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Protein

Visual pigment-like receptor peropsin

Gene

RRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

GO - Molecular functioni

  • G-protein coupled photoreceptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • cellular response to light stimulus Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • phototransduction Source: GO_Central
  • protein-chromophore linkage Source: UniProtKB-KW
  • visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180245-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419771. Opsins.

Names & Taxonomyi

Protein namesi
Recommended name:
Visual pigment-like receptor peropsin
Gene namesi
Name:RRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10450. RRH.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularAdd BLAST26
Transmembranei27 – 49Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini50 – 61CytoplasmicAdd BLAST12
Transmembranei62 – 87Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini88 – 101ExtracellularAdd BLAST14
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicAdd BLAST19
Transmembranei141 – 164Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini165 – 188ExtracellularAdd BLAST24
Transmembranei189 – 212Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini213 – 240CytoplasmicAdd BLAST28
Transmembranei241 – 264Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini265 – 272Extracellular8
Transmembranei273 – 297Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini298 – 337CytoplasmicAdd BLAST40

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10692.
OpenTargetsiENSG00000180245.
PharmGKBiPA34865.

Polymorphism and mutation databases

BioMutaiRRH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978191 – 337Visual pigment-like receptor peropsinAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation
Modified residuei284N6-(retinylidene)lysine1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14718.
PeptideAtlasiO14718.
PRIDEiO14718.

PTM databases

PhosphoSitePlusiO14718.

Expressioni

Tissue specificityi

Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.

Gene expression databases

BgeeiENSG00000180245.
CleanExiHS_RRH.
GenevisibleiO14718. HS.

Organism-specific databases

HPAiHPA042374.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314992.

Structurei

3D structure databases

ProteinModelPortaliO14718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115897.
HOVERGENiHBG098035.
InParanoidiO14718.
KOiK04253.
OMAiAGCQIYA.
OrthoDBiEOG091G0ALC.
PhylomeDBiO14718.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
IPR032972. RRH.
[Graphical view]
PANTHERiPTHR24240:SF77. PTHR24240:SF77. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF
60 70 80 90 100
IKYKELRTPT NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV
110 120 130 140 150
YAGLNIFFGM ASIGLLTVVA VDRYLTICLP DVGRRMTTNT YIGLILGAWI
160 170 180 190 200
NGLFWALMPI IGWASYAPDP TGATCTINWR KNDRSFVSYT MTVIAINFIV
210 220 230 240 250
PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK MSVIMICMFL
260 270 280 290 300
VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK
310 320 330
FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI
Length:337
Mass (Da):37,423
Last modified:January 1, 1998 - v1
Checksum:i9DFD8847F07A28EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012270 mRNA. Translation: AAC51757.1.
CH471057 Genomic DNA. Translation: EAX06255.1.
BC128120 mRNA. Translation: AAI28121.1.
BC128121 mRNA. Translation: AAI28122.1.
BC128401 mRNA. Translation: AAI28402.1.
BK000958 Genomic DNA. Translation: DAA00976.1.
CCDSiCCDS3687.1.
RefSeqiNP_006574.1. NM_006583.2.
UniGeneiHs.658310.

Genome annotation databases

EnsembliENST00000317735; ENSP00000314992; ENSG00000180245.
GeneIDi10692.
KEGGihsa:10692.
UCSCiuc003hzv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012270 mRNA. Translation: AAC51757.1.
CH471057 Genomic DNA. Translation: EAX06255.1.
BC128120 mRNA. Translation: AAI28121.1.
BC128121 mRNA. Translation: AAI28122.1.
BC128401 mRNA. Translation: AAI28402.1.
BK000958 Genomic DNA. Translation: DAA00976.1.
CCDSiCCDS3687.1.
RefSeqiNP_006574.1. NM_006583.2.
UniGeneiHs.658310.

3D structure databases

ProteinModelPortaliO14718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000314992.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO14718.

Polymorphism and mutation databases

BioMutaiRRH.

Proteomic databases

PaxDbiO14718.
PeptideAtlasiO14718.
PRIDEiO14718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317735; ENSP00000314992; ENSG00000180245.
GeneIDi10692.
KEGGihsa:10692.
UCSCiuc003hzv.4. human.

Organism-specific databases

CTDi10692.
DisGeNETi10692.
GeneCardsiRRH.
HGNCiHGNC:10450. RRH.
HPAiHPA042374.
MIMi605224. gene.
neXtProtiNX_O14718.
OpenTargetsiENSG00000180245.
PharmGKBiPA34865.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115897.
HOVERGENiHBG098035.
InParanoidiO14718.
KOiK04253.
OMAiAGCQIYA.
OrthoDBiEOG091G0ALC.
PhylomeDBiO14718.
TreeFamiTF324998.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180245-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419771. Opsins.

Miscellaneous databases

GeneWikiiRRH.
GenomeRNAii10692.
PROiO14718.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180245.
CleanExiHS_RRH.
GenevisibleiO14718. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
IPR032972. RRH.
[Graphical view]
PANTHERiPTHR24240:SF77. PTHR24240:SF77. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPSX_HUMAN
AccessioniPrimary (citable) accession number: O14718
Secondary accession number(s): A1A4V2, Q7RTS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.