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O14753 (OVOL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative transcription factor Ovo-like 1

Short name=hOvo1
Gene names
Name:OVOL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.

Sequence similarities

Contains 4 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processepidermis development

Inferred from electronic annotation. Source: Ensembl

germline cell cycle switching, mitotic to meiotic cell cycle

Inferred from electronic annotation. Source: Ensembl

kidney development

Inferred from electronic annotation. Source: Ensembl

mesoderm development

Inferred from electronic annotation. Source: Ensembl

negative regulation of meiotic cell cycle phase transition

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Putative transcription factor Ovo-like 1
PRO_0000047011

Regions

Zinc finger118 – 14023C2H2-type 1
Zinc finger146 – 16823C2H2-type 2
Zinc finger174 – 19724C2H2-type 3
Zinc finger213 – 23523C2H2-type 4

Experimental info

Sequence conflict1501Y → G in AAB72084. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O14753 [UniParc].

Last modified November 23, 2004. Version 3.
Checksum: 57C67CD8A060A9B8

FASTA26730,259
        10         20         30         40         50         60 
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS VAEPPSCPLA 

        70         80         90        100        110        120 
LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF LRTKMKVTLG DSPSGDLFTC 

       130        140        150        160        170        180 
RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD 

       190        200        210        220        230        240 
KAFTQRCSLE SHLKKIHGVQ QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP 

       250        260 
LLRKTSKKVA VALQNTVTSL LQGSPHL 

« Hide

References

« Hide 'large scale' references
[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Salivary gland.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[3]"Characterization of a human homolog (OVOL1) of the Drosophila ovo gene, which maps to chromosome 11q13."
Chidambaram A., Allikmets R., Chandrasekarappa S., Guru S.C., Modi W., Gerrard B., Dean M.
Mamm. Genome 8:950-951(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-267.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX648725 mRNA. Translation: CAH56127.1.
BC059408 mRNA. Translation: AAH59408.1.
AF016045 mRNA. Translation: AAB72084.1.
RefSeqNP_004552.2. NM_004561.3.
UniGeneHs.134434.

3D structure databases

ProteinModelPortalO14753.
SMRO14753. Positions 118-240.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111057. 4 interactions.
IntActO14753. 1 interaction.
STRING9606.ENSP00000337862.

Proteomic databases

PaxDbO14753.
PRIDEO14753.

Protocols and materials databases

DNASU5017.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335987; ENSP00000337862; ENSG00000172818.
GeneID5017.
KEGGhsa:5017.
UCSCuc001ofp.3. human.

Organism-specific databases

CTD5017.
GeneCardsGC11P065555.
HGNCHGNC:8525. OVOL1.
HPAHPA003984.
MIM602313. gene.
neXtProtNX_O14753.
PharmGKBPA32853.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG255026.
HOGENOMHOG000231694.
HOVERGENHBG053384.
InParanoidO14753.
KOK09216.
OMAVAPGPCV.
PhylomeDBO14753.
TreeFamTF337552.

Gene expression databases

ArrayExpressO14753.
BgeeO14753.
CleanExHS_OVOL1.
GenevestigatorO14753.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR027775. C2H2_Znf_fam.
IPR027771. Ovo/Ovo-like_1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF131. PTHR10032:SF131. 1 hit.
SMARTSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi5017.
NextBio19314.
PROO14753.
SOURCESearch...

Entry information

Entry nameOVOL1_HUMAN
AccessionPrimary (citable) accession number: O14753
Secondary accession number(s): Q6PCB1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM