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Protein

Syntaxin-16

Gene

STX16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.1 Publication

GO - Molecular functioni

  • SNAP receptor activity Source: HGNC
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • Golgi ribbon formation Source: UniProtKB
  • intracellular protein transport Source: GO_Central
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SIGNORiO14662

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-16
Short name:
Syn16
Gene namesi
Name:STX16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124222.21
HGNCiHGNC:11431 STX16
MIMi603666 gene
neXtProtiNX_O14662

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 301CytoplasmicSequence analysisAdd BLAST301
Transmembranei302 – 322Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini323 – 325VesicularSequence analysis3

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Pseudohypoparathyroidism 1B (PHP1B)2 Publications
The gene represented in this entry is involved in disease pathogenesis. Microdeletions involving STX16 can cause loss of methylation at exon A/B of GNAS, resulting in PHP1B.
Disease descriptionA disorder characterized by end-organ resistance to parathyroid hormone, hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH.
See also OMIM:603233

Organism-specific databases

DisGeNETi8675
MalaCardsiSTX16
MIMi603233 phenotype
OpenTargetsiENSG00000124222
Orphaneti94089 Pseudohypoparathyroidism type 1B
PharmGKBiPA36231

Polymorphism and mutation databases

BioMutaiSTX16

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102261 – 325Syntaxin-16Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14662
PaxDbiO14662
PeptideAtlasiO14662
PRIDEiO14662

PTM databases

iPTMnetiO14662
PhosphoSitePlusiO14662

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000124222
ExpressionAtlasiO14662 baseline and differential
GenevisibleiO14662 HS

Organism-specific databases

HPAiHPA041019
HPA042033

Interactioni

Subunit structurei

Interacts with GCC2.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • SNAP receptor activity Source: HGNC
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114223, 19 interactors
CORUMiO14662
DIPiDIP-57570N
IntActiO14662, 15 interactors
MINTiO14662
STRINGi9606.ENSP00000360183

Structurei

3D structure databases

ProteinModelPortaliO14662
SMRiO14662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 292t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0809 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00880000138049
HOGENOMiHOG000190358
HOVERGENiHBG057612
InParanoidiO14662
KOiK08489
OMAiRENQSSC
OrthoDBiEOG091G0GY1
PhylomeDBiO14662
TreeFamiTF314090

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR028673 STX16
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF141 PTHR19957:SF141, 1 hit
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF00804 Syntaxin, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: O14662-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRRLTDAF LLLRNNSIQN RQLLAEQVSS HITSSPLHSR SIAAELDELA
60 70 80 90 100
DDRMALVSGI SLDPEAAIGV TKRPPPKWVD GVDEIQYDVG RIKQKMKELA
110 120 130 140 150
SLHDKHLNRP TLDDSSEEEH AIEITTQEIT QLFHRCQRAV QALPSRARAC
160 170 180 190 200
SEQEGRLLGN VVASLAQALQ ELSTSFRHAQ SGYLKRMKNR EERSQHFFDT
210 220 230 240 250
SVPLMDDGDD NTLYHRGFTE DQLVLVEQNT LMVEEREREI RQIVQSISDL
260 270 280 290 300
NEIFRDLGAM IVEQGTVLDR IDYNVEQSCI KTEDGLKQLH KAEQYQKKNR
310 320
KMLVILILFV IIIVLIVVLV GVKSR
Length:325
Mass (Da):37,031
Last modified:January 24, 2006 - v3
Checksum:i65F566541A042C3C
GO
Isoform A (identifier: O14662-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-48: Missing.

Show »
Length:304
Mass (Da):34,813
Checksum:i9EEF54F753B7AB83
GO
Isoform C (identifier: O14662-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-44: Missing.
     132-132: L → A
     133-325: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:115
Mass (Da):13,018
Checksum:i51BBBACE2158720E
GO
Isoform D (identifier: O14662-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-44: Missing.

Show »
Length:308
Mass (Da):35,299
Checksum:i1915107ACB686EAA
GO
Isoform E (identifier: O14662-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-48: Missing.

Show »
Length:321
Mass (Da):36,545
Checksum:i9F8316610F6C97C0
GO
Isoform 6 (identifier: O14662-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):31,074
Checksum:i8EE1A85AE716237C
GO

Sequence cautioni

The sequence AAB69282 differs from that shown. Reason: Frameshift at positions 142, 163 and 165.Curated
The sequence AAB69283 differs from that shown. Reason: Frameshift at positions 142, 163 and 165.Curated
The sequence AAC05647 differs from that shown. Reason: Frameshift at positions 142, 163 and 165.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99L → S in AAB69282 (PubMed:9587053).Curated1
Sequence conflicti99L → S in AAB69283 (PubMed:9587053).Curated1
Sequence conflicti147A → E in AAC05647 (PubMed:9587053).Curated1
Sequence conflicti243I → M in AAB69282 (PubMed:9587053).Curated1
Sequence conflicti243I → M in AAB69283 (PubMed:9587053).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0450731 – 53Missing in isoform 6. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_00634828 – 48Missing in isoform A. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_00634928 – 44Missing in isoform C and isoform D. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_04384945 – 48Missing in isoform E. 1 Publication4
Alternative sequenceiVSP_006350132L → A in isoform C. 1 Publication1
Alternative sequenceiVSP_006351133 – 325Missing in isoform C. 1 PublicationAdd BLAST193

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008936 mRNA Translation: AAB69283.1 Frameshift.
AF008935 mRNA Translation: AAB69282.1 Frameshift.
AF008937 mRNA Translation: AAB69284.1
AF038897 mRNA Translation: AAC05647.1 Frameshift.
AL139349 Genomic DNA No translation available.
AL050327 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75481.1
CH471077 Genomic DNA Translation: EAW75482.1
CH471077 Genomic DNA Translation: EAW75484.1
CH471077 Genomic DNA Translation: EAW75485.1
CH471077 Genomic DNA Translation: EAW75486.1
BC019042 mRNA Translation: AAH19042.1
BC073876 mRNA Translation: AAH73876.1
BX396221 mRNA No translation available.
CCDSiCCDS13468.1 [O14662-1]
CCDS13469.1 [O14662-2]
CCDS46619.1 [O14662-5]
CCDS46620.1 [O14662-4]
CCDS56199.1 [O14662-6]
PIRiJC5927
RefSeqiNP_001001433.1, NM_001001433.2 [O14662-1]
NP_001128244.1, NM_001134772.2 [O14662-5]
NP_001128245.1, NM_001134773.2 [O14662-4]
NP_001191797.1, NM_001204868.1 [O14662-6]
NP_003754.2, NM_003763.5 [O14662-2]
UniGeneiHs.307913

Genome annotation databases

EnsembliENST00000355957; ENSP00000348229; ENSG00000124222 [O14662-4]
ENST00000358029; ENSP00000350723; ENSG00000124222 [O14662-5]
ENST00000359617; ENSP00000352634; ENSG00000124222 [O14662-6]
ENST00000361830; ENSP00000354445; ENSG00000124222 [O14662-6]
ENST00000371132; ENSP00000360173; ENSG00000124222 [O14662-2]
ENST00000371141; ENSP00000360183; ENSG00000124222 [O14662-1]
ENST00000467096; ENSP00000434369; ENSG00000124222 [O14662-3]
GeneIDi8675
KEGGihsa:8675
UCSCiuc002xzi.4 human [O14662-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTX16_HUMAN
AccessioniPrimary (citable) accession number: O14662
Secondary accession number(s): A6NK32
, A6NN69, A8MPP0, B7ZBN1, B7ZBN2, B7ZBN3, E1P5M0, E1P607, O14661, O14663, O60517, Q5W084, Q5W086, Q5W087, Q5XKI6, Q6GMS8, Q9H0Z0, Q9H1T7, Q9H1T8, Q9UIX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health