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Protein

Transmembrane gamma-carboxyglutamic acid protein 1

Gene

PRRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane gamma-carboxyglutamic acid protein 1
Alternative name(s):
Proline-rich gamma-carboxyglutamic acid protein 1
Short name:
Proline-rich Gla protein 1
Gene namesi
Name:PRRG1
Synonyms:PRGP1, TMG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:9469. PRRG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 8363ExtracellularSequence analysisAdd
BLAST
Transmembranei84 – 10623HelicalSequence analysisAdd
BLAST
Topological domaini107 – 218112CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular region Source: InterPro
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33824.

Polymorphism and mutation databases

BioMutaiPRRG1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 2020Sequence analysisPRO_0000022541Add
BLAST
Chaini21 – 218198Transmembrane gamma-carboxyglutamic acid protein 1PRO_0000022542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 42PROSITE-ProRule annotation

Post-translational modificationi

Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO14668.
PaxDbiO14668.
PRIDEiO14668.

PTM databases

iPTMnetiO14668.
PhosphoSiteiO14668.

Expressioni

Tissue specificityi

Highly expressed in the spinal cord.

Gene expression databases

BgeeiO14668.
CleanExiHS_PRRG1.
ExpressionAtlasiO14668. baseline and differential.
GenevisibleiO14668. HS.

Organism-specific databases

HPAiHPA056029.

Interactioni

Protein-protein interaction databases

BioGridi111621. 5 interactions.
STRINGi9606.ENSP00000367894.

Structurei

3D structure databases

ProteinModelPortaliO14668.
SMRiO14668. Positions 22-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 6646GlaPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi131 – 1355Poly-Pro

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ1X. Eukaryota.
ENOG4111T6S. LUCA.
GeneTreeiENSGT00530000063110.
HOGENOMiHOG000186286.
HOVERGENiHBG023183.
InParanoidiO14668.
OMAiSPGFLEY.
PhylomeDBiO14668.
TreeFamiTF332123.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14668-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRVFLTGEK ANSILKRYPR ANGFFEEIRQ GNIERECKEE FCTFEEAREA
60 70 80 90 100
FENNEKTKEF WSTYTKAQQG ESNRGSDWFQ FYLTFPLIFG LFIILLVIFL
110 120 130 140 150
IWRCFLRNKT RRQTVTEGHI PFPQHLNIIT PPPPPDEVFD SSGLSPGFLG
160 170 180 190 200
YVVGRSDSVS TRLSNCDPPP TYEEATGQVN LQRSETEPHL DPPPEYEDIV
210
NSNSASAIPM VPVVTTIK
Length:218
Mass (Da):24,947
Last modified:January 1, 1998 - v1
Checksum:i26538A61AB0AEB98
GO
Isoform 2 (identifier: O14668-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-82: KEFWSTYTKAQQGESNRGSDWFQFY → GLVLLPRLECSCEHGSLQPQLPVPK
     83-218: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:82
Mass (Da):9,461
Checksum:iCD37609739CFD97D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: O14668-2)
Sequence conflicti75 – 751Q → R in BC041591 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601F → I in a breast cancer sample; somatic mutation. 1 Publication
VAR_036268

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei58 – 8225KEFWS…WFQFY → GLVLLPRLECSCEHGSLQPQ LPVPK in isoform 2. 1 PublicationVSP_044789Add
BLAST
Alternative sequencei83 – 218136Missing in isoform 2. 1 PublicationVSP_044790Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009242 mRNA. Translation: AAB67070.1.
AK312904 mRNA. Translation: BAG35750.1.
AL356858 Genomic DNA. Translation: CAI40412.1.
CH471141 Genomic DNA. Translation: EAW59457.1.
CH471141 Genomic DNA. Translation: EAW59458.1.
BC041591 mRNA. No translation available.
BC060833 mRNA. Translation: AAH60833.1.
CCDSiCCDS14239.1. [O14668-1]
CCDS55397.1. [O14668-2]
RefSeqiNP_000941.1. NM_000950.2. [O14668-1]
NP_001135867.1. NM_001142395.1. [O14668-1]
NP_001166957.1. NM_001173486.1. [O14668-2]
NP_001166960.1. NM_001173489.1. [O14668-1]
NP_001166961.1. NM_001173490.1. [O14668-1]
UniGeneiHs.190341.

Genome annotation databases

EnsembliENST00000378628; ENSP00000367894; ENSG00000130962. [O14668-1]
ENST00000449135; ENSP00000390332; ENSG00000130962. [O14668-1]
ENST00000463135; ENSP00000419999; ENSG00000130962. [O14668-2]
ENST00000542554; ENSP00000444278; ENSG00000130962. [O14668-1]
ENST00000543642; ENSP00000443271; ENSG00000130962. [O14668-1]
GeneIDi5638.
KEGGihsa:5638.
UCSCiuc004ddn.4. human. [O14668-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009242 mRNA. Translation: AAB67070.1.
AK312904 mRNA. Translation: BAG35750.1.
AL356858 Genomic DNA. Translation: CAI40412.1.
CH471141 Genomic DNA. Translation: EAW59457.1.
CH471141 Genomic DNA. Translation: EAW59458.1.
BC041591 mRNA. No translation available.
BC060833 mRNA. Translation: AAH60833.1.
CCDSiCCDS14239.1. [O14668-1]
CCDS55397.1. [O14668-2]
RefSeqiNP_000941.1. NM_000950.2. [O14668-1]
NP_001135867.1. NM_001142395.1. [O14668-1]
NP_001166957.1. NM_001173486.1. [O14668-2]
NP_001166960.1. NM_001173489.1. [O14668-1]
NP_001166961.1. NM_001173490.1. [O14668-1]
UniGeneiHs.190341.

3D structure databases

ProteinModelPortaliO14668.
SMRiO14668. Positions 22-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111621. 5 interactions.
STRINGi9606.ENSP00000367894.

PTM databases

iPTMnetiO14668.
PhosphoSiteiO14668.

Polymorphism and mutation databases

BioMutaiPRRG1.

Proteomic databases

MaxQBiO14668.
PaxDbiO14668.
PRIDEiO14668.

Protocols and materials databases

DNASUi5638.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378628; ENSP00000367894; ENSG00000130962. [O14668-1]
ENST00000449135; ENSP00000390332; ENSG00000130962. [O14668-1]
ENST00000463135; ENSP00000419999; ENSG00000130962. [O14668-2]
ENST00000542554; ENSP00000444278; ENSG00000130962. [O14668-1]
ENST00000543642; ENSP00000443271; ENSG00000130962. [O14668-1]
GeneIDi5638.
KEGGihsa:5638.
UCSCiuc004ddn.4. human. [O14668-1]

Organism-specific databases

CTDi5638.
GeneCardsiPRRG1.
HGNCiHGNC:9469. PRRG1.
HPAiHPA056029.
MIMi300935. gene.
neXtProtiNX_O14668.
PharmGKBiPA33824.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ1X. Eukaryota.
ENOG4111T6S. LUCA.
GeneTreeiENSGT00530000063110.
HOGENOMiHOG000186286.
HOVERGENiHBG023183.
InParanoidiO14668.
OMAiSPGFLEY.
PhylomeDBiO14668.
TreeFamiTF332123.

Miscellaneous databases

ChiTaRSiPRRG1. human.
GenomeRNAii5638.
NextBioi21908.
PROiO14668.
SOURCEiSearch...

Gene expression databases

BgeeiO14668.
CleanExiHS_PRRG1.
ExpressionAtlasiO14668. baseline and differential.
GenevisibleiO14668. HS.

Family and domain databases

Gene3Di4.10.740.10. 1 hit.
InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
IPR000294. GLA_domain.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00001. GLABLOOD.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins."
    Kulman J.D., Harris J.E., Haldeman B.A., Davie E.W.
    Proc. Natl. Acad. Sci. U.S.A. 94:9058-9062(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Astrocytoma and Placenta.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-60.

Entry informationi

Entry nameiTMG1_HUMAN
AccessioniPrimary (citable) accession number: O14668
Secondary accession number(s): B2R7A3
, C9JXL7, D3DWA9, Q5JT66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: March 16, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.