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O14730 (RIOK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase RIO3

EC=2.7.11.1
Alternative name(s):
RIO kinase 3
sudD homolog
Gene names
Name:RIOK3
Synonyms:SUDD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Tissue specificity

Widely expressed. Ref.1

Sequence similarities

Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

Contains 1 protein kinase domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CASP10Q928514EBI-1047061,EBI-495095

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O14730-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O14730-2)

The sequence of this isoform differs from the canonical sequence as follows:
     449-451: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Serine/threonine-protein kinase RIO3
PRO_0000213529

Regions

Domain251 – 519269Protein kinase
Nucleotide binding257 – 2659ATP By similarity

Sites

Active site4061Proton acceptor By similarity
Binding site2901ATP By similarity

Amino acid modifications

Modified residue1221Phosphotyrosine Ref.4
Modified residue1251Phosphoserine By similarity
Modified residue1271Phosphoserine Ref.4
Modified residue1281Phosphoserine Ref.4

Natural variations

Alternative sequence449 – 4513Missing in isoform 2.
VSP_012164
Natural variant3361L → V. Ref.6
Corresponds to variant rs35401850 [ dbSNP | Ensembl ].
VAR_042355
Natural variant4411R → Q. Ref.6
Corresponds to variant rs33969048 [ dbSNP | Ensembl ].
VAR_042356
Natural variant4471S → L. Ref.6
Corresponds to variant rs56282762 [ dbSNP | Ensembl ].
VAR_042357

Experimental info

Sequence conflict3251I → H in AAC26080. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 3C3392BAC4ECB912

FASTA51959,093
        10         20         30         40         50         60 
MDLVGVASPE PGTAAAWGPS KCPWAIPQNT ISCSLADVMS EQLAKELQLE EEAAVFPEVA 

        70         80         90        100        110        120 
VAEGPFITGE NIDTSSDLML AQMLQMEYDR EYDAQLRREE KKFNGDSKVS ISFENYRKVH 

       130        140        150        160        170        180 
PYEDSDSSED EVDWQDTRDD PYRPAKPVPT PKKGFIGKGK DITTKHDEVV CGRKNTARME 

       190        200        210        220        230        240 
NFAPEFQVGD GIGMDLKLSN HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL 

       250        260        270        280        290        300 
MYKMVNSGML ETITGCISTG KESVVFHAYG GSMEDEKEDS KVIPTECAIK VFKTTLNEFK 

       310        320        330        340        350        360 
NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLARMQ RAGIPCPTVV LLKKHILVMS 

       370        380        390        400        410        420 
FIGHDQVPAP KLKEVKLNSE EMKEAYYQTL HLMRQLYHEC TLVHADLSEY NMLWHAGKVW 

       430        440        450        460        470        480 
LIDVSQSVEP THPHGLEFLF RDCRNVSQFF QKGGVKEALS ERELFNAVSG LNITADNEAD 

       490        500        510 
FLAEIEALEK MNEDHVQKNG RKAASFLKDD GDPPLLYDE 

« Hide

Isoform 2 [UniParc].

Checksum: 2CA9BC88DD00CFE5
Show »

FASTA51658,671

References

« Hide 'large scale' references
[1]"Isolation of the Aspergillus nidulans sudD gene and its human homologue."
Anaya P., Evans S.C., Dai C., Lozano G., May G.S.
Gene 211:323-329(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-122; SER-127 AND SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-336; GLN-441 AND LEU-447.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF013591 mRNA. Translation: AAC26080.1.
AC026634 Genomic DNA. No translation available.
BC039729 mRNA. Translation: AAH39729.1.
RefSeqNP_003822.2. NM_003831.3.
UniGeneHs.445511.
Hs.728452.

3D structure databases

ProteinModelPortalO14730.
SMRO14730. Positions 219-461.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114309. 15 interactions.
IntActO14730. 6 interactions.
STRING9606.ENSP00000341874.

Chemistry

BindingDBO14730.
ChEMBLCHEMBL5659.
GuidetoPHARMACOLOGY2188.

PTM databases

PhosphoSiteO14730.

Proteomic databases

PaxDbO14730.
PRIDEO14730.

Protocols and materials databases

DNASU8780.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339486; ENSP00000341874; ENSG00000101782. [O14730-1]
ENST00000577501; ENSP00000462548; ENSG00000101782. [O14730-2]
GeneID8780.
KEGGhsa:8780.
UCSCuc002kui.4. human. [O14730-1]
uc010dls.3. human. [O14730-2]

Organism-specific databases

CTD8780.
GeneCardsGC18P021032.
HGNCHGNC:11451. RIOK3.
HPAHPA001620.
HPA024184.
MIM603579. gene.
neXtProtNX_O14730.
PharmGKBPA36248.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1718.
HOGENOMHOG000007623.
HOVERGENHBG057475.
InParanoidO14730.
KOK08872.
OMAKEAYYQT.
OrthoDBEOG7JT6W1.
PhylomeDBO14730.
TreeFamTF105831.

Gene expression databases

ArrayExpressO14730.
BgeeO14730.
CleanExHS_RIOK3.
GenevestigatorO14730.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR018934. RIO-like_kinase.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
[Graphical view]
PfamPF01163. RIO1. 1 hit.
[Graphical view]
PIRSFPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01245. RIO1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8780.
NextBio32920.
PROO14730.
SOURCESearch...

Entry information

Entry nameRIOK3_HUMAN
AccessionPrimary (citable) accession number: O14730
Secondary accession number(s): Q8IXN9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM