O14709 (ZN197_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 197

Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 9
ZnF20
pVHL-associated KRAB domain-containing protein

Gene names

Name:	ZNF197
Synonyms:	ZKSCAN9, ZNF166

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1029 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 22 C2H2-type zinc fingers. Contains 1 KRAB domain. Contains 1 SCAN box domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Traceable author statement PubMed 8353497. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14709-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14709-2)

Also known as: VHLaK;

The sequence of this isoform differs from the canonical sequence as follows:
     257-267: EWETMTENEEV → GYRKYRRQRNK
     268-1029: Missing.

Note: Negative regulator of HIF1A transactivation.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1029	1029	Zinc finger protein 197		PRO_0000047448
Regions
	Domain	42 – 124	83	SCAN box
	Domain	217 – 289	73	KRAB
	Zinc finger	370 – 392	23	C2H2-type 1
	Zinc finger	398 – 420	23	C2H2-type 2
	Zinc finger	426 – 448	23	C2H2-type 3
	Zinc finger	454 – 476	23	C2H2-type 4
	Zinc finger	482 – 504	23	C2H2-type 5
	Zinc finger	510 – 532	23	C2H2-type 6
	Zinc finger	538 – 560	23	C2H2-type 7
	Zinc finger	566 – 588	23	C2H2-type 8
	Zinc finger	594 – 616	23	C2H2-type 9
	Zinc finger	622 – 644	23	C2H2-type 10
	Zinc finger	650 – 672	23	C2H2-type 11
	Zinc finger	678 – 700	23	C2H2-type 12
	Zinc finger	706 – 728	23	C2H2-type 13
	Zinc finger	734 – 756	23	C2H2-type 14
	Zinc finger	762 – 784	23	C2H2-type 15
	Zinc finger	790 – 812	23	C2H2-type 16
	Zinc finger	818 – 840	23	C2H2-type 17
	Zinc finger	846 – 868	23	C2H2-type 18
	Zinc finger	874 – 896	23	C2H2-type 19
	Zinc finger	902 – 924	23	C2H2-type 20
	Zinc finger	930 – 952	23	C2H2-type 21
	Zinc finger	958 – 980	23	C2H2-type 22
Natural variations
	Alternative sequence	257 – 267	11	EWETMTENEEV → GYRKYRRQRNK in isoform 2.		VSP_043021
	Alternative sequence	268 – 1029	762	Missing in isoform 2.		VSP_043022

