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Protein

Visual pigment-like receptor peropsin

Gene

RRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
  • phototransduction Source: UniProtKB-KW
  • protein-chromophore linkage Source: UniProtKB-KW
  • visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiREACT_18426. Opsins.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Visual pigment-like receptor peropsin
Gene namesi
Name:RRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10450. RRH.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularAdd
BLAST
Transmembranei27 – 4923Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 6112CytoplasmicAdd
BLAST
Transmembranei62 – 8726Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 10114ExtracellularAdd
BLAST
Transmembranei102 – 12120Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicAdd
BLAST
Transmembranei141 – 16424Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini165 – 18824ExtracellularAdd
BLAST
Transmembranei189 – 21224Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini213 – 24028CytoplasmicAdd
BLAST
Transmembranei241 – 26424Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini265 – 2728Extracellular
Transmembranei273 – 29725Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini298 – 33740CytoplasmicAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34865.

Polymorphism and mutation databases

BioMutaiRRH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Visual pigment-like receptor peropsinPRO_0000197819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation
Modified residuei284 – 2841N6-(retinylidene)lysine

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14718.
PRIDEiO14718.

Expressioni

Tissue specificityi

Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.

Gene expression databases

BgeeiO14718.
CleanExiHS_RRH.
GenevisibleiO14718. HS.

Organism-specific databases

HPAiHPA042374.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314992.

Structurei

3D structure databases

ProteinModelPortaliO14718.
SMRiO14718. Positions 28-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285278.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115897.
HOVERGENiHBG098035.
InParanoidiO14718.
KOiK04253.
OMAiAGCQIYA.
OrthoDBiEOG77M8NX.
PhylomeDBiO14718.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNNLGNSS DSKNEDGSVF SQTEHNIVAT YLIMAGMISI ISNIIVLGIF
60 70 80 90 100
IKYKELRTPT NAIIINLAVT DIGVSSIGYP MSAASDLYGS WKFGYAGCQV
110 120 130 140 150
YAGLNIFFGM ASIGLLTVVA VDRYLTICLP DVGRRMTTNT YIGLILGAWI
160 170 180 190 200
NGLFWALMPI IGWASYAPDP TGATCTINWR KNDRSFVSYT MTVIAINFIV
210 220 230 240 250
PLTVMFYCYY HVTLSIKHHT TSDCTESLNR DWSDQIDVTK MSVIMICMFL
260 270 280 290 300
VAWSPYSIVC LWASFGDPKK IPPPMAIIAP LFAKSSTFYN PCIYVVANKK
310 320 330
FRRAMLAMFK CQTHQTMPVT SILPMDVSQN PLASGRI
Length:337
Mass (Da):37,423
Last modified:January 1, 1998 - v1
Checksum:i9DFD8847F07A28EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012270 mRNA. Translation: AAC51757.1.
CH471057 Genomic DNA. Translation: EAX06255.1.
BC128120 mRNA. Translation: AAI28121.1.
BC128121 mRNA. Translation: AAI28122.1.
BC128401 mRNA. Translation: AAI28402.1.
BK000958 Genomic DNA. Translation: DAA00976.1.
CCDSiCCDS3687.1.
RefSeqiNP_006574.1. NM_006583.2.
UniGeneiHs.658310.

Genome annotation databases

EnsembliENST00000317735; ENSP00000314992; ENSG00000180245.
GeneIDi10692.
KEGGihsa:10692.
UCSCiuc003hzv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012270 mRNA. Translation: AAC51757.1.
CH471057 Genomic DNA. Translation: EAX06255.1.
BC128120 mRNA. Translation: AAI28121.1.
BC128121 mRNA. Translation: AAI28122.1.
BC128401 mRNA. Translation: AAI28402.1.
BK000958 Genomic DNA. Translation: DAA00976.1.
CCDSiCCDS3687.1.
RefSeqiNP_006574.1. NM_006583.2.
UniGeneiHs.658310.

3D structure databases

ProteinModelPortaliO14718.
SMRiO14718. Positions 28-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000314992.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiRRH.

Proteomic databases

PaxDbiO14718.
PRIDEiO14718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317735; ENSP00000314992; ENSG00000180245.
GeneIDi10692.
KEGGihsa:10692.
UCSCiuc003hzv.3. human.

Organism-specific databases

CTDi10692.
GeneCardsiGC04P110749.
HGNCiHGNC:10450. RRH.
HPAiHPA042374.
MIMi605224. gene.
neXtProtiNX_O14718.
PharmGKBiPA34865.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG285278.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115897.
HOVERGENiHBG098035.
InParanoidiO14718.
KOiK04253.
OMAiAGCQIYA.
OrthoDBiEOG77M8NX.
PhylomeDBiO14718.
TreeFamiTF324998.

Enzyme and pathway databases

ReactomeiREACT_18426. Opsins.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiRRH.
GenomeRNAii10692.
NextBioi40641.
PROiO14718.
SOURCEiSearch...

Gene expression databases

BgeeiO14718.
CleanExiHS_RRH.
GenevisibleiO14718. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium."
    Sun H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 94:9893-9898(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "In silico characterisation and chromosomal localisation of human RRH (peropsin) -- implications for opsin evolution."
    Bellingham J., Wells D.J., Foster R.G.
    BMC Genomics 4:3-3(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE.

Entry informationi

Entry nameiOPSX_HUMAN
AccessioniPrimary (citable) accession number: O14718
Secondary accession number(s): A1A4V2, Q7RTS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 24, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.