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Protein

Prostaglandin E synthase

Gene

PTGES

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).1 Publication

Catalytic activityi

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.1 Publication

Cofactori

glutathione1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117Glutathione1
Binding sitei126Glutathione1
Binding sitei130Glutathione1
Binding sitei134Glutathione1

GO - Molecular functioni

  • glutathione binding Source: UniProtKB
  • prostaglandin-E synthase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS07518-MONOMER.
ZFISH:HS07518-MONOMER.
BRENDAi5.3.99.3. 2681.
ReactomeiR-HSA-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
SABIO-RKO14684.

Chemistry databases

SwissLipidsiSLP:000001631.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E synthase (EC:5.3.99.3)
Alternative name(s):
Microsomal glutathione S-transferase 1-like 1
Short name:
MGST1-L1
Microsomal prostaglandin E synthase 1
Short name:
MPGES-1
p53-induced gene 12 protein
Gene namesi
Name:PTGES
Synonyms:MGST1L1, MPGES1, PGES, PIG12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:9599. PTGES.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12LumenalAdd BLAST12
Transmembranei13 – 41HelicalAdd BLAST29
Topological domaini42 – 60CytoplasmicAdd BLAST19
Transmembranei61 – 90HelicalAdd BLAST30
Topological domaini91 – 95Lumenal5
Transmembranei96 – 119HelicalAdd BLAST24
Topological domaini120 – 123Cytoplasmic4
Transmembranei124 – 152HelicalAdd BLAST29

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: Reactome
  • integral component of membrane Source: UniProtKB
  • membrane Source: ProtInc
  • nuclear envelope lumen Source: Ensembl
  • perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi66E → A: Reduces enzyme activity by 50%. 1 Publication1
Mutagenesisi67R → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi70R → A: Slightly reduced enzyme activity. 1 Publication1
Mutagenesisi72H → A: Reduces enzyme activity by 70%. 1 Publication1
Mutagenesisi110R → A or S: Loss of enzyme activity. 1 Publication1
Mutagenesisi117Y → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi117Y → F: No effect on enzyme activity. 1 Publication1

Organism-specific databases

DisGeNETi9536.
OpenTargetsiENSG00000148344.
PharmGKBiPA33948.

Chemistry databases

ChEMBLiCHEMBL5658.
GuidetoPHARMACOLOGYi1377.

Polymorphism and mutation databases

BioMutaiPTGES.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177451 – 152Prostaglandin E synthaseAdd BLAST152

Proteomic databases

EPDiO14684.
MaxQBiO14684.
PaxDbiO14684.
PeptideAtlasiO14684.
PRIDEiO14684.
TopDownProteomicsiO14684.

PTM databases

PhosphoSitePlusiO14684.
SwissPalmiO14684.

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000148344.
CleanExiHS_PTGES.
GenevisibleiO14684. HS.

Organism-specific databases

HPAiHPA045064.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi114912. 2 interactors.
IntActiO14684. 1 interactor.
STRINGi9606.ENSP00000342385.

Chemistry databases

BindingDBiO14684.

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Helixi13 – 41Combined sources29
Beta strandi44 – 46Combined sources3
Helixi47 – 52Combined sources6
Helixi56 – 58Combined sources3
Helixi63 – 90Combined sources28
Helixi96 – 118Combined sources23
Helixi125 – 150Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DWWelectron microscopy3.50A/B/C1-152[»]
4AL0X-ray1.16A1-152[»]
4AL1X-ray1.95A1-152[»]
4BPMX-ray2.08A10-152[»]
4WABX-ray2.70A10-151[»]
4YK5X-ray1.42A2-152[»]
4YL0X-ray1.52A5-152[»]
4YL1X-ray1.41A5-152[»]
4YL3X-ray1.41A5-152[»]
5BQGX-ray1.44A2-152[»]
5BQHX-ray1.60A2-152[»]
5BQIX-ray1.88A2-152[»]
5K0IX-ray1.30A2-152[»]
ProteinModelPortaliO14684.
SMRiO14684.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14684.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 38Glutathione bindingAdd BLAST11
Regioni70 – 77Glutathione binding8
Regioni110 – 113Glutathione binding4

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY81. Eukaryota.
ENOG4111VJG. LUCA.
GeneTreeiENSGT00390000011980.
HOGENOMiHOG000231759.
HOVERGENiHBG052470.
InParanoidiO14684.
KOiK15729.
OMAiCFSMALQ.
OrthoDBiEOG091G14I4.
PhylomeDBiO14684.
TreeFamiTF105327.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAHSLVMSS PALPAFLLCS TLLVIKMYVV AIITGQVRLR KKAFANPEDA
60 70 80 90 100
LRHGGPQYCR SDPDVERCLR AHRNDMETIY PFLFLGFVYS FLGPNPFVAW
110 120 130 140 150
MHFLVFLVGR VAHTVAYLGK LRAPIRSVTY TLAQLPCASM ALQILWEAAR

HL
Length:152
Mass (Da):17,102
Last modified:May 30, 2000 - v2
Checksum:iBF9B9ED81CA67A3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55G → GG in AAC39534 (PubMed:9305847).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010316 mRNA. Translation: AAC39534.1.
AF027740 mRNA. Translation: AAB82299.1.
AJ271802, AJ271803, AJ271804 Genomic DNA. Translation: CAB72099.1.
AK311947 mRNA. Translation: BAG34888.1.
EF543149 Genomic DNA. Translation: ABQ01233.1.
AL590369, AL592219 Genomic DNA. Translation: CAI14506.1.
AL592219, AL590369 Genomic DNA. Translation: CAI16116.1.
BC008280 mRNA. Translation: AAH08280.1.
CCDSiCCDS6927.1.
RefSeqiNP_004869.1. NM_004878.4.
UniGeneiHs.146688.

Genome annotation databases

EnsembliENST00000340607; ENSP00000342385; ENSG00000148344.
GeneIDi9536.
KEGGihsa:9536.
UCSCiuc004byi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010316 mRNA. Translation: AAC39534.1.
AF027740 mRNA. Translation: AAB82299.1.
AJ271802, AJ271803, AJ271804 Genomic DNA. Translation: CAB72099.1.
AK311947 mRNA. Translation: BAG34888.1.
EF543149 Genomic DNA. Translation: ABQ01233.1.
AL590369, AL592219 Genomic DNA. Translation: CAI14506.1.
AL592219, AL590369 Genomic DNA. Translation: CAI16116.1.
BC008280 mRNA. Translation: AAH08280.1.
CCDSiCCDS6927.1.
RefSeqiNP_004869.1. NM_004878.4.
UniGeneiHs.146688.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DWWelectron microscopy3.50A/B/C1-152[»]
4AL0X-ray1.16A1-152[»]
4AL1X-ray1.95A1-152[»]
4BPMX-ray2.08A10-152[»]
4WABX-ray2.70A10-151[»]
4YK5X-ray1.42A2-152[»]
4YL0X-ray1.52A5-152[»]
4YL1X-ray1.41A5-152[»]
4YL3X-ray1.41A5-152[»]
5BQGX-ray1.44A2-152[»]
5BQHX-ray1.60A2-152[»]
5BQIX-ray1.88A2-152[»]
5K0IX-ray1.30A2-152[»]
ProteinModelPortaliO14684.
SMRiO14684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114912. 2 interactors.
IntActiO14684. 1 interactor.
STRINGi9606.ENSP00000342385.

Chemistry databases

BindingDBiO14684.
ChEMBLiCHEMBL5658.
GuidetoPHARMACOLOGYi1377.
SwissLipidsiSLP:000001631.

PTM databases

PhosphoSitePlusiO14684.
SwissPalmiO14684.

Polymorphism and mutation databases

BioMutaiPTGES.

Proteomic databases

EPDiO14684.
MaxQBiO14684.
PaxDbiO14684.
PeptideAtlasiO14684.
PRIDEiO14684.
TopDownProteomicsiO14684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340607; ENSP00000342385; ENSG00000148344.
GeneIDi9536.
KEGGihsa:9536.
UCSCiuc004byi.4. human.

Organism-specific databases

CTDi9536.
DisGeNETi9536.
GeneCardsiPTGES.
HGNCiHGNC:9599. PTGES.
HPAiHPA045064.
MIMi605172. gene.
neXtProtiNX_O14684.
OpenTargetsiENSG00000148344.
PharmGKBiPA33948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY81. Eukaryota.
ENOG4111VJG. LUCA.
GeneTreeiENSGT00390000011980.
HOGENOMiHOG000231759.
HOVERGENiHBG052470.
InParanoidiO14684.
KOiK15729.
OMAiCFSMALQ.
OrthoDBiEOG091G14I4.
PhylomeDBiO14684.
TreeFamiTF105327.

Enzyme and pathway databases

BioCyciMetaCyc:HS07518-MONOMER.
ZFISH:HS07518-MONOMER.
BRENDAi5.3.99.3. 2681.
ReactomeiR-HSA-2162123. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
SABIO-RKO14684.

Miscellaneous databases

ChiTaRSiPTGES. human.
EvolutionaryTraceiO14684.
GeneWikiiPTGES.
GenomeRNAii9536.
PROiO14684.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148344.
CleanExiHS_PTGES.
GenevisibleiO14684. HS.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTGES_HUMAN
AccessioniPrimary (citable) accession number: O14684
Secondary accession number(s): O14900, Q5SZC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.