O14718 (OPSX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Visual pigment-like receptor peropsin

Gene names

Name:

RRH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Ontologies

Keywords
Biological process	Sensory transduction
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Chromophore
Molecular function	G-protein coupled receptor Photoreceptor protein Receptor Retinal protein Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phototransduction Inferred from electronic annotation. Source: UniProtKB-KW protein-chromophore linkage Inferred from electronic annotation. Source: UniProtKB-KW visual perception Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc photoreceptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Visual pigment-like receptor peropsin		PRO_0000197819
Regions
	Topological domain	1 – 26	26	Extracellular
	Transmembrane	27 – 49	23	Helical; Name=1; Potential
	Topological domain	50 – 61	12	Cytoplasmic
	Transmembrane	62 – 87	26	Helical; Name=2; Potential
	Topological domain	88 – 101	14	Extracellular
	Transmembrane	102 – 121	20	Helical; Name=3; Potential
	Topological domain	122 – 140	19	Cytoplasmic
	Transmembrane	141 – 164	24	Helical; Name=4; Potential
	Topological domain	165 – 188	24	Extracellular
	Transmembrane	189 – 212	24	Helical; Name=5; Potential
	Topological domain	213 – 240	28	Cytoplasmic
	Transmembrane	241 – 264	24	Helical; Name=6; Potential
	Topological domain	265 – 272	8	Extracellular
	Transmembrane	273 – 297	25	Helical; Name=7; Potential
	Topological domain	298 – 337	40	Cytoplasmic
Amino acid modifications
	Modified residue	284	1	N6-(retinylidene)lysine
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 175		Potential

Sequences

	Sequence		Length	Mass (Da)
	O14718 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9DFD8847F07A28EA	FASTA	337	37,423
	10 20 30 40 50 60 MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF IKYKELRTPT 70 80 90 100 110 120 NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV YAGLNIFFGM ASIGLLTVVA 130 140 150 160 170 180 VDRYLTICLP DVGRRMTTNT YIGLILGAWI NGLFWALMPI IGWASYAPDP TGATCTINWR 190 200 210 220 230 240 KNDRSFVSYT MTVIAINFIV PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK 250 260 270 280 290 300 MSVIMICMFL VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK 310 320 330 FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium." Sun H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J. Proc. Natl. Acad. Sci. U.S.A. 94:9893-9898(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"In silico characterisation and chromosomal localisation of human RRH (peropsin) -- implications for opsin evolution." Bellingham J., Wells D.J., Foster R.G. BMC Genomics 4:3-3(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GENE STRUCTURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF012270 mRNA. Translation: AAC51757.1. CH471057 Genomic DNA. Translation: EAX06255.1. BC128120 mRNA. Translation: AAI28121.1. BC128121 mRNA. Translation: AAI28122.1. BC128401 mRNA. Translation: AAI28402.1. BK000958 Genomic DNA. Translation: DAA00976.1.
IPI	IPI00023623.
RefSeq	NP_006574.1. NM_006583.2.
UniGene	Hs.658310.
3D structure databases
ProteinModelPortal	O14718.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000314992.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PaxDb	O14718.
PRIDE	O14718.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317735; ENSP00000314992; ENSG00000180245.
GeneID	10692.
KEGG	hsa:10692.
UCSC	uc003hzv.3. human.
Organism-specific databases
CTD	10692.
GeneCards	GC04P110749.
HGNC	HGNC:10450. RRH.
HPA	HPA042374.
MIM	605224. gene.
neXtProt	NX_O14718.
PharmGKB	PA34865.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG285278.
HOGENOM	HOG000115897.
HOVERGEN	HBG098035.
InParanoid	O14718.
KO	K04253.
OMA	AGCQIYA.
OrthoDB	EOG4HHP2R.
PhylomeDB	O14718.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O14718.
CleanEx	HS_RRH.
Genevestigator	O14718.
GermOnline	ENSG00000180245. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001760. Opsin. IPR002962. Peropsin. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01244. PEROPSIN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. PS00238. OPSIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10692.
NextBio	40641.
SOURCE	Search...

Entry information

Entry name

OPSX_HUMAN

Accession

Primary (citable) accession number: O14718
Secondary accession number(s): A1A4V2, Q7RTS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.