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O14753

- OVOL1_HUMAN

UniProt

O14753 - OVOL1_HUMAN

Protein

Putative transcription factor Ovo-like 1

Gene

OVOL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri174 – 19724C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri213 – 23523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cytoskeleton organization Source: InterPro
    2. epidermal cell differentiation Source: InterPro
    3. germline cell cycle switching, mitotic to meiotic cell cycle Source: Ensembl
    4. kidney development Source: Ensembl
    5. mesoderm development Source: Ensembl
    6. negative regulation of meiotic cell cycle phase transition Source: Ensembl
    7. spermatogenesis Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative transcription factor Ovo-like 1
    Short name:
    hOvo1
    Gene namesi
    Name:OVOL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8525. OVOL1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32853.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Putative transcription factor Ovo-like 1PRO_0000047011Add
    BLAST

    Proteomic databases

    PaxDbiO14753.
    PRIDEiO14753.

    Expressioni

    Tissue specificityi

    Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.

    Gene expression databases

    ArrayExpressiO14753.
    BgeeiO14753.
    CleanExiHS_OVOL1.
    GenevestigatoriO14753.

    Organism-specific databases

    HPAiHPA003984.

    Interactioni

    Protein-protein interaction databases

    BioGridi111057. 4 interactions.
    IntActiO14753. 1 interaction.
    STRINGi9606.ENSP00000337862.

    Structurei

    3D structure databases

    ProteinModelPortaliO14753.
    SMRiO14753. Positions 92-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri174 – 19724C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri213 – 23523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG255026.
    HOGENOMiHOG000231694.
    HOVERGENiHBG053384.
    InParanoidiO14753.
    KOiK09216.
    OMAiVAPGPCV.
    PhylomeDBiO14753.
    TreeFamiTF337552.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR027756. Ovo/OVOL1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF131. PTHR10032:SF131. 1 hit.
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14753-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS    50
    VAEPPSCPLA LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF 100
    LRTKMKVTLG DSPSGDLFTC RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY 150
    CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD KAFTQRCSLE SHLKKIHGVQ 200
    QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP LLRKTSKKVA 250
    VALQNTVTSL LQGSPHL 267
    Length:267
    Mass (Da):30,259
    Last modified:November 23, 2004 - v3
    Checksum:i57C67CD8A060A9B8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1501Y → G in AAB72084. (PubMed:9383297)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX648725 mRNA. Translation: CAH56127.1.
    BC059408 mRNA. Translation: AAH59408.1.
    AF016045 mRNA. Translation: AAB72084.1.
    CCDSiCCDS8112.1.
    RefSeqiNP_004552.2. NM_004561.3.
    UniGeneiHs.134434.

    Genome annotation databases

    EnsembliENST00000335987; ENSP00000337862; ENSG00000172818.
    GeneIDi5017.
    KEGGihsa:5017.
    UCSCiuc001ofp.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX648725 mRNA. Translation: CAH56127.1 .
    BC059408 mRNA. Translation: AAH59408.1 .
    AF016045 mRNA. Translation: AAB72084.1 .
    CCDSi CCDS8112.1.
    RefSeqi NP_004552.2. NM_004561.3.
    UniGenei Hs.134434.

    3D structure databases

    ProteinModelPortali O14753.
    SMRi O14753. Positions 92-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111057. 4 interactions.
    IntActi O14753. 1 interaction.
    STRINGi 9606.ENSP00000337862.

    Proteomic databases

    PaxDbi O14753.
    PRIDEi O14753.

    Protocols and materials databases

    DNASUi 5017.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335987 ; ENSP00000337862 ; ENSG00000172818 .
    GeneIDi 5017.
    KEGGi hsa:5017.
    UCSCi uc001ofp.3. human.

    Organism-specific databases

    CTDi 5017.
    GeneCardsi GC11P065555.
    HGNCi HGNC:8525. OVOL1.
    HPAi HPA003984.
    MIMi 602313. gene.
    neXtProti NX_O14753.
    PharmGKBi PA32853.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255026.
    HOGENOMi HOG000231694.
    HOVERGENi HBG053384.
    InParanoidi O14753.
    KOi K09216.
    OMAi VAPGPCV.
    PhylomeDBi O14753.
    TreeFami TF337552.

    Miscellaneous databases

    GenomeRNAii 5017.
    NextBioi 19314.
    PROi O14753.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14753.
    Bgeei O14753.
    CleanExi HS_OVOL1.
    Genevestigatori O14753.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR027756. Ovo/OVOL1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF131. PTHR10032:SF131. 1 hit.
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Salivary gland.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "Characterization of a human homolog (OVOL1) of the Drosophila ovo gene, which maps to chromosome 11q13."
      Chidambaram A., Allikmets R., Chandrasekarappa S., Guru S.C., Modi W., Gerrard B., Dean M.
      Mamm. Genome 8:950-951(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-267.

    Entry informationi

    Entry nameiOVOL1_HUMAN
    AccessioniPrimary (citable) accession number: O14753
    Secondary accession number(s): Q6PCB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3