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O14718 (OPSX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Visual pigment-like receptor peropsin
Gene names
Name:RRH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Visual pigment-like receptor peropsin
PRO_0000197819

Regions

Topological domain1 – 2626Extracellular
Transmembrane27 – 4923Helical; Name=1; Potential
Topological domain50 – 6112Cytoplasmic
Transmembrane62 – 8726Helical; Name=2; Potential
Topological domain88 – 10114Extracellular
Transmembrane102 – 12120Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic
Transmembrane141 – 16424Helical; Name=4; Potential
Topological domain165 – 18824Extracellular
Transmembrane189 – 21224Helical; Name=5; Potential
Topological domain213 – 24028Cytoplasmic
Transmembrane241 – 26424Helical; Name=6; Potential
Topological domain265 – 2728Extracellular
Transmembrane273 – 29725Helical; Name=7; Potential
Topological domain298 – 33740Cytoplasmic

Amino acid modifications

Modified residue2841N6-(retinylidene)lysine
Glycosylation81N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 175 Potential

Sequences

Sequence LengthMass (Da)Tools
O14718 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9DFD8847F07A28EA

FASTA33737,423
        10         20         30         40         50         60 
MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF IKYKELRTPT 

        70         80         90        100        110        120 
NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV YAGLNIFFGM ASIGLLTVVA 

       130        140        150        160        170        180 
VDRYLTICLP DVGRRMTTNT YIGLILGAWI NGLFWALMPI IGWASYAPDP TGATCTINWR 

       190        200        210        220        230        240 
KNDRSFVSYT MTVIAINFIV PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK 

       250        260        270        280        290        300 
MSVIMICMFL VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK 

       310        320        330 
FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI 

« Hide

References

« Hide 'large scale' references
[1]"Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium."
Sun H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
Proc. Natl. Acad. Sci. U.S.A. 94:9893-9898(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"In silico characterisation and chromosomal localisation of human RRH (peropsin) -- implications for opsin evolution."
Bellingham J., Wells D.J., Foster R.G.
BMC Genomics 4:3-3(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE STRUCTURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF012270 mRNA. Translation: AAC51757.1.
CH471057 Genomic DNA. Translation: EAX06255.1.
BC128120 mRNA. Translation: AAI28121.1.
BC128121 mRNA. Translation: AAI28122.1.
BC128401 mRNA. Translation: AAI28402.1.
BK000958 Genomic DNA. Translation: DAA00976.1.
CCDSCCDS3687.1.
RefSeqNP_006574.1. NM_006583.2.
UniGeneHs.658310.

3D structure databases

ProteinModelPortalO14718.
SMRO14718. Positions 28-311.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000314992.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbO14718.
PRIDEO14718.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317735; ENSP00000314992; ENSG00000180245.
GeneID10692.
KEGGhsa:10692.
UCSCuc003hzv.3. human.

Organism-specific databases

CTD10692.
GeneCardsGC04P110749.
HGNCHGNC:10450. RRH.
HPAHPA042374.
MIM605224. gene.
neXtProtNX_O14718.
PharmGKBPA34865.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG285278.
HOGENOMHOG000115897.
HOVERGENHBG098035.
InParanoidO14718.
KOK04253.
OMAAGCQIYA.
OrthoDBEOG77M8NX.
PhylomeDBO14718.
TreeFamTF324998.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO14718.
CleanExHS_RRH.
GenevestigatorO14718.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRRH.
GenomeRNAi10692.
NextBio40641.
PROO14718.
SOURCESearch...

Entry information

Entry nameOPSX_HUMAN
AccessionPrimary (citable) accession number: O14718
Secondary accession number(s): A1A4V2, Q7RTS4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries