ID   OVOL1_HUMAN             Reviewed;         267 AA.
AC   O14753; Q6PCB1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 3.
DT   24-JAN-2024, entry version 185.
DE   RecName: Full=Putative transcription factor Ovo-like 1;
DE            Short=hOvo1;
GN   Name=OVOL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 87-267.
RX   PubMed=9383297; DOI=10.1007/s003359900620;
RA   Chidambaram A., Allikmets R., Chandrasekarappa S., Guru S.C., Modi W.,
RA   Gerrard B., Dean M.;
RT   "Characterization of a human homolog (OVOL1) of the Drosophila ovo gene,
RT   which maps to chromosome 11q13.";
RL   Mamm. Genome 8:950-951(1997).
CC   -!- FUNCTION: Putative transcription factor. Involved in hair formation and
CC       spermatogenesis. May function in the differentiation and/or maintenance
CC       of the urogenital system (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       O14753; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-3917713, EBI-6658203;
CC       O14753; Q03252: LMNB2; NbExp=3; IntAct=EBI-3917713, EBI-2830427;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in fetal kidney, and also in adult
CC       pancreas and placenta. Not expressed in intestine, peripheral blood
CC       lymphocytes and ovary.
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DR   EMBL; BX648725; CAH56127.1; -; mRNA.
DR   EMBL; BC059408; AAH59408.1; -; mRNA.
DR   EMBL; AF016045; AAB72084.1; -; mRNA.
DR   CCDS; CCDS8112.1; -.
DR   RefSeq; NP_004552.2; NM_004561.3.
DR   AlphaFoldDB; O14753; -.
DR   SMR; O14753; -.
DR   BioGRID; 111057; 13.
DR   IntAct; O14753; 4.
DR   STRING; 9606.ENSP00000337862; -.
DR   iPTMnet; O14753; -.
DR   PhosphoSitePlus; O14753; -.
DR   BioMuta; OVOL1; -.
DR   jPOST; O14753; -.
DR   MassIVE; O14753; -.
DR   MaxQB; O14753; -.
DR   PaxDb; 9606-ENSP00000337862; -.
DR   PeptideAtlas; O14753; -.
DR   ProteomicsDB; 48206; -.
DR   Antibodypedia; 1312; 269 antibodies from 28 providers.
DR   DNASU; 5017; -.
DR   Ensembl; ENST00000335987.8; ENSP00000337862.3; ENSG00000172818.10.
DR   GeneID; 5017; -.
DR   KEGG; hsa:5017; -.
DR   MANE-Select; ENST00000335987.8; ENSP00000337862.3; NM_004561.4; NP_004552.2.
DR   UCSC; uc001ofp.4; human.
DR   AGR; HGNC:8525; -.
DR   CTD; 5017; -.
DR   DisGeNET; 5017; -.
DR   GeneCards; OVOL1; -.
DR   HGNC; HGNC:8525; OVOL1.
DR   HPA; ENSG00000172818; Tissue enhanced (esophagus, skin, testis).
DR   MIM; 602313; gene.
DR   neXtProt; NX_O14753; -.
DR   OpenTargets; ENSG00000172818; -.
DR   PharmGKB; PA32853; -.
DR   VEuPathDB; HostDB:ENSG00000172818; -.
DR   eggNOG; KOG3576; Eukaryota.
DR   GeneTree; ENSGT00940000161363; -.
DR   HOGENOM; CLU_087964_0_0_1; -.
DR   InParanoid; O14753; -.
DR   OMA; ECGCTSD; -.
DR   OrthoDB; 5406109at2759; -.
DR   PhylomeDB; O14753; -.
DR   TreeFam; TF337552; -.
DR   PathwayCommons; O14753; -.
DR   SignaLink; O14753; -.
DR   BioGRID-ORCS; 5017; 9 hits in 1178 CRISPR screens.
DR   GenomeRNAi; 5017; -.
DR   Pharos; O14753; Tbio.
DR   PRO; PR:O14753; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; O14753; Protein.
DR   Bgee; ENSG00000172818; Expressed in gingival epithelium and 129 other cell types or tissues.
DR   ExpressionAtlas; O14753; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0009913; P:epidermal cell differentiation; IBA:GO_Central.
DR   GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IEA:Ensembl.
DR   GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0044771; P:meiotic cell cycle phase transition; IEA:Ensembl.
DR   GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR   GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Ensembl.
DR   GO; GO:1901994; P:negative regulation of meiotic cell cycle phase transition; IEA:Ensembl.
DR   GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR   InterPro; IPR027756; Ovo-like.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR10032:SF217; TRANSCRIPTION FACTOR OVO-LIKE 1-RELATED; 1.
DR   PANTHER; PTHR10032; ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
DR   Genevisible; O14753; HS.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..267
FT                   /note="Putative transcription factor Ovo-like 1"
FT                   /id="PRO_0000047011"
FT   ZN_FING         118..140
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         146..168
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         174..197
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         213..235
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   CONFLICT        150
FT                   /note="Y -> G (in Ref. 3; AAB72084)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   267 AA;  30259 MW;  57C67CD8A060A9B8 CRC64;
     MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS VAEPPSCPLA
     LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF LRTKMKVTLG DSPSGDLFTC
     RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD
     KAFTQRCSLE SHLKKIHGVQ QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP
     LLRKTSKKVA VALQNTVTSL LQGSPHL
//