Homeobox protein Meis2 - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
Homeobox protein Meis2
Alternative name(s):
Meis1-related protein 1

Gene names

Name:	MEIS2
Synonyms:	MRG1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in various tissues. In hematopoietic tissues, the lymphoid organs express high levels of MEIS2. Also expressed in some regions of the brain, such as the putamen.

Sequence similarities

Belongs to the TALE/MEIS homeobox family.

Contains 1 homeobox DNA-binding domain.

Hide | Top

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Gene Ontology (GO)
Biological process	negative regulation of transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular function	sequence-specific DNA binding Inferred from direct assay. Source: MGI specific RNA polymerase II transcription factor activity Ref.1 Traceable author statement. Source: ProtInc transcription corepressor activity Ref.1 Traceable author statement. Source: ProtInc transcription factor activity Ref.1 Non-traceable author statement. Source: ProtInc
Complete GO annotation...

Hide | Top

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform Meis2C (identifier: O14770-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Meis2A (identifier: O14770-2) The sequence of this isoform differs from the canonical sequence as follows: 384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM 402-477: Missing.

Isoform Meis2B (identifier: O14770-3) The sequence of this isoform differs from the canonical sequence as follows: 346-352: Missing. 384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM 402-477: Missing.

Isoform Meis2D (identifier: O14770-4) The sequence of this isoform differs from the canonical sequence as follows: 346-352: Missing.

Isoform Meis2E (identifier: O14770-5) The sequence of this isoform differs from the canonical sequence as follows: 301-302: HP → VY 303-477: Missing.

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 477

477

Homeobox protein Meis2

PRO_0000049108

Regions

DNA binding

276 – 338

63

Homeobox; TALE-type

Compositional bias

195 – 244

50

Ser/Thr-rich

Compositional bias

246 – 273

28

Asp/Glu-rich (acidic)

Compositional bias

266 – 273

8

Poly-Asp

Natural variations

Alternative sequence

301 – 302

2

HP → VY in isoform Meis2E.

VSP_002243

Alternative sequence

303 – 477

175

Missing in isoform Meis2E.

VSP_002244

Alternative sequence

346 – 352

7

Missing in isoform Meis2B and isoform Meis2D.

VSP_002242

Alternative sequence

384 – 401

18

LQSMP…PMGMS → PMSGMGMNMGMDGQWHYM in isoform Meis2A and isoform Meis2B.

VSP_002245

Alternative sequence

402 – 477

76

Missing in isoform Meis2A and isoform Meis2B.

VSP_002246

Hide | Top

Sequences

Sequence		Length	Mass (Da)
Isoform Meis2C [UniParc]. Last modified February 21, 2001. Version 2. Checksum: 94EBD0801A312B24 Show »	FASTA	477	51,790
10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 310 320 330 340 350 360 HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS 370 380 390 400 410 420 PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM SMAQPSYTPP QMTPHPTQLR 430 440 450 460 470 HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ « Hide
Isoform Meis2A. Checksum: 0682C0E92326516D Show »	FASTA	401	43,791
10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 310 320 330 340 350 360 HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS 370 380 390 400 PEGQPMGSFV LDGQQHMGIR PAGPMSGMGM NMGMDGQWHY M « Hide
Isoform Meis2B. Checksum: 6BCC0382F0C55296 Show »	FASTA	394	43,061
10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 310 320 330 340 350 360 HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAVSQGA AYSPEGQPMG 370 380 390 SFVLDGQQHM GIRPAGPMSG MGMNMGMDGQ WHYM « Hide
Isoform Meis2D. Checksum: C15C82B9F0098CB9 Show »	FASTA	470	51,060
10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 310 320 330 340 350 360 HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAVSQGA AYSPEGQPMG 370 380 390 400 410 420 SFVLDGQQHM GIRPAGLQSM PGDYVSQGGP MGMSMAQPSY TPPQMTPHPT QLRHGPPMHS 430 440 450 460 470 YLPSHPHHPA MMMHGGPPTH PGMTMSAQSP TMLNSVDPNV GGQVMDIHAQ « Hide
Isoform Meis2E. Checksum: 059D4D332A95FE5F Show »	FASTA	302	32,837
10 20 30 40 50 60 MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 70 80 90 100 110 120 MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 130 140 150 160 170 180 EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 190 200 210 220 230 240 GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 250 260 270 280 290 300 ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT VY « Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription." Yang Y., Hwang C.K., D'Souza U.M., Lee S.-H., Junn E., Mouradian M.M. J. Biol. Chem. 275:20734-20741(2000) [PubMed: 10764806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MEIS2A; MEIS2B; MEIS2C; MEIS2D AND MEIS2E). Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MEIS2D). Tissue: Testis.
[3]	"Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene." Smith J.E. Jr., Afonja O., Yee H.T., Inghirami G., Takeshita K. Mamm. Genome 8:951-952(1997) [PubMed: 9383298] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-477 (ISOFORM MEIS2B).
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
	AF178948 mRNA. Translation: AAF81638.1. AF179896 mRNA. Translation: AAF81639.1. AF179897 mRNA. Translation: AAF81640.1. AF179898 mRNA. Translation: AAF81641.1. AF179899 mRNA. Translation: AAF81642.1. BC050431 mRNA. Translation: AAH50431.1. AF017418 mRNA. Translation: AAB70270.1.
IPI	IPI00023696. IPI00221237. IPI00221238. IPI00221239. IPI00746958.
RefSeq	NP_733774.1. NP_733775.1. NP_733776.1. NP_733777.1.
UniGene	Hs.510989
3D structure databases
HSSP	HSSP built from PDB template 1B8I based on UniProtKB P40427.
SMR	O14770. Positions 277-336.
ModBase	Search...
PTM databases
PhosphoSite	O14770.
Proteomic databases
PRIDE	O14770.
Genome annotation databases
Ensembl	ENSG00000134138. Homo sapiens. [Contig view]
GeneID	4212.
Organism-specific databases
GeneCards	GC15M034970.
HGNC	HGNC:7001. MEIS2.
HPA	CAB004999. HPA003256.
MIM	601740. gene.
PharmGKB	PA30741.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O14770.
OMA	O14770. LHAYLPD.
Gene expression databases
ArrayExpress	O14770.
Bgee	O14770.
CleanEx	HS_MEIS2.
GermOnline	ENSG00000134138. Homo sapiens.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	16594.
SOURCE	Search...

Hide | Top

Entry information

Entry name

MEIS2_HUMAN

Accession

Primary (citable) accession number: O14770
Secondary accession number(s): Q96KI4

Q9NRS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 21, 2001
Last modified:	June 16, 2009
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents