Reviewed,
UniProtKB/Swiss-Prot O14763 (TR10B_HUMAN)
Last modified
November 3, 2009.
Version 110.
History...
Clusters with 100%,
90%,
50% identity |
Documents (7) |
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Names and origin
| Protein names | Recommended name: Tumor necrosis factor receptor superfamily member 10B Alternative name(s): Death receptor 5 TNF-related apoptosis-inducing ligand receptor 2 Short name=TRAIL receptor 2 Short name=TRAIL-R2 CD_antigen=CD262 | ||||||
| Gene names |
| ||||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 440 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. |
| Subunit structure | Homotrimer. Can interact with TRADD and RIP. |
| Subcellular location | |
| Tissue specificity | Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 and G361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. |
| Induction | TNFRSF10B is regulated by the tumor suppressor p53. |
| Involvement in disease | Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck. |
| Sequence similarities | Contains 1 death domain. Contains 3 TNFR-Cys repeats. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Long (identifier: O14763-1) Also known as: TRICK2B; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. | ||||||
| Isoform Short (identifier: O14763-2) Also known as: TRICK2A; The sequence of this isoform differs from the canonical sequence as follows: 185-213: Missing. | ||||||
| Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 55 | 55 | |||||||||||||||||||||||||||||||
| Chain | 56 – 440 | 385 | Tumor necrosis factor receptor superfamily member 10B | PRO_0000034580 | |||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||
| Topological domain | 56 – 210 | 155 | Extracellular Potential | ||||||||||||||||||||||||||||||
| Transmembrane | 211 – 231 | 21 | Potential | ||||||||||||||||||||||||||||||
| Topological domain | 232 – 440 | 209 | Cytoplasmic Potential | ||||||||||||||||||||||||||||||
| Repeat | 57 – 94 | 38 | TNFR-Cys 1 | ||||||||||||||||||||||||||||||
| Repeat | 97 – 137 | 41 | TNFR-Cys 2 | ||||||||||||||||||||||||||||||
| Repeat | 138 – 178 | 41 | TNFR-Cys 3 | ||||||||||||||||||||||||||||||
| Repeat | 192 – 206 | 15 | TAPE | ||||||||||||||||||||||||||||||
| Domain | 339 – 422 | 84 | Death | ||||||||||||||||||||||||||||||
| Compositional bias | 250 – 253 | 4 | Poly-Gly | ||||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||||
| Disulfide bond | 81 ↔ 94 | ||||||||||||||||||||||||||||||||
| Disulfide bond | 97 ↔ 113 | ||||||||||||||||||||||||||||||||
| Disulfide bond | 116 ↔ 129 | ||||||||||||||||||||||||||||||||
| Disulfide bond | 119 ↔ 137 | ||||||||||||||||||||||||||||||||
| Disulfide bond | 139 ↔ 153 | ||||||||||||||||||||||||||||||||
| Disulfide bond | 156 ↔ 170 | ||||||||||||||||||||||||||||||||
| Disulfide bond | 160 ↔ 178 | ||||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||
| Alternative sequence | 185 – 213 | 29 | Missing in isoform Short. | VSP_006490 | |||||||||||||||||||||||||||||
| Natural variant | 32 | 1 | P → L: dbSNP rs1129424. Ref.2 Ref.3 Ref.6 Ref.7 Ref.8 Ref.9 Ref.11 Ref.12 Ref.13 | VAR_016153 | |||||||||||||||||||||||||||||
| Natural variant | 67 | 1 | A → V: dbSNP rs1047266. Ref.2 Ref.3 Ref.6 Ref.7 Ref.9 Ref.11 | VAR_016154 | |||||||||||||||||||||||||||||
| Natural variant | 191 | 1 | A → V: dbSNP rs13265018. | VAR_059831 | |||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||
| Sequence conflict | 439 | 1 | M → L in AAB67103. Ref.8 | ||||||||||||||||||||||||||||||
| Sequence conflict | 439 | 1 | M → L in AAQ88644. Ref.12 | ||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||
| Beta strand | 85 – 87 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 89 – 92 | 4 | |||||||||||||||||||||||||||||||
| Beta strand | 94 – 96 | 3 | |||||||||||||||||||||||||||||||
| Turn | 99 – 101 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 106 – 108 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 123 – 127 | 5 | |||||||||||||||||||||||||||||||
| Beta strand | 131 – 133 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 136 – 139 | 4 | |||||||||||||||||||||||||||||||
| Beta strand | 143 – 146 | 4 | |||||||||||||||||||||||||||||||
