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O14730

- RIOK3_HUMAN

UniProt

O14730 - RIOK3_HUMAN

Protein

Serine/threonine-protein kinase RIO3

Gene

RIOK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei290 – 2901ATPBy similarity
    Active sitei406 – 4061Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi257 – 2659ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. chromosome segregation Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase RIO3 (EC:2.7.11.1)
    Alternative name(s):
    RIO kinase 3
    sudD homolog
    Gene namesi
    Name:RIOK3
    Synonyms:SUDD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:11451. RIOK3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36248.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Serine/threonine-protein kinase RIO3PRO_0000213529Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei122 – 1221Phosphotyrosine1 Publication
    Modified residuei125 – 1251PhosphoserineBy similarity
    Modified residuei127 – 1271Phosphoserine1 Publication
    Modified residuei128 – 1281Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO14730.
    PaxDbiO14730.
    PRIDEiO14730.

    PTM databases

    PhosphoSiteiO14730.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiO14730.
    BgeeiO14730.
    CleanExiHS_RIOK3.
    GenevestigatoriO14730.

    Organism-specific databases

    HPAiHPA001620.
    HPA024184.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CASP10Q928514EBI-1047061,EBI-495095

    Protein-protein interaction databases

    BioGridi114309. 15 interactions.
    IntActiO14730. 6 interactions.
    STRINGi9606.ENSP00000341874.

    Structurei

    3D structure databases

    ProteinModelPortaliO14730.
    SMRiO14730. Positions 219-461.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini251 – 519269Protein kinaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.Curated

    Phylogenomic databases

    eggNOGiCOG1718.
    HOGENOMiHOG000007623.
    HOVERGENiHBG057475.
    InParanoidiO14730.
    KOiK08872.
    OMAiKEAYYQT.
    OrthoDBiEOG7JT6W1.
    PhylomeDBiO14730.
    TreeFamiTF105831.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR018934. RIO-like_kinase.
    IPR000687. RIO_kinase.
    IPR018935. RIO_kinase_CS.
    IPR017406. Ser/Thr_kinase_Rio3.
    [Graphical view]
    PfamiPF01163. RIO1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
    SMARTiSM00090. RIO. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01245. RIO1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14730-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLVGVASPE PGTAAAWGPS KCPWAIPQNT ISCSLADVMS EQLAKELQLE    50
    EEAAVFPEVA VAEGPFITGE NIDTSSDLML AQMLQMEYDR EYDAQLRREE 100
    KKFNGDSKVS ISFENYRKVH PYEDSDSSED EVDWQDTRDD PYRPAKPVPT 150
    PKKGFIGKGK DITTKHDEVV CGRKNTARME NFAPEFQVGD GIGMDLKLSN 200
    HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL MYKMVNSGML 250
    ETITGCISTG KESVVFHAYG GSMEDEKEDS KVIPTECAIK VFKTTLNEFK 300
    NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLARMQ RAGIPCPTVV 350
    LLKKHILVMS FIGHDQVPAP KLKEVKLNSE EMKEAYYQTL HLMRQLYHEC 400
    TLVHADLSEY NMLWHAGKVW LIDVSQSVEP THPHGLEFLF RDCRNVSQFF 450
    QKGGVKEALS ERELFNAVSG LNITADNEAD FLAEIEALEK MNEDHVQKNG 500
    RKAASFLKDD GDPPLLYDE 519
    Length:519
    Mass (Da):59,093
    Last modified:February 20, 2007 - v2
    Checksum:i3C3392BAC4ECB912
    GO
    Isoform 2 (identifier: O14730-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         449-451: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:516
    Mass (Da):58,671
    Checksum:i2CA9BC88DD00CFE5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti325 – 3251I → H in AAC26080. (PubMed:9602165)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti336 – 3361L → V.1 Publication
    Corresponds to variant rs35401850 [ dbSNP | Ensembl ].
    VAR_042355
    Natural varianti441 – 4411R → Q.1 Publication
    Corresponds to variant rs33969048 [ dbSNP | Ensembl ].
    VAR_042356
    Natural varianti447 – 4471S → L.1 Publication
    Corresponds to variant rs56282762 [ dbSNP | Ensembl ].
    VAR_042357

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei449 – 4513Missing in isoform 2. 1 PublicationVSP_012164

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013591 mRNA. Translation: AAC26080.1.
    AC026634 Genomic DNA. No translation available.
    BC039729 mRNA. Translation: AAH39729.1.
    CCDSiCCDS11877.1. [O14730-1]
    RefSeqiNP_003822.2. NM_003831.3. [O14730-1]
    UniGeneiHs.445511.
    Hs.728452.

    Genome annotation databases

    EnsembliENST00000339486; ENSP00000341874; ENSG00000101782. [O14730-1]
    ENST00000577501; ENSP00000462548; ENSG00000101782. [O14730-2]
    GeneIDi8780.
    KEGGihsa:8780.
    UCSCiuc002kui.4. human. [O14730-1]
    uc010dls.3. human. [O14730-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013591 mRNA. Translation: AAC26080.1 .
    AC026634 Genomic DNA. No translation available.
    BC039729 mRNA. Translation: AAH39729.1 .
    CCDSi CCDS11877.1. [O14730-1 ]
    RefSeqi NP_003822.2. NM_003831.3. [O14730-1 ]
    UniGenei Hs.445511.
    Hs.728452.

    3D structure databases

    ProteinModelPortali O14730.
    SMRi O14730. Positions 219-461.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114309. 15 interactions.
    IntActi O14730. 6 interactions.
    STRINGi 9606.ENSP00000341874.

    Chemistry

    BindingDBi O14730.
    ChEMBLi CHEMBL5659.
    GuidetoPHARMACOLOGYi 2188.

    PTM databases

    PhosphoSitei O14730.

    Proteomic databases

    MaxQBi O14730.
    PaxDbi O14730.
    PRIDEi O14730.

    Protocols and materials databases

    DNASUi 8780.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339486 ; ENSP00000341874 ; ENSG00000101782 . [O14730-1 ]
    ENST00000577501 ; ENSP00000462548 ; ENSG00000101782 . [O14730-2 ]
    GeneIDi 8780.
    KEGGi hsa:8780.
    UCSCi uc002kui.4. human. [O14730-1 ]
    uc010dls.3. human. [O14730-2 ]

    Organism-specific databases

    CTDi 8780.
    GeneCardsi GC18P021032.
    HGNCi HGNC:11451. RIOK3.
    HPAi HPA001620.
    HPA024184.
    MIMi 603579. gene.
    neXtProti NX_O14730.
    PharmGKBi PA36248.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1718.
    HOGENOMi HOG000007623.
    HOVERGENi HBG057475.
    InParanoidi O14730.
    KOi K08872.
    OMAi KEAYYQT.
    OrthoDBi EOG7JT6W1.
    PhylomeDBi O14730.
    TreeFami TF105831.

    Miscellaneous databases

    GenomeRNAii 8780.
    NextBioi 32920.
    PROi O14730.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14730.
    Bgeei O14730.
    CleanExi HS_RIOK3.
    Genevestigatori O14730.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR018934. RIO-like_kinase.
    IPR000687. RIO_kinase.
    IPR018935. RIO_kinase_CS.
    IPR017406. Ser/Thr_kinase_Rio3.
    [Graphical view ]
    Pfami PF01163. RIO1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
    SMARTi SM00090. RIO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01245. RIO1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the Aspergillus nidulans sudD gene and its human homologue."
      Anaya P., Evans S.C., Dai C., Lozano G., May G.S.
      Gene 211:323-329(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-122; SER-127 AND SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-336; GLN-441 AND LEU-447.

    Entry informationi

    Entry nameiRIOK3_HUMAN
    AccessioniPrimary (citable) accession number: O14730
    Secondary accession number(s): Q8IXN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3