Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O14763

- TR10B_HUMAN

UniProt

O14763 - TR10B_HUMAN

Protein

Tumor necrosis factor receptor superfamily member 10B

Gene

TNFRSF10B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 164 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. receptor activity Source: UniProtKB
    3. TRAIL binding Source: UniProtKB

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
    2. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
    3. apoptotic process Source: UniProtKB
    4. apoptotic signaling pathway Source: Reactome
    5. cell surface receptor signaling pathway Source: ProtInc
    6. cellular response to mechanical stimulus Source: UniProtKB
    7. extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
    8. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
    9. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    10. regulation of apoptotic process Source: UniProtKB
    11. regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Reactome
    12. response to endoplasmic reticulum stress Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_1503. Caspase-8 activation.
    REACT_164011. Regulation by c-FLIP.
    REACT_402. TRAIL signaling.
    REACT_832. Dimerization of procaspase-8.
    SignaLinkiO14763.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10B
    Alternative name(s):
    Death receptor 5
    TNF-related apoptosis-inducing ligand receptor 2
    Short name:
    TRAIL receptor 2
    Short name:
    TRAIL-R2
    CD_antigen: CD262
    Gene namesi
    Name:TNFRSF10B
    Synonyms:DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
    ORF Names:UNQ160/PRO186
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:11905. TNFRSF10B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
    Note: The disease may be caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi275355. phenotype.
    Orphaneti67037. Squamous cell carcinoma of head and neck.
    PharmGKBiPA36598.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 55551 PublicationAdd
    BLAST
    Chaini56 – 440385Tumor necrosis factor receptor superfamily member 10BPRO_0000034580Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi81 ↔ 94
    Disulfide bondi97 ↔ 113
    Disulfide bondi116 ↔ 129
    Disulfide bondi119 ↔ 137
    Disulfide bondi139 ↔ 153
    Disulfide bondi156 ↔ 170
    Disulfide bondi160 ↔ 178

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiO14763.
    PaxDbiO14763.
    PRIDEiO14763.

    PTM databases

    PhosphoSiteiO14763.

    Expressioni

    Tissue specificityi

    Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

    Inductioni

    By ER stress. Regulated by p53/TP53.1 Publication

    Gene expression databases

    ArrayExpressiO14763.
    BgeeiO14763.
    CleanExiHS_TNFRSF10B.
    GenevestigatoriO14763.

    Organism-specific databases

    HPAiHPA023625.

    Interactioni

    Subunit structurei

    Homotrimer. Can interact with TRADD and RIPK1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TNFSF10P5059121EBI-518882,EBI-495373

    Protein-protein interaction databases

    BioGridi114323. 24 interactions.
    DIPiDIP-33566N.
    IntActiO14763. 6 interactions.
    MINTiMINT-109111.
    STRINGi9606.ENSP00000276431.

    Structurei

    Secondary structure

    1
    440
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi77 – 793
    Beta strandi85 – 873
    Beta strandi89 – 913
    Beta strandi94 – 963
    Turni99 – 1013
    Beta strandi106 – 1083
    Beta strandi110 – 1123
    Beta strandi123 – 1275
    Beta strandi131 – 1333
    Beta strandi136 – 1394
    Beta strandi143 – 1453
    Beta strandi153 – 1553
    Beta strandi164 – 1663
    Beta strandi172 – 1743
    Beta strandi178 – 1803

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D0GX-ray2.40R/S/T54-183[»]
    1D4VX-ray2.20A69-184[»]
    1DU3X-ray2.20A/B/C/G/H/I54-183[»]
    1ZA3X-ray3.35R/S54-183[»]
    2H9GX-ray2.32R/S54-183[»]
    4I9XX-ray2.10C/D58-184[»]
    4OD2X-ray3.20S73-183[»]
    ProteinModelPortaliO14763.
    SMRiO14763. Positions 75-182.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14763.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini56 – 210155ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 440209CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei211 – 23121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati57 – 9438TNFR-Cys 1Add
    BLAST
    Repeati97 – 13741TNFR-Cys 2Add
    BLAST
    Repeati138 – 17841TNFR-Cys 3Add
    BLAST
    Repeati192 – 20615TAPEAdd
    BLAST
    Domaini339 – 42284DeathPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi250 – 2534Poly-Gly

    Sequence similaritiesi

    Contains 1 death domain.PROSITE-ProRule annotation
    Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG131298.
    HOVERGENiHBG061626.
    InParanoidiO14763.
    KOiK04722.
    OMAiEMEVQEP.
    OrthoDBiEOG71VSSN.
    PhylomeDBiO14763.
    TreeFamiTF333916.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020465. TNFR_10.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00020. TNFR_c6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037867. CD261_antigen. 1 hit.
    PRINTSiPR01956. TNFACTORR10.
    SMARTiSM00005. DEATH. 1 hit.
    SM00208. TNFR. 2 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: O14763-1) [UniParc]FASTAAdd to Basket

    Also known as: TRICK2B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS    50
    AESALITQQD LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG 100
    QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP 150
    EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KESGTKHSGE VPAVEETVTS 200
    SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV LPYLKGICSG 250
    GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV 300
    NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP 350
    FDSWEPLMRK LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH 400
    TLLDALETLG ERLAKQKIED HLLSSGKFMY LEGNADSAMS 440

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Length:440
    Mass (Da):47,878
    Last modified:November 30, 2010 - v2
    Checksum:i60358EAF2A835870
    GO
    Isoform 3 (identifier: O14763-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         119-440: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:118
    Mass (Da):12,793
    Checksum:i6ED1332A3DF0FD39
    GO
    Isoform Short (identifier: O14763-2) [UniParc]FASTAAdd to Basket

    Also known as: TRICK2A

    The sequence of this isoform differs from the canonical sequence as follows:
         185-213: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:411
    Mass (Da):45,083
    Checksum:i57D50020E72CC954
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti439 – 4391M → L in AAB67103. (PubMed:9242611)Curated
    Sequence conflicti439 – 4391M → L in AAQ88644. (PubMed:12975309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti32 – 321P → L.10 Publications
    Corresponds to variant rs1129424 [ dbSNP | Ensembl ].
    VAR_016153
    Natural varianti67 – 671A → V.6 Publications
    Corresponds to variant rs1047266 [ dbSNP | Ensembl ].
    VAR_016154
    Natural varianti191 – 1911V → A.5 Publications
    Corresponds to variant rs13265018 [ dbSNP | Ensembl ].
    VAR_059831

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei119 – 440322Missing in isoform 3. 1 PublicationVSP_039125Add
    BLAST
    Alternative sequencei185 – 21329Missing in isoform Short. 9 PublicationsVSP_006490Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018657 mRNA. Translation: AAB70577.1.
    AF018658 mRNA. Translation: AAB70578.1.
    AF016849 mRNA. Translation: AAC51778.1.
    AF016266 mRNA. Translation: AAB81180.1.
    AF016268 mRNA. Translation: AAC01565.1.
    AF020501 mRNA. Translation: AAB71412.1.
    AF022386 mRNA. Translation: AAB71949.1.
    AF012628 mRNA. Translation: AAB67109.1.
    AF012535 mRNA. Translation: AAB67103.1.
    AB014718 Genomic DNA. Translation: BAA33723.1.
    AF153687 mRNA. Translation: AAF75587.1.
    AF192548 mRNA. Translation: AAF07175.1.
    AY358277 mRNA. Translation: AAQ88644.1.
    BX538104 mRNA. Translation: CAD98017.1.
    AC107959 Genomic DNA. No translation available.
    BC001281 mRNA. Translation: AAH01281.1.
    CCDSiCCDS6035.1. [O14763-1]
    CCDS6036.1. [O14763-2]
    RefSeqiNP_003833.4. NM_003842.4. [O14763-1]
    NP_671716.2. NM_147187.2. [O14763-2]
    UniGeneiHs.521456.

    Genome annotation databases

    EnsembliENST00000276431; ENSP00000276431; ENSG00000120889. [O14763-1]
    ENST00000347739; ENSP00000317859; ENSG00000120889. [O14763-2]
    GeneIDi8795.
    KEGGihsa:8795.
    UCSCiuc003xct.2. human. [O14763-2]
    uc003xcu.2. human. [O14763-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018657 mRNA. Translation: AAB70577.1 .
    AF018658 mRNA. Translation: AAB70578.1 .
    AF016849 mRNA. Translation: AAC51778.1 .
    AF016266 mRNA. Translation: AAB81180.1 .
    AF016268 mRNA. Translation: AAC01565.1 .
    AF020501 mRNA. Translation: AAB71412.1 .
    AF022386 mRNA. Translation: AAB71949.1 .
    AF012628 mRNA. Translation: AAB67109.1 .
    AF012535 mRNA. Translation: AAB67103.1 .
    AB014718 Genomic DNA. Translation: BAA33723.1 .
    AF153687 mRNA. Translation: AAF75587.1 .
    AF192548 mRNA. Translation: AAF07175.1 .
    AY358277 mRNA. Translation: AAQ88644.1 .
    BX538104 mRNA. Translation: CAD98017.1 .
    AC107959 Genomic DNA. No translation available.
    BC001281 mRNA. Translation: AAH01281.1 .
    CCDSi CCDS6035.1. [O14763-1 ]
    CCDS6036.1. [O14763-2 ]
    RefSeqi NP_003833.4. NM_003842.4. [O14763-1 ]
    NP_671716.2. NM_147187.2. [O14763-2 ]
    UniGenei Hs.521456.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D0G X-ray 2.40 R/S/T 54-183 [» ]
    1D4V X-ray 2.20 A 69-184 [» ]
    1DU3 X-ray 2.20 A/B/C/G/H/I 54-183 [» ]
    1ZA3 X-ray 3.35 R/S 54-183 [» ]
    2H9G X-ray 2.32 R/S 54-183 [» ]
    4I9X X-ray 2.10 C/D 58-184 [» ]
    4OD2 X-ray 3.20 S 73-183 [» ]
    ProteinModelPortali O14763.
    SMRi O14763. Positions 75-182.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114323. 24 interactions.
    DIPi DIP-33566N.
    IntActi O14763. 6 interactions.
    MINTi MINT-109111.
    STRINGi 9606.ENSP00000276431.

    Chemistry

    ChEMBLi CHEMBL1075153.
    GuidetoPHARMACOLOGYi 1880.

    PTM databases

    PhosphoSitei O14763.

    Proteomic databases

    MaxQBi O14763.
    PaxDbi O14763.
    PRIDEi O14763.

    Protocols and materials databases

    DNASUi 8795.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276431 ; ENSP00000276431 ; ENSG00000120889 . [O14763-1 ]
    ENST00000347739 ; ENSP00000317859 ; ENSG00000120889 . [O14763-2 ]
    GeneIDi 8795.
    KEGGi hsa:8795.
    UCSCi uc003xct.2. human. [O14763-2 ]
    uc003xcu.2. human. [O14763-1 ]

    Organism-specific databases

    CTDi 8795.
    GeneCardsi GC08M022877.
    HGNCi HGNC:11905. TNFRSF10B.
    HPAi HPA023625.
    MIMi 275355. phenotype.
    603612. gene.
    neXtProti NX_O14763.
    Orphaneti 67037. Squamous cell carcinoma of head and neck.
    PharmGKBi PA36598.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG131298.
    HOVERGENi HBG061626.
    InParanoidi O14763.
    KOi K04722.
    OMAi EMEVQEP.
    OrthoDBi EOG71VSSN.
    PhylomeDBi O14763.
    TreeFami TF333916.

    Enzyme and pathway databases

    Reactomei REACT_1503. Caspase-8 activation.
    REACT_164011. Regulation by c-FLIP.
    REACT_402. TRAIL signaling.
    REACT_832. Dimerization of procaspase-8.
    SignaLinki O14763.

    Miscellaneous databases

    EvolutionaryTracei O14763.
    GeneWikii TNFRSF10B.
    GenomeRNAii 8795.
    NextBioi 32984.
    PROi O14763.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14763.
    Bgeei O14763.
    CleanExi HS_TNFRSF10B.
    Genevestigatori O14763.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020465. TNFR_10.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00020. TNFR_c6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037867. CD261_antigen. 1 hit.
    PRINTSi PR01956. TNFACTORR10.
    SMARTi SM00005. DEATH. 1 hit.
    SM00208. TNFR. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL."
      Screaton G.R., Mongkolsapaya J., Xu X.-N., Cowper A.E., McMichael A.J., Bell J.I.
      Curr. Biol. 7:693-696(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), ALTERNATIVE SPLICING, VARIANTS LEU-32; VAL-67 AND ALA-191.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), PROTEIN SEQUENCE OF N-TERMINUS, VARIANT ALA-191.
      Tissue: Foreskin fibroblast.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), CHARACTERIZATION, VARIANTS LEU-32; VAL-67 AND ALA-191.
      Tissue: Liver and Spleen.
    4. "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway."
      Chaudhary P.M., Eby M., Jasmin A., Bookwalter A., Murray J., Hood L.
      Immunity 7:821-830(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), VARIANTS LEU-32 AND VAL-67.
    5. "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL."
      MacFarlane M., Ahmad M., Srinivasula S.M., Fernandes-Alnemri T., Cohen G.M., Alnemri E.S.
      J. Biol. Chem. 272:25417-25420(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), VARIANTS LEU-32 AND VAL-67.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Tissue: Ovary.
    7. "An antagonist decoy receptor and a death domain-containing receptor for TRAIL."
      Pan G., Ni J., Wei Y.-F., Yu G.-L., Gentz R., Dixit V.M.
      Science 277:815-818(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    8. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), VARIANT LEU-32.
    9. "Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas."
      Arai T., Akiyama Y., Okabe S., Saito K., Iwai T., Yuasa Y.
      Cancer Lett. 133:197-204(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANTS LEU-32; VAL-67 AND ALA-191.
    10. Cao X., Zhang W., Wan T.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    11. "Homo sapiens homolog of tumor necrosis factor receptor."
      Farrah T., Vu T., Gilbert T., Gross J., O'Hara P.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), VARIANTS LEU-32 AND VAL-67.
    12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT), VARIANT LEU-32.
    13. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LEU-32.
      Tissue: Colon endothelium.
    14. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    15. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG), VARIANTS LEU-32 AND ALA-191.
      Tissue: Cervix.
    16. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    17. "CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells."
      Yamaguchi H., Wang H.G.
      J. Biol. Chem. 279:45495-45502(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    18. "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5."
      Hymowitz S.G., Christinger H.W., Fuh G., Ultsch M., O'Connell M., Kelley R.F., Ashkenazi A., de Vos A.M.
      Mol. Cell 4:563-571(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 54-183.
    19. "Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation."
      Mongkolsapaya J., Grimes J.M., Chen N., Xu X.-N., Stuart D.I., Jones E.Y., Screaton G.R.
      Nat. Struct. Biol. 6:1048-1053(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 69-184.

    Entry informationi

    Entry nameiTR10B_HUMAN
    AccessioniPrimary (citable) accession number: O14763
    Secondary accession number(s): O14720
    , O15508, O15517, O15531, Q6UXM8, Q7Z360, Q9BVE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 164 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3