##gff-version 3
O14654	UniProtKB	Chain	1	1257	.	.	.	ID=PRO_0000314678;Note=Insulin receptor substrate 4	
O14654	UniProtKB	Domain	78	199	.	.	.	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145	
O14654	UniProtKB	Domain	231	335	.	.	.	Note=IRS-type PTB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00389	
O14654	UniProtKB	Region	406	653	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Region	678	921	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Region	678	800	.	.	.	Note=CRK-binding	
O14654	UniProtKB	Region	895	897	.	.	.	Note=GRB2-binding	
O14654	UniProtKB	Region	1179	1257	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Motif	487	490	.	.	.	Note=YXXM motif 1	
O14654	UniProtKB	Motif	700	703	.	.	.	Note=YXXM motif 2	
O14654	UniProtKB	Motif	717	720	.	.	.	Note=YXXM motif 3	
O14654	UniProtKB	Motif	743	746	.	.	.	Note=YXXM motif 4	
O14654	UniProtKB	Motif	779	782	.	.	.	Note=YXXM motif 5	
O14654	UniProtKB	Motif	828	831	.	.	.	Note=YXXM motif 6	
O14654	UniProtKB	Motif	921	924	.	.	.	Note=YXXM motif 7	
O14654	UniProtKB	Compositional bias	454	470	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Compositional bias	494	551	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Compositional bias	625	642	.	.	.	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Compositional bias	678	701	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Compositional bias	716	730	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Compositional bias	762	776	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Compositional bias	794	825	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Compositional bias	904	918	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Compositional bias	1220	1257	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O14654	UniProtKB	Modified residue	921	921	.	.	.	Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15316024;Dbxref=PMID:15316024	
O14654	UniProtKB	Natural variant	20	20	.	.	.	ID=VAR_038042;Note=In a colorectal cancer sample%3B somatic mutation. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974	
O14654	UniProtKB	Natural variant	34	34	.	.	.	ID=VAR_051078;Note=L->F;Dbxref=dbSNP:rs1801162	
O14654	UniProtKB	Natural variant	215	1257	.	.	.	ID=VAR_083291;Note=In CHNG9. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:30061370;Dbxref=PMID:30061370	
O14654	UniProtKB	Natural variant	215	215	.	.	.	ID=VAR_038043;Note=In a colorectal cancer sample%3B somatic mutation. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974	
O14654	UniProtKB	Natural variant	508	508	.	.	.	ID=VAR_051079;Note=N->K;Dbxref=dbSNP:rs34287560	
O14654	UniProtKB	Natural variant	557	557	.	.	.	ID=VAR_038044;Note=In a colorectal cancer sample%3B somatic mutation. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974	
O14654	UniProtKB	Natural variant	879	879	.	.	.	ID=VAR_051080;Note=H->D;Dbxref=dbSNP:rs1801164	
O14654	UniProtKB	Natural variant	1230	1230	.	.	.	ID=VAR_061669;Note=D->Y;Dbxref=dbSNP:rs28546943	
O14654	UniProtKB	Mutagenesis	700	700	.	.	.	Note=No effect. Reduces interaction with CRK by 50%25%3B when associated with F-717. Abolishes interaction with CRK%3B when associated with F-717%3B F-743 and F-779. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11316748;Dbxref=PMID:11316748	
O14654	UniProtKB	Mutagenesis	717	717	.	.	.	Note=No effect. Reduces interaction with CRK by 50%25%3B when associated with F-700. Abolishes interaction with CRK%3B when associated with F-700%3B F-743 and F-779. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11316748;Dbxref=PMID:11316748	
O14654	UniProtKB	Mutagenesis	743	743	.	.	.	Note=No effect. Reduces interaction with CRK by 50%25%3B when associated with F-779. Abolishes interaction with CRK%3B when associated with F-700%3B F-717 and F-779. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11316748;Dbxref=PMID:11316748	
O14654	UniProtKB	Mutagenesis	779	779	.	.	.	Note=No effect. Reduces interaction with CRK by 50%25%3B when associated with F-743. Abolishes interaction with CRK%3B when associated with F-700%3B F-717 and F-743. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11316748;Dbxref=PMID:11316748