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Protein

Programmed cell death protein 5

Gene

PDCD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function in the process of apoptosis.

GO - Molecular functioni

  • acetyltransferase activator activity Source: UniProtKB
  • beta-tubulin binding Source: UniProtKB
  • DNA binding Source: InterPro
  • heparin binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to transforming growth factor beta stimulus Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of chaperone-mediated protein folding Source: UniProtKB
  • positive regulation of apoptotic process Source: FlyBase
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of protein import into mitochondrial outer membrane Source: UniProtKB
  • positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105185-MONOMER.
SIGNORiO14737.

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 5
Alternative name(s):
TF-1 cell apoptosis-related protein 19
Short name:
Protein TFAR19
Gene namesi
Name:PDCD5
Synonyms:TFAR19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8764. PDCD5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9141.
OpenTargetsiENSG00000105185.
PharmGKBiPA33114.

Polymorphism and mutation databases

BioMutaiPDCD5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001215452 – 125Programmed cell death protein 5Add BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei63N6-acetyllysineCombined sources1
Modified residuei119PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14737.
MaxQBiO14737.
PaxDbiO14737.
PeptideAtlasiO14737.
PRIDEiO14737.
TopDownProteomicsiO14737-1. [O14737-1]

PTM databases

iPTMnetiO14737.
PhosphoSitePlusiO14737.

Expressioni

Tissue specificityi

Widely expressed. Highest levels in heart, testis, kidney, pituitary gland, adrenal gland and placenta.

Developmental stagei

Expression in fetal tissues is significantly lower than in adult tissues.

Inductioni

Activated in cells undergoing apoptosis.

Gene expression databases

BgeeiENSG00000105185.
CleanExiHS_PDCD5.
ExpressionAtlasiO14737. baseline and differential.
GenevisibleiO14737. HS.

Organism-specific databases

HPAiHPA018471.

Interactioni

GO - Molecular functioni

  • beta-tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114588. 26 interactors.
DIPiDIP-50602N.
IntActiO14737. 20 interactors.
MINTiMINT-5002173.
STRINGi9606.ENSP00000466214.

Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 19Combined sources18
Helixi26 – 47Combined sources22
Helixi50 – 62Combined sources13
Helixi64 – 80Combined sources17
Helixi89 – 99Combined sources11
Beta strandi100 – 102Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YYBNMR-A1-26[»]
2CRUNMR-A9-113[»]
2K6BNMR-A2-112[»]
ProteinModelPortaliO14737.
SMRiO14737.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14737.

Family & Domainsi

Sequence similaritiesi

Belongs to the PDCD5 family.Curated

Phylogenomic databases

eggNOGiKOG3431. Eukaryota.
COG2118. LUCA.
GeneTreeiENSGT00390000011085.
HOGENOMiHOG000194121.
HOVERGENiHBG053536.
InParanoidiO14737.
KOiK06875.
OMAiQQLVMLA.
OrthoDBiEOG091G0XYP.
PhylomeDBiO14737.

Family and domain databases

Gene3Di1.10.8.140. 1 hit.
InterProiIPR002836. PDCD5-related.
[Graphical view]
PANTHERiPTHR10840. PTHR10840. 1 hit.
PfamiPF01984. dsDNA_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF015730. TFAR19. 1 hit.
SUPFAMiSSF46950. SSF46950. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEELEALR RQRLAELQAK HGDPGDAAQQ EAKHREAEMR NSILAQVLDQ
60 70 80 90 100
SARARLSNLA LVKPEKTKAV ENYLIQMARY GQLSEKVSEQ GLIEILKKVS
110 120
QQTEKTTTVK FNRRKVMDSD EDDDY
Length:125
Mass (Da):14,285
Last modified:January 23, 2007 - v3
Checksum:i9569E0679C3DC20D
GO
Isoform 2 (identifier: O14737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-125: EQGLIEILKK...VMDSDEDDDY → LDSLEELYCY...LTLRRNCWRE

Note: No experimental confirmation available.
Show »
Length:129
Mass (Da):14,997
Checksum:i222EF19836188BA0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104E → K in CAG33215 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05620389 – 125EQGLI…EDDDY → LDSLEELYCYLLYQNMASKG QLHLHWITEFLLTLRRNCWR E in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014955 mRNA. Translation: AAD11579.1.
BT006694 mRNA. Translation: AAP35340.1.
AK293486 mRNA. Translation: BAG56975.1.
CR456934 mRNA. Translation: CAG33215.1.
AC008474 Genomic DNA. No translation available.
BC015519 mRNA. Translation: AAH15519.1.
CCDSiCCDS12423.1. [O14737-1]
PIRiJG0192.
RefSeqiNP_004699.1. NM_004708.3. [O14737-1]
XP_005259449.1. XM_005259392.4. [O14737-2]
UniGeneiHs.443831.

Genome annotation databases

EnsembliENST00000419343; ENSP00000476525; ENSG00000105185. [O14737-2]
ENST00000590247; ENSP00000466214; ENSG00000105185. [O14737-1]
GeneIDi9141.
KEGGihsa:9141.
UCSCiuc002ntl.4. human. [O14737-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014955 mRNA. Translation: AAD11579.1.
BT006694 mRNA. Translation: AAP35340.1.
AK293486 mRNA. Translation: BAG56975.1.
CR456934 mRNA. Translation: CAG33215.1.
AC008474 Genomic DNA. No translation available.
BC015519 mRNA. Translation: AAH15519.1.
CCDSiCCDS12423.1. [O14737-1]
PIRiJG0192.
RefSeqiNP_004699.1. NM_004708.3. [O14737-1]
XP_005259449.1. XM_005259392.4. [O14737-2]
UniGeneiHs.443831.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YYBNMR-A1-26[»]
2CRUNMR-A9-113[»]
2K6BNMR-A2-112[»]
ProteinModelPortaliO14737.
SMRiO14737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114588. 26 interactors.
DIPiDIP-50602N.
IntActiO14737. 20 interactors.
MINTiMINT-5002173.
STRINGi9606.ENSP00000466214.

PTM databases

iPTMnetiO14737.
PhosphoSitePlusiO14737.

Polymorphism and mutation databases

BioMutaiPDCD5.

Proteomic databases

EPDiO14737.
MaxQBiO14737.
PaxDbiO14737.
PeptideAtlasiO14737.
PRIDEiO14737.
TopDownProteomicsiO14737-1. [O14737-1]

Protocols and materials databases

DNASUi9141.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419343; ENSP00000476525; ENSG00000105185. [O14737-2]
ENST00000590247; ENSP00000466214; ENSG00000105185. [O14737-1]
GeneIDi9141.
KEGGihsa:9141.
UCSCiuc002ntl.4. human. [O14737-1]

Organism-specific databases

CTDi9141.
DisGeNETi9141.
GeneCardsiPDCD5.
HGNCiHGNC:8764. PDCD5.
HPAiHPA018471.
MIMi604583. gene.
neXtProtiNX_O14737.
OpenTargetsiENSG00000105185.
PharmGKBiPA33114.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3431. Eukaryota.
COG2118. LUCA.
GeneTreeiENSGT00390000011085.
HOGENOMiHOG000194121.
HOVERGENiHBG053536.
InParanoidiO14737.
KOiK06875.
OMAiQQLVMLA.
OrthoDBiEOG091G0XYP.
PhylomeDBiO14737.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105185-MONOMER.
SIGNORiO14737.

Miscellaneous databases

EvolutionaryTraceiO14737.
GeneWikiiPDCD5.
GenomeRNAii9141.
PROiO14737.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105185.
CleanExiHS_PDCD5.
ExpressionAtlasiO14737. baseline and differential.
GenevisibleiO14737. HS.

Family and domain databases

Gene3Di1.10.8.140. 1 hit.
InterProiIPR002836. PDCD5-related.
[Graphical view]
PANTHERiPTHR10840. PTHR10840. 1 hit.
PfamiPF01984. dsDNA_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF015730. TFAR19. 1 hit.
SUPFAMiSSF46950. SSF46950. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDCD5_HUMAN
AccessioniPrimary (citable) accession number: O14737
Secondary accession number(s): B4DE64, Q53YC9, Q6IB70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.