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Protein

Tumor protein p53-inducible protein 11

Gene

TP53I11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc
  • response to stress Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p53-inducible protein 11
Alternative name(s):
p53-induced gene 11 protein
Gene namesi
Name:TP53I11
Synonyms:PIG11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175274.18.
HGNCiHGNC:16842. TP53I11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 108ExtracellularSequence analysisAdd BLAST24
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130CytoplasmicSequence analysis1
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 155ExtracellularSequence analysis4
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 189CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9537.
OpenTargetsiENSG00000175274.
PharmGKBiPA134967898.

Polymorphism and mutation databases

BioMutaiTP53I11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581421 – 189Tumor protein p53-inducible protein 11Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14683.
MaxQBiO14683.
PaxDbiO14683.
PeptideAtlasiO14683.
PRIDEiO14683.

PTM databases

iPTMnetiO14683.
PhosphoSitePlusiO14683.

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000175274.
CleanExiHS_TP53I11.
ExpressionAtlasiO14683. baseline and differential.
GenevisibleiO14683. HS.

Organism-specific databases

HPAiHPA059727.
HPA061276.

Interactioni

Protein-protein interaction databases

BioGridi114913. 6 interactors.
IntActiO14683. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliO14683.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 165Poly-Leu4
Compositional biasi177 – 180Poly-Tyr4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV8J. Eukaryota.
ENOG4111H6J. LUCA.
GeneTreeiENSGT00390000017249.
HOGENOMiHOG000063728.
HOVERGENiHBG054028.
InParanoidiO14683.
OMAiYYQVGRK.
OrthoDBiEOG091G10KG.
PhylomeDBiO14683.
TreeFamiTF321310.

Family and domain databases

InterProiView protein in InterPro
IPR028266. TP53I11.
PANTHERiPTHR31584. PTHR31584. 1 hit.
PfamiView protein in Pfam
PF14936. p53-inducible11. 1 hit.

Sequencei

Sequence statusi: Complete.

O14683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKQPPPLM KKHSQTDLVS RLKTRKILGV GGEDDDGEVH RSKISQVLGN
60 70 80 90 100
EIKFTIREPL GLRVWQFVSA VLFSGIAIMA LAFPDQLYDA VFDGAQVTSK
110 120 130 140 150
TPIRLYGGAL LSISLIMWNA LYTAEKVIIR WTLLTEACYF GVQFLVVTAT
160 170 180
LAETGLMSLG ILLLLVSRLL FVVISIYYYY QVGRRPKKA
Length:189
Mass (Da):21,054
Last modified:June 15, 2010 - v2
Checksum:i5E858F5872FE3171
GO

Sequence cautioni

The sequence AAC39533 differs from that shown. Localized in an untranslated region: wrong choice of CDS.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010315 mRNA. Translation: AAC39533.1. Sequence problems.
AK292837 mRNA. Translation: BAF85526.1.
AC068858 Genomic DNA. No translation available.
AC092733 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68052.1.
CH471064 Genomic DNA. Translation: EAW68053.1.
CH471064 Genomic DNA. Translation: EAW68055.1.
CH471064 Genomic DNA. Translation: EAW68057.1.
BC045666 mRNA. Translation: AAH45666.1.
CCDSiCCDS7911.1.
RefSeqiNP_001245249.1. NM_001258320.1.
NP_001245250.1. NM_001258321.1.
NP_001245251.1. NM_001258322.1.
NP_001245252.1. NM_001258323.2.
NP_001245253.1. NM_001258324.1.
NP_001305313.1. NM_001318384.1.
NP_001305314.1. NM_001318385.1.
NP_001305315.1. NM_001318386.1.
NP_006025.2. NM_006034.4.
XP_005253284.1. XM_005253227.4.
XP_011518777.1. XM_011520475.2.
XP_011518778.1. XM_011520476.2.
XP_011518779.1. XM_011520477.2.
XP_011518780.1. XM_011520478.2.
XP_016874069.1. XM_017018580.1.
XP_016874070.1. XM_017018581.1.
UniGeneiHs.554791.

Genome annotation databases

EnsembliENST00000308212; ENSP00000309532; ENSG00000175274.
ENST00000395648; ENSP00000379009; ENSG00000175274.
ENST00000525680; ENSP00000433474; ENSG00000175274.
ENST00000533940; ENSP00000436152; ENSG00000175274.
ENST00000616990; ENSP00000481456; ENSG00000175274.
GeneIDi9537.
KEGGihsa:9537.
UCSCiuc001myi.5. human.

Similar proteinsi

Entry informationi

Entry nameiP5I11_HUMAN
AccessioniPrimary (citable) accession number: O14683
Secondary accession number(s): Q3ZCS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 15, 2010
Last modified: November 22, 2017
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM