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O14770 (MEIS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Meis2
Alternative name(s):
Meis1-related protein 1
Gene names
Name:MEIS2
Synonyms:MRG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length477 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2Bis required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2Band isoform 4/Meis2Dcan bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2Ecannot activate DRD1 transcription. Ref.1 Ref.7 Ref.11

Subunit structure

Isoform 2/Meis2Ainteracts with TLX1. Isoform 3/Meis2Binteracts with HOXA13 and PBX1 isoform PBX1b Isoform 4/Meis2Dinteracts with SP1, SP3 and KLF4. Isoform 4/Meis2Dand isoform 5/Meis2Einteract with PBX1 isoform PBX1a;the interaction partially relieves MEIS2 autoinhibition. Isoform 3/Meis2Bis part of a PDX1:PBX1b:MEIS2b complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4/Meis2Din a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3. Ref.9 Ref.10 Ref.11

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.

Developmental stage

Expressed in the proliferative zones of the fetal neocortex. Expressed at a very high level in the developing ganglionic eminence and at a more moderate level in the cortical plate. Ref.8

Sequence similarities

Belongs to the TALE/MEIS homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processeye development

Inferred from electronic annotation. Source: Ensembl

negative regulation of myeloid cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

pancreas development

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

response to growth factor

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from direct assay PubMed 17178831PubMed 17178831. Source: MGI

sequence-specific DNA binding transcription factor activity

Non-traceable author statement Ref.1. Source: ProtInc

transcription cofactor activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription corepressor activity

Traceable author statement Ref.1. Source: ProtInc

transcription factor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O14770-1)

Also known as: Meis2C;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O14770-2)

Also known as: Meis2A;

The sequence of this isoform differs from the canonical sequence as follows:
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.
Isoform 3 (identifier: O14770-3)

Also known as: Meis2B;

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.
Isoform 4 (identifier: O14770-4)

Also known as: Meis2D;

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.
Isoform 5 (identifier: O14770-5)

Also known as: Meis2E;

The sequence of this isoform differs from the canonical sequence as follows:
     301-302: HP → VY
     303-477: Missing.
Isoform 6 (identifier: O14770-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MAQRYDELPH...IYGHPLFPLL → M
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.
Isoform 7 (identifier: O14770-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.
Note: No experimental confirmation available.
Isoform 8 (identifier: O14770-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 477477Homeobox protein Meis2
PRO_0000049108

Regions

DNA binding276 – 33863Homeobox; TALE-type
Region71 – 191121Required for interaction with PBX1 By similarity
Region340 – 477138Transcriptional activation domain
Compositional bias195 – 24450Ser/Thr-rich
Compositional bias246 – 27328Asp/Glu-rich (acidic)
Compositional bias266 – 2738Poly-Asp

Natural variations

Alternative sequence1 – 8989MAQRY…LFPLL → M in isoform 6.
VSP_043219
Alternative sequence1 – 1313Missing in isoform 7 and isoform 8.
VSP_043494
Alternative sequence301 – 3022HP → VY in isoform 5.
VSP_002243
Alternative sequence303 – 477175Missing in isoform 5.
VSP_002244
Alternative sequence346 – 3527Missing in isoform 3, isoform 4, isoform 6 and isoform 7.
VSP_002242
Alternative sequence384 – 40118LQSMP…PMGMS → PMSGMGMNMGMDGQWHYM in isoform 2, isoform 3, isoform 6, isoform 7 and isoform 8.
VSP_002245
Alternative sequence402 – 47776Missing in isoform 2, isoform 3, isoform 6, isoform 7 and isoform 8.
VSP_002246

Experimental info

Mutagenesis851L → A: Impairs interaction with PBX1; when associated with A-88. Ref.9
Mutagenesis881L → A: Impairs interaction with PBX1; when associated with A-85. HELIX 285 297.
Mutagenesis94 – 974EKCE → NNGT: Impairs interaction with PBX1. Ref.9
Mutagenesis1511I → A: Impairs interaction with PBX1; when associated with A-154. Ref.9
Mutagenesis1541L → A: Impairs interaction with PBX1; when associated with A-151. Ref.9
Mutagenesis158 – 1592LL → AA: Impairs interaction with PBX1; when associated with A-161.
Mutagenesis1611L → A: Impairs interaction with PBX1; when associated with 158-A-A-159. Ref.9
Mutagenesis3321R → M: Impairs DNA binding and PBX1-dependent trasncriptional activation. No effect on interaction with PBX1. Ref.9 Ref.11

Secondary structure

........ 477
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Meis2C) [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 94EBD0801A312B24

FASTA47751,790
        10         20         30         40         50         60 
MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH YGAHAPHPNV 

        70         80         90        100        110        120 
MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT CTPREPGVAG GDVCSSDSFN 

       130        140        150        160        170        180 
EDIAVFAKQV RAEKPLFSSN PELDNLMIQA IQVLRFHLLE LEKVHELCDN FCHRYISCLK 

       190        200        210        220        230        240 
GKMPIDLVID ERDGSSKSDH EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH 

       250        260        270        280        290        300 
ASQSGDNSSE QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT 

       310        320        330        340        350        360 
HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD PSVSQGAAYS 

       370        380        390        400        410        420 
PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM SMAQPSYTPP QMTPHPTQLR 

       430        440        450        460        470 
HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM TMSAQSPTML NSVDPNVGGQ VMDIHAQ 

« Hide

Isoform 2 (Meis2A) [UniParc].

Checksum: 0682C0E92326516D
Show »

FASTA40143,791
Isoform 3 (Meis2B) [UniParc].

Checksum: 6BCC0382F0C55296
Show »

FASTA39443,061
Isoform 4 (Meis2D) [UniParc].

Checksum: C15C82B9F0098CB9
Show »

FASTA47051,060
Isoform 5 (Meis2E) [UniParc].

Checksum: 059D4D332A95FE5F
Show »

FASTA30232,837
Isoform 6 [UniParc].

Checksum: 4DF1350FB0F28AF1
Show »

FASTA30633,598
Isoform 7 [UniParc].

Checksum: 4F6D947B1EDA0528
Show »

FASTA38141,542
Isoform 8 [UniParc].

Checksum: E9F5455311C5BC69
Show »

FASTA38842,272

References

« Hide 'large scale' references
[1]"Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription."
Yang Y., Hwang C.K., D'Souza U.M., Lee S.-H., Junn E., Mouradian M.M.
J. Biol. Chem. 275:20734-20741(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), FUNCTION.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 8).
Tissue: Tongue.
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 7).
Tissue: Muscle and Testis.
[6]"Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene."
Smith J.E. Jr., Afonja O., Yee H.T., Inghirami G., Takeshita K.
Mamm. Genome 8:951-952(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-477 (ISOFORM 3).
[7]"DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex."
Liu Y., MacDonald R.J., Swift G.H.
J. Biol. Chem. 276:17985-17993(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain."
Larsen K.B., Lutterodt M.C., Laursen H., Graem N., Pakkenberg B., Mollgard K., Moller M.
Dev. Neurosci. 32:149-162(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[9]"An autoinhibitory effect of the homothorax domain of Meis2."
Hyman-Walsh C., Bjerke G.A., Wotton D.
FEBS J. 277:2584-2597(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN, INTERACTION WITH PBX1, MUTAGENESIS OF LEU-85; LEU-88; 94-GLU--GLU-97; ILE-151; LEU-154; 158-LEU-LEU-159; LEU-161 AND ARG-332.
[10]"MEIS proteins as partners of the TLX1/HOX11 oncoprotein."
Milech N., Gottardo N.G., Ford J., D'Souza D., Greene W.K., Kees U.R., Watt P.M.
Leuk. Res. 34:358-363(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TLX1.
[11]"Cooperative transcriptional activation by Klf4, Meis2, and Pbx1."
Bjerke G.A., Hyman-Walsh C., Wotton D.
Mol. Cell. Biol. 31:3723-3733(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SP1; SP3 AND KLF4, MUTAGENESIS OF ARG-332.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF178948 mRNA. Translation: AAF81638.1.
AF179896 mRNA. Translation: AAF81639.1.
AF179897 mRNA. Translation: AAF81640.1.
AF179898 mRNA. Translation: AAF81641.1.
AF179899 mRNA. Translation: AAF81642.1.
AK056038 mRNA. Translation: BAG51610.1.
AK056620 mRNA. Translation: BAG51768.1.
AC018563 Genomic DNA. No translation available.
AC069483 Genomic DNA. No translation available.
AC078909 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92353.1.
CH471125 Genomic DNA. Translation: EAW92354.1.
CH471125 Genomic DNA. Translation: EAW92356.1.
BC001516 mRNA. Translation: AAH01516.1.
BC001844 mRNA. Translation: AAH01844.3.
BC007202 mRNA. Translation: AAH07202.1.
BC050431 mRNA. Translation: AAH50431.1.
AF017418 mRNA. Translation: AAB70270.1.
RefSeqNP_001207411.1. NM_001220482.1.
NP_002390.1. NM_002399.3.
NP_733774.1. NM_170674.4.
NP_733775.1. NM_170675.4.
NP_733776.1. NM_170676.4.
NP_733777.1. NM_170677.4.
NP_758526.1. NM_172315.2.
NP_758527.1. NM_172316.2.
UniGeneHs.510989.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3K2AX-ray1.95A/B281-345[»]
ProteinModelPortalO14770.
SMRO14770. Positions 283-338.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110376. 7 interactions.
IntActO14770. 4 interactions.
STRING9606.ENSP00000326296.

PTM databases

PhosphoSiteO14770.

Proteomic databases

PaxDbO14770.
PRIDEO14770.

Protocols and materials databases

DNASU4212.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314177; ENSP00000326296; ENSG00000134138. [O14770-5]
ENST00000338564; ENSP00000341400; ENSG00000134138. [O14770-4]
ENST00000340545; ENSP00000339549; ENSG00000134138. [O14770-7]
ENST00000382766; ENSP00000372216; ENSG00000134138. [O14770-4]
ENST00000397620; ENSP00000380745; ENSG00000134138. [O14770-6]
ENST00000397624; ENSP00000380749; ENSG00000134138. [O14770-6]
ENST00000424352; ENSP00000404185; ENSG00000134138. [O14770-2]
ENST00000444725; ENSP00000391887; ENSG00000134138. [O14770-3]
ENST00000557796; ENSP00000452693; ENSG00000134138. [O14770-7]
ENST00000559085; ENSP00000453390; ENSG00000134138. [O14770-8]
ENST00000559561; ENSP00000453497; ENSG00000134138. [O14770-3]
ENST00000561208; ENSP00000453793; ENSG00000134138. [O14770-1]
GeneID4212.
KEGGhsa:4212.
UCSCuc001zjl.3. human. [O14770-8]
uc001zjm.3. human. [O14770-6]
uc001zjo.4. human. [O14770-2]
uc001zjp.4. human. [O14770-3]
uc001zjr.4. human. [O14770-1]
uc001zjs.4. human. [O14770-4]
uc001zju.3. human. [O14770-7]

Organism-specific databases

CTD4212.
GeneCardsGC15M037183.
HGNCHGNC:7001. MEIS2.
HPACAB004999.
HPA003256.
MIM601740. gene.
neXtProtNX_O14770.
PharmGKBPA30741.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302919.
HOGENOMHOG000253923.
HOVERGENHBG055193.
InParanoidO14770.
KOK16670.
OMASQHYGAH.
OrthoDBEOG76HQ2W.
PhylomeDBO14770.
TreeFamTF318093.

Gene expression databases

ArrayExpressO14770.
BgeeO14770.
CleanExHS_MEIS2.
GenevestigatorO14770.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMEIS2. human.
EvolutionaryTraceO14770.
GeneWikiMEIS2.
GenomeRNAi4212.
NextBio16594.
PROO14770.
SOURCESearch...

Entry information

Entry nameMEIS2_HUMAN
AccessionPrimary (citable) accession number: O14770
Secondary accession number(s): A6NJI5 expand/collapse secondary AC list , A8MWD5, B3KP98, B3KPQ6, Q96DI2, Q96KI4, Q96KI5, Q9NRS1, Q9NRS2, Q9NRS3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 21, 2001
Last modified: April 16, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM