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Protein

Putative transcription factor Ovo-like 1

Gene

OVOL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19724C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. cytoskeleton organization Source: InterPro
  2. epidermal cell differentiation Source: InterPro
  3. germline cell cycle switching, mitotic to meiotic cell cycle Source: Ensembl
  4. kidney development Source: Ensembl
  5. mesoderm development Source: Ensembl
  6. negative regulation of meiotic cell cycle phase transition Source: Ensembl
  7. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor Ovo-like 1
Short name:
hOvo1
Gene namesi
Name:OVOL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8525. OVOL1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Putative transcription factor Ovo-like 1PRO_0000047011Add
BLAST

Proteomic databases

PaxDbiO14753.
PRIDEiO14753.

Expressioni

Tissue specificityi

Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.

Gene expression databases

BgeeiO14753.
CleanExiHS_OVOL1.
ExpressionAtlasiO14753. baseline and differential.
GenevestigatoriO14753.

Organism-specific databases

HPAiHPA003984.

Interactioni

Protein-protein interaction databases

BioGridi111057. 4 interactions.
IntActiO14753. 1 interaction.
STRINGi9606.ENSP00000337862.

Structurei

3D structure databases

ProteinModelPortaliO14753.
SMRiO14753. Positions 118-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri118 – 14023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri146 – 16823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19724C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG255026.
GeneTreeiENSGT00740000115492.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiO14753.
KOiK09216.
OMAiVAPGPCV.
PhylomeDBiO14753.
TreeFamiTF337552.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027756. Ovo/OVOL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF131. PTHR10032:SF131. 1 hit.
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS
60 70 80 90 100
VAEPPSCPLA LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF
110 120 130 140 150
LRTKMKVTLG DSPSGDLFTC RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY
160 170 180 190 200
CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD KAFTQRCSLE SHLKKIHGVQ
210 220 230 240 250
QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP LLRKTSKKVA
260
VALQNTVTSL LQGSPHL
Length:267
Mass (Da):30,259
Last modified:November 23, 2004 - v3
Checksum:i57C67CD8A060A9B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501Y → G in AAB72084 (PubMed:9383297).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648725 mRNA. Translation: CAH56127.1.
BC059408 mRNA. Translation: AAH59408.1.
AF016045 mRNA. Translation: AAB72084.1.
CCDSiCCDS8112.1.
RefSeqiNP_004552.2. NM_004561.3.
UniGeneiHs.134434.

Genome annotation databases

EnsembliENST00000335987; ENSP00000337862; ENSG00000172818.
GeneIDi5017.
KEGGihsa:5017.
UCSCiuc001ofp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX648725 mRNA. Translation: CAH56127.1.
BC059408 mRNA. Translation: AAH59408.1.
AF016045 mRNA. Translation: AAB72084.1.
CCDSiCCDS8112.1.
RefSeqiNP_004552.2. NM_004561.3.
UniGeneiHs.134434.

3D structure databases

ProteinModelPortaliO14753.
SMRiO14753. Positions 118-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111057. 4 interactions.
IntActiO14753. 1 interaction.
STRINGi9606.ENSP00000337862.

Proteomic databases

PaxDbiO14753.
PRIDEiO14753.

Protocols and materials databases

DNASUi5017.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335987; ENSP00000337862; ENSG00000172818.
GeneIDi5017.
KEGGihsa:5017.
UCSCiuc001ofp.3. human.

Organism-specific databases

CTDi5017.
GeneCardsiGC11P065555.
HGNCiHGNC:8525. OVOL1.
HPAiHPA003984.
MIMi602313. gene.
neXtProtiNX_O14753.
PharmGKBiPA32853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG255026.
GeneTreeiENSGT00740000115492.
HOGENOMiHOG000231694.
HOVERGENiHBG053384.
InParanoidiO14753.
KOiK09216.
OMAiVAPGPCV.
PhylomeDBiO14753.
TreeFamiTF337552.

Miscellaneous databases

GenomeRNAii5017.
NextBioi19314.
PROiO14753.
SOURCEiSearch...

Gene expression databases

BgeeiO14753.
CleanExiHS_OVOL1.
ExpressionAtlasiO14753. baseline and differential.
GenevestigatoriO14753.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027756. Ovo/OVOL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF131. PTHR10032:SF131. 1 hit.
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Characterization of a human homolog (OVOL1) of the Drosophila ovo gene, which maps to chromosome 11q13."
    Chidambaram A., Allikmets R., Chandrasekarappa S., Guru S.C., Modi W., Gerrard B., Dean M.
    Mamm. Genome 8:950-951(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-267.

Entry informationi

Entry nameiOVOL1_HUMAN
AccessioniPrimary (citable) accession number: O14753
Secondary accession number(s): Q6PCB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 23, 2004
Last modified: February 4, 2015
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.