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Protein

Dual specificity mitogen-activated protein kinase kinase 7

Gene

MAP2K7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Enzyme regulationi

Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei149 – 1491ATPPROSITE-ProRule annotation
Active sitei243 – 2431Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi126 – 1349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • enzyme binding Source: BHF-UCL
  • JUN kinase kinase activity Source: Ensembl
  • magnesium ion binding Source: UniProtKB
  • MAP kinase kinase activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein phosphatase binding Source: BHF-UCL
  • protein tyrosine kinase activity Source: UniProtKB-KW
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • activation of JUN kinase activity Source: BHF-UCL
  • apoptotic process Source: UniProtKB-KW
  • cellular response to sorbitol Source: Ensembl
  • Fc-epsilon receptor signaling pathway Source: Reactome
  • JNK cascade Source: Reactome
  • positive regulation of neuron apoptotic process Source: Ensembl
  • positive regulation of telomerase activity Source: BHF-UCL
  • positive regulation of telomere capping Source: BHF-UCL
  • positive regulation of telomere maintenance via telomerase Source: BHF-UCL
  • proteolysis in other organism Source: Reactome
  • response to heat Source: UniProtKB
  • response to osmotic stress Source: UniProtKB
  • response to tumor necrosis factor Source: UniProtKB
  • response to UV Source: UniProtKB
  • signal transduction Source: ProtInc
  • stress-activated MAPK cascade Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Apoptosis, Stress response

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2. 2681.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-5210891. Uptake and function of anthrax toxins.
SignaLinkiO14733.
SIGNORiO14733.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity mitogen-activated protein kinase kinase 7 (EC:2.7.12.2)
Short name:
MAP kinase kinase 7
Short name:
MAPKK 7
Alternative name(s):
JNK-activating kinase 2
MAPK/ERK kinase 7
Short name:
MEK 7
Stress-activated protein kinase kinase 4
Short name:
SAPK kinase 4
Short name:
SAPKK-4
Short name:
SAPKK4
c-Jun N-terminal kinase kinase 2
Short name:
JNK kinase 2
Short name:
JNKK 2
Gene namesi
Name:MAP2K7
Synonyms:JNKK2, MEK7, MKK7, PRKMK7, SKK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6847. MAP2K7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA284.

Chemistry

ChEMBLiCHEMBL3530.
GuidetoPHARMACOLOGYi2068.

Polymorphism and mutation databases

BioMutaiMAP2K7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 419418Dual specificity mitogen-activated protein kinase kinase 7PRO_0000086388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei271 – 2711Phosphoserine; by MAP3KBy similarity
Modified residuei275 – 2751Phosphothreonine; by MAP3KBy similarity
Modified residuei411 – 4111PhosphoserineCombined sources

Post-translational modificationi

Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei44 – 452Cleavage; by anthrax lethal factor
Sitei76 – 772Cleavage; by anthrax lethal factor

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14733.
MaxQBiO14733.
PaxDbiO14733.
PeptideAtlasiO14733.
PRIDEiO14733.

PTM databases

iPTMnetiO14733.
PhosphoSiteiO14733.

Miscellaneous databases

PMAP-CutDBO14733.

Expressioni

Tissue specificityi

Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.3 Publications

Gene expression databases

BgeeiENSG00000076984.
CleanExiHS_MAP2K7.
GenevisibleiO14733. HS.

Organism-specific databases

HPAiCAB004262.
HPA001633.
HPA064711.

Interactioni

Subunit structurei

Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CFLARO15519-12EBI-492605,EBI-4567563
GADD45BO752938EBI-492605,EBI-448187
LRRK2Q5S0073EBI-492605,EBI-5323863
MAP3K7O433183EBI-492605,EBI-358684
MAPK8P459834EBI-492605,EBI-286483
MAPK8IP1Q9UQF25EBI-492605,EBI-78404

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • protein kinase binding Source: UniProtKB
  • protein phosphatase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111595. 57 interactions.
IntActiO14733. 24 interactions.
MINTiMINT-1378223.
STRINGi9606.ENSP00000381066.

Chemistry

BindingDBiO14733.

Structurei

Secondary structure

1
419
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi105 – 1084Combined sources
Beta strandi111 – 1144Combined sources
Helixi117 – 1193Combined sources
Beta strandi120 – 1278Combined sources
Beta strandi129 – 1313Combined sources
Beta strandi134 – 1396Combined sources
Turni140 – 1423Combined sources
Beta strandi145 – 1528Combined sources
Helixi157 – 17216Combined sources
Turni173 – 1753Combined sources
Beta strandi182 – 1876Combined sources
Beta strandi189 – 1968Combined sources
Beta strandi200 – 2023Combined sources
Helixi203 – 2108Combined sources
Helixi216 – 23722Combined sources
Helixi246 – 2483Combined sources
Beta strandi249 – 2513Combined sources
Beta strandi257 – 2593Combined sources
Turni262 – 2654Combined sources
Helixi281 – 2833Combined sources
Helixi286 – 2894Combined sources
Beta strandi292 – 2976Combined sources
Helixi302 – 31716Combined sources
Turni321 – 3244Combined sources
Helixi328 – 33710Combined sources
Beta strandi345 – 3473Combined sources
Helixi351 – 36010Combined sources
Helixi365 – 3673Combined sources
Helixi371 – 3744Combined sources
Helixi378 – 3858Combined sources
Helixi390 – 40011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DYLX-ray2.45A101-405[»]
3WZUX-ray3.01A103-419[»]
4UX9X-ray2.34F/G/H/I37-48[»]
5B2KX-ray2.75A103-419[»]
5B2LX-ray2.10A103-419[»]
5B2MX-ray3.06A103-419[»]
ProteinModelPortaliO14733.
SMRiO14733. Positions 51-402.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14733.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 380261Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 5721D domainBy similarityAdd
BLAST
Regioni377 – 40024DVD domainAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2 – 3029Sequence analysisAdd
BLAST

Domaini

The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.1 Publication
The D domain (residues 37-57) contains a conserved docking site and is required for the binding to MAPK substrates.1 Publication

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0983. Eukaryota.
ENOG410XTNQ. LUCA.
GeneTreeiENSGT00760000119199.
HOVERGENiHBG108518.
InParanoidiO14733.
KOiK04431.
OMAiHAPSSAY.
OrthoDBiEOG091G0A9H.
PhylomeDBiO14733.
TreeFamiTF350701.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14733-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND
60 70 80 90 100
GGSRSPSSES SPQHPTPPAR PRHMLGLPST LFTPRSMESI EIDQKLQEIM
110 120 130 140 150
KQTGYLTIGG QRYQAEINDL ENLGEMGSGT CGQVWKMRFR KTGHVIAVKQ
160 170 180 190 200
MRRSGNKEEN KRILMDLDVV LKSHDCPYIV QCFGTFITNT DVFIAMELMG
210 220 230 240 250
TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI HRDVKPSNIL
260 270 280 290 300
LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD
310 320 330 340 350
IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS
360 370 380 390 400
GDFQSFVKDC LTKDHRKRPK YNKLLEHSFI KRYETLEVDV ASWFKDVMAK
410
TESPRTSGVL SQPHLPFFR
Length:419
Mass (Da):47,485
Last modified:May 30, 2000 - v2
Checksum:iF1B22E050F54299A
GO
Isoform 2 (identifier: O14733-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: Q → QVPPSLWRGEGGGPARLDPSWERQWGAGGGGRAPGTLQPSLSSQ

Note: May be due to intron retention.
Show »
Length:462
Mass (Da):51,881
Checksum:iDF3496066961B0C7
GO
Isoform 3 (identifier: O14733-3) [UniParc]FASTAAdd to basket
Also known as: gamma1

The sequence of this isoform differs from the canonical sequence as follows:
     42-42: T → IIVITLSPAPAPSQRAA

Show »
Length:435
Mass (Da):49,071
Checksum:i8812A87DB28F2C22
GO
Isoform 4 (identifier: O14733-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-312: L → LPCPSPSQ

Note: No experimental confirmation available.
Show »
Length:426
Mass (Da):48,182
Checksum:i7934E29217D8A137
GO

Sequence cautioni

The sequence AAB97813 differs from that shown. Reason: Frameshift at positions 402 and 410. Curated
The sequence AAB97813 differs from that shown. Reason: Erroneous termination at position 420. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941Q → H in AAB97813 (PubMed:9312068).Curated
Sequence conflicti106 – 1061L → P in ABE03013 (PubMed:16442502).Curated
Sequence conflicti133 – 1331Q → P in AAB97813 (PubMed:9312068).Curated
Sequence conflicti142 – 1421T → N in AAB88048 (PubMed:9372971).Curated
Sequence conflicti407 – 4071S → N in AAB97813 (PubMed:9312068).Curated
Sequence conflicti415 – 4151L → LG in AAB97813 (PubMed:9312068).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181N → S.1 Publication
Corresponds to variant rs56316660 [ dbSNP | Ensembl ].
VAR_040825
Natural varianti138 – 1381R → C.1 Publication
Corresponds to variant rs56106612 [ dbSNP | Ensembl ].
VAR_040826
Natural varianti162 – 1621R → C in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040827
Natural varianti162 – 1621R → H in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_040828
Natural varianti195 – 1951A → T.1 Publication
Corresponds to variant rs55800262 [ dbSNP | Ensembl ].
VAR_040829
Natural varianti259 – 2591L → F.1 Publication
Corresponds to variant rs1053566 [ dbSNP | Ensembl ].
VAR_029890

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei42 – 421T → IIVITLSPAPAPSQRAA in isoform 3. 1 PublicationVSP_022309
Alternative sequencei111 – 1111Q → QVPPSLWRGEGGGPARLDPS WERQWGAGGGGRAPGTLQPS LSSQ in isoform 2. 1 PublicationVSP_004883
Alternative sequencei312 – 3121L → LPCPSPSQ in isoform 4. 1 PublicationVSP_022310

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014401 mRNA. Translation: AAB88048.1.
AF006689 mRNA. Translation: AAB97813.1. Sequence problems.
AF013588 mRNA. Translation: AAC16272.1.
AF013589 mRNA. Translation: AAC16273.1.
DQ445915 mRNA. Translation: ABE03013.1.
AF022805 mRNA. Translation: AAC26142.1.
AK313899 mRNA. Translation: BAG36622.1.
CH471139 Genomic DNA. Translation: EAW68964.1.
CH471139 Genomic DNA. Translation: EAW68968.1.
BC038295 mRNA. Translation: AAH38295.1.
AF003199 mRNA. Translation: AAB63374.1.
CCDSiCCDS42491.1. [O14733-1]
CCDS74277.1. [O14733-3]
CCDS74278.1. [O14733-4]
RefSeqiNP_001284484.1. NM_001297555.1. [O14733-3]
NP_001284485.1. NM_001297556.1. [O14733-4]
NP_660186.1. NM_145185.3. [O14733-1]
UniGeneiHs.531754.

Genome annotation databases

EnsembliENST00000397979; ENSP00000381066; ENSG00000076984. [O14733-1]
ENST00000397981; ENSP00000381068; ENSG00000076984. [O14733-4]
ENST00000397983; ENSP00000381070; ENSG00000076984. [O14733-3]
GeneIDi5609.
KEGGihsa:5609.
UCSCiuc002mit.4. human. [O14733-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF014401 mRNA. Translation: AAB88048.1.
AF006689 mRNA. Translation: AAB97813.1. Sequence problems.
AF013588 mRNA. Translation: AAC16272.1.
AF013589 mRNA. Translation: AAC16273.1.
DQ445915 mRNA. Translation: ABE03013.1.
AF022805 mRNA. Translation: AAC26142.1.
AK313899 mRNA. Translation: BAG36622.1.
CH471139 Genomic DNA. Translation: EAW68964.1.
CH471139 Genomic DNA. Translation: EAW68968.1.
BC038295 mRNA. Translation: AAH38295.1.
AF003199 mRNA. Translation: AAB63374.1.
CCDSiCCDS42491.1. [O14733-1]
CCDS74277.1. [O14733-3]
CCDS74278.1. [O14733-4]
RefSeqiNP_001284484.1. NM_001297555.1. [O14733-3]
NP_001284485.1. NM_001297556.1. [O14733-4]
NP_660186.1. NM_145185.3. [O14733-1]
UniGeneiHs.531754.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DYLX-ray2.45A101-405[»]
3WZUX-ray3.01A103-419[»]
4UX9X-ray2.34F/G/H/I37-48[»]
5B2KX-ray2.75A103-419[»]
5B2LX-ray2.10A103-419[»]
5B2MX-ray3.06A103-419[»]
ProteinModelPortaliO14733.
SMRiO14733. Positions 51-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111595. 57 interactions.
IntActiO14733. 24 interactions.
MINTiMINT-1378223.
STRINGi9606.ENSP00000381066.

Chemistry

BindingDBiO14733.
ChEMBLiCHEMBL3530.
GuidetoPHARMACOLOGYi2068.

PTM databases

iPTMnetiO14733.
PhosphoSiteiO14733.

Polymorphism and mutation databases

BioMutaiMAP2K7.

Proteomic databases

EPDiO14733.
MaxQBiO14733.
PaxDbiO14733.
PeptideAtlasiO14733.
PRIDEiO14733.

Protocols and materials databases

DNASUi5609.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397979; ENSP00000381066; ENSG00000076984. [O14733-1]
ENST00000397981; ENSP00000381068; ENSG00000076984. [O14733-4]
ENST00000397983; ENSP00000381070; ENSG00000076984. [O14733-3]
GeneIDi5609.
KEGGihsa:5609.
UCSCiuc002mit.4. human. [O14733-1]

Organism-specific databases

CTDi5609.
GeneCardsiMAP2K7.
HGNCiHGNC:6847. MAP2K7.
HPAiCAB004262.
HPA001633.
HPA064711.
MIMi603014. gene.
neXtProtiNX_O14733.
PharmGKBiPA284.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0983. Eukaryota.
ENOG410XTNQ. LUCA.
GeneTreeiENSGT00760000119199.
HOVERGENiHBG108518.
InParanoidiO14733.
KOiK04431.
OMAiHAPSSAY.
OrthoDBiEOG091G0A9H.
PhylomeDBiO14733.
TreeFamiTF350701.

Enzyme and pathway databases

BRENDAi2.7.12.2. 2681.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-HSA-5210891. Uptake and function of anthrax toxins.
SignaLinkiO14733.
SIGNORiO14733.

Miscellaneous databases

ChiTaRSiMAP2K7. human.
EvolutionaryTraceiO14733.
GeneWikiiMAP2K7.
GenomeRNAii5609.
PMAP-CutDBO14733.
PROiO14733.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000076984.
CleanExiHS_MAP2K7.
GenevisibleiO14733. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMP2K7_HUMAN
AccessioniPrimary (citable) accession number: O14733
Secondary accession number(s): B2R9S5
, D6W659, O14648, O14816, O60452, O60453, Q1PG43, Q8IY10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.