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Reviewed, UniProtKB/Swiss-Prot O14732 (IMPA2_HUMAN)

Last modified June 16, 2009. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Inositol monophosphatase 2
    EC=3.1.3.25
Alternative name(s):
    Inositol-1(or 4)-monophosphatase 2
      Short name=IMPase 2
      Short name=IMP 2
    Myo-inositol monophosphatase A2
Gene names
Name: IMPA2
Synonyms: IMP.18P
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Sequence similarities

Belongs to the inositol monophosphatase family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical term3D-structure
Gene Ontology (GO)
   Biological processphosphate metabolic process Ref.1

Traceable author statement. Source: ProtInc

signal transduction Ref.1

Traceable author statement. Source: ProtInc

   Molecular functioninositol-1(or 4)-monophosphatase activity Ref.1

Traceable author statement. Source: ProtInc

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O14732-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O14732-2)

Also known as: A2b;

The sequence of this isoform differs from the canonical sequence as follows:
     6-34: EDQAALAAGPWEECFQAAVQLALRAGQII → QD

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Inositol monophosphatase 2
PRO_0000142520

Sites

Metal binding811Magnesium 1 By similarity
Metal binding1011Magnesium 1 By similarity
Metal binding1011Magnesium 2 By similarity
Metal binding1031Magnesium 1; via carbonyl oxygen By similarity
Metal binding1041Magnesium 2 By similarity
Metal binding2311Magnesium 2 By similarity

Natural variations

Alternative sequence6 – 3429EDQAA…AGQII → QD in isoform 2.
VSP_013674
Natural variant881A → T: dbSNP rs16976948.
VAR_049601

Secondary structure

........................................ 288
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 30D83FA339AC69B4

FASTA28831,321
        10         20         30         40         50         60 
MKPSGEDQAA LAAGPWEECF QAAVQLALRA GQIIRKALTE EKRVSTKTSA ADLVTETDHL 

        70         80         90        100        110        120 
VEDLIISELR ERFPSHRFIA EEAAASGAKC VLTHSPTWII DPIDGTCNFV HRFPTVAVSI 

       130        140        150        160        170        180 
GFAVRQELEF GVIYHCTEER LYTGRRGRGA FCNGQRLRVS GETDLSKALV LTEIGPKRDP 

       190        200        210        220        230        240 
ATLKLFLSNM ERLLHAKAHG VRVIGSSTLA LCHLASGAAD AYYQFGLHCW DLAAATVIIR 

       250        260        270        280 
EAGGIVIDTS GGPLDLMACR VVAASTREMA MLIAQALQTI NYGRDDEK 

« Hide

Isoform 2 (A2b).

Checksum: A9D2BC0A05D0DF2F
Show »

FASTA26128,512

References

« Hide 'large scale' references
[1]"A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder."
Yoshikawa T., Turner G., Esterling L.E., Sanders A.R., Detera-Wadleigh S.D.
Mol. Psychiatry 2:393-397(1997) [PubMed: 9322233] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients."
Sjoholt G., Gulbrandsen A.K., Lovlie R., Berle J., Molven A., Steen V.M.
Mol. Psychiatry 5:172-180(2000) [PubMed: 10822345] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Molecular characterization of a novel form of human brain inositol monophosphatase A2b."
Parthasarathy L., Parthasarathy R.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF014398 mRNA. Translation: AAB70915.1.
AF157102 expand/collapse EMBL AC list , AF157096, AF157097, AF157098, AF157099, AF157100, AF157101 Genomic DNA. Translation: AAD40683.1.
AF200432 mRNA. Translation: AAF07824.1.
BT007061 mRNA. Translation: AAP35710.1.
BC017176 mRNA. Translation: AAH17176.1.
IPIIPI00023635.
IPI00555726.
RefSeqNP_055029.1.
UniGeneHs.367992

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2CZHX-ray2.70A/B1-288[»]
2CZIX-ray3.00A1-288[»]
2CZKX-ray2.90A1-288[»]
2DDKX-ray2.70A/B1-288[»]
2FVZX-ray2.40A/B/C/D16-288[»]
ModBaseSearch...

Protein-protein interaction databases

IntActO14732. 1 interaction.

Proteomic databases

PRIDEO14732.

Genome annotation databases

EnsemblENSG00000141401. Homo sapiens. [Contig view]
GeneID3613.
KEGGhsa:3613.

Organism-specific databases

GeneCardsGC18P011971.
H-InvDBHIX0017884.
HGNCHGNC:6051. IMPA2.
MIM605922. gene.
PharmGKBPA29861.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO14732.
HOVERGENO14732.
OMAO14732. PLEITEK.

Enzyme and pathway databases

BRENDA3.1.3.25. 247.

Gene expression databases

ArrayExpressO14732.
BgeeO14732.
CleanExHS_IMPA2.

Family and domain databases

InterProIPR000760. Inositol_P.
[Graphical view]
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSPR00378. INOSPHPHTASE.
ProDomPD023420. Inositol_P. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB01356. Lithium.
NextBio14131.
SOURCESearch...

Entry information

Entry nameIMPA2_HUMAN
AccessionPrimary (citable) accession number: O14732
Secondary accession number(s): Q9UJT3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 16, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents