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Protein

Transmembrane gamma-carboxyglutamic acid protein 2

Gene

PRRG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126460-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane gamma-carboxyglutamic acid protein 2
Alternative name(s):
Proline-rich gamma-carboxyglutamic acid protein 2
Short name:
Proline-rich Gla protein 2
Gene namesi
Name:PRRG2
Synonyms:PRGP2, TMG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9470. PRRG2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 109ExtracellularSequence analysisAdd BLAST60
Transmembranei110 – 132HelicalSequence analysisAdd BLAST23
Topological domaini133 – 202CytoplasmicSequence analysisAdd BLAST70

GO - Cellular componenti

  • extracellular region Source: InterPro
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5639.
OpenTargetsiENSG00000126460.
PharmGKBiPA33825.

Polymorphism and mutation databases

BioMutaiPRRG2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000002254324 – 49Add BLAST26
ChainiPRO_000002254450 – 202Transmembrane gamma-carboxyglutamic acid protein 2Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi67 ↔ 72PROSITE-ProRule annotation

Post-translational modificationi

Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO14669.
PRIDEiO14669.

PTM databases

iPTMnetiO14669.
PhosphoSitePlusiO14669.

Expressioni

Tissue specificityi

Highly expressed in the thyroid.

Gene expression databases

BgeeiENSG00000126460.
CleanExiHS_PRRG2.
ExpressionAtlasiO14669. baseline and differential.
GenevisibleiO14669. HS.

Organism-specific databases

HPAiHPA010702.

Interactioni

Subunit structurei

Interacts with NEDD4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
YAP1P469373EBI-9824765,EBI-1044059

Protein-protein interaction databases

BioGridi111622. 4 interactors.
DIPiDIP-60947N.
IntActiO14669. 2 interactors.
STRINGi9606.ENSP00000246794.

Structurei

3D structure databases

ProteinModelPortaliO14669.
SMRiO14669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 96GlaPROSITE-ProRule annotationAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi161 – 173Poly-ProAdd BLAST13
Compositional biasi191 – 194Poly-Pro4

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J02V. Eukaryota.
ENOG4111S2Z. LUCA.
GeneTreeiENSGT00530000063110.
HOGENOMiHOG000115997.
HOVERGENiHBG018454.
InParanoidiO14669.
OMAiYNGKGGR.
OrthoDBiEOG091G0P8C.
PhylomeDBiO14669.
TreeFamiTF332123.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGHPSLLLL YMALTTCLDT SPSEETDQEV FLGPPEAQSF LSSHTRIPRA
60 70 80 90 100
NHWDLELLTP GNLERECLEE RCSWEEAREY FEDNTLTERF WESYIYNGKG
110 120 130 140 150
GRGRVDVASL AVGLTGGILL IVLAGLGAFW YLRWRQHRGQ QPCPQEAGLI
160 170 180 190 200
SPLSPLNPLG PPTPLPPPPP PPPGLPTYEQ ALAASGVHDA PPPPYTSLRR

PH
Length:202
Mass (Da):22,393
Last modified:January 1, 1998 - v1
Checksum:iBC79400C98492060
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05144222P → S.Corresponds to variant rs35016366dbSNPEnsembl.1
Natural variantiVAR_020332116G → C.Corresponds to variant rs2288920dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009243 mRNA. Translation: AAB67071.1.
CR456846 mRNA. Translation: CAG33127.1.
CCDSiCCDS12773.1.
RefSeqiNP_000942.1. NM_000951.2.
XP_006723349.1. XM_006723286.2.
UniGeneiHs.35101.

Genome annotation databases

EnsembliENST00000246794; ENSP00000246794; ENSG00000126460.
GeneIDi5639.
KEGGihsa:5639.
UCSCiuc002pon.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009243 mRNA. Translation: AAB67071.1.
CR456846 mRNA. Translation: CAG33127.1.
CCDSiCCDS12773.1.
RefSeqiNP_000942.1. NM_000951.2.
XP_006723349.1. XM_006723286.2.
UniGeneiHs.35101.

3D structure databases

ProteinModelPortaliO14669.
SMRiO14669.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111622. 4 interactors.
DIPiDIP-60947N.
IntActiO14669. 2 interactors.
STRINGi9606.ENSP00000246794.

PTM databases

iPTMnetiO14669.
PhosphoSitePlusiO14669.

Polymorphism and mutation databases

BioMutaiPRRG2.

Proteomic databases

PaxDbiO14669.
PRIDEiO14669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246794; ENSP00000246794; ENSG00000126460.
GeneIDi5639.
KEGGihsa:5639.
UCSCiuc002pon.4. human.

Organism-specific databases

CTDi5639.
DisGeNETi5639.
GeneCardsiPRRG2.
HGNCiHGNC:9470. PRRG2.
HPAiHPA010702.
MIMi604429. gene.
neXtProtiNX_O14669.
OpenTargetsiENSG00000126460.
PharmGKBiPA33825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J02V. Eukaryota.
ENOG4111S2Z. LUCA.
GeneTreeiENSGT00530000063110.
HOGENOMiHOG000115997.
HOVERGENiHBG018454.
InParanoidiO14669.
OMAiYNGKGGR.
OrthoDBiEOG091G0P8C.
PhylomeDBiO14669.
TreeFamiTF332123.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126460-MONOMER.

Miscellaneous databases

GenomeRNAii5639.
PROiO14669.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126460.
CleanExiHS_PRRG2.
ExpressionAtlasiO14669. baseline and differential.
GenevisibleiO14669. HS.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMG2_HUMAN
AccessioniPrimary (citable) accession number: O14669
Secondary accession number(s): Q6IBF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.