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O14730

- RIOK3_HUMAN

UniProt

O14730 - RIOK3_HUMAN

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Protein
Serine/threonine-protein kinase RIO3
Gene
RIOK3, SUDD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei290 – 2901ATP By similarity
Active sitei406 – 4061Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi257 – 2659ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. chromosome segregation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIO3 (EC:2.7.11.1)
Alternative name(s):
RIO kinase 3
sudD homolog
Gene namesi
Name:RIOK3
Synonyms:SUDD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:11451. RIOK3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Serine/threonine-protein kinase RIO3
PRO_0000213529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221Phosphotyrosine1 Publication
Modified residuei125 – 1251Phosphoserine By similarity
Modified residuei127 – 1271Phosphoserine1 Publication
Modified residuei128 – 1281Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14730.
PaxDbiO14730.
PRIDEiO14730.

PTM databases

PhosphoSiteiO14730.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiO14730.
BgeeiO14730.
CleanExiHS_RIOK3.
GenevestigatoriO14730.

Organism-specific databases

HPAiHPA001620.
HPA024184.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CASP10Q928514EBI-1047061,EBI-495095

Protein-protein interaction databases

BioGridi114309. 15 interactions.
IntActiO14730. 6 interactions.
STRINGi9606.ENSP00000341874.

Structurei

3D structure databases

ProteinModelPortaliO14730.
SMRiO14730. Positions 219-461.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini251 – 519269Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1718.
HOGENOMiHOG000007623.
HOVERGENiHBG057475.
InParanoidiO14730.
KOiK08872.
OMAiKEAYYQT.
OrthoDBiEOG7JT6W1.
PhylomeDBiO14730.
TreeFamiTF105831.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR018934. RIO-like_kinase.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
[Graphical view]
PfamiPF01163. RIO1. 1 hit.
[Graphical view]
PIRSFiPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14730-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLVGVASPE PGTAAAWGPS KCPWAIPQNT ISCSLADVMS EQLAKELQLE    50
EEAAVFPEVA VAEGPFITGE NIDTSSDLML AQMLQMEYDR EYDAQLRREE 100
KKFNGDSKVS ISFENYRKVH PYEDSDSSED EVDWQDTRDD PYRPAKPVPT 150
PKKGFIGKGK DITTKHDEVV CGRKNTARME NFAPEFQVGD GIGMDLKLSN 200
HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL MYKMVNSGML 250
ETITGCISTG KESVVFHAYG GSMEDEKEDS KVIPTECAIK VFKTTLNEFK 300
NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLARMQ RAGIPCPTVV 350
LLKKHILVMS FIGHDQVPAP KLKEVKLNSE EMKEAYYQTL HLMRQLYHEC 400
TLVHADLSEY NMLWHAGKVW LIDVSQSVEP THPHGLEFLF RDCRNVSQFF 450
QKGGVKEALS ERELFNAVSG LNITADNEAD FLAEIEALEK MNEDHVQKNG 500
RKAASFLKDD GDPPLLYDE 519
Length:519
Mass (Da):59,093
Last modified:February 20, 2007 - v2
Checksum:i3C3392BAC4ECB912
GO
Isoform 2 (identifier: O14730-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-451: Missing.

Note: No experimental confirmation available.

Show »
Length:516
Mass (Da):58,671
Checksum:i2CA9BC88DD00CFE5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti336 – 3361L → V.1 Publication
Corresponds to variant rs35401850 [ dbSNP | Ensembl ].
VAR_042355
Natural varianti441 – 4411R → Q.1 Publication
Corresponds to variant rs33969048 [ dbSNP | Ensembl ].
VAR_042356
Natural varianti447 – 4471S → L.1 Publication
Corresponds to variant rs56282762 [ dbSNP | Ensembl ].
VAR_042357

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei449 – 4513Missing in isoform 2.
VSP_012164

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti325 – 3251I → H in AAC26080. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013591 mRNA. Translation: AAC26080.1.
AC026634 Genomic DNA. No translation available.
BC039729 mRNA. Translation: AAH39729.1.
CCDSiCCDS11877.1. [O14730-1]
RefSeqiNP_003822.2. NM_003831.3. [O14730-1]
UniGeneiHs.445511.
Hs.728452.

Genome annotation databases

EnsembliENST00000339486; ENSP00000341874; ENSG00000101782. [O14730-1]
ENST00000577501; ENSP00000462548; ENSG00000101782. [O14730-2]
GeneIDi8780.
KEGGihsa:8780.
UCSCiuc002kui.4. human. [O14730-1]
uc010dls.3. human. [O14730-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013591 mRNA. Translation: AAC26080.1 .
AC026634 Genomic DNA. No translation available.
BC039729 mRNA. Translation: AAH39729.1 .
CCDSi CCDS11877.1. [O14730-1 ]
RefSeqi NP_003822.2. NM_003831.3. [O14730-1 ]
UniGenei Hs.445511.
Hs.728452.

3D structure databases

ProteinModelPortali O14730.
SMRi O14730. Positions 219-461.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114309. 15 interactions.
IntActi O14730. 6 interactions.
STRINGi 9606.ENSP00000341874.

Chemistry

BindingDBi O14730.
ChEMBLi CHEMBL5659.
GuidetoPHARMACOLOGYi 2188.

PTM databases

PhosphoSitei O14730.

Proteomic databases

MaxQBi O14730.
PaxDbi O14730.
PRIDEi O14730.

Protocols and materials databases

DNASUi 8780.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339486 ; ENSP00000341874 ; ENSG00000101782 . [O14730-1 ]
ENST00000577501 ; ENSP00000462548 ; ENSG00000101782 . [O14730-2 ]
GeneIDi 8780.
KEGGi hsa:8780.
UCSCi uc002kui.4. human. [O14730-1 ]
uc010dls.3. human. [O14730-2 ]

Organism-specific databases

CTDi 8780.
GeneCardsi GC18P021032.
HGNCi HGNC:11451. RIOK3.
HPAi HPA001620.
HPA024184.
MIMi 603579. gene.
neXtProti NX_O14730.
PharmGKBi PA36248.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1718.
HOGENOMi HOG000007623.
HOVERGENi HBG057475.
InParanoidi O14730.
KOi K08872.
OMAi KEAYYQT.
OrthoDBi EOG7JT6W1.
PhylomeDBi O14730.
TreeFami TF105831.

Miscellaneous databases

GenomeRNAii 8780.
NextBioi 32920.
PROi O14730.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14730.
Bgeei O14730.
CleanExi HS_RIOK3.
Genevestigatori O14730.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR018934. RIO-like_kinase.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
[Graphical view ]
Pfami PF01163. RIO1. 1 hit.
[Graphical view ]
PIRSFi PIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTi SM00090. RIO. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01245. RIO1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the Aspergillus nidulans sudD gene and its human homologue."
    Anaya P., Evans S.C., Dai C., Lozano G., May G.S.
    Gene 211:323-329(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-122; SER-127 AND SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-336; GLN-441 AND LEU-447.

Entry informationi

Entry nameiRIOK3_HUMAN
AccessioniPrimary (citable) accession number: O14730
Secondary accession number(s): Q8IXN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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