ID   OPSX_HUMAN              Reviewed;         337 AA.
AC   O14718; A1A4V2; Q7RTS4;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   24-JAN-2024, entry version 173.
DE   RecName: Full=Visual pigment-like receptor peropsin;
GN   Name=RRH;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=9275222; DOI=10.1073/pnas.94.18.9893;
RA   Sun H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.;
RT   "Peropsin, a novel visual pigment-like protein located in the apical
RT   microvilli of the retinal pigment epithelium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:9893-9898(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   GENE STRUCTURE.
RX   PubMed=12542842; DOI=10.1186/1471-2164-4-3;
RA   Bellingham J., Wells D.J., Foster R.G.;
RT   "In silico characterisation and chromosomal localisation of human RRH
RT   (peropsin) -- implications for opsin evolution.";
RL   BMC Genomics 4:3-3(2003).
CC   -!- FUNCTION: May play a role in rpe physiology either by detecting light
CC       directly or by monitoring the concentration of retinoids or other
CC       photoreceptor-derived compounds.
CC   -!- INTERACTION:
CC       O14718; Q9Y328: NSG2; NbExp=3; IntAct=EBI-12855824, EBI-7101695;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Found only in the eye, where it is localized to the
CC       retinal pigment epithelium (RPE). In the RPE, it is localized to the
CC       microvilli that surround the photoreceptor outer segments.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF012270; AAC51757.1; -; mRNA.
DR   EMBL; CH471057; EAX06255.1; -; Genomic_DNA.
DR   EMBL; BC128120; AAI28121.1; -; mRNA.
DR   EMBL; BC128121; AAI28122.1; -; mRNA.
DR   EMBL; BC128401; AAI28402.1; -; mRNA.
DR   EMBL; BK000958; DAA00976.1; -; Genomic_DNA.
DR   CCDS; CCDS3687.1; -.
DR   RefSeq; NP_006574.1; NM_006583.2.
DR   AlphaFoldDB; O14718; -.
DR   SMR; O14718; -.
DR   BioGRID; 115931; 1.
DR   IntAct; O14718; 1.
DR   STRING; 9606.ENSP00000314992; -.
DR   GlyCosmos; O14718; 1 site, No reported glycans.
DR   GlyGen; O14718; 1 site.
DR   PhosphoSitePlus; O14718; -.
DR   BioMuta; RRH; -.
DR   MassIVE; O14718; -.
DR   PaxDb; 9606-ENSP00000314992; -.
DR   PeptideAtlas; O14718; -.
DR   ProteomicsDB; 48181; -.
DR   Antibodypedia; 15375; 157 antibodies from 26 providers.
DR   DNASU; 10692; -.
DR   Ensembl; ENST00000317735.7; ENSP00000314992.4; ENSG00000180245.7.
DR   GeneID; 10692; -.
DR   KEGG; hsa:10692; -.
DR   MANE-Select; ENST00000317735.7; ENSP00000314992.4; NM_006583.5; NP_006574.1.
DR   UCSC; uc003hzv.4; human.
DR   AGR; HGNC:10450; -.
DR   CTD; 10692; -.
DR   DisGeNET; 10692; -.
DR   GeneCards; RRH; -.
DR   HGNC; HGNC:10450; RRH.
DR   HPA; ENSG00000180245; Tissue enriched (retina).
DR   MIM; 605224; gene.
DR   neXtProt; NX_O14718; -.
DR   OpenTargets; ENSG00000180245; -.
DR   PharmGKB; PA34865; -.
DR   VEuPathDB; HostDB:ENSG00000180245; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01100000263524; -.
DR   HOGENOM; CLU_009579_3_0_1; -.
DR   InParanoid; O14718; -.
DR   OMA; MHWNDSS; -.
DR   OrthoDB; 3044063at2759; -.
DR   PhylomeDB; O14718; -.
DR   TreeFam; TF324998; -.
DR   PathwayCommons; O14718; -.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   Reactome; R-HSA-419771; Opsins.
DR   SignaLink; O14718; -.
DR   BioGRID-ORCS; 10692; 16 hits in 1139 CRISPR screens.
DR   GeneWiki; RRH; -.
DR   GenomeRNAi; 10692; -.
DR   Pharos; O14718; Tbio.
DR   PRO; PR:O14718; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; O14718; Protein.
DR   Bgee; ENSG00000180245; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 97 other cell types or tissues.
DR   ExpressionAtlas; O14718; baseline and differential.
DR   GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
DR   GO; GO:0008020; F:G protein-coupled photoreceptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR   GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007602; P:phototransduction; IBA:GO_Central.
DR   GO; GO:0007601; P:visual perception; TAS:ProtInc.
DR   CDD; cd15073; 7tmA_Peropsin; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002962; Peropsin.
DR   InterPro; IPR027430; Retinal_BS.
DR   PANTHER; PTHR24240; OPSIN; 1.
DR   PANTHER; PTHR24240:SF77; VISUAL PIGMENT-LIKE RECEPTOR PEROPSIN; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01244; PEROPSIN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS00238; OPSIN; 1.
DR   Genevisible; O14718; HS.
PE   1: Evidence at protein level;
KW   Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Photoreceptor protein; Receptor; Reference proteome;
KW   Retinal protein; Sensory transduction; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..337
FT                   /note="Visual pigment-like receptor peropsin"
FT                   /id="PRO_0000197819"
FT   TOPO_DOM        1..26
FT                   /note="Extracellular"
FT   TRANSMEM        27..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..61
FT                   /note="Cytoplasmic"
FT   TRANSMEM        62..87
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..101
FT                   /note="Extracellular"
FT   TRANSMEM        102..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..140
FT                   /note="Cytoplasmic"
FT   TRANSMEM        141..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..188
FT                   /note="Extracellular"
FT   TRANSMEM        189..212
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        213..240
FT                   /note="Cytoplasmic"
FT   TRANSMEM        241..264
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..272
FT                   /note="Extracellular"
FT   TRANSMEM        273..297
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..337
FT                   /note="Cytoplasmic"
FT   MOD_RES         284
FT                   /note="N6-(retinylidene)lysine"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..175
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   337 AA;  37423 MW;  9DFD8847F07A28EA CRC64;
     MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF IKYKELRTPT
     NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV YAGLNIFFGM ASIGLLTVVA
     VDRYLTICLP DVGRRMTTNT YIGLILGAWI NGLFWALMPI IGWASYAPDP TGATCTINWR
     KNDRSFVSYT MTVIAINFIV PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK
     MSVIMICMFL VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK
     FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI
//