ExpressionAtlasiO14771. baseline and differential.
GenevisibleiO14771. HS.

Organism-specific databases

HPAiHPA035000.
HPA056750.

Interactioni

Protein-protein interaction databases

BioGridi113543. 8 interactions.
STRINGi9606.ENSP00000380087.

Structurei

3D structure databases

ProteinModelPortaliO14771.
SMRiO14771. Positions 40-126, 285-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12682SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini202 – 29291KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 33923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128328.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiO14771.
KOiK09229.
OMAiLEPQDQT.
PhylomeDBiO14771.
TreeFamiTF350828.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14771-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPLEAQDQ APGEGEGLLI VKVEDSSWEQ ESAQHEDGRD SEACRQRFRQ
60 70 80 90 100
FCYGDVHGPH EAFSQLWELC CRWLRPELRT KEQILELLVL EQFLTVLPGE
110 120 130 140 150
IQGWVREQHP GSGEEAVALV EDLQKQPVKA WRQDVPSEEA EPEAAGRGSQ
160 170 180 190 200
ATGPPPTVGA RRRPSVPQEQ HSHSAQPPAL LKEGRPGETT DTCFVSGVHG
210 220 230 240 250
PVALGDIPFY FSREEWGTLD PAQRDLFWDI KRENSRNTTL GFGLKGQSEK
260 270 280 290 300
SLLQEMVPVV PGQTGSDVTV SWSPEEAEAW ESENRPRAAL GPVVGARRGR
310 320 330 340 350
PPTRRRQFRD LAAEKPHSCG QCGKRFRWGS DLARHQRTHT GEKPHKCPEC
360 370 380 390 400
DKSFRSSSDL VRHQGVHTGE KPFSCSECGK SFSRSAYLAD HQRIHTGEKP
410 420 430 440 450
FGCSDCGKSF SLRSYLLDHR RVHTGERPFG CGECDKSFKQ RAHLIAHQSL

HAKMAQPVG
Length:459
Mass (Da):51,263
Last modified:April 30, 2003 - v2
Checksum:i062F64A205533541
GO
Isoform 2 (identifier: O14771-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MAAPLEAQDQ...SAQHEDGRDS → MCPRRRRNPR...LFPRSSTAIA
     42-199: Missing.

Note: No experimental confirmation available.
Show »
Length:301
Mass (Da):33,828
Checksum:i5E242674FE09451A
GO

Sequence cautioni

The sequence AAB70531.1 differs from that shown. Reason: Frameshift at positions 400, 405 and 457. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071G → A in AAB70531 (PubMed:10023065).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141MAAPL…DGRDS → MCPRRRRNPRLQAGDPRPRG LPRRWGHGGGRLFPRSSTAI A in isoform 2. 1 PublicationVSP_055942Add
BLAST
Alternative sequencei42 – 199158Missing in isoform 2. 1 PublicationVSP_055943Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017433 mRNA. Translation: AAB70531.1. Frameshift.
AK289834 mRNA. Translation: BAF82523.1.
AK291789 mRNA. Translation: BAF84478.1.
AK297454 mRNA. Translation: BAG59878.1.
AC108134 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85394.1.
BC007287 mRNA. Translation: AAH07287.1.
CCDSiCCDS10495.1. [O14771-1]
RefSeqiNP_001128127.1. NM_001134655.1. [O14771-1]
NP_004211.1. NM_004220.2. [O14771-1]
UniGeneiHs.115284.

Genome annotation databases

EnsembliENST00000396878; ENSP00000380087; ENSG00000085644. [O14771-1]
ENST00000416391; ENSP00000403892; ENSG00000085644. [O14771-1]
ENST00000574902; ENSP00000460157; ENSG00000085644. [O14771-1]
ENST00000576416; ENSP00000459177; ENSG00000085644. [O14771-1]
GeneIDi7760.
KEGGihsa:7760.
UCSCiuc010bth.4. human. [O14771-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017433 mRNA. Translation: AAB70531.1. Frameshift.
AK289834 mRNA. Translation: BAF82523.1.
AK291789 mRNA. Translation: BAF84478.1.
AK297454 mRNA. Translation: BAG59878.1.
AC108134 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85394.1.
BC007287 mRNA. Translation: AAH07287.1.
CCDSiCCDS10495.1. [O14771-1]
RefSeqiNP_001128127.1. NM_001134655.1. [O14771-1]
NP_004211.1. NM_004220.2. [O14771-1]
UniGeneiHs.115284.

3D structure databases

ProteinModelPortaliO14771.
SMRiO14771. Positions 40-126, 285-451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113543. 8 interactions.
STRINGi9606.ENSP00000380087.

PTM databases

PhosphoSiteiO14771.

Polymorphism and mutation databases

BioMutaiZNF213.

Proteomic databases

PaxDbiO14771.
PRIDEiO14771.

Protocols and materials databases

DNASUi7760.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396878; ENSP00000380087; ENSG00000085644. [O14771-1]
ENST00000416391; ENSP00000403892; ENSG00000085644. [O14771-1]
ENST00000574902; ENSP00000460157; ENSG00000085644. [O14771-1]
ENST00000576416; ENSP00000459177; ENSG00000085644. [O14771-1]
GeneIDi7760.
KEGGihsa:7760.
UCSCiuc010bth.4. human. [O14771-1]

Organism-specific databases

CTDi7760.
GeneCardsiZNF213.
HGNCiHGNC:13005. ZNF213.
HPAiHPA035000.
HPA056750.
MIMi608387. gene.
neXtProtiNX_O14771.
PharmGKBiPA37584.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128328.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiO14771.
KOiK09229.
OMAiLEPQDQT.
PhylomeDBiO14771.
TreeFamiTF350828.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7760.
NextBioi30039.
PROiO14771.
SOURCEiSearch...

Gene expression databases

BgeeiO14771.
CleanExiHS_ZNF213.
ExpressionAtlasiO14771. baseline and differential.
GenevisibleiO14771. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a zinc finger gene (ZNF213) from 16p13.3."
    Chen X., Hamon M., Deng Z., Centola M., Sood R., Taylor K., Kastner D.L., Fischel-Ghodsian N.
    Biochim. Biophys. Acta 1444:218-230(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Peripheral blood leukocyte.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Placenta.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.

Entry informationi

Entry nameiZN213_HUMAN
AccessioniPrimary (citable) accession number: O14771
Secondary accession number(s): A8K1B9, B4DMG6, Q96IS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: April 30, 2003
Last modified: March 16, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.