| Beta strand | 149 – 155 | 7 | |||||||||||||||||||||||||||||||
| Beta strand | 165 – 168 | 4 | |||||||||||||||||||||||||||||||
| Beta strand | 177 – 179 | 3 | |||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL." Walczak H., Degli-Esposti M.A., Johnson R.S., Smolak P.J., Waugh J.Y., Boiani N., Timour M.S., Gerhart M.J., Schooley K.A., Smith C.A., Goodwin R.G., Rauch C.T. EMBO J. 16:5386-5397(1997) [PubMed: 9311998] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), PROTEIN SEQUENCE OF N-TERMINUS. Tissue: Foreskin fibroblast. |
| [2] | "TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL." Screaton G.R., Mongkolsapaya J., Xu X.-N., Cowper A.E., McMichael A.J., Bell J.I. Curr. Biol. 7:693-696(1997) [PubMed: 9285725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), ALTERNATIVE SPLICING, VARIANTS LEU-32 AND VAL-67. |
| [3] | "Characterization of two receptors for TRAIL." Schneider P., Bodmer J.-L., Thome M., Hofmann K., Holler N., Tschopp J. FEBS Lett. 416:329-334(1997) [PubMed: 9373179] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), CHARACTERIZATION, VARIANTS LEU-32 AND VAL-67. Tissue: Liver and Spleen. |
| [4] | "KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene." Wu G.S., Burns T.F., McDonald E.R. III, Jiang W., Meng R., Krantz I.D., Kao G., Gan D.D., Zhou J.Y., Muschel R., Hamilton S.R., Spinner N.B., Markowitz S., Wu G., el-Deiry W.S. Nat. Genet. 17:141-143(1997) [PubMed: 9326928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Tissue: Ovary. |
| [5] | "An antagonist decoy receptor and a death domain-containing receptor for TRAIL." Pan G., Ni J., Wei Y.-F., Yu G.-L., Gentz R., Dixit V.M. Science 277:815-818(1997) [PubMed: 9242610] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). |
| [6] | "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL." MacFarlane M., Ahmad M., Srinivasula S.M., Fernandes-Alnemri T., Cohen G.M., Alnemri E.S. J. Biol. Chem. 272:25417-25420(1997) [PubMed: 9325248] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), VARIANTS LEU-32 AND VAL-67. |
| [7] | "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway." Chaudhary P.M., Eby M., Jasmin A., Bookwalter A., Murray J., Hood L. Immunity 7:821-830(1997) [PubMed: 9430227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), VARIANTS LEU-32 AND VAL-67. |
| [8] | "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors." Sheridan J.P., Marsters S.A., Pitti R.M., Gurney A., Skubatch M., Baldwin D.T., Ramakrishnan L., Gray C.L., Baker K., Wood W.I., Goddard A.D., Godowski P.J., Ashkenazi A. Science 277:818-821(1997) [PubMed: 9242611] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), VARIANT LEU-32. |
| [9] | "Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas." Arai T., Akiyama Y., Okabe S., Saito K., Iwai T., Yuasa Y. Cancer Lett. 133:197-204(1998) [PubMed: 10072170] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANTS LEU-32 AND VAL-67. |
| [10] | Cao X., Zhang W., Wan T. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). |
| [11] | "Homo sapiens homolog of tumor necrosis factor receptor." Farrah T., Vu T., Gilbert T., Gross J., O'Hara P. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), VARIANTS LEU-32 AND VAL-67. |
| [12] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT), VARIANT LEU-32. |
| [13] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG), VARIANT LEU-32. Tissue: Cervix. |
| [14] | "An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S). |
| [15] | "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5." Hymowitz S.G., Christinger H.W., Fuh G., Ultsch M., O'Connell M., Kelley R.F., Ashkenazi A., de Vos A.M. Mol. Cell 4:563-571(1999) [PubMed: 10549288] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 54-183. |
| [16] | "Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation." Mongkolsapaya J., Grimes J.M., Chen N., Xu X.-N., Stuart D.I., Jones E.Y., Screaton G.R. Nat. Struct. Biol. 6:1048-1053(1999) [PubMed: 10542098] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 69-184. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF016849 mRNA. Translation: AAC51778.1. AF018657 mRNA. Translation: AAB70577.1. AF018658 mRNA. Translation: AAB70578.1. AF016266 mRNA. Translation: AAB81180.1. AF022386 mRNA. Translation: AAB71949.1. AF012628 mRNA. Translation: AAB67109.1. AF020501 mRNA. Translation: AAB71412.1. AF016268 mRNA. Translation: AAC01565.1. AF012535 mRNA. Translation: AAB67103.1. AB014718 Genomic DNA. Translation: BAA33723.1. AF153687 mRNA. Translation: AAF75587.1. AF192548 mRNA. Translation: AAF07175.1. AY358277 mRNA. Translation: AAQ88644.1. BC001281 mRNA. Translation: AAH01281.1. | |||||||||||||||||||||||||||||||||||||
| IPI | IPI00296379. IPI00296380. | ||||||||||||||||||||||||||||||||||||
| RefSeq | NP_003833.4. NP_671716.2. | ||||||||||||||||||||||||||||||||||||
| UniGene | Hs.521456 | ||||||||||||||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||
| SMR | O14763. Positions 69-184. | ||||||||||||||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||||||||||||||
| IntAct | O14763. 3 interactions. | ||||||||||||||||||||||||||||||||||||
| STRING | O14763. | ||||||||||||||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||||||||||||||
| PRIDE | O14763. | ||||||||||||||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||||||||||||||
| Ensembl | ENST00000276431; ENSP00000276431; ENSG00000120889; Homo sapiens. [Genome view] ENST00000347739; ENSP00000317859; ENSG00000120889; Homo sapiens. [Genome view] | ||||||||||||||||||||||||||||||||||||
| GeneID | 8795. | ||||||||||||||||||||||||||||||||||||
| KEGG | hsa:8795. | ||||||||||||||||||||||||||||||||||||
| UCSC | uc003xct.1. human. uc003xcu.1. human. | ||||||||||||||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||||||||||||||
| CTD | 8795. | ||||||||||||||||||||||||||||||||||||
| GeneCards | GC08M022933. | ||||||||||||||||||||||||||||||||||||
| H-InvDB | HIX0021066. | ||||||||||||||||||||||||||||||||||||
| HGNC | HGNC:11905. TNFRSF10B. | ||||||||||||||||||||||||||||||||||||
| HPA | HPA023625. | ||||||||||||||||||||||||||||||||||||
| MIM | 275355. phenotype. 603612. gene. | ||||||||||||||||||||||||||||||||||||
| Orphanet | 67037. Squamous cell carcinoma of head and neck. | ||||||||||||||||||||||||||||||||||||
| PharmGKB | PA36598. | ||||||||||||||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||||||||||||||
| HOGENOM | O14763. | ||||||||||||||||||||||||||||||||||||
| HOVERGEN | O14763. | ||||||||||||||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||||||||||||||
| Pathway_Interaction_DB | trail_pathway. TRAIL signaling pathway. | ||||||||||||||||||||||||||||||||||||
| Reactome | REACT_578. Apoptosis. | ||||||||||||||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||||||||||||||
| ArrayExpress | O14763. | ||||||||||||||||||||||||||||||||||||
| Bgee | O14763. | ||||||||||||||||||||||||||||||||||||
| CleanEx | HS_TNFRSF10B. | ||||||||||||||||||||||||||||||||||||
| Genevestigator | O14763. | ||||||||||||||||||||||||||||||||||||
| GermOnline | ENSG00000120889. Homo sapiens. | ||||||||||||||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||||||||||||||
| InterPro | IPR000488. Death. IPR011029. DEATH-like. IPR017301. TNF-rel_apoptosis-ind_lig_rcpt. IPR001368. TNFR_Cys_rich_reg. IPR020465. Tumour_necrosis_factor_rcpt_10. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| Gene3D | G3DSA:1.10.533.10. DEATH_like. 1 hit. | ||||||||||||||||||||||||||||||||||||
| Pfam | PF00531. Death. 1 hit. PF00020. TNFR_c6. 2 hits. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| PIRSF | PIRSF037867. CD261_antigen. 1 hit. | ||||||||||||||||||||||||||||||||||||
| PRINTS | PR01956. TNFACTORR10. | ||||||||||||||||||||||||||||||||||||
| SMART | SM00005. DEATH. 1 hit. SM00208. TNFR. 2 hits. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| PROSITE | PS50017. DEATH_DOMAIN. 1 hit. PS00652. TNFR_NGFR_1. 2 hits. PS50050. TNFR_NGFR_2. 2 hits. [Graphical view] | ||||||||||||||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||||||||||||||
| NextBio | 32984. | ||||||||||||||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||||||||||||||
Entry information
| Entry name | TR10B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O14763 Secondary accession number(s): O14720 Q9BVE0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


