O14770 (MEIS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Meis2

Alternative name(s):
Meis1-related protein 1

Gene names

Name:	MEIS2
Synonyms:	MRG1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Probable.
Tissue specificity	Expressed in various tissues. In hematopoietic tissues, the lymphoid organs express high levels of MEIS2. Also expressed in some regions of the brain, such as the putamen.
Sequence similarities	Belongs to the TALE/MEIS homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from direct assay. Source: MGI sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: ProtInc transcription corepressor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform Meis2C (identifier: O14770-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Meis2A (identifier: O14770-2)

The sequence of this isoform differs from the canonical sequence as follows:
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Isoform Meis2B (identifier: O14770-3)

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Isoform Meis2D (identifier: O14770-4)

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.

Isoform Meis2E (identifier: O14770-5)

The sequence of this isoform differs from the canonical sequence as follows:
     301-302: HP → VY
     303-477: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 477

477

Homeobox protein Meis2

PRO_0000049108

Regions

DNA binding

276 – 338

63

Homeobox; TALE-type

Compositional bias

195 – 244

50

Ser/Thr-rich

Compositional bias

246 – 273

28

Asp/Glu-rich (acidic)

Compositional bias

266 – 273

8

Poly-Asp

Amino acid modifications

Modified residue

198

1

Phosphoserine By similarity

Natural variations

Alternative sequence

301 – 302

2

HP → VY in isoform Meis2E.

VSP_002243

Alternative sequence

303 – 477

175

Missing in isoform Meis2E.

VSP_002244

Alternative sequence

346 – 352

7

Missing in isoform Meis2B and isoform Meis2D.

VSP_002242

Alternative sequence

384 – 401

18

LQSMP…PMGMS → PMSGMGMNMGMDGQWHYM in isoform Meis2A and isoform Meis2B.

VSP_002245

Alternative sequence

402 – 477

76

Missing in isoform Meis2A and isoform Meis2B.

VSP_002246

Secondary structure

1

.

.

.

.

.

.

.

.

477

Helix Strand Turn

Details...

Helix

285 – 297

13

Turn

298 – 300

3

Helix

306 – 315

10

Helix

320 – 335

16

Sequences

	Sequence		Length	Mass (Da)
	Isoform Meis2C [UniParc]. Last modified February 21, 2001. Version 2. Checksum: 94EBD0801A312B24	FASTA	477	51,790
	10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 310 320 330 340 350 360 HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS 370 380 390 400 410 420 PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM SMAQPSYTPP QMTPHPTQLR 430 440 450 460 470 HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ
	Isoform Meis2A [UniParc]. Checksum: 0682C0E92326516D	FASTA	401	43,791
	10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 310 320 330 340 350 360 HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS 370 380 390 400 PEGQPMGSFV LDGQQHMGIR PAGPMSGMGM NMGMDGQWHY M
	Isoform Meis2B [UniParc]. Checksum: 6BCC0382F0C55296	FASTA	394	43,061
	10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 310 320 330 340 350 360 HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAVSQGA AYSPEGQPMG 370 380 390 SFVLDGQQHM GIRPAGPMSG MGMNMGMDGQ WHYM
	Isoform Meis2D [UniParc]. Checksum: C15C82B9F0098CB9	FASTA	470	51,060
	10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 310 320 330 340 350 360 HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAVSQGA AYSPEGQPMG 370 380 390 400 410 420 SFVLDGQQHM GIRPAGLQSM PGDYVSQGGP MGMSMAQPSY TPPQMTPHPT QLRHGPPMHS 430 440 450 460 470 YLPSHPHHPA MMMHGGPPTH PGMTMSAQSP TMLNSVDPNV GGQVMDIHAQ
	Isoform Meis2E [UniParc]. Checksum: 059D4D332A95FE5F	FASTA	302	32,837
	10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT VY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription." Yang Y., Hwang C.K., D'Souza U.M., Lee S.-H., Junn E., Mouradian M.M. J. Biol. Chem. 275:20734-20741(2000) [PubMed: 10764806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MEIS2A; MEIS2B; MEIS2C; MEIS2D AND MEIS2E). Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MEIS2D). Tissue: Testis.
[3]	"Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene." Smith J.E. Jr., Afonja O., Yee H.T., Inghirami G., Takeshita K. Mamm. Genome 8:951-952(1997) [PubMed: 9383298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-477 (ISOFORM MEIS2B).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF178948 mRNA. Translation: AAF81638.1.
AF179896 mRNA. Translation: AAF81639.1.
AF179897 mRNA. Translation: AAF81640.1.
AF179898 mRNA. Translation: AAF81641.1.
AF179899 mRNA. Translation: AAF81642.1.
BC050431 mRNA. Translation: AAH50431.1.
AF017418 mRNA. Translation: AAB70270.1.

IPI

IPI00023696.
IPI00171219.
IPI00221237.
IPI00221238.
IPI00746958.

RefSeq

NP_001207411.1. NM_001220482.1.
NP_733774.1. NM_170674.3.
NP_733775.1. NM_170675.3.
NP_733776.1. NM_170676.3.
NP_733777.1. NM_170677.3.

UniGene

Hs.510989.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3K2A	X-ray	1.95	A/B	281-345	[»]

ProteinModelPortal

O14770.

SMR

O14770. Positions 283-338.

ModBase

Search...

Protein-protein interaction databases

IntAct

O14770. 1 interaction.

STRING

O14770.

PTM databases

PhosphoSite

O14770.

Proteomic databases

PRIDE

O14770.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000314177; ENSP00000326296; ENSG00000134138.

GeneID

4212.

KEGG

hsa:4212.

UCSC

uc001zjl.1. human.
uc001zjr.1. human.
uc001zjs.1. human.

Organism-specific databases

CTD

4212.

GeneCards

GC15M037183.

HGNC

HGNC:7001. MEIS2.

HPA

CAB004999.
HPA003256.

MIM

601740. gene.

neXtProt

NX_O14770.

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00550000074260.

HOGENOM

HBG445075.

HOVERGEN

HBG055193.

InParanoid

O14770.

OMA

YDELAHY.

OrthoDB

EOG4XPQFW.

PhylomeDB

O14770.

Gene expression databases

ArrayExpress

O14770.

Bgee

O14770.

CleanEx

HS_MEIS2.

Genevestigator

O14770.

GermOnline

ENSG00000134138. Homo sapiens.

Family and domain databases

InterPro

IPR001356. Homeobox.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
[Graphical view]

Gene3D

G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.

Pfam

PF05920. Homeobox_KN. 1 hit.
[Graphical view]

SMART

SM00389. HOX. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.

PROSITE

PS00027. HOMEOBOX_1. False negative.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

16594.

SOURCE

Search...

Entry information

Entry name

MEIS2_HUMAN

Accession

Primary (citable) accession number: O14770
Secondary accession number(s): Q96KI4 , Q96KI5, Q9NRS1, Q9NRS2, Q9NRS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 21, 2001
Last modified:	January 25, 2012
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.