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 95DB6F65A170F76B	FASTA	1,029	118,847
	10 20 30 40 50 60 MTRENVAHNA LRQEGLVKGK DDTWKWGTSF QGSSSSVWET SHLHFRQLRY HETSGPQEAL 70 80 90 100 110 120 SRLRELCRRW LRPEARTKAQ ILELLVLEQF LSILPGEIRT WVQLHHPGSG EEAVALVEEL 130 140 150 160 170 180 QKDLDGPAIQ VPVLVKDQDT LQKVVSAPGT TLPPVLPGSH IAAEICPHPP TDLVAFNLQD 190 200 210 220 230 240 PQHDSPAPEA SALSQEENPR NQLMALMLLT AQPQELVMFE EVSVCFTSEE WACLGPIQRA 250 260 270 280 290 300 LYWDVMLENY GNVTSLEWET MTENEEVTSK PSSSQRADSH KGTSKRLQGS VPQVLDFEEE 310 320 330 340 350 360 CEWQVLASQW GNETDERADT VKKVSLCERD KKKRTPPEKQ GQKWKELGDS LTFGSAISES 370 380 390 400 410 420 LIGTEGKKFY KCDMCCKHFN KISHLINHRR IHTGEKPHKC KECGKGFIQR SSLLMHLRNH 430 440 450 460 470 480 SGEKPYKCNE CGKAFSQSAY LLNHQRIHTG EKPYKCKECG KGFYRHSGLI IHLRRHSGER 490 500 510 520 530 540 PYKCNECGKV FSQNAYLIDH QRLHKGEEPY KCNKCQKAFI LKKSLILHQR IHSGEKPYKC 550 560 570 580 590 600 DECGKTFAQT TYLIDHQRLH SAENPYKCKE CGKVFIRSKS LLLHQRVHTE KKTFGCKKCG 610 620 630 640 650 660 KIFSSKSNFI DHKRMHSREK PYKCTECGKA FTQSAYLFDH QRLHNGEKPY ECNECGKVFI 670 680 690 700 710 720 LKKSLILHQR FHTGENLYEC KDCGKVFGSN RNLIDHERLH NGEKPYECRE CGKTFIMSKS 730 740 750 760 770 780 FMVHQKLHTQ EKAYKCEDCG KAFSYNSSLL VHRRIHTGEK PFECSECGRA FSSNRNLIEH 790 800 810 820 830 840 KRIHSGEKPY ECDECGKCFI LKKSLIGHQR IHTREKSYKC NDCGKVFSYR SNLIAHQRIH 850 860 870 880 890 900 TGEKPYACSE CGKGFTYNRN LIEHQRIHSG EKTYECHVCR KVLTSSRNLM VHQRIHTGEK 910 920 930 940 950 960 PYKCNECGKD FSQNKNLVVH QRMHTGEKPY ECDKCRKSFT SKRNLVGHQR IHTGEKPYGC 970 980 990 1000 1010 1020 NDCSKVFRQR KNLTVHQKIH TDEKPCECDV SEKEFSQTSN LHLQQKIHTI EEFSWLQNTN ESKIEIQKI
	Isoform 2 (VHLaK) [UniParc]. Checksum: E93D82A22B930CE3	FASTA	267	30,229
	10 20 30 40 50 60 MTRENVAHNA LRQEGLVKGK DDTWKWGTSF QGSSSSVWET SHLHFRQLRY HETSGPQEAL 70 80 90 100 110 120 SRLRELCRRW LRPEARTKAQ ILELLVLEQF LSILPGEIRT WVQLHHPGSG EEAVALVEEL 130 140 150 160 170 180 QKDLDGPAIQ VPVLVKDQDT LQKVVSAPGT TLPPVLPGSH IAAEICPHPP TDLVAFNLQD 190 200 210 220 230 240 PQHDSPAPEA SALSQEENPR NQLMALMLLT AQPQELVMFE EVSVCFTSEE WACLGPIQRA 250 260 LYWDVMLENY GNVTSLGYRK YRRQRNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets." Gonsky R., Knauf J.A., Elisei R., Wang J.W., Su S., Fagin J.A. Nucleic Acids Res. 25:3823-3831(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity." Li Z., Wang D., Na X., Schoen S.R., Messing E.M., Wu G. EMBO J. 22:1857-1867(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Tongue.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF011573 mRNA. Translation: AAB84385.1. AY074878 mRNA. Translation: AAL79677.1. AK314196 mRNA. Translation: BAG36875.1. AC099669 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW64714.1.
IPI	IPI00023617. IPI00744049.
RefSeq	NP_001020026.1. NM_001024855.1. NP_008922.1. NM_006991.3.
UniGene	Hs.157035.
3D structure databases
ProteinModelPortal	O14709.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14709. 2 interactions.
STRING	9606.ENSP00000345809.
PTM databases
PhosphoSite	O14709.
Proteomic databases
PaxDb	O14709.
PRIDE	O14709.
Protocols and materials databases
DNASU	10168.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344387; ENSP00000345809; ENSG00000186448. ENST00000383744; ENSP00000373250; ENSG00000186448. ENST00000383745; ENSP00000373251; ENSG00000186448. ENST00000396058; ENSP00000379370; ENSG00000186448.
GeneID	10168.
KEGG	hsa:10168.
UCSC	uc003cnm.3. human.
Organism-specific databases
CTD	10168.
GeneCards	GC03P044674.
HGNC	HGNC:12988. ZNF197.
HPA	HPA054567.
neXtProt	NX_O14709.
PharmGKB	PA37568.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	O14709.
OMA	TDEKPCE.
OrthoDB	EOG4CC40J.
PhylomeDB	O14709.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	O14709.
Bgee	O14709.
CleanEx	HS_ZNF197.
Genevestigator	O14709.
GermOnline	ENSG00000186448. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 23 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR008916. Retrov_capsid_C. IPR003309. Tscrpt_reg_SCAN. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF02023. SCAN. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00431. SCAN. 1 hit. SM00355. ZnF_C2H2. 22 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit. SSF47353. Retrov_capsid_C. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 22 hits. PS50157. ZINC_FINGER_C2H2_2. 22 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10168.
NextBio	38496.

Entry information

Entry name

ZN197_HUMAN

Accession

Primary (citable) accession number: O14709
Secondary accession number(s): B2RAH8, Q86VG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.