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Protein

Putative transcription factor Ovo-like 1

Gene

OVOL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri213 – 235C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor Ovo-like 1
Short name:
hOvo1
Gene namesi
Name:OVOL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172818.9.
HGNCiHGNC:8525. OVOL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5017.
OpenTargetsiENSG00000172818.
PharmGKBiPA32853.

Polymorphism and mutation databases

BioMutaiOVOL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470111 – 267Putative transcription factor Ovo-like 1Add BLAST267

Proteomic databases

MaxQBiO14753.
PaxDbiO14753.
PeptideAtlasiO14753.
PRIDEiO14753.

PTM databases

iPTMnetiO14753.
PhosphoSitePlusiO14753.

Expressioni

Tissue specificityi

Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.

Gene expression databases

BgeeiENSG00000172818.
CleanExiHS_OVOL1.
ExpressionAtlasiO14753. baseline and differential.
GenevisibleiO14753. HS.

Organism-specific databases

HPAiHPA003984.

Interactioni

Protein-protein interaction databases

BioGridi111057. 5 interactors.
IntActiO14753. 1 interactor.
STRINGi9606.ENSP00000337862.

Structurei

3D structure databases

ProteinModelPortaliO14753.
SMRiO14753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri146 – 168C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 197C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri213 – 235C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3576. Eukaryota.
ENOG4111H28. LUCA.
GeneTreeiENSGT00860000133786.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiO14753.
KOiK09216.
OMAiQPYQEPE.
OrthoDBiEOG091G0LB1.
PhylomeDBiO14753.
TreeFamiTF337552.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR027756. Ovo-like.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR10032. PTHR10032. 1 hit.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequencei

Sequence statusi: Complete.

O14753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS
60 70 80 90 100
VAEPPSCPLA LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF
110 120 130 140 150
LRTKMKVTLG DSPSGDLFTC RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY
160 170 180 190 200
CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD KAFTQRCSLE SHLKKIHGVQ
210 220 230 240 250
QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP LLRKTSKKVA
260
VALQNTVTSL LQGSPHL
Length:267
Mass (Da):30,259
Last modified:November 23, 2004 - v3
Checksum:i57C67CD8A060A9B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150Y → G in AAB72084 (PubMed:9383297).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648725 mRNA. Translation: CAH56127.1.
BC059408 mRNA. Translation: AAH59408.1.
AF016045 mRNA. Translation: AAB72084.1.
CCDSiCCDS8112.1.
RefSeqiNP_004552.2. NM_004561.3.
UniGeneiHs.134434.

Genome annotation databases

EnsembliENST00000335987; ENSP00000337862; ENSG00000172818.
GeneIDi5017.
KEGGihsa:5017.
UCSCiuc001ofp.4. human.

Similar proteinsi

Entry informationi

Entry nameiOVOL1_HUMAN
AccessioniPrimary (citable) accession number: O14753
Secondary accession number(s): Q6PCB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot