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O14770

- MEIS2_HUMAN

UniProt

O14770 - MEIS2_HUMAN

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Protein

Homeobox protein Meis2

Gene

MEIS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi276 – 33863Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
  5. transcription cofactor activity Source: UniProtKB
  6. transcription corepressor activity Source: ProtInc
  7. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. eye development Source: Ensembl
  2. negative regulation of myeloid cell differentiation Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  4. pancreas development Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  6. response to growth factor Source: Ensembl
  7. response to mechanical stimulus Source: Ensembl
  8. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Meis2
Alternative name(s):
Meis1-related protein 1
Gene namesi
Name:MEIS2
Synonyms:MRG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:7001. MEIS2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi85 – 851L → A: Impairs interaction with PBX1; when associated with A-88. 1 Publication
Mutagenesisi88 – 881L → A: Impairs interaction with PBX1; when associated with A-85. HELIX 285 297. 1 Publication
Mutagenesisi94 – 974EKCE → NNGT: Impairs interaction with PBX1. 1 Publication
Mutagenesisi151 – 1511I → A: Impairs interaction with PBX1; when associated with A-154. 1 Publication
Mutagenesisi154 – 1541L → A: Impairs interaction with PBX1; when associated with A-151. 1 Publication
Mutagenesisi158 – 1592LL → AA: Impairs interaction with PBX1; when associated with A-161. 1 Publication
Mutagenesisi161 – 1611L → A: Impairs interaction with PBX1; when associated with 158-A-A-159. 1 Publication
Mutagenesisi332 – 3321R → M: Impairs DNA binding and PBX1-dependent transcriptional activation. No effect on interaction with PBX1. 2 Publications

Organism-specific databases

Orphaneti261190. 15q14 microdeletion syndrome.
PharmGKBiPA30741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Homeobox protein Meis2PRO_0000049108Add
BLAST

Proteomic databases

MaxQBiO14770.
PaxDbiO14770.
PRIDEiO14770.

PTM databases

PhosphoSiteiO14770.

Expressioni

Tissue specificityi

Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.

Developmental stagei

Expressed in the proliferative zones of the fetal neocortex. Expressed at a very high level in the developing ganglionic eminence and at a more moderate level in the cortical plate.1 Publication

Gene expression databases

BgeeiO14770.
CleanExiHS_MEIS2.
ExpressionAtlasiO14770. baseline and differential.
GenevestigatoriO14770.

Organism-specific databases

HPAiCAB004999.
HPA003256.

Interactioni

Subunit structurei

Isoform 2/Meis2A interacts with TLX1. Isoform 3/Meis2B interacts with HOXA13 and PBX1 isoform PBX1b. Isoform 4/Meis2D interacts with SP1, SP3 and KLF4. Isoform 4/Meis2D and isoform 5/Meis2E interact with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3/Meis2B is part of a PDX1:PBX1b:MEIS2b complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4/Meis2D in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
gag-pro-polP033633EBI-2804934,EBI-9676133From a different organism.
PBX1P404246EBI-8025850,EBI-301611
TLX1P313144EBI-6390216,EBI-2820655

Protein-protein interaction databases

BioGridi110376. 20 interactions.
IntActiO14770. 5 interactions.
STRINGi9606.ENSP00000326296.

Structurei

Secondary structure

1
477
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi285 – 29713Combined sources
Turni298 – 3003Combined sources
Helixi306 – 31611Combined sources
Helixi320 – 33516Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K2AX-ray1.95A/B281-345[»]
ProteinModelPortaliO14770.
SMRiO14770. Positions 283-338.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14770.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni71 – 191121Required for interaction with PBX1By similarityAdd
BLAST
Regioni340 – 477138Transcriptional activation domainAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 24450Ser/Thr-richAdd
BLAST
Compositional biasi246 – 27328Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi266 – 2738Poly-Asp

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG302919.
GeneTreeiENSGT00550000074260.
HOGENOMiHOG000253923.
HOVERGENiHBG055193.
InParanoidiO14770.
KOiK16670.
OMAiSQHYGAH.
OrthoDBiEOG76HQ2W.
PhylomeDBiO14770.
TreeFamiTF318093.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14770-1) [UniParc]FASTAAdd to Basket

Also known as: Meis2C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRYDELPH YGGMDGVGVP ASMYGDPHAP RPIPPVHHLN HGPPLHATQH
60 70 80 90 100
YGAHAPHPNV MPASMGSAVN DALKRDKDAI YGHPLFPLLA LVFEKCELAT
110 120 130 140 150
CTPREPGVAG GDVCSSDSFN EDIAVFAKQV RAEKPLFSSN PELDNLMIQA
160 170 180 190 200
IQVLRFHLLE LEKVHELCDN FCHRYISCLK GKMPIDLVID ERDGSSKSDH
210 220 230 240 250
EELSGSSTNL ADHNPSSWRD HDDATSTHSA GTPGPSSGGH ASQSGDNSSE
260 270 280 290 300
QGDGLDNSVA SPGTGDDDDP DKDKKRQKKR GIFPKVATNI MRAWLFQHLT
310 320 330 340 350
HPYPSEEQKK QLAQDTGLTI LQVNNWFINA RRRIVQPMID QSNRAGFLLD
360 370 380 390 400
PSVSQGAAYS PEGQPMGSFV LDGQQHMGIR PAGLQSMPGD YVSQGGPMGM
410 420 430 440 450
SMAQPSYTPP QMTPHPTQLR HGPPMHSYLP SHPHHPAMMM HGGPPTHPGM
460 470
TMSAQSPTML NSVDPNVGGQ VMDIHAQ
Length:477
Mass (Da):51,790
Last modified:February 21, 2001 - v2
Checksum:i94EBD0801A312B24
GO
Isoform 2 (identifier: O14770-2) [UniParc]FASTAAdd to Basket

Also known as: Meis2A

The sequence of this isoform differs from the canonical sequence as follows:
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:401
Mass (Da):43,791
Checksum:i0682C0E92326516D
GO
Isoform 3 (identifier: O14770-3) [UniParc]FASTAAdd to Basket

Also known as: Meis2B

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:394
Mass (Da):43,061
Checksum:i6BCC0382F0C55296
GO
Isoform 4 (identifier: O14770-4) [UniParc]FASTAAdd to Basket

Also known as: Meis2D

The sequence of this isoform differs from the canonical sequence as follows:
     346-352: Missing.

Show »
Length:470
Mass (Da):51,060
Checksum:iC15C82B9F0098CB9
GO
Isoform 5 (identifier: O14770-5) [UniParc]FASTAAdd to Basket

Also known as: Meis2E

The sequence of this isoform differs from the canonical sequence as follows:
     301-302: HP → VY
     303-477: Missing.

Show »
Length:302
Mass (Da):32,837
Checksum:i059D4D332A95FE5F
GO
Isoform 6 (identifier: O14770-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MAQRYDELPH...IYGHPLFPLL → M
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Show »
Length:306
Mass (Da):33,598
Checksum:i4DF1350FB0F28AF1
GO
Isoform 7 (identifier: O14770-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     346-352: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Note: No experimental confirmation available.

Show »
Length:381
Mass (Da):41,542
Checksum:i4F6D947B1EDA0528
GO
Isoform 8 (identifier: O14770-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     384-401: LQSMPGDYVSQGGPMGMS → PMSGMGMNMGMDGQWHYM
     402-477: Missing.

Note: No experimental confirmation available.

Show »
Length:388
Mass (Da):42,272
Checksum:iE9F5455311C5BC69
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8989MAQRY…LFPLL → M in isoform 6. 1 PublicationVSP_043219Add
BLAST
Alternative sequencei1 – 1313Missing in isoform 7 and isoform 8. 2 PublicationsVSP_043494Add
BLAST
Alternative sequencei301 – 3022HP → VY in isoform 5. 1 PublicationVSP_002243
Alternative sequencei303 – 477175Missing in isoform 5. 1 PublicationVSP_002244Add
BLAST
Alternative sequencei346 – 3527Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 4 PublicationsVSP_002242
Alternative sequencei384 – 40118LQSMP…PMGMS → PMSGMGMNMGMDGQWHYM in isoform 2, isoform 3, isoform 6, isoform 7 and isoform 8. 4 PublicationsVSP_002245Add
BLAST
Alternative sequencei402 – 47776Missing in isoform 2, isoform 3, isoform 6, isoform 7 and isoform 8. 4 PublicationsVSP_002246Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF178948 mRNA. Translation: AAF81638.1.
AF179896 mRNA. Translation: AAF81639.1.
AF179897 mRNA. Translation: AAF81640.1.
AF179898 mRNA. Translation: AAF81641.1.
AF179899 mRNA. Translation: AAF81642.1.
AK056038 mRNA. Translation: BAG51610.1.
AK056620 mRNA. Translation: BAG51768.1.
AC018563 Genomic DNA. No translation available.
AC069483 Genomic DNA. No translation available.
AC078909 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92353.1.
CH471125 Genomic DNA. Translation: EAW92354.1.
CH471125 Genomic DNA. Translation: EAW92356.1.
BC001516 mRNA. Translation: AAH01516.1.
BC001844 mRNA. Translation: AAH01844.3.
BC007202 mRNA. Translation: AAH07202.1.
BC050431 mRNA. Translation: AAH50431.1.
AF017418 mRNA. Translation: AAB70270.1.
CCDSiCCDS10044.1. [O14770-1]
CCDS10045.1. [O14770-4]
CCDS42014.1. [O14770-7]
CCDS45217.1. [O14770-2]
CCDS45218.1. [O14770-3]
CCDS45219.1. [O14770-8]
CCDS45220.1. [O14770-6]
RefSeqiNP_001207411.1. NM_001220482.1. [O14770-4]
NP_002390.1. NM_002399.3. [O14770-7]
NP_733774.1. NM_170674.4. [O14770-3]
NP_733775.1. NM_170675.4. [O14770-1]
NP_733776.1. NM_170676.4. [O14770-4]
NP_733777.1. NM_170677.4. [O14770-2]
NP_758526.1. NM_172315.2. [O14770-8]
NP_758527.1. NM_172316.2. [O14770-6]
XP_006720585.1. XM_006720522.1. [O14770-1]
UniGeneiHs.510989.

Genome annotation databases

EnsembliENST00000314177; ENSP00000326296; ENSG00000134138. [O14770-5]
ENST00000338564; ENSP00000341400; ENSG00000134138. [O14770-4]
ENST00000340545; ENSP00000339549; ENSG00000134138. [O14770-7]
ENST00000397620; ENSP00000380745; ENSG00000134138. [O14770-6]
ENST00000397624; ENSP00000380749; ENSG00000134138. [O14770-6]
ENST00000424352; ENSP00000404185; ENSG00000134138. [O14770-2]
ENST00000557796; ENSP00000452693; ENSG00000134138. [O14770-7]
ENST00000559085; ENSP00000453390; ENSG00000134138. [O14770-8]
ENST00000559561; ENSP00000453497; ENSG00000134138. [O14770-3]
ENST00000561208; ENSP00000453793; ENSG00000134138. [O14770-1]
GeneIDi4212.
KEGGihsa:4212.
UCSCiuc001zjl.3. human. [O14770-8]
uc001zjm.3. human. [O14770-6]
uc001zjo.4. human. [O14770-2]
uc001zjp.4. human. [O14770-3]
uc001zjr.4. human. [O14770-1]
uc001zjs.4. human. [O14770-4]
uc001zju.3. human. [O14770-7]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF178948 mRNA. Translation: AAF81638.1 .
AF179896 mRNA. Translation: AAF81639.1 .
AF179897 mRNA. Translation: AAF81640.1 .
AF179898 mRNA. Translation: AAF81641.1 .
AF179899 mRNA. Translation: AAF81642.1 .
AK056038 mRNA. Translation: BAG51610.1 .
AK056620 mRNA. Translation: BAG51768.1 .
AC018563 Genomic DNA. No translation available.
AC069483 Genomic DNA. No translation available.
AC078909 Genomic DNA. No translation available.
CH471125 Genomic DNA. Translation: EAW92353.1 .
CH471125 Genomic DNA. Translation: EAW92354.1 .
CH471125 Genomic DNA. Translation: EAW92356.1 .
BC001516 mRNA. Translation: AAH01516.1 .
BC001844 mRNA. Translation: AAH01844.3 .
BC007202 mRNA. Translation: AAH07202.1 .
BC050431 mRNA. Translation: AAH50431.1 .
AF017418 mRNA. Translation: AAB70270.1 .
CCDSi CCDS10044.1. [O14770-1 ]
CCDS10045.1. [O14770-4 ]
CCDS42014.1. [O14770-7 ]
CCDS45217.1. [O14770-2 ]
CCDS45218.1. [O14770-3 ]
CCDS45219.1. [O14770-8 ]
CCDS45220.1. [O14770-6 ]
RefSeqi NP_001207411.1. NM_001220482.1. [O14770-4 ]
NP_002390.1. NM_002399.3. [O14770-7 ]
NP_733774.1. NM_170674.4. [O14770-3 ]
NP_733775.1. NM_170675.4. [O14770-1 ]
NP_733776.1. NM_170676.4. [O14770-4 ]
NP_733777.1. NM_170677.4. [O14770-2 ]
NP_758526.1. NM_172315.2. [O14770-8 ]
NP_758527.1. NM_172316.2. [O14770-6 ]
XP_006720585.1. XM_006720522.1. [O14770-1 ]
UniGenei Hs.510989.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3K2A X-ray 1.95 A/B 281-345 [» ]
ProteinModelPortali O14770.
SMRi O14770. Positions 283-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110376. 20 interactions.
IntActi O14770. 5 interactions.
STRINGi 9606.ENSP00000326296.

PTM databases

PhosphoSitei O14770.

Proteomic databases

MaxQBi O14770.
PaxDbi O14770.
PRIDEi O14770.

Protocols and materials databases

DNASUi 4212.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314177 ; ENSP00000326296 ; ENSG00000134138 . [O14770-5 ]
ENST00000338564 ; ENSP00000341400 ; ENSG00000134138 . [O14770-4 ]
ENST00000340545 ; ENSP00000339549 ; ENSG00000134138 . [O14770-7 ]
ENST00000397620 ; ENSP00000380745 ; ENSG00000134138 . [O14770-6 ]
ENST00000397624 ; ENSP00000380749 ; ENSG00000134138 . [O14770-6 ]
ENST00000424352 ; ENSP00000404185 ; ENSG00000134138 . [O14770-2 ]
ENST00000557796 ; ENSP00000452693 ; ENSG00000134138 . [O14770-7 ]
ENST00000559085 ; ENSP00000453390 ; ENSG00000134138 . [O14770-8 ]
ENST00000559561 ; ENSP00000453497 ; ENSG00000134138 . [O14770-3 ]
ENST00000561208 ; ENSP00000453793 ; ENSG00000134138 . [O14770-1 ]
GeneIDi 4212.
KEGGi hsa:4212.
UCSCi uc001zjl.3. human. [O14770-8 ]
uc001zjm.3. human. [O14770-6 ]
uc001zjo.4. human. [O14770-2 ]
uc001zjp.4. human. [O14770-3 ]
uc001zjr.4. human. [O14770-1 ]
uc001zjs.4. human. [O14770-4 ]
uc001zju.3. human. [O14770-7 ]

Organism-specific databases

CTDi 4212.
GeneCardsi GC15M037183.
HGNCi HGNC:7001. MEIS2.
HPAi CAB004999.
HPA003256.
MIMi 601740. gene.
neXtProti NX_O14770.
Orphaneti 261190. 15q14 microdeletion syndrome.
PharmGKBi PA30741.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG302919.
GeneTreei ENSGT00550000074260.
HOGENOMi HOG000253923.
HOVERGENi HBG055193.
InParanoidi O14770.
KOi K16670.
OMAi SQHYGAH.
OrthoDBi EOG76HQ2W.
PhylomeDBi O14770.
TreeFami TF318093.

Miscellaneous databases

ChiTaRSi MEIS2. human.
EvolutionaryTracei O14770.
GeneWikii MEIS2.
GenomeRNAii 4212.
NextBioi 16594.
PROi O14770.
SOURCEi Search...

Gene expression databases

Bgeei O14770.
CleanExi HS_MEIS2.
ExpressionAtlasi O14770. baseline and differential.
Genevestigatori O14770.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF05920. Homeobox_KN. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription."
    Yang Y., Hwang C.K., D'Souza U.M., Lee S.-H., Junn E., Mouradian M.M.
    J. Biol. Chem. 275:20734-20741(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), FUNCTION.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 8).
    Tissue: Tongue.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 7).
    Tissue: Muscle and Testis.
  6. "Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene."
    Smith J.E. Jr., Afonja O., Yee H.T., Inghirami G., Takeshita K.
    Mamm. Genome 8:951-952(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-477 (ISOFORM 3).
  7. "DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex."
    Liu Y., MacDonald R.J., Swift G.H.
    J. Biol. Chem. 276:17985-17993(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain."
    Larsen K.B., Lutterodt M.C., Laursen H., Graem N., Pakkenberg B., Mollgard K., Moller M.
    Dev. Neurosci. 32:149-162(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  9. "An autoinhibitory effect of the homothorax domain of Meis2."
    Hyman-Walsh C., Bjerke G.A., Wotton D.
    FEBS J. 277:2584-2597(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN, INTERACTION WITH PBX1, MUTAGENESIS OF LEU-85; LEU-88; 94-GLU--GLU-97; ILE-151; LEU-154; 158-LEU-LEU-159; LEU-161 AND ARG-332.
  10. Cited for: INTERACTION WITH TLX1.
  11. "Cooperative transcriptional activation by Klf4, Meis2, and Pbx1."
    Bjerke G.A., Hyman-Walsh C., Wotton D.
    Mol. Cell. Biol. 31:3723-3733(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SP1; SP3 AND KLF4, MUTAGENESIS OF ARG-332.

Entry informationi

Entry nameiMEIS2_HUMAN
AccessioniPrimary (citable) accession number: O14770
Secondary accession number(s): A6NJI5
, A8MWD5, B3KP98, B3KPQ6, Q96DI2, Q96KI4, Q96KI5, Q9NRS1, Q9NRS2, Q9NRS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 21, 2001
Last modified: October 29, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3