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O14654

- IRS4_HUMAN

UniProt

O14654 - IRS4_HUMAN

Protein

Insulin receptor substrate 4

Gene

IRS4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.5 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. SH3/SH2 adaptor activity Source: ProtInc
    3. signal transducer activity Source: ProtInc

    GO - Biological processi

    1. positive regulation of signal transduction Source: GOC
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_150203. IRS-related events triggered by IGF1R.
    SignaLinkiO14654.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin receptor substrate 4
    Short name:
    IRS-4
    Alternative name(s):
    160 kDa phosphotyrosine protein
    Short name:
    py160
    Phosphoprotein of 160 kDa
    Short name:
    pp160
    Gene namesi
    Name:IRS4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:6128. IRS4.

    Subcellular locationi

    Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

    GO - Cellular componenti

    1. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi700 – 7001Y → F: No effect. Reduces interaction with CRK by 50%; when associated with F-717. Abolishes interaction with CRK; when associated with F-717; F-743 and F-779. 1 Publication
    Mutagenesisi717 – 7171Y → F: No effect. Reduces interaction with CRK by 50%; when associated with F-700. Abolishes interaction with CRK; when associated with F-700; F-743 and F-779. 1 Publication
    Mutagenesisi743 – 7431Y → F: No effect. Reduces interaction with CRK by 50%; when associated with F-779. Abolishes interaction with CRK; when associated with F-700; F-717 and F-779. 1 Publication
    Mutagenesisi779 – 7791Y → F: No effect. Reduces interaction with CRK by 50%; when associated with F-743. Abolishes interaction with CRK; when associated with F-700; F-717 and F-743. 1 Publication

    Organism-specific databases

    PharmGKBiPA29923.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12571257Insulin receptor substrate 4PRO_0000314678Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei921 – 9211Phosphotyrosine1 Publication

    Post-translational modificationi

    Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-921 in response to FGF2 signaling. Phosphorylation of Tyr-921 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO14654.
    PaxDbiO14654.
    PRIDEiO14654.

    PTM databases

    PhosphoSiteiO14654.

    Expressioni

    Tissue specificityi

    Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma.2 Publications

    Inductioni

    Down-regulated by PPP4C in a phosphatase activity-dependent manner.1 Publication

    Gene expression databases

    BgeeiO14654.
    CleanExiHS_IRS4.
    GenevestigatoriO14654.

    Organism-specific databases

    HPAiHPA017372.

    Interactioni

    Subunit structurei

    Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1 By similarity. Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with GRB2 and PIK3R1. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH.By similarity8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CRKP461088EBI-356594,EBI-886
    EGFRP005332EBI-356594,EBI-297353
    PTGES3Q151852EBI-356594,EBI-1049387

    Protein-protein interaction databases

    BioGridi114048. 35 interactions.
    IntActiO14654. 81 interactions.
    MINTiMINT-1151881.
    STRINGi9606.ENSP00000361202.

    Structurei

    3D structure databases

    ProteinModelPortaliO14654.
    SMRiO14654. Positions 78-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini78 – 199122PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 335105IRS-type PTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni678 – 800123CRK-bindingAdd
    BLAST
    Regioni895 – 8973GRB2-binding

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi487 – 4904YXXM motif 1
    Motifi700 – 7034YXXM motif 2
    Motifi717 – 7204YXXM motif 3
    Motifi743 – 7464YXXM motif 4
    Motifi779 – 7824YXXM motif 5
    Motifi828 – 8314YXXM motif 6
    Motifi921 – 9244YXXM motif 7

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 2811Poly-AlaAdd
    BLAST
    Compositional biasi124 – 13714Ala-richAdd
    BLAST
    Compositional biasi218 – 2269Poly-Ala
    Compositional biasi628 – 63912Pro-richAdd
    BLAST
    Compositional biasi1094 – 1212119Ala-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG81285.
    HOGENOMiHOG000113104.
    HOVERGENiHBG107140.
    InParanoidiO14654.
    KOiK17446.
    OMAiRCGHSEQ.
    OrthoDBiEOG7XM2X6.
    PhylomeDBiO14654.
    TreeFamiTF325994.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    InterProiIPR002404. Insln_rcpt_S1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF02174. IRS. 1 hit.
    [Graphical view]
    PRINTSiPR00628. INSULINRSI.
    SMARTiSM00233. PH. 1 hit.
    SM00310. PTBI. 1 hit.
    [Graphical view]
    PROSITEiPS51064. IRS_PTB. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14654-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASCSFTRDQ ATRRLRGAAA AAAAALAAVV TTPLLSSGTP TALIGTGSSC     50
    PGAMWLSTAT GSRSDSESEE EDLPVGEEVC KRGYLRKQKH GHRRYFVLKL 100
    ETADAPARLE YYENARKFRH SVRAAAAAAA AAASGAAIPP LIPPRRVITL 150
    YQCFSVSQRA DARYRHLIAL FTQDEYFAMV AENESEQESW YLLLSRLILE 200
    SKRRRCGTLG AQPDGEPAAL AAAAAAEPPF YKDVWQVIVK PRGLGHRKEL 250
    SGVFRLCLTD EEVVFVRLNT EVASVVVQLL SIRRCGHSEQ YFFLEVGRST 300
    VIGPGELWMQ VDDCVVAQNM HELFLEKMRA LCADEYRARC RSYSISIGAH 350
    LLTLLSARRH LGLVPLEPGG WLRRSRFEQF CHLRAIGDGE DEMLFTRRFV 400
    TPSEPVAHSR RGRLHLPRGR RSRRAVSVPA SFFRRLAPSP ARPRHPAEAP 450
    NNGARLSSEV SGSGSGNFGE EGNPQGKEDQ EGSGGDYMPM NNWGSGNGRG 500
    SGGGQGSNGQ GSSSHSSGGN QCSGEGQGSR GGQGSNGQGS GGNQCSRDGQ 550
    GTAGGHGSGG GQRPGGGHGS GGGQGPGDGH GSGGGKNSGG GKGSGSGKGS 600
    DGDGERGKSL KKRSYFGKLT QSKQQQMPPP PPPPPPPPPA GGTGGKGKSG 650
    GRFRLYFCVD RGATKECKEA KEVKDAEIPE GAARGPHRAR AFDEDEDDPY 700
    VPMRPGVATP LVSSSDYMPM APQNVSASKK RHSRSPFEDS RGYMMMFPRV 750
    SPPPAPSPPK APDTNKEDDS KDNDSESDYM FMAPGAGAIP KNPRNPQGGS 800
    SSKSWSSYFS LPNPFRSSPL GQNDNSEYVP MLPGKFLGRG LDKEVSYNWD 850
    PKDAASKPSG EGSFSKPGDG GSPSKPSDHE PPKNKAKRPN RLSFITKGYK 900
    IKPKPQKPTH EQREADSSSD YVNMDFTKRE SNTPAPSTQG LPDSWGIIAE 950
    PRQSAFSNYV NVEFGVPFPN PANDLSDLLR AIPRANPLSL DSARWPLPPL 1000
    PLSATGSNAI EEEGDYIEVI FNSAMTPAMA LADSAIRYDA ETGRIYVVDP 1050
    FSECCMDISL SPSRCSEPPP VARLLQEEEQ ERRRPQSRSQ SFFAAARAAV 1100
    SAFPTDSLER DLSPSSAPAV ASAAEPTLAL SQVVAAASAL AAAPGIGAAA 1150
    AAAGFDSASA RWFQPVANAA DAEAVRGAQD VAGGSNPGAH NPSANLARGD 1200
    NQAGGAAAAA AAPEPPPRSR RVPRPPERED SDNDDDTHVR MDFARRDNQF 1250
    DSPKRGR 1257
    Length:1,257
    Mass (Da):133,768
    Last modified:January 1, 1998 - v1
    Checksum:i4D512D65A7A80374
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti20 – 201A → V in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_038042
    Natural varianti34 – 341L → F.
    Corresponds to variant rs1801162 [ dbSNP | Ensembl ].
    VAR_051078
    Natural varianti215 – 2151G → E in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_038043
    Natural varianti508 – 5081N → K.
    Corresponds to variant rs34287560 [ dbSNP | Ensembl ].
    VAR_051079
    Natural varianti557 – 5571G → R in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_038044
    Natural varianti879 – 8791H → D.
    Corresponds to variant rs1801164 [ dbSNP | Ensembl ].
    VAR_051080
    Natural varianti1230 – 12301D → Y.
    Corresponds to variant rs28546943 [ dbSNP | Ensembl ].
    VAR_061669

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007567 mRNA. Translation: AAC51738.1.
    AL035425 Genomic DNA. Translation: CAB90290.1.
    CH471120 Genomic DNA. Translation: EAX02682.1.
    CCDSiCCDS14544.1.
    RefSeqiNP_003595.1. NM_003604.2.
    UniGeneiHs.460872.

    Genome annotation databases

    EnsembliENST00000372129; ENSP00000361202; ENSG00000133124.
    GeneIDi8471.
    KEGGihsa:8471.
    UCSCiuc004eoc.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007567 mRNA. Translation: AAC51738.1 .
    AL035425 Genomic DNA. Translation: CAB90290.1 .
    CH471120 Genomic DNA. Translation: EAX02682.1 .
    CCDSi CCDS14544.1.
    RefSeqi NP_003595.1. NM_003604.2.
    UniGenei Hs.460872.

    3D structure databases

    ProteinModelPortali O14654.
    SMRi O14654. Positions 78-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114048. 35 interactions.
    IntActi O14654. 81 interactions.
    MINTi MINT-1151881.
    STRINGi 9606.ENSP00000361202.

    PTM databases

    PhosphoSitei O14654.

    Proteomic databases

    MaxQBi O14654.
    PaxDbi O14654.
    PRIDEi O14654.

    Protocols and materials databases

    DNASUi 8471.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372129 ; ENSP00000361202 ; ENSG00000133124 .
    GeneIDi 8471.
    KEGGi hsa:8471.
    UCSCi uc004eoc.2. human.

    Organism-specific databases

    CTDi 8471.
    GeneCardsi GC0XM107975.
    HGNCi HGNC:6128. IRS4.
    HPAi HPA017372.
    MIMi 300904. gene.
    neXtProti NX_O14654.
    PharmGKBi PA29923.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81285.
    HOGENOMi HOG000113104.
    HOVERGENi HBG107140.
    InParanoidi O14654.
    KOi K17446.
    OMAi RCGHSEQ.
    OrthoDBi EOG7XM2X6.
    PhylomeDBi O14654.
    TreeFami TF325994.

    Enzyme and pathway databases

    Reactomei REACT_150203. IRS-related events triggered by IGF1R.
    SignaLinki O14654.

    Miscellaneous databases

    GeneWikii IRS4.
    GenomeRNAii 8471.
    NextBioi 31702.
    PROi O14654.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14654.
    CleanExi HS_IRS4.
    Genevestigatori O14654.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    InterProi IPR002404. Insln_rcpt_S1.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF02174. IRS. 1 hit.
    [Graphical view ]
    PRINTSi PR00628. INSULINRSI.
    SMARTi SM00233. PH. 1 hit.
    SM00310. PTBI. 1 hit.
    [Graphical view ]
    PROSITEi PS51064. IRS_PTB. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family."
      Lavan B.E., Fantin V.R., Chang E.T., Lane W.S., Keller S.R., Lienhard G.E.
      J. Biol. Chem. 272:21403-21407(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 100-117; 233-240; 613-618; 836-843 AND 844-852, PHOSPHORYLATION.
      Tissue: Kidney.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells."
      Fantin V.R., Sparling J.D., Slot J.W., Keller S.R., Lienhard G.E., Lavan B.E.
      J. Biol. Chem. 273:10726-10732(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GRB2 AND PIK3R1, PHOSPHORYLATION.
    5. "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction."
      Koval A.P., Karas M., Zick Y., LeRoith D.
      J. Biol. Chem. 273:14780-14787(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRK AND CRKL.
    6. "Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation."
      Qu B.-H., Karas M., Koval A., LeRoith D.
      J. Biol. Chem. 274:31179-31184(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis."
      Uchida T., Myers M.G. Jr., White M.F.
      Mol. Cell. Biol. 20:126-138(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GRB2 AND PIK3R1.
    8. "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II."
      Karas M., Koval A.P., Zick Y., LeRoith D.
      Endocrinology 142:1835-1840(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRK, MUTAGENESIS OF TYR-700; TYR-717; TYR-743 AND TYR-779.
    9. "Insulin receptor substrate 4 associates with the protein IRAS."
      Sano H., Liu S.C.H., Lane W.S., Piletz J.E., Lienhard G.E.
      J. Biol. Chem. 277:19439-19447(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NISCH.
    10. "Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor."
      Schreyer S., Ledwig D., Rakatzi I., Kloeting I., Eckel J.
      Endocrinology 144:1211-1218(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    11. "Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4."
      Hinsby A.M., Olsen J.V., Mann M.
      J. Biol. Chem. 279:46438-46447(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-921, INTERACTION WITH SHC1; GRB2; PHOSPHOLIPASE C-GAMMA AND PHOSPHATIDYLINOSITOL 3-KINASE, IDENTIFICATION BY MASS SPECTROMETRY.
    12. "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation."
      Mihindukulasuriya K.A., Zhou G., Qin J., Tan T.-H.
      J. Biol. Chem. 279:46588-46594(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPP4C, INDUCTION, IDENTIFICATION BY MASS SPECTROMETRY.
    13. "Interaction between Brk kinase and insulin receptor substrate-4."
      Qiu H., Zappacosta F., Su W., Annan R.S., Miller W.T.
      Oncogene 24:5656-5664(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTK6, IDENTIFICATION BY MASS SPECTROMETRY.
    14. "Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation."
      Cuevas E.P., Escribano O., Chiloeches A., Ramirez Rubio S., Roman I.D., Fernandez-Moreno M.D., Guijarro L.G.
      J. Hepatol. 46:1089-1098(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-20; GLU-215 AND ARG-557.

    Entry informationi

    Entry nameiIRS4_HUMAN
    AccessioniPrimary (citable) accession number: O14654
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3