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Protein

Serine/threonine-protein kinase RIO3

Gene

RIOK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei290ATPBy similarity1
Active sitei406Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi257 – 265ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

  • chromosome segregation Source: ProtInc
  • rRNA processing Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS02302-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIO3 (EC:2.7.11.1)
Alternative name(s):
RIO kinase 3
sudD homolog
Gene namesi
Name:RIOK3
Synonyms:SUDD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:11451. RIOK3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi8780.
OpenTargetsiENSG00000101782.
PharmGKBiPA36248.

Chemistry databases

ChEMBLiCHEMBL5659.
GuidetoPHARMACOLOGYi2188.

Polymorphism and mutation databases

BioMutaiRIOK3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135291 – 519Serine/threonine-protein kinase RIO3Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei122PhosphotyrosineCombined sources1
Modified residuei125PhosphoserineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Modified residuei128PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14730.
MaxQBiO14730.
PaxDbiO14730.
PeptideAtlasiO14730.
PRIDEiO14730.

PTM databases

iPTMnetiO14730.
PhosphoSitePlusiO14730.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000101782.
CleanExiHS_RIOK3.
ExpressionAtlasiO14730. baseline and differential.
GenevisibleiO14730. HS.

Organism-specific databases

HPAiHPA001620.
HPA024184.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CASP10Q928514EBI-1047061,EBI-495095

Protein-protein interaction databases

BioGridi114309. 25 interactors.
IntActiO14730. 14 interactors.
STRINGi9606.ENSP00000341874.

Chemistry databases

BindingDBiO14730.

Structurei

3D structure databases

ProteinModelPortaliO14730.
SMRiO14730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 519Protein kinaseAdd BLAST269

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Phylogenomic databases

eggNOGiKOG2269. Eukaryota.
COG1718. LUCA.
GeneTreeiENSGT00390000004370.
HOGENOMiHOG000007623.
HOVERGENiHBG057475.
InParanoidiO14730.
KOiK08872.
OMAiSFIGQDQ.
OrthoDBiEOG091G064C.
PhylomeDBiO14730.
TreeFamiTF105831.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
[Graphical view]
PANTHERiPTHR10593:SF22. PTHR10593:SF22. 1 hit.
PIRSFiPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14730-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLVGVASPE PGTAAAWGPS KCPWAIPQNT ISCSLADVMS EQLAKELQLE
60 70 80 90 100
EEAAVFPEVA VAEGPFITGE NIDTSSDLML AQMLQMEYDR EYDAQLRREE
110 120 130 140 150
KKFNGDSKVS ISFENYRKVH PYEDSDSSED EVDWQDTRDD PYRPAKPVPT
160 170 180 190 200
PKKGFIGKGK DITTKHDEVV CGRKNTARME NFAPEFQVGD GIGMDLKLSN
210 220 230 240 250
HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL MYKMVNSGML
260 270 280 290 300
ETITGCISTG KESVVFHAYG GSMEDEKEDS KVIPTECAIK VFKTTLNEFK
310 320 330 340 350
NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLARMQ RAGIPCPTVV
360 370 380 390 400
LLKKHILVMS FIGHDQVPAP KLKEVKLNSE EMKEAYYQTL HLMRQLYHEC
410 420 430 440 450
TLVHADLSEY NMLWHAGKVW LIDVSQSVEP THPHGLEFLF RDCRNVSQFF
460 470 480 490 500
QKGGVKEALS ERELFNAVSG LNITADNEAD FLAEIEALEK MNEDHVQKNG
510
RKAASFLKDD GDPPLLYDE
Length:519
Mass (Da):59,093
Last modified:February 20, 2007 - v2
Checksum:i3C3392BAC4ECB912
GO
Isoform 2 (identifier: O14730-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-451: Missing.

Note: No experimental confirmation available.
Show »
Length:516
Mass (Da):58,671
Checksum:i2CA9BC88DD00CFE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti325I → H in AAC26080 (PubMed:9602165).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042355336L → V.1 PublicationCorresponds to variant rs35401850dbSNPEnsembl.1
Natural variantiVAR_042356441R → Q.1 PublicationCorresponds to variant rs33969048dbSNPEnsembl.1
Natural variantiVAR_042357447S → L.1 PublicationCorresponds to variant rs56282762dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012164449 – 451Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013591 mRNA. Translation: AAC26080.1.
AC026634 Genomic DNA. No translation available.
BC039729 mRNA. Translation: AAH39729.1.
CCDSiCCDS11877.1. [O14730-1]
RefSeqiNP_003822.2. NM_003831.3. [O14730-1]
UniGeneiHs.445511.
Hs.728452.

Genome annotation databases

EnsembliENST00000339486; ENSP00000341874; ENSG00000101782. [O14730-1]
ENST00000577501; ENSP00000462548; ENSG00000101782. [O14730-2]
GeneIDi8780.
KEGGihsa:8780.
UCSCiuc002kui.5. human. [O14730-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013591 mRNA. Translation: AAC26080.1.
AC026634 Genomic DNA. No translation available.
BC039729 mRNA. Translation: AAH39729.1.
CCDSiCCDS11877.1. [O14730-1]
RefSeqiNP_003822.2. NM_003831.3. [O14730-1]
UniGeneiHs.445511.
Hs.728452.

3D structure databases

ProteinModelPortaliO14730.
SMRiO14730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114309. 25 interactors.
IntActiO14730. 14 interactors.
STRINGi9606.ENSP00000341874.

Chemistry databases

BindingDBiO14730.
ChEMBLiCHEMBL5659.
GuidetoPHARMACOLOGYi2188.

PTM databases

iPTMnetiO14730.
PhosphoSitePlusiO14730.

Polymorphism and mutation databases

BioMutaiRIOK3.

Proteomic databases

EPDiO14730.
MaxQBiO14730.
PaxDbiO14730.
PeptideAtlasiO14730.
PRIDEiO14730.

Protocols and materials databases

DNASUi8780.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339486; ENSP00000341874; ENSG00000101782. [O14730-1]
ENST00000577501; ENSP00000462548; ENSG00000101782. [O14730-2]
GeneIDi8780.
KEGGihsa:8780.
UCSCiuc002kui.5. human. [O14730-1]

Organism-specific databases

CTDi8780.
DisGeNETi8780.
GeneCardsiRIOK3.
HGNCiHGNC:11451. RIOK3.
HPAiHPA001620.
HPA024184.
MIMi603579. gene.
neXtProtiNX_O14730.
OpenTargetsiENSG00000101782.
PharmGKBiPA36248.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2269. Eukaryota.
COG1718. LUCA.
GeneTreeiENSGT00390000004370.
HOGENOMiHOG000007623.
HOVERGENiHBG057475.
InParanoidiO14730.
KOiK08872.
OMAiSFIGQDQ.
OrthoDBiEOG091G064C.
PhylomeDBiO14730.
TreeFamiTF105831.

Enzyme and pathway databases

BioCyciZFISH:HS02302-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

ChiTaRSiRIOK3. human.
GenomeRNAii8780.
PROiO14730.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101782.
CleanExiHS_RIOK3.
ExpressionAtlasiO14730. baseline and differential.
GenevisibleiO14730. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
[Graphical view]
PANTHERiPTHR10593:SF22. PTHR10593:SF22. 1 hit.
PIRSFiPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRIOK3_HUMAN
AccessioniPrimary (citable) accession number: O14730
Secondary accession number(s): Q8IXN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.