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Protein

RANBP2-like and GRIP domain-containing protein 8

Gene

RGPD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • Ran GTPase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RANBP2-like and GRIP domain-containing protein 8
Alternative name(s):
Ran-binding protein 2-like 3
Short name:
RanBP2-like 3
Short name:
RanBP2L3
Gene namesi
Name:RGPD8
Synonyms:RANBP2ALPHA, RANBP2L1, RANBP2L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:9849. RGPD8.

Subcellular locationi

GO - Cellular componenti

  • nuclear pore Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34210.

Polymorphism and mutation databases

BioMutaiRGPD8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17651765RANBP2-like and GRIP domain-containing protein 8PRO_0000204917Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphothreonineCombined sources
Modified residuei21 – 211PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14715.
MaxQBiO14715.
PaxDbiO14715.
PRIDEiO14715.

PTM databases

iPTMnetiO14715.
PhosphoSiteiO14715.

Expressioni

Gene expression databases

BgeeiO14715.
CleanExiHS_RGPD8.
ExpressionAtlasiO14715. baseline and differential.
GenevisibleiO14715. HS.

Organism-specific databases

HPAiHPA049497.
HPA051675.

Interactioni

Subunit structurei

Interacts with GTP-bound ARL1.1 Publication

GO - Molecular functioni

  • Ran GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi608294. 27 interactions.
IntActiO14715. 9 interactions.
STRINGi9606.ENSP00000306637.

Structurei

3D structure databases

ProteinModelPortaliO14715.
SMRiO14715. Positions 3-145, 1051-1178, 1663-1700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 5934TPR 1Add
BLAST
Repeati60 – 9334TPR 2Add
BLAST
Repeati648 – 68134TPR 3Add
BLAST
Domaini1036 – 1172137RanBD1 1PROSITE-ProRule annotationAdd
BLAST
Domaini1333 – 1469137RanBD1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1702 – 175251GRIPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1261 – 12666Poly-Ser

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation
Contains 2 RanBD1 domains.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
HOGENOMiHOG000089994.
HOVERGENiHBG108404.
InParanoidiO14715.
KOiK12172.
OrthoDBiEOG7X0VG5.
PhylomeDBiO14715.
TreeFamiTF314797.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
1.25.40.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP.
IPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
PF00638. Ran_BP1. 2 hits.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
SM00160. RanBD. 2 hits.
SM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50913. GRIP. 1 hit.
PS50196. RANBD1. 2 hits.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSKADVER YVASVLGLTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC
60 70 80 90 100
TYINVQERDP KAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI
110 120 130 140 150
AELLCKNDVT DGRAKYWVER AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL
160 170 180 190 200
FDLIQSELYV RPDDVHVNIR LVELYRSTKR LKDAVAHCHE AERNIALRSS
210 220 230 240 250
LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA NLMLLTLSTR
260 270 280 290 300
DVQENRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMYAGSLLLK
310 320 330 340 350
MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLREGKAG QNLLEMMACD
360 370 380 390 400
RLSQSGHMLL SLSRGKQDFL KEVVETFANK IGQSALYDAL FSSQSPKDTS
410 420 430 440 450
FLGSDDIGKI DVQEPELEDL ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA
460 470 480 490 500
LPGIRKWLKQ LFHRLPHETS RLETNAPESI CILDLEVFLL GVVYTSHLQL
510 520 530 540 550
KEKCNSHHSS YQPLCLPFPV CKQLCTERQK SWWDAVCTLI HRKAVPGNLA
560 570 580 590 600
KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KYLQKTGSGL NSFYGQLEYI
610 620 630 640 650
GRSVHYWKKV LPLLKIIKKN SIPEPIDPLF KHFHSVDIQA SEIVEYEEDA
660 670 680 690 700
HITFAILDAV NGNIEDAVTA FESIKSVVSY WNLALIFHRK AEDIENDALS
710 720 730 740 750
PEEQEECRNY LTKTRDYLIK IIDDGDSNLS VVKKLPVPLE SVKQMLNSVM
760 770 780 790 800
QELEDYSEGG PLYKNGSLRN ADSEIKHSTP SPTKYSLSPS KSYKYSPETP
810 820 830 840 850
PRWTEDRNSL LNMICQQVEA IKKEMQELKL NSSKSASRHR WPTENYGPDS
860 870 880 890 900
VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLLR PAANVTPTKG
910 920 930 940 950
SSNTEFKSTK EGFSIPVSAD GFKFGISEPG NQEKKREKPL ENDTGLQAQD
960 970 980 990 1000
IRGRKKGRGV IFGQTSSTFT FADVAKSTSG EGFQFGKKDL NFKGFSGAGE
1010 1020 1030 1040 1050
KLFSSRYGKM ANKANTSGDF EKDDDAYKTE DSDDIHFEPV VQMPEKVELV
1060 1070 1080 1090 1100
TGEEGEKVLY SQGVKLFRFD AEVRQWKERG LGNLKILKNE VNGKLRMLMR
1110 1120 1130 1140 1150
REQVLKVCAN HWITTTMNLK PLSGSDRAWM WSASDFSDGD AKLERLAAKF
1160 1170 1180 1190 1200
KTPELAEEFK QKFEECQRLL LDIPLQTPHK LVDTGRAAKL IQRAEEMKSG
1210 1220 1230 1240 1250
LKDFKTFLTN DQTKVTEEEN KGSGTGVAGA SDTTIKPNAE NTGPTLEWDN
1260 1270 1280 1290 1300
YDLREDALDD SVSSSSVHAS PLASSPVRKN LFRFDESTTG SNFSFKSALS
1310 1320 1330 1340 1350
LSKSPAKLNQ SGTSVGTDEE SVVTQEEERD GQYFEPVVPL PDLVEVSSGE
1360 1370 1380 1390 1400
ENEQVVFSHR AEIYRYDKDV GQWKERGIGD IKILQNYDNK QVRIVMRRDQ
1410 1420 1430 1440 1450
VLKLCANHRI TPDMSLQNMK GTERVWVWTA CDFADGERKV EHLAVRFKLQ
1460 1470 1480 1490 1500
DVADSFKKIF DEAKTAQEKD SLITPHVSRS STPRESPCGK IAVAVLEEIT
1510 1520 1530 1540 1550
RERTDVIQGD DVADAASEVE VSSTSETTTK AVVSPPKFVF VSESVKRIFS
1560 1570 1580 1590 1600
SEKSKPFAFG NSSATGSLFG FSFNAPLKSN NSETSSVAQS GSESKVEPKK
1610 1620 1630 1640 1650
CELSKNSDIE QSSDSKVKNL SASFPTEESS INYTFKTPEK EPPLWHAEFT
1660 1670 1680 1690 1700
KEELVQKLRS TTKSADHLNG LLREIEATNA VLMEQIKLLK SEIRRLERNQ
1710 1720 1730 1740 1750
EREKSAANLE YLKNVLLQFI FLKPGSERER LLPVINTMLQ LSPEEKGKLA
1760
AVAQDEEENP SRSSG
Length:1,765
Mass (Da):198,993
Last modified:April 20, 2010 - v2
Checksum:iE8B7462EE211D670
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1541 – 15411V → G in AAC05596 (PubMed:9480752).Curated
Sequence conflicti1640 – 16401K → A in CAI56757 (PubMed:17974005).Curated
Sequence conflicti1741 – 17411L → P in CAI56757 (PubMed:17974005).Curated
Sequence conflicti1760 – 17601P → A in CAI56757 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012086 mRNA. Translation: AAC05596.1.
CR936614 mRNA. Translation: CAI56757.1.
CCDSiCCDS46394.1.
RefSeqiNP_001157935.1. NM_001164463.1.
UniGeneiHs.469630.
Hs.535589.

Genome annotation databases

EnsembliENST00000302558; ENSP00000306637; ENSG00000169629.
GeneIDi727851.
KEGGihsa:727851.
UCSCiuc002ths.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012086 mRNA. Translation: AAC05596.1.
CR936614 mRNA. Translation: CAI56757.1.
CCDSiCCDS46394.1.
RefSeqiNP_001157935.1. NM_001164463.1.
UniGeneiHs.469630.
Hs.535589.

3D structure databases

ProteinModelPortaliO14715.
SMRiO14715. Positions 3-145, 1051-1178, 1663-1700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608294. 27 interactions.
IntActiO14715. 9 interactions.
STRINGi9606.ENSP00000306637.

PTM databases

iPTMnetiO14715.
PhosphoSiteiO14715.

Polymorphism and mutation databases

BioMutaiRGPD8.

Proteomic databases

EPDiO14715.
MaxQBiO14715.
PaxDbiO14715.
PRIDEiO14715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302558; ENSP00000306637; ENSG00000169629.
GeneIDi727851.
KEGGihsa:727851.
UCSCiuc002ths.3. human.

Organism-specific databases

CTDi727851.
GeneCardsiRGPD8.
H-InvDBHIX0029791.
HGNCiHGNC:9849. RGPD8.
HPAiHPA049497.
HPA051675.
MIMi602752. gene.
neXtProtiNX_O14715.
PharmGKBiPA34210.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
HOGENOMiHOG000089994.
HOVERGENiHBG108404.
InParanoidiO14715.
KOiK12172.
OrthoDBiEOG7X0VG5.
PhylomeDBiO14715.
TreeFamiTF314797.

Miscellaneous databases

GenomeRNAii727851.
NextBioi125308.
PROiO14715.
SOURCEiSearch...

Gene expression databases

BgeeiO14715.
CleanExiHS_RGPD8.
ExpressionAtlasiO14715. baseline and differential.
GenevisibleiO14715. HS.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
1.25.40.10. 2 hits.
2.30.29.30. 2 hits.
InterProiIPR032023. GCC2_Rab_bind.
IPR000237. GRIP.
IPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
PF16704. Rab_bind. 1 hit.
PF00638. Ran_BP1. 2 hits.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
SM00160. RanBD. 2 hits.
SM00028. TPR. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50913. GRIP. 1 hit.
PS50196. RANBD1. 2 hits.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12."
    Nothwang H.G., Rensing C., Kubler M., Denich D., Brandl B., Stubanus M., Haaf T., Kurnit D., Hildebrandt F.
    Genomics 47:383-392(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1011-1765.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1640-1765.
    Tissue: Amygdala.
  4. "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins."
    Van Valkenburgh H., Shern J.F., Sharer J.D., Zhu X., Kahn R.A.
    J. Biol. Chem. 276:22826-22837(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARL1.
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19 AND SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiRGPD8_HUMAN
AccessioniPrimary (citable) accession number: O14715
Secondary accession number(s): Q5CZA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: April 20, 2010
Last modified: May 11, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

One of the 8 copies of RANBP2 clustered close to the chromosome 2 centromere.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.