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O14718

- OPSX_HUMAN

UniProt

O14718 - OPSX_HUMAN

Protein

Visual pigment-like receptor peropsin

Gene

RRH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. photoreceptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc
    2. phototransduction Source: UniProtKB-KW
    3. protein-chromophore linkage Source: UniProtKB-KW
    4. visual perception Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Keywords - Ligandi

    Chromophore

    Enzyme and pathway databases

    ReactomeiREACT_18426. Opsins.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Visual pigment-like receptor peropsin
    Gene namesi
    Name:RRH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:10450. RRH.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34865.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Visual pigment-like receptor peropsinPRO_0000197819Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 175PROSITE-ProRule annotation
    Modified residuei284 – 2841N6-(retinylidene)lysine

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO14718.
    PRIDEiO14718.

    Expressioni

    Tissue specificityi

    Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.

    Gene expression databases

    BgeeiO14718.
    CleanExiHS_RRH.
    GenevestigatoriO14718.

    Organism-specific databases

    HPAiHPA042374.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000314992.

    Structurei

    3D structure databases

    ProteinModelPortaliO14718.
    SMRiO14718. Positions 28-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularAdd
    BLAST
    Topological domaini50 – 6112CytoplasmicAdd
    BLAST
    Topological domaini88 – 10114ExtracellularAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicAdd
    BLAST
    Topological domaini165 – 18824ExtracellularAdd
    BLAST
    Topological domaini213 – 24028CytoplasmicAdd
    BLAST
    Topological domaini265 – 2728Extracellular
    Topological domaini298 – 33740CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4923Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8726Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16424Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 21224Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26424Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29725Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285278.
    HOGENOMiHOG000115897.
    HOVERGENiHBG098035.
    InParanoidiO14718.
    KOiK04253.
    OMAiAGCQIYA.
    OrthoDBiEOG77M8NX.
    PhylomeDBiO14718.
    TreeFamiTF324998.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002962. Peropsin.
    IPR027430. Retinal_BS.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01244. PEROPSIN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14718-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF    50
    IKYKELRTPT NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV 100
    YAGLNIFFGM ASIGLLTVVA VDRYLTICLP DVGRRMTTNT YIGLILGAWI 150
    NGLFWALMPI IGWASYAPDP TGATCTINWR KNDRSFVSYT MTVIAINFIV 200
    PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK MSVIMICMFL 250
    VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK 300
    FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI 337
    Length:337
    Mass (Da):37,423
    Last modified:January 1, 1998 - v1
    Checksum:i9DFD8847F07A28EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012270 mRNA. Translation: AAC51757.1.
    CH471057 Genomic DNA. Translation: EAX06255.1.
    BC128120 mRNA. Translation: AAI28121.1.
    BC128121 mRNA. Translation: AAI28122.1.
    BC128401 mRNA. Translation: AAI28402.1.
    BK000958 Genomic DNA. Translation: DAA00976.1.
    CCDSiCCDS3687.1.
    RefSeqiNP_006574.1. NM_006583.2.
    UniGeneiHs.658310.

    Genome annotation databases

    EnsembliENST00000317735; ENSP00000314992; ENSG00000180245.
    GeneIDi10692.
    KEGGihsa:10692.
    UCSCiuc003hzv.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012270 mRNA. Translation: AAC51757.1 .
    CH471057 Genomic DNA. Translation: EAX06255.1 .
    BC128120 mRNA. Translation: AAI28121.1 .
    BC128121 mRNA. Translation: AAI28122.1 .
    BC128401 mRNA. Translation: AAI28402.1 .
    BK000958 Genomic DNA. Translation: DAA00976.1 .
    CCDSi CCDS3687.1.
    RefSeqi NP_006574.1. NM_006583.2.
    UniGenei Hs.658310.

    3D structure databases

    ProteinModelPortali O14718.
    SMRi O14718. Positions 28-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000314992.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O14718.
    PRIDEi O14718.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317735 ; ENSP00000314992 ; ENSG00000180245 .
    GeneIDi 10692.
    KEGGi hsa:10692.
    UCSCi uc003hzv.3. human.

    Organism-specific databases

    CTDi 10692.
    GeneCardsi GC04P110749.
    HGNCi HGNC:10450. RRH.
    HPAi HPA042374.
    MIMi 605224. gene.
    neXtProti NX_O14718.
    PharmGKBi PA34865.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285278.
    HOGENOMi HOG000115897.
    HOVERGENi HBG098035.
    InParanoidi O14718.
    KOi K04253.
    OMAi AGCQIYA.
    OrthoDBi EOG77M8NX.
    PhylomeDBi O14718.
    TreeFami TF324998.

    Enzyme and pathway databases

    Reactomei REACT_18426. Opsins.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii RRH.
    GenomeRNAii 10692.
    NextBioi 40641.
    PROi O14718.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14718.
    CleanExi HS_RRH.
    Genevestigatori O14718.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002962. Peropsin.
    IPR027430. Retinal_BS.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01244. PEROPSIN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium."
      Sun H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
      Proc. Natl. Acad. Sci. U.S.A. 94:9893-9898(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "In silico characterisation and chromosomal localisation of human RRH (peropsin) -- implications for opsin evolution."
      Bellingham J., Wells D.J., Foster R.G.
      BMC Genomics 4:3-3(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE STRUCTURE.

    Entry informationi

    Entry nameiOPSX_HUMAN
    AccessioniPrimary (citable) accession number: O14718
    Secondary accession number(s): A1A4V2, Q7RTS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3