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Protein

Homeobox protein Meis2

Gene

MEIS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi276 – 338Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription cofactor activity Source: UniProtKB
  • transcription corepressor activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134138-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Meis2
Alternative name(s):
Meis1-related protein 1
Gene namesi
Name:MEIS2
Synonyms:MRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:7001. MEIS2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Cytoplasmperinuclear region By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi85L → A: Impairs interaction with PBX1; when associated with A-88. 1 Publication1
Mutagenesisi88L → A: Impairs interaction with PBX1; when associated with A-85. HELIX 285 297. 1 Publication1
Mutagenesisi94 – 97EKCE → NNGT: Impairs interaction with PBX1. 1 Publication4
Mutagenesisi151I → A: Impairs interaction with PBX1; when associated with A-154. 1 Publication1
Mutagenesisi154L → A: Impairs interaction with PBX1; when associated with A-151. 1 Publication1
Mutagenesisi158 – 159LL → AA: Impairs interaction with PBX1; when associated with A-161. 1 Publication2
Mutagenesisi161L → A: Impairs interaction with PBX1; when associated with 158-A-A-159. 1 Publication1
Mutagenesisi332R → M: Impairs DNA binding and PBX1-dependent transcriptional activation. No effect on interaction with PBX1. 2 Publications1

Organism-specific databases

DisGeNETi4212.
MalaCardsiMEIS2.
OpenTargetsiENSG00000134138.
Orphaneti261190. 15q14 microdeletion syndrome.
PharmGKBiPA30741.

Polymorphism and mutation databases

BioMutaiMEIS2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491081 – 477Homeobox protein Meis2Add BLAST477

Proteomic databases

MaxQBiO14770.
PaxDbiO14770.
PeptideAtlasiO14770.
PRIDEiO14770.

PTM databases

iPTMnetiO14770.
PhosphoSitePlusiO14770.

Expressioni

Tissue specificityi

Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.

Developmental stagei

Expressed in the proliferative zones of the fetal neocortex. Expressed at a very high level in the developing ganglionic eminence and at a more moderate level in the cortical plate.1 Publication

Gene expression databases

BgeeiENSG00000134138.
CleanExiHS_MEIS2.
ExpressionAtlasiO14770. baseline and differential.
GenevisibleiO14770. HS.

Organism-specific databases

HPAiCAB004999.
HPA003256.

Interactioni

Subunit structurei

Isoform 2 interacts with TLX1. Isoform 3 interacts with HOXA13 and PBX1 isoform PBX1b. Isoform 4 interacts with SP1, SP3 and KLF4. Isoform 4 and isoform 5 interact with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3 also known as MEIS2b is part of a PDX1:PBX1b:Meis2B complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4 in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANXA1Q5TZZ93EBI-2804934,EBI-10181435
C1orf94Q6P1W53EBI-2804934,EBI-946029
gag-pro-polP033633EBI-2804934,EBI-9676133From a different organism.
OSGIN1Q9UJX03EBI-2804934,EBI-9057006
PBX1P404246EBI-8025850,EBI-301611
TLX1P313144EBI-6390216,EBI-2820655

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110376. 30 interactors.
DIPiDIP-61027N.
IntActiO14770. 14 interactors.
STRINGi9606.ENSP00000453793.

Structurei

Secondary structure

1477
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi287 – 296Combined sources10
Turni298 – 300Combined sources3
Helixi306 – 316Combined sources11
Helixi320 – 333Combined sources14
Helixi335 – 339Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K2AX-ray1.95A/B281-345[»]
4XRMX-ray1.60A/B281-342[»]
5BNGX-ray3.50A/B283-342[»]
ProteinModelPortaliO14770.
SMRiO14770.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14770.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 191Required for interaction with PBX1By similarityAdd BLAST121
Regioni340 – 477Transcriptional activation domainAdd BLAST138

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 244Ser/Thr-richAdd BLAST50
Compositional biasi246 – 273Asp/Glu-rich (acidic)Add BLAST28
Compositional biasi266 – 273Poly-Asp8

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000253923.
HOVERGENiHBG055193.
InParanoidiO14770.
KOiK16670.
OMAiLHASQHY.
OrthoDBiEOG091G0KDP.
PhylomeDBiO14770.
TreeFamiTF318093.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR032453. PKNOX/Meis_N.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF16493. Meis_PKNOX_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14770-1) [UniParc]FASTAAdd to basket
Also known as: Meis2C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH
60 70 80 90 100
YGAHAPHPNV MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT
110 120 130 140 150
CTPREPGVAG GDVCSSDSFN EDIAVFAKQV RAEKPLFSSN PELDNLMIQA
160 170 180 190 200
IQVLRFHLLE LEKVHELCDN FCHRYISCLK GKMPIDLVID ERDGSSKSDH
210 220 230 240 250
EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH ASQSGDNSSE
260 270 280 290 300
QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT
310 320 330 340 350
HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD
360 370 380 390 400
PSVSQGAAYS PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM
410 420 430 440 450
SMAQPSYTPP QMTPHPTQLR HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM
460 470
TMSAQSPTML NSVDPNVGGQ VMDIHAQ
Length:477
Mass (Da):51,790
Last modified:February 21, 2001 - v2
Checksum:i94EBD0801A312B24
GO
Isoform 2 (identifier: O14770-2) [UniParc]FASTAAdd to basket
Also known as: Meis2A

The sequence of this isoform differs from the canonical sequence as follows:
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:401
Mass (Da):43,791
Checksum:i0682C0E92326516D
GO
Isoform 3 (identifier: O14770-3) [UniParc]FASTAAdd to basket
Also known as: Meis2B

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:394
Mass (Da):43,061
Checksum:i6BCC0382F0C55296
GO
Isoform 4 (identifier: O14770-4) [UniParc]FASTAAdd to basket
Also known as: Meis2D

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.

Show »
Length:470
Mass (Da):51,060
Checksum:iC15C82B9F0098CB9
GO
Isoform 5 (identifier: O14770-5) [UniParc]FASTAAdd to basket
Also known as: Meis2E

The sequence of this isoform differs from the canonical sequence as follows:
     301-302: HP → VY
     303-477: Missing.

Show »
Length:302
Mass (Da):32,837
Checksum:i059D4D332A95FE5F
GO
Isoform 6 (identifier: O14770-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MAQRYDELPH...IYGHPLFPLL → M
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:306
Mass (Da):33,598
Checksum:i4DF1350FB0F28AF1
GO
Isoform 7 (identifier: O14770-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):41,542
Checksum:i4F6D947B1EDA0528
GO
Isoform 8 (identifier: O14770-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):42,272
Checksum:iE9F5455311C5BC69
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0432191 – 89MAQRY…LFPLL → M in isoform 6. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0434941 – 13Missing in isoform 7 and isoform 8. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_002243301 – 302HP → VY in isoform 5. 1 Publication2
Alternative sequenceiVSP_002244303 – 477Missing in isoform 5. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_002242346 – 352Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 4 Publications7
Alternative sequenceiVSP_002245384 – 401LQSMP…PMGMS → PMSGMGMNMGMDGQWHYM in isoform 2, isoform 3, isoform 6, isoform 7 and isoform 8. 4 PublicationsAdd BLAST18
Alternative sequenceiVSP_002246402 – 477Missing in isoform 2, isoform 3, isoform 6, isoform 7 and isoform 8. 4 PublicationsAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178948 mRNA. Translation: AAF81638.1.
AF179896 mRNA. Translation: AAF81639.1.
AF179897 mRNA. Translation: AAF81640.1.
AF179898 mRNA. Translation: AAF81641.1.
AF179899 mRNA. Translation: AAF81642.1.
AK056038 mRNA. Translation: BAG51610.1.
AK056620 mRNA. Translation: BAG51768.1.
AC018563 Genomic DNA. No translation available.
AC069483 Genomic DNA. No translation available.
AC078909 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92353.1.
CH471125 Genomic DNA. Translation: EAW92354.1.
CH471125 Genomic DNA. Translation: EAW92356.1.
BC001516 mRNA. Translation: AAH01516.1.
BC001844 mRNA. Translation: AAH01844.3.
BC007202 mRNA. Translation: AAH07202.1.
BC050431 mRNA. Translation: AAH50431.1.
AF017418 mRNA. Translation: AAB70270.1.
CCDSiCCDS10044.1. [O14770-1]
CCDS10045.1. [O14770-4]
CCDS42014.1. [O14770-7]
CCDS45217.1. [O14770-2]
CCDS45218.1. [O14770-3]
CCDS45219.1. [O14770-8]
CCDS45220.1. [O14770-6]
RefSeqiNP_001207411.1. NM_001220482.1. [O14770-4]
NP_002390.1. NM_002399.3. [O14770-7]
NP_733774.1. NM_170674.4. [O14770-3]
NP_733775.1. NM_170675.4. [O14770-1]
NP_733776.1. NM_170676.4. [O14770-4]
NP_733777.1. NM_170677.4. [O14770-2]
NP_758526.1. NM_172315.2. [O14770-8]
NP_758527.1. NM_172316.2. [O14770-6]
XP_016877694.1. XM_017022205.1. [O14770-6]
UniGeneiHs.510989.

Genome annotation databases

EnsembliENST00000314177; ENSP00000326296; ENSG00000134138. [O14770-5]
ENST00000338564; ENSP00000341400; ENSG00000134138. [O14770-4]
ENST00000340545; ENSP00000339549; ENSG00000134138. [O14770-7]
ENST00000397620; ENSP00000380745; ENSG00000134138. [O14770-6]
ENST00000397624; ENSP00000380749; ENSG00000134138. [O14770-6]
ENST00000424352; ENSP00000404185; ENSG00000134138. [O14770-2]
ENST00000557796; ENSP00000452693; ENSG00000134138. [O14770-7]
ENST00000559085; ENSP00000453390; ENSG00000134138. [O14770-8]
ENST00000559561; ENSP00000453497; ENSG00000134138. [O14770-3]
ENST00000561208; ENSP00000453793; ENSG00000134138. [O14770-1]
GeneIDi4212.
KEGGihsa:4212.
UCSCiuc001zjl.4. human. [O14770-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178948 mRNA. Translation: AAF81638.1.
AF179896 mRNA. Translation: AAF81639.1.
AF179897 mRNA. Translation: AAF81640.1.
AF179898 mRNA. Translation: AAF81641.1.
AF179899 mRNA. Translation: AAF81642.1.
AK056038 mRNA. Translation: BAG51610.1.
AK056620 mRNA. Translation: BAG51768.1.
AC018563 Genomic DNA. No translation available.
AC069483 Genomic DNA. No translation available.
AC078909 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92353.1.
CH471125 Genomic DNA. Translation: EAW92354.1.
CH471125 Genomic DNA. Translation: EAW92356.1.
BC001516 mRNA. Translation: AAH01516.1.
BC001844 mRNA. Translation: AAH01844.3.
BC007202 mRNA. Translation: AAH07202.1.
BC050431 mRNA. Translation: AAH50431.1.
AF017418 mRNA. Translation: AAB70270.1.
CCDSiCCDS10044.1. [O14770-1]
CCDS10045.1. [O14770-4]
CCDS42014.1. [O14770-7]
CCDS45217.1. [O14770-2]
CCDS45218.1. [O14770-3]
CCDS45219.1. [O14770-8]
CCDS45220.1. [O14770-6]
RefSeqiNP_001207411.1. NM_001220482.1. [O14770-4]
NP_002390.1. NM_002399.3. [O14770-7]
NP_733774.1. NM_170674.4. [O14770-3]
NP_733775.1. NM_170675.4. [O14770-1]
NP_733776.1. NM_170676.4. [O14770-4]
NP_733777.1. NM_170677.4. [O14770-2]
NP_758526.1. NM_172315.2. [O14770-8]
NP_758527.1. NM_172316.2. [O14770-6]
XP_016877694.1. XM_017022205.1. [O14770-6]
UniGeneiHs.510989.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K2AX-ray1.95A/B281-345[»]
4XRMX-ray1.60A/B281-342[»]
5BNGX-ray3.50A/B283-342[»]
ProteinModelPortaliO14770.
SMRiO14770.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110376. 30 interactors.
DIPiDIP-61027N.
IntActiO14770. 14 interactors.
STRINGi9606.ENSP00000453793.

PTM databases

iPTMnetiO14770.
PhosphoSitePlusiO14770.

Polymorphism and mutation databases

BioMutaiMEIS2.

Proteomic databases

MaxQBiO14770.
PaxDbiO14770.
PeptideAtlasiO14770.
PRIDEiO14770.

Protocols and materials databases

DNASUi4212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314177; ENSP00000326296; ENSG00000134138. [O14770-5]
ENST00000338564; ENSP00000341400; ENSG00000134138. [O14770-4]
ENST00000340545; ENSP00000339549; ENSG00000134138. [O14770-7]
ENST00000397620; ENSP00000380745; ENSG00000134138. [O14770-6]
ENST00000397624; ENSP00000380749; ENSG00000134138. [O14770-6]
ENST00000424352; ENSP00000404185; ENSG00000134138. [O14770-2]
ENST00000557796; ENSP00000452693; ENSG00000134138. [O14770-7]
ENST00000559085; ENSP00000453390; ENSG00000134138. [O14770-8]
ENST00000559561; ENSP00000453497; ENSG00000134138. [O14770-3]
ENST00000561208; ENSP00000453793; ENSG00000134138. [O14770-1]
GeneIDi4212.
KEGGihsa:4212.
UCSCiuc001zjl.4. human. [O14770-1]

Organism-specific databases

CTDi4212.
DisGeNETi4212.
GeneCardsiMEIS2.
HGNCiHGNC:7001. MEIS2.
HPAiCAB004999.
HPA003256.
MalaCardsiMEIS2.
MIMi601740. gene.
neXtProtiNX_O14770.
OpenTargetsiENSG00000134138.
Orphaneti261190. 15q14 microdeletion syndrome.
PharmGKBiPA30741.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000253923.
HOVERGENiHBG055193.
InParanoidiO14770.
KOiK16670.
OMAiLHASQHY.
OrthoDBiEOG091G0KDP.
PhylomeDBiO14770.
TreeFamiTF318093.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134138-MONOMER.

Miscellaneous databases

ChiTaRSiMEIS2. human.
EvolutionaryTraceiO14770.
GeneWikiiMEIS2.
GenomeRNAii4212.
PROiO14770.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134138.
CleanExiHS_MEIS2.
ExpressionAtlasiO14770. baseline and differential.
GenevisibleiO14770. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR032453. PKNOX/Meis_N.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF16493. Meis_PKNOX_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEIS2_HUMAN
AccessioniPrimary (citable) accession number: O14770
Secondary accession number(s): A6NJI5
, A8MWD5, B3KP98, B3KPQ6, Q96DI2, Q96KI4, Q96KI5, Q9NRS1, Q9NRS2, Q9NRS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 21, 2001
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.