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O14753

- OVOL1_HUMAN

UniProt

O14753 - OVOL1_HUMAN

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Protein
Putative transcription factor Ovo-like 1
Gene
OVOL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1
Add
BLAST
Zinc fingeri146 – 16823C2H2-type 2
Add
BLAST
Zinc fingeri174 – 19724C2H2-type 3
Add
BLAST
Zinc fingeri213 – 23523C2H2-type 4
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. cytoskeleton organization Source: InterPro
  2. epidermal cell differentiation Source: InterPro
  3. germline cell cycle switching, mitotic to meiotic cell cycle Source: Ensembl
  4. kidney development Source: Ensembl
  5. mesoderm development Source: Ensembl
  6. negative regulation of meiotic cell cycle phase transition Source: Ensembl
  7. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor Ovo-like 1
Short name:
hOvo1
Gene namesi
Name:OVOL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8525. OVOL1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Putative transcription factor Ovo-like 1
PRO_0000047011Add
BLAST

Proteomic databases

PaxDbiO14753.
PRIDEiO14753.

Expressioni

Tissue specificityi

Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.

Gene expression databases

ArrayExpressiO14753.
BgeeiO14753.
CleanExiHS_OVOL1.
GenevestigatoriO14753.

Organism-specific databases

HPAiHPA003984.

Interactioni

Protein-protein interaction databases

BioGridi111057. 4 interactions.
IntActiO14753. 1 interaction.
STRINGi9606.ENSP00000337862.

Structurei

3D structure databases

ProteinModelPortaliO14753.
SMRiO14753. Positions 92-240.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG255026.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiO14753.
KOiK09216.
OMAiVAPGPCV.
PhylomeDBiO14753.
TreeFamiTF337552.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027756. Ovo/OVOL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF131. PTHR10032:SF131. 1 hit.
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14753-1 [UniParc]FASTAAdd to Basket

« Hide

MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS    50
VAEPPSCPLA LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF 100
LRTKMKVTLG DSPSGDLFTC RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY 150
CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD KAFTQRCSLE SHLKKIHGVQ 200
QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP LLRKTSKKVA 250
VALQNTVTSL LQGSPHL 267
Length:267
Mass (Da):30,259
Last modified:November 23, 2004 - v3
Checksum:i57C67CD8A060A9B8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501Y → G in AAB72084. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX648725 mRNA. Translation: CAH56127.1.
BC059408 mRNA. Translation: AAH59408.1.
AF016045 mRNA. Translation: AAB72084.1.
CCDSiCCDS8112.1.
RefSeqiNP_004552.2. NM_004561.3.
UniGeneiHs.134434.

Genome annotation databases

EnsembliENST00000335987; ENSP00000337862; ENSG00000172818.
GeneIDi5017.
KEGGihsa:5017.
UCSCiuc001ofp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX648725 mRNA. Translation: CAH56127.1 .
BC059408 mRNA. Translation: AAH59408.1 .
AF016045 mRNA. Translation: AAB72084.1 .
CCDSi CCDS8112.1.
RefSeqi NP_004552.2. NM_004561.3.
UniGenei Hs.134434.

3D structure databases

ProteinModelPortali O14753.
SMRi O14753. Positions 92-240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111057. 4 interactions.
IntActi O14753. 1 interaction.
STRINGi 9606.ENSP00000337862.

Proteomic databases

PaxDbi O14753.
PRIDEi O14753.

Protocols and materials databases

DNASUi 5017.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335987 ; ENSP00000337862 ; ENSG00000172818 .
GeneIDi 5017.
KEGGi hsa:5017.
UCSCi uc001ofp.3. human.

Organism-specific databases

CTDi 5017.
GeneCardsi GC11P065555.
HGNCi HGNC:8525. OVOL1.
HPAi HPA003984.
MIMi 602313. gene.
neXtProti NX_O14753.
PharmGKBi PA32853.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255026.
HOGENOMi HOG000231694.
HOVERGENi HBG053384.
InParanoidi O14753.
KOi K09216.
OMAi VAPGPCV.
PhylomeDBi O14753.
TreeFami TF337552.

Miscellaneous databases

GenomeRNAii 5017.
NextBioi 19314.
PROi O14753.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14753.
Bgeei O14753.
CleanExi HS_OVOL1.
Genevestigatori O14753.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR027756. Ovo/OVOL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
PTHR10032:SF131. PTHR10032:SF131. 1 hit.
SMARTi SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Characterization of a human homolog (OVOL1) of the Drosophila ovo gene, which maps to chromosome 11q13."
    Chidambaram A., Allikmets R., Chandrasekarappa S., Guru S.C., Modi W., Gerrard B., Dean M.
    Mamm. Genome 8:950-951(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-267.

Entry informationi

Entry nameiOVOL1_HUMAN
AccessioniPrimary (citable) accession number: O14753
Secondary accession number(s): Q6PCB